Detailed information for compound 1660886

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 546.654 | Formula: C32H38N2O6
  • H donors: 2 H acceptors: 4 LogP: 3.56 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(CN1CCN(CC1)CC(COc1ccc(cc1C(=O)C)C)O)COc1ccccc1C(=O)c1ccccc1
  • InChi: 1S/C32H38N2O6/c1-23-12-13-31(29(18-23)24(2)35)40-22-27(37)20-34-16-14-33(15-17-34)19-26(36)21-39-30-11-7-6-10-28(30)32(38)25-8-4-3-5-9-25/h3-13,18,26-27,36-37H,14-17,19-22H2,1-2H3
  • InChiKey: OWJOVPIFAIJRFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0612 0.4759 0.684
Trichomonas vaginalis ABC transporter, putative 0.0013 0 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 0 0.5
Loa Loa (eye worm) steroid hormone receptor 0.1228 0.9654 0.9654
Loa Loa (eye worm) hypothetical protein 0.0339 0.2595 0.2595
Loa Loa (eye worm) hypothetical protein 0.0339 0.2595 0.2595
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0339 0.2595 0.2595
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0612 0.4759 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0612 0.4759 0.684
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Brugia malayi hypothetical protein 0.0339 0.2595 0.2595
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0 0.5
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0612 0.4759 0.4759
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0612 0.4759 0.4759
Brugia malayi Nuclear hormone receptor E75 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0612 0.4759 0.4759
Leishmania major p-glycoprotein 0.0013 0 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0612 0.4759 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0612 0.4759 0.4759
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0612 0.4759 0.4759
Brugia malayi photoreceptor-specific nuclear receptor 0.0612 0.4759 0.4759
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Schistosoma mansoni nuclear receptor 0.0272 0.2062 0.4333
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0339 0.2595 0.5454
Trichomonas vaginalis abcb9, putative 0.0013 0 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0612 0.4759 1
Loa Loa (eye worm) hypothetical protein 0.0339 0.2595 0.2595
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0612 0.4759 0.4759
Schistosoma mansoni nuclear receptor 0.0272 0.2062 0.4333
Echinococcus granulosus ecdysone induced protein 78C 0.0612 0.4759 0.684
Brugia malayi nuclear receptor NHR-88 0.0272 0.2062 0.2062
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Brugia malayi nuclear hormone receptor 0.0612 0.4759 0.4759
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0272 0.2062 0.2062
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0612 0.4759 0.4759
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0612 0.4759 0.684
Brugia malayi Nuclear hormone receptor E75 0.0272 0.2062 0.2062
Echinococcus granulosus Nuclear hormone receptor HR96 0.0272 0.2062 0.2964
Echinococcus multilocularis FTZ F1 alpha 0.0612 0.4759 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0272 0.2062 0.4333
Schistosoma mansoni coup transcription factor 0.0612 0.4759 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Loa Loa (eye worm) DR-78 0.0272 0.2062 0.2062
Brugia malayi nuclear hormone receptor family member odr-7 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Brugia malayi nuclear hormone receptor 0.0272 0.2062 0.2062
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Loa Loa (eye worm) nuclear receptor NHR-67 0.0272 0.2062 0.2062
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0272 0.2062 0.4333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0612 0.4759 0.684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0612 0.4759 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0272 0.2062 0.2062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0339 0.2595 0.5454
Entamoeba histolytica P-glycoprotein-5 0.0013 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0612 0.4759 0.4759
Trichomonas vaginalis taga, putative 0.0013 0 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0339 0.2595 0.5454
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0272 0.2062 0.4333
Echinococcus granulosus Nuclear hormone receptor HR96 0.0272 0.2062 0.2964
Schistosoma mansoni steroid hormone receptor ad4bp 0.0612 0.4759 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0612 0.4759 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0272 0.2062 0.4333
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0612 0.4759 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0272 0.2062 0.2964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0612 0.4759 0.4759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0612 0.4759 0.4759
Brugia malayi Nuclear hormone receptor-like 1 0.0612 0.4759 0.4759
Schistosoma mansoni nuclear receptor nhr-48 0.0272 0.2062 0.4333
Trichomonas vaginalis ABC transporter, putative 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0612 0.4759 0.4759
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0612 0.4759 0.4759
