Detailed information for compound 166175

Basic information

Technical information
  • TDR Targets ID: 166175
  • Name: [(E,2R)-5-(3-formyl-2,6-dihydroxy-4-methylphe nyl)-3-methyl-1-[(1S,2R,6R)-1,2,6-trimethyl-3 -oxocyclohexyl]pent-3-en-2-yl] propanoate
  • MW: 444.56 | Formula: C26H36O6
  • H donors: 2 H acceptors: 5 LogP: 5.53 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)O[C@@H](/C(=C/Cc1c(O)cc(c(c1O)C=O)C)/C)C[C@@]1(C)[C@H](C)CCC(=O)[C@@H]1C
  • InChi: 1S/C26H36O6/c1-7-24(30)32-23(13-26(6)17(4)9-11-21(28)18(26)5)15(2)8-10-19-22(29)12-16(3)20(14-27)25(19)31/h8,12,14,17-18,23,29,31H,7,9-11,13H2,1-6H3/b15-8+/t17-,18+,23-,26+/m1/s1
  • InChiKey: VLFRJRBSRCFKPU-AXNCTASFSA-N  

Network

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Synonyms

  • [(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methyl-phenyl)-2-methyl-1-[[(1S,2R,6R)-1,2,6-trimethyl-3-oxo-cyclohexyl]methyl]but-2-enyl] propanoate
  • propanoic acid [(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methylphenyl)-2-methyl-1-[[(1S,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]methyl]but-2-enyl] ester
  • [(E,2R)-5-(2,6-dihydroxy-3-methanoyl-4-methyl-phenyl)-3-methyl-1-[(1S,2R,6R)-1,2,6-trimethyl-3-oxo-cyclohexyl]pent-3-en-2-yl] propanoate
  • propionic acid [(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methyl-phenyl)-1-[[(1S,2R,6R)-3-keto-1,2,6-trimethyl-cyclohexyl]methyl]-2-methyl-but-2-enyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Protein farnesyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma brucei protein farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Giardia lamblia Prenyltransferase Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania major farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum protein farnesyltranstransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium hominis chain B, structure of fpt bound to ggpp Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania braziliensis farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus granulosus protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Entamoeba histolytica protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania infantum farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium parvum protein geranyl-geranyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma mansoni protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium vivax conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma brucei gambiense protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania donovani farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania mexicana farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium vivax farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium yoelii Prenyltransferase and squalene oxidase repeat, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei lanosterol synthase 0.0074 0.0448 0.3469
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0067 0.0395 0.3004
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.039 0.0271
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0166 0.1193 0.816
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0166 0.0451
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.5205 0.6547
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5537 0.6981
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0175
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.039 0.0271
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.1388
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0207 0.1531 0.1759
Mycobacterium tuberculosis Probable thioesterase TesA 0.055 0.4312 0.5384
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0187 0.0536
Mycobacterium ulcerans polyketide synthase Pks13 0.0987 0.7853 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0025 0.0052 0.0028
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0182 0.0515
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0616 0.4948
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0067 0.0395 0.1359
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0188 0.0969
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1193 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0166 0.1193 0.4525
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.039 0.3267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0028
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0056 0.0038
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0067 0.0395 0.1359
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1193 1
Leishmania major oxidoreductase, putative 0.0041 0.0182 0.1241
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.039 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0161
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0395 0.0417
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0474 0.3696 0.4581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.039 0.9861
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.016 0.0768
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0182 0.1138
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.0448 0.3752
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.1157 0.1272
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0182 0.1522
Toxoplasma gondii type I fatty acid synthase, putative 0.0701 0.5537 1
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.067 0.0637
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5537 0.6981
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.039 0.134
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0067 0.0395 0.2431
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.039 0.0271
Schistosoma mansoni hypothetical protein 0.0336 0.2574 1
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.097 0.1069
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0187 0.0247
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0395 0.2431
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0169 0.0118
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0617 0.4853 0.6089
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0187 0.1567
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0175
Leishmania major d-xylulose reductase, putative 0.0041 0.0182 0.1241
