TDR Targets

Basic information

Technical information

TDR Targets ID: 166133
Name: 7-amino-6-chloro-3-(8-methyl-8-azabicyclo[3.2 .1]octan-3-yl)-1,2,3-benzotriazin-4-one
MW: 319.789 | Formula: C15H18ClN5O
H donors: 1 H acceptors: 1 LogP: 2.73 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1C2CCC1CC(C2)n1nnc2c(c1=O)cc(c(c2)N)Cl
InChi: 1S/C15H18ClN5O/c1-20-8-2-3-9(20)5-10(4-8)21-15(22)11-6-12(16)13(17)7-14(11)18-19-21/h6-10H,2-5,17H2,1H3
InChiKey: LBPYTDJACAWXKH-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

7-azanyl-6-chloro-3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-1,2,3-benzotriazin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.3602	1
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Leishmania major	glucose transporter, lmgt1	0.0016	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.3602	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0	0.5
Brugia malayi	conserved hypotetical protein	0.0017	0.0208	0.0579
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.3602	0.3602
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Trypanosoma cruzi	sugar transporter, putative	0.0016	0	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Brugia malayi	steroid hormone receptor	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Schistosoma mansoni	coup transcription factor	0.0036	0.3602	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.3602	0.3602
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0208	0.0579
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Brugia malayi	nuclear hormone receptor	0.0017	0.0208	0.0579
Brugia malayi	ecdysone receptor	0.0017	0.0208	0.0579
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.3602	0.3602
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.3602	1
Brugia malayi	hypothetical protein	0.0019	0.0572	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Giardia lamblia	Sugar-proton symporter	0.0016	0	0.5
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0016	0	0.5
Brugia malayi	hypothetical protein	0.0017	0.0208	0.0579
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.3602	1
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trypanosoma brucei	glucose transporter 2A	0.0016	0	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Plasmodium falciparum	hexose transporter	0.0016	0	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Leishmania major	hypothetical protein, conserved	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0208	0.0208
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.3602	1
Brugia malayi	nuclear receptor RXR	0.0019	0.0572	0.1588
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.3602	0.3602
Toxoplasma gondii	facilitative glucose transporter GT1	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0572	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.3602	1
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.3602	0.3602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.3602	1
Leishmania major	glucose transporter, lmgt2	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.3602	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0208	0.0208
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Brugia malayi	nuclear receptor NHR-88	0.0036	0.3602	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0208	0.0579
Schistosoma mansoni	nuclear receptor	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Brugia malayi	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.3602	1
Leishmania major	glucose transporter, lmgt3	0.0016	0	0.5
Brugia malayi	nuclear receptor RXR	0.0017	0.0208	0.0579
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.3602	1
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.3602	0.3602
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0208	0.0579
Schistosoma mansoni	nuclear receptor	0.0017	0.0208	0.0579
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0208	0.0579
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Plasmodium vivax	hexose transporter	0.0016	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trypanosoma cruzi	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.3602	1
Loa Loa (eye worm)	DR-78	0.0017	0.0208	0.0579
Trypanosoma cruzi	hexose transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0208	0.0208
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.3602	0.3602
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.3602	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0208	0.0579
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.3602	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0208	0.0579
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Toxoplasma gondii	sugar transporter ST1	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.3602	0.3602
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.3602	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0208	0.0579
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0572	0.1588
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Giardia lamblia	Hexose transporter	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0208	0.0208
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.3602	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0208	0.0208
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.3602	1
Trypanosoma brucei	glucose transporter 1E	0.0016	0	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.3602	0.3602
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0208	0.0208
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Toxoplasma gondii	sugar transporter ST3	0.0016	0	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.3602	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.3602	1
Brugia malayi	ecdysteroid receptor	0.0036	0.3602	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.3602	0.3602
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Mycobacterium ulcerans	sugar transporter	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.3602	1
Plasmodium vivax	sugar transporter, putative	0.0016	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0572	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Onchocerca volvulus		0.0017	0.0208	0.0579
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0208	0.0579
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0208	0.0579
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.3602	1
Brugia malayi	hypothetical protein	0.0019	0.0572	0.1588
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.3602	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0572	0.1588
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0	0.5
Schistosoma mansoni	zinc finger protein	0.0017	0.0208	0.0579
Trypanosoma brucei	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Trypanosoma cruzi	hexose transporter	0.0016	0	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0016	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0208	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Brugia malayi	nuclear hormone receptor	0.0036	0.3602	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0208	0.0579
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.3602	0.3602
Toxoplasma gondii	sugar transporter ST2	0.0016	0	0.5
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0	0.5
Brugia malayi	tailless protein	0.0017	0.0208	0.0579
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.3602	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.3602	0.3602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.3602	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0208	0.0208
Trichomonas vaginalis	sugar transporter, putative	0.0016	0	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0017	0.0208	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.3602	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0572	0.1588
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0572	0.0572
Onchocerca volvulus		0.0017	0.0208	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3602	1
Trypanosoma brucei	glucose transporter, putative	0.0016	0	0.5
Onchocerca volvulus		0.0036	0.3602	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 0.17 ug kg-1	Antagonistic activity against 5-hydroxytryptamine 3 receptor as inhibition of 5-HT-induced bradycardia (von Bezold-jarisch reflex) in anesthetized rat	ChEMBL.	2231593
ID50 (functional)	= 0.17 ug kg-1	Antagonistic activity against 5-hydroxytryptamine 3 receptor as inhibition of 5-HT-induced bradycardia (von Bezold-jarisch reflex) in anesthetized rat	ChEMBL.	2231593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 15634093

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 166133