TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.41 | Formula: C21H20N4O2
H donors: 1 H acceptors: 3 LogP: 2.9 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [11CH3]Oc1ncccc1c1cccc2c1nc1CN(C(=O)c1c2N)C1CCC1
InChi: 1S/C21H20N4O2/c1-27-20-14(9-4-10-23-20)13-7-3-8-15-18(22)17-16(24-19(13)15)11-25(21(17)26)12-5-2-6-12/h3-4,7-10,12H,2,5-6,11H2,1H3,(H2,22,24)/i1-1
InChiKey: NRBRKRZMKXLHTR-BJUDXGSMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine kinase	0.0123	0.9983	0.9983
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0531	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.6008	1
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Onchocerca volvulus		0.0046	0.3203	0.2827
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.6549	0.656
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0531	0.0531
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0531	0.0532
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0077	0.5991	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Srms	0.0123	0.9983	0.9983
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0123	0.9983	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosin kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0077	0.5991	0.5991
Giardia lamblia	Kinase, NEK	0.0077	0.5991	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0046	0.3203	0.3209
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	insulin receptor	0.0077	0.5991	0.6001
Entamoeba histolytica	ankyrin repeat protein	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0531	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0046	0.322	0.3226
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0077	0.5991	0.9972
Loa Loa (eye worm)	serine/threonine protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.3203	0.3209
Echinococcus multilocularis	SHC transforming protein 3	0.0046	0.3203	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Tensin	0.0046	0.3203	0.3209
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0077	0.5991	0.6001
Loa Loa (eye worm)	SH2 domain-containing protein	0.0046	0.3203	0.3209
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0531	0.0532
Echinococcus granulosus	tyrosine protein kinase Blk	0.0123	0.9983	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0077	0.5991	0.5
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0042	0.285	0.2855
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0531	0.0532
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0531	0.0532
Echinococcus granulosus	expressed conserved protein	0.0046	0.3203	0.3203
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	ephrin receptor	0.0077	0.5991	0.6001
Schistosoma mansoni	tensin-related	0.0046	0.3203	0.3209
Schistosoma mansoni	hypothetical protein	0.0077	0.5991	0.6001
Brugia malayi	Receptor family ligand binding region containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/ACK protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	receptor protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.5991	0.6001
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0046	0.3203	0.3203
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0531	0.0532
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0046	0.3203	0.3209
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0077	0.5991	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0077	0.5991	0.6001
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0077	0.5991	0.6001
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0531	0.0531
Echinococcus granulosus	tyrosine protein kinase HCK	0.0077	0.5991	0.5991
Schistosoma mansoni	ephrin receptor	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0052	0.3761	0.3767
Brugia malayi	ephrin receptor 1 precursor	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/DDR protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	atypical protein kinase C	0.0015	0.0558	0.0559
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0046	0.3203	0.3203
Echinococcus granulosus	c src tyrosine kinase	0.0123	0.9983	0.9983
Loa Loa (eye worm)	TK/CSK protein kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0123	0.9983	0.9983
Loa Loa (eye worm)	SH2 domain-containing protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Schistosoma mansoni	hypothetical protein	0.0046	0.3203	0.3209
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0531	0.0532
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Onchocerca volvulus	Tyrosine kinase homolog	0.0077	0.5991	0.5776
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0046	0.3203	0.3209
Echinococcus granulosus	tyrosine protein kinase	0.0077	0.5991	0.5991
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	growth factor receptor bound protein 2	0.0046	0.3203	0.3203
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	receptor type guanylyl cyclase	0.0077	0.5991	0.5991
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0046	0.3203	0.3209
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0077	0.5991	0.6001
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0531	0.0532
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0123	0.9983	1
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.3203	0.3209
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0123	0.9983	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0046	0.3203	0.3209
Echinococcus granulosus	integrin linked protein kinase	0.0077	0.5991	0.5991
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0531	0.0532
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0077	0.5991	0.6001
Echinococcus multilocularis	integrin linked protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	tyrosine protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	GTPase activating protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0531	0.0532
Entamoeba histolytica	protein kinase domain containing protein	0.0078	0.6008	0.6018
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0046	0.3203	0.2827
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0077	0.5991	0.6001
Entamoeba histolytica	SH2 domain containing protein	0.0046	0.3203	0.3209
Onchocerca volvulus		0.0123	0.9983	1
Echinococcus multilocularis	protein tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.5991	0.6001
Schistosoma mansoni	suppressor of cytokine signaling	0.0046	0.3203	0.3209
Echinococcus multilocularis	FL cytokine receptor	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	shc transforming protein	0.0046	0.3203	0.3209
Toxoplasma gondii	protein kinase domain-containing protein	0.0077	0.5991	0.9972
Brugia malayi	Protein kinase domain containing protein	0.0123	0.9983	1
Trichomonas vaginalis	CAMK family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0052	0.3761	0.3767
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0077	0.5991	0.6001
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0123	0.9983	0.9983