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0187 0.1185
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0067 0.0395 0.2431
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0188 0.1197
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0182 0.0515
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0701 0.5537 0.6981
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0182 0.0131
Giardia lamblia Prenyltransferase 0.0067 0.0395 0.2431
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0317 0.0267
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0187 0.1185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.0181
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0166 0.1193 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0166 0.0451
Brugia malayi MH2 domain containing protein 0.0138 0.097 0.0923
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0987 0.7853 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.039 0.0271
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0182 0.0515
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0182 0.1522
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.039 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0166 0.0807
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0182 0.1241
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0052 0.0433
Brugia malayi AMP-binding enzyme family protein 0.0617 0.4853 0.4826
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0182 0.1522
Mycobacterium ulcerans acyl carrier protein 0.0067 0.039 0.0271
Leishmania major hypothetical protein, conserved 0.0042 0.0187 0.1278
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0188 0.0249
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0052 0.0433
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0025 0.0052 0.0028
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0067 0.0395 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.039 0.0271
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0334 0.2556 0.4564
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1003 0.3771
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.097 0.1069
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0182 0.1522
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0182 0.3787
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0056 0.0004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0617 0.4853 0.5472
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0188 0.0542
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.039 0.0411
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0187 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0056 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0166 0.0807
Leishmania major farnesyltransferase beta subunit 0.0067 0.0395 0.2698
Onchocerca volvulus 0.0617 0.4853 0.508
Toxoplasma gondii type I fatty acid synthase 0.0101 0.067 0.1128
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.039 0.0616
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.067 0.0637
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0166 0.3321
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.054 0.4229 0.5275
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0049 0.0247 0.1707
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0067 0.0395 0.3004
Onchocerca volvulus 0.0041 0.0182 0.0137
Mycobacterium ulcerans thioesterase TesA 0.055 0.4312 0.5384
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0187 0.1567
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0182 0.1241
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0203 0.1495 0.1713
Mycobacterium ulcerans fatty acid synthase Fas 0.0207 0.1531 0.1759
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.066 0.5205 0.6547
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.5205 0.6547
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0182 0.1241
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.5205 0.6547
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0052 0.0433
Loa Loa (eye worm) acyl carrier protein 0.0304 0.2312 0.2591
Loa Loa (eye worm) hypothetical protein 0.037 0.2849 0.32
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.055 0.4312 0.5384
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0437 0.339 0.4183
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0182 0.3787
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0166 0.1193 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0701 0.5537 0.6981
Mycobacterium ulcerans polyketide synthase 0.066 0.5205 0.6547
Toxoplasma gondii type I fatty acid synthase, putative 0.047 0.3661 0.658
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0166 0.1193 1
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0187 0.0007
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.039 0.034
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0056 0.0008
Loa Loa (eye worm) acetyltransferase 0.0142 0.1003 0.1107
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0052 0.0433
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.016 0.316
Loa Loa (eye worm) hypothetical protein 0.1109 0.8846 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0166 0.1132
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1193 0.1319
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0052 0.0433
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.039 0.0271
Loa Loa (eye worm) fatty acid synthase 0.0651 0.5133 0.579
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0701 0.5537 0.6981
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0166 0.0451
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0182 0.1138
Leishmania major lanosterol synthase, putative 0.0056 0.03 0.2049
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0428 0.3323 0.5964
Mycobacterium tuberculosis Conserved protein 0.0199 0.1462 0.1669
Schistosoma mansoni hypothetical protein 0.0067 0.039 0.134
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.5205 0.6547
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0166 0.0451
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.0395 0.3307
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.0395 0.3307
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0166 0.0451