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0272 0.2062 0.4333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0612 0.4759 0.4759
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0612 0.4759 1
Brugia malayi Nuclear hormone receptor-like 1 0.0339 0.2595 0.2595
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0612 0.4759 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0 0.5
Brugia malayi nuclear receptor NHR-67 0.0272 0.2062 0.2062
Brugia malayi hypothetical protein 0.0272 0.2062 0.2062
Brugia malayi Nuclear hormone receptor-like 1 0.0339 0.2595 0.2595
Loa Loa (eye worm) hypothetical protein 0.0339 0.2595 0.2595
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0272 0.2062 0.4333
Onchocerca volvulus Protein ultraspiracle homolog 0.0612 0.4759 0.4759
Echinococcus multilocularis thyroid hormone receptor alpha 0.0612 0.4759 1
Brugia malayi hypothetical protein 0.0272 0.2062 0.2062
Trichomonas vaginalis abcb9, putative 0.0013 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0612 0.4759 0.4759
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0612 0.4759 0.4759
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0612 0.4759 0.4759
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0612 0.4759 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0612 0.4759 1
Brugia malayi tailless protein 0.0272 0.2062 0.2062
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.0888 0.6957 1
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0612 0.4759 0.4759
Schistosoma mansoni nuclear hormone receptor 0.0272 0.2062 0.4333
Brugia malayi nuclear receptor RXR 0.0272 0.2062 0.2062
Echinococcus multilocularis ecdysone induced protein 78C 0.0612 0.4759 1
Brugia malayi nuclear receptor RXR 0.0339 0.2595 0.2595
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0612 0.4759 0.4759
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0612 0.4759 0.684
Onchocerca volvulus 0.0612 0.4759 0.4759
Brugia malayi conserved hypotetical protein 0.0272 0.2062 0.2062
Trichomonas vaginalis ABC transporter, putative 0.0013 0 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0339 0.2595 0.2595
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0612 0.4759 0.4759
Onchocerca volvulus 0.0272 0.2062 0.2062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Entamoeba histolytica P-glycoprotein-2 0.0013 0 0.5
Onchocerca volvulus Bile acid receptor homolog 0.1271 1 1
Schistosoma mansoni zinc finger protein 0.0272 0.2062 0.4333
Echinococcus multilocularis nuclear receptor nhr 48 0.0272 0.2062 0.4333
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0272 0.2062 0.4333
Brugia malayi steroid hormone receptor 0.1228 0.9654 0.9654
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0272 0.2062 0.4333
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0612 0.4759 0.4759
Echinococcus granulosus nuclear receptor nhr 48 0.0272 0.2062 0.2964
Brugia malayi orphan nuclear receptor NR2E1 0.0272 0.2062 0.2062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0612 0.4759 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0339 0.2595 0.373
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0272 0.2062 0.2964
Schistosoma mansoni thyroid hormone receptor 0.0612 0.4759 1
Schistosoma mansoni nuclear hormone receptor 0.0612 0.4759 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0612 0.4759 0.684
Schistosoma mansoni RAR-like nuclear receptor 0.0612 0.4759 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0612 0.4759 0.4759
Trichomonas vaginalis abcb9, putative 0.0013 0 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0272 0.2062 0.2062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0612 0.4759 0.4759
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0612 0.4759 0.684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0612 0.4759 0.4759
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0272 0.2062 0.2062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0612 0.4759 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0612 0.4759 0.684
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.0612 0.4759 1
Entamoeba histolytica P-glycoprotein-1 0.0013 0 0.5
Plasmodium falciparum multidrug resistance protein 1 0.0013 0 0.5
Brugia malayi hypothetical protein 0.0339 0.2595 0.2595
Brugia malayi Steroid receptor seven-up type 2 0.0612 0.4759 0.4759
Loa Loa (eye worm) hypothetical protein 0.1271 1 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Loa Loa (eye worm) nuclear hormone receptor 0.0272 0.2062 0.2062
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0 0.5
Onchocerca volvulus 0.0272 0.2062 0.2062
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0272 0.2062 0.2062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0612 0.4759 1
Brugia malayi ecdysone receptor 0.0272 0.2062 0.2062

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.48 uM Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis ChEMBL. 22452412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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