Trichomonas vaginalis	protein kinase atn1, putative	0.0077	0.5991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.3203	0.3209
Schistosoma mansoni	tensin	0.0046	0.3203	0.3209
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	N chimaerin	0.0052	0.3761	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	activin receptor type	0.0078	0.6008	0.6008
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0052	0.3761	0.3767
Toxoplasma gondii	protein kinase	0.0077	0.5991	0.9972
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0531	0.0531
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0123	0.9983	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0047	0.3319	0.3325
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	hypothetical protein	0.0046	0.3203	0.3209
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0531	0.0531
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0531	0.0532
Giardia lamblia	Protein 21.1	0.0077	0.5991	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0077	0.5991	0.5991
Echinococcus multilocularis	signal transduction protein lnk realted	0.0046	0.3203	0.3209
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0531	0.0531
Brugia malayi	Cation transporter family protein	0.0015	0.0531	0.0532
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0123	0.9983	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	STE family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0077	0.5991	1
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0531	0.0531
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0123	0.9983	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0123	0.9983	1
Giardia lamblia	Kinase	0.0077	0.5991	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0046	0.3203	0.3209
Brugia malayi	hypothetical protein	0.0123	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0531	0.0532
Echinococcus multilocularis	tyrosine protein kinase csk	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0123	0.9983	0.9983
Entamoeba histolytica	receptor protein kinase, putative	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0123	0.9983	0.9983
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0046	0.3203	0.3203
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Plasmodium falciparum	protein kinase, putative	0.0078	0.6008	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0077	0.5991	0.6001
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	activated cdc42 kinase 1	0.0077	0.5991	0.5991
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	vav2	0.0052	0.3761	0.3767
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0077	0.5991	0.5991
Schistosoma mansoni	serine/threonine RGC	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine kinase	0.0077	0.5991	0.5991
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Brugia malayi	hypothetical protein	0.0077	0.5991	0.6001
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0123	0.9983	1
Echinococcus granulosus	protein kinase	0.0077	0.5991	0.5991
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0531	0.0532
Entamoeba histolytica	ankyrin repeat protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Brugia malayi	Cation transporter family protein	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.3203	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0046	0.3203	0.3203
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Trichomonas vaginalis	TK family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Onchocerca volvulus		0.0077	0.5991	0.5776
Echinococcus granulosus	natriuretic peptide receptor 1	0.0077	0.5991	0.5991
Schistosoma mansoni	tensin	0.0046	0.3203	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine protein kinase csk	0.0077	0.5991	0.6001
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Onchocerca volvulus		0.0046	0.3203	0.2827
Loa Loa (eye worm)	SRC-1	0.0123	0.9983	1
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0077	0.5991	0.6001
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0052	0.3761	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0077	0.5991	0.5991
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Entamoeba histolytica	tyrosin kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0077	0.5991	0.5991
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0531	0.0532
Brugia malayi	SH2 domain containing protein	0.0123	0.9983	1
Brugia malayi	RhoGAP domain containing protein	0.0052	0.3761	0.3767
Schistosoma mansoni	nck2/grb4	0.0046	0.3203	0.3209
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0078	0.6008	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0077	0.5991	0.5991
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0077	0.5991	0.6001
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0674	0.0675
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0046	0.3203	0.3203
Schistosoma mansoni	adapter molecule crk	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0046	0.3203	0.3203
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0077	0.5991	0.5991
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosin kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	activated cdc42 kinase 1	0.0077	0.5991	0.6001
Echinococcus granulosus	signal transduction protein lnk realted	0.0046	0.3203	0.3203
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0123	0.9983	0.9983
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	activated cdc42 kinase 1	0.0077	0.5991	0.5991
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0123	0.9983	1
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0046	0.3203	0.3209
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0531	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase c protein 2	0.0049	0.3541	0.3547
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0077	0.5991	0.9972
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0123	0.9983	1
Brugia malayi	Raf kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Plasmodium vivax	protein kinase, putative	0.0077	0.5991	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Giardia lamblia	Kinase, NEK	0.0077	0.5991	0.5
Brugia malayi	hypothetical protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	protein kinase c epsilon type	0.0017	0.0674	0.0675
Echinococcus granulosus	nAChR subunit	0.0015	0.0531	0.0531
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tensin	0.0046	0.3203	0.3209
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Guanylyl cyclase protein 23	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	hypothetical protein, conserved	0.0077	0.5991	0.6001
Echinococcus multilocularis	serine threonine protein kinase	0.0052	0.3755	0.3762
Echinococcus granulosus	SHC transforming protein 3	0.0046	0.3203	0.3203
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.6008	1
Echinococcus multilocularis	protein kinase c iota type	0.0015	0.0558	0.0559
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosin kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	protein kinase	0.0078	0.6008	0.6018
Echinococcus granulosus	tyrosine kinase	0.0123	0.9983	0.9983
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Leishmania major	protein kinase, putative	0.0078	0.6008	1
Brugia malayi	protein-tyrosine kinase	0.0123	0.9983	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Brugia malayi	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0123	0.9983	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0077	0.5991	0.6001
Brugia malayi	SRC-1	0.0123	0.9983	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0077	0.5991	0.6001
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0046	0.3203	0.3203
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	SH2 motif	0.0046	0.3203	0.3209
Schistosoma mansoni	protein kinase	0.0078	0.6008	0.6018
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0531	0.0532
Echinococcus granulosus	hypothetical protein	0.0046	0.3203	0.3203
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0052	0.3761	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0046	0.322	0.3226
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0531	0.0532
Echinococcus multilocularis		0.0046	0.3203	0.3209
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0077	0.5991	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0046	0.3203	0.3209
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0123	0.9983	0.9983
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.5991	0.5991
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.3319	0.3325
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0531	0.0532
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0531	0.0531
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0077	0.5991	0.5991
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0077	0.5991	0.5991
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0531	0.0531
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0123	0.9983	1
Trypanosoma brucei	protein kinase, putative	0.0078	0.6008	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Toxoplasma gondii	STE kinase	0.0077	0.5991	0.9972
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0531	0.0532
Schistosoma mansoni	SH2A	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK/EPH protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.4313	0.4321
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus granulosus	protein tyrosine kinase	0.0077	0.5991	0.5991
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Brugia malayi	integrin-linked kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0531	0.0531
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/INSR protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine protein kinase shark	0.0123	0.9983	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0123	0.9983	1
Brugia malayi	Variant SH3 domain containing protein	0.0052	0.3761	0.3767
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase csk	0.0077	0.5991	0.5991
Onchocerca volvulus		0.0046	0.3203	0.2827
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0123	0.9983	1
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Schistosoma mansoni	tensin-related	0.0046	0.3203	0.3209
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	RNA directed DNA polymerase	0.0042	0.285	0.2855
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0017	0.0674	0.0675
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0077	0.5991	0.5991
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0123	0.9983	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0531	0.0532
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.5991	0.5991
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0046	0.3203	0.3209
Echinococcus granulosus	SH2 motif	0.0046	0.3203	0.3203
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0123	0.9983	1
Trypanosoma brucei	Pseudokinase, putative	0.0077	0.5991	0.9972
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Echinococcus multilocularis	SH2 motif	0.0046	0.3203	0.3209
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0531	0.0532
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0123	0.9983	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0077	0.5991	0.6001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0123	0.9983	1
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0058	0.4313	0.4321
Loa Loa (eye worm)	SH2 domain-containing protein	0.0046	0.3203	0.3209
Loa Loa (eye worm)	STAT protein	0.0046	0.3203	0.3209
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Brugia malayi	Protein kinase domain containing protein	0.0123	0.9983	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0123	0.9983	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	SH2 motif	0.0046	0.3203	0.3203
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0077	0.5991	0.5991
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	protein kinase C gamma type	0.0052	0.3755	0.3755
Brugia malayi	SH2 domain containing protein	0.0123	0.9983	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0531	0.0532
Echinococcus granulosus	tensin	0.0046	0.3203	0.3203
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.5991	0.5991
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0077	0.5991	0.6001
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0078	0.6008	0.6018
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0077	0.5991	0.5991
Entamoeba histolytica	cysteine surface protein, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Entamoeba histolytica	serine/threonine kinase, putative	0.0077	0.5991	0.6001
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Echinococcus multilocularis	transfer RNA-Thr	0.0077	0.5991	0.6001
Echinococcus granulosus	NCK adaptor protein	0.0046	0.3203	0.3203
Brugia malayi	Cation transporter family protein	0.0015	0.0531	0.0532
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0531	0.0531
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0077	0.5991	0.6001
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0046	0.3203	0.3209
Onchocerca volvulus		0.0077	0.5991	0.5776
Loa Loa (eye worm)	TK protein kinase	0.0123	0.9983	1
Onchocerca volvulus		0.0046	0.3203	0.2827
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	heat shock protein 70	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase shark	0.0123	0.9983	0.9983
Schistosoma mansoni	protein tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	nAChR subunit	0.0015	0.0531	0.0532
Echinococcus granulosus	Protein kinase C brain isozyme	0.0058	0.4313	0.4313
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0077	0.5991	0.5
Echinococcus granulosus	RNA directed DNA polymerase	0.0042	0.285	0.285
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0043	0.2983	0.2988
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0123	0.9983	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0123	0.9983	0.9983
Echinococcus granulosus	SH2 domain containing protein 7	0.0046	0.3203	0.3203
Brugia malayi	Protein kinase domain containing protein	0.0123	0.9983	1
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.5991	0.6001
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0077	0.5991	0.9972
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.5991	0.6001
Onchocerca volvulus		0.0077	0.5991	0.5776
Loa Loa (eye worm)	TK/FAK protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0046	0.3203	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Onchocerca volvulus		0.0046	0.3203	0.2827
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0077	0.5991	0.5776
Loa Loa (eye worm)	TK/ABL protein kinase	0.0123	0.9983	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0123	0.9983	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.5991	0.5991
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0531	0.0532
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Echinococcus multilocularis	tyrosine kinase	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0531	0.0532
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0077	0.5991	0.5991
Brugia malayi	protein kinase C II.	0.0017	0.0674	0.0675
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK protein kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	NCK adaptor protein	0.0046	0.3203	0.3209
Brugia malayi	Tyrosine-protein kinase PR2	0.0077	0.5991	0.6001
Brugia malayi	C-terminal src kinase protein 1	0.0077	0.5991	0.6001
Echinococcus granulosus	N chimaerin	0.0052	0.3761	0.3761
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0046	0.3203	0.2827
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	protein kinase c epsilon type	0.0017	0.0674	0.0674
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.4313	0.4321
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0046	0.3203	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0531	0.0532
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0077	0.5991	0.5991
Schistosoma mansoni	nAChR subunit	0.0015	0.0531	0.0532
Echinococcus multilocularis	tensin	0.0046	0.3203	0.3209
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0123	0.9983	1
Schistosoma mansoni	protein kinase	0.0077	0.5991	0.6001
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0046	0.3203	0.3209
Echinococcus granulosus	tyrosine protein kinase pr2	0.0077	0.5991	0.5991
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0531	0.0531
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0123	0.9983	0.9983
Echinococcus multilocularis	tensin	0.0046	0.3203	0.3209
Brugia malayi	Protein kinase domain containing protein	0.0123	0.9983	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Echinococcus multilocularis	protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0078	0.6008	1
Echinococcus multilocularis	activin receptor type	0.0078	0.6008	0.6018
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	ephrin type A receptor 4 A	0.0077	0.5991	0.5991
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus granulosus	insulin receptor	0.0077	0.5991	0.5991
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0077	0.5991	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0077	0.5991	0.5776
Onchocerca volvulus		0.0077	0.5991	0.5776
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0077	0.5991	0.6001
Brugia malayi	SH2 domain containing protein	0.0046	0.3203	0.3209
Schistosoma mansoni	suppressor of cytokine signaling	0.0046	0.3203	0.3209
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0123	0.9983	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3203	0.3209
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Echinococcus granulosus	raf serine:threonine protein kinase	0.0084	0.6549	0.6549
Loa Loa (eye worm)	hypothetical protein	0.0042	0.285	0.2855
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0077	0.5991	0.9972
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0046	0.3203	0.3203
Echinococcus multilocularis	SH2 motif	0.0046	0.3203	0.3209
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0077	0.5991	0.5991
Echinococcus multilocularis	c src tyrosine kinase	0.0123	0.9983	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0077	0.5991	0.6001
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0048	0.3408	0.3414
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0531	0.0532
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0077	0.5991	0.6001
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	protein kinase c iota type	0.0015	0.0558	0.0558
Echinococcus multilocularis	tyrosine protein kinase csk	0.0077	0.5991	0.6001
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0046	0.3203	0.3209
Entamoeba histolytica	protein kinase, putative	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0123	0.9983	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0077	0.5991	0.6001
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0531	0.0531
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine kinase	0.0123	0.9983	1
Onchocerca volvulus		0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0077	0.5991	0.5991
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0077	0.5991	0.6001
Entamoeba histolytica	protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine protein kinase	0.0077	0.5991	0.6001
Brugia malayi	Protein kinase domain containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	hypothetical protein	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0077	0.5991	0.5991
Loa Loa (eye worm)	TK/RYK protein kinase	0.0077	0.5991	0.6001
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Onchocerca volvulus		0.0046	0.3203	0.2827
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0531	0.0531
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0077	0.5991	0.6001
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0077	0.5991	0.6001
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.9983	1
Trichomonas vaginalis	TKL family protein kinase	0.0077	0.5991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.5991	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0077	0.5991	0.6001
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0084	0.6549	0.656
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0046	0.3203	0.3209
Entamoeba histolytica	hypothetical protein	0.0077	0.5991	0.6001
Entamoeba histolytica	tyrosine kinase, putative	0.0077	0.5991	0.6001
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0046	0.3203	0.3209
Schistosoma mansoni	protein kinase	0.0078	0.6008	0.6018
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0078	0.6008	0.6008
Brugia malayi	Tyrosine-protein kinase abl-1	0.0123	0.9983	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0123	0.9983	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2057672

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1661526