Echinococcus multilocularis geminin 0.0336 0.2574 1
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.039 0.134
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1003 0.3771
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0175
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.064 0.504 0.6333
Schistosoma mansoni hypothetical protein 0.0039 0.0169 0.0465
Schistosoma mansoni acyl carrier protein 0.0067 0.039 0.134
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0701 0.5537 0.6981
Leishmania major hypothetical protein, conserved 0.0199 0.1462 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0166 0.0451
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0207 0.1531 0.1759
Echinococcus granulosus geminin 0.0336 0.2574 1
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0187 0.1185
Mycobacterium leprae conserved hypothetical protein 0.0067 0.039 0.0271
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0182 0.0175
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1315 0.1337
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0166 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.039 0.0271
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0375 0.2894 0.3535
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.039 0.0271
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0067 0.0395 0.2431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.039 0.9861
Leishmania major oxidoreductase-like protein 0.0041 0.0182 0.1241
Mycobacterium leprae Probable polyketide synthase Pks1 0.0701 0.5537 0.6981
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.067 0.0637
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0056 0.0017
Mycobacterium ulcerans polyketide synthase Pks9 0.0437 0.339 0.4183
Schistosoma mansoni hypothetical protein 0.0336 0.2574 1
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0182 0.1522
Schistosoma mansoni methyltransferase-related 0.0199 0.1462 0.5591
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.066 0.5205 0.6547
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0166 0.1193 0.2081
Mycobacterium ulcerans polyketide synthase 0.0701 0.5537 0.6981
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0067 0.0395 0.3004
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0187 0.0536
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0987 0.7853 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.039 0.2059
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.0448 0.3752
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0395 0.0345
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.039 0.2962
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.039 0.0271
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0437 0.339 0.4183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0317 0.0267
Mycobacterium ulcerans polyketide synthase MbtC 0.0166 0.1193 0.1319
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0182 0.0131
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0182 0.3787
Loa Loa (eye worm) hypothetical protein 0.0101 0.067 0.0729
Mycobacterium tuberculosis Hypothetical protein 0.0199 0.1462 0.1669
Chlamydia trachomatis acyl carrier protein 0.0067 0.039 0.2016
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0395 0.2431
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.067 0.0637
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0074 0.0448 0.0347
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0182 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0203 0.1495 0.1451
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0166 0.1193 0.1147
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0166 0.0451
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.5205 0.6547
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.1462 1
Mycobacterium leprae Polyketide synthase Pks13 0.0987 0.7853 1
Plasmodium falciparum acyl carrier protein 0.0067 0.039 0.2962
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0187 0.0136
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0166 0.0451
Mycobacterium ulcerans polyketide synthase MbtD 0.0203 0.1495 0.1713
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.039 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0317 0.0329
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0166 0.0807
Loa Loa (eye worm) hypothetical protein 0.0039 0.0166 0.0157
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0182 0.0921
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0182 0.1241
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0166 0.1193 0.1322
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1193 0.1319
Mycobacterium ulcerans thioesterase 0.055 0.4312 0.5384
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.016 0.0949
Giardia lamblia Methyltransferase like 2 0.0199 0.1462 1
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0182 0.0131
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0182 0.1138
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0187 0.0536
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.1388
Onchocerca volvulus Fatty acid synthase homolog 0.119 0.9503 1
Loa Loa (eye worm) acyl carrier protein 0.0067 0.039 0.0411
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0056 0.0017
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.039 0.0271
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0267 0.2015 0.2389
Mycobacterium tuberculosis Polyketide synthase Pks2 0.064 0.504 0.6333
Leishmania major acyl carrier protein, putative 0.0067 0.039 0.2666
Echinococcus granulosus NADH dehydrogenase 0.0067 0.039 0.134
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.039 0.034
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0227 0.169 0.1966
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0182 0.0137
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0067 0.0395 0.1359
Onchocerca volvulus 0.0041 0.0182 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0616 0.4948
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0166 0.1193 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.066 0.5205 0.518
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0182 0.1522
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0166 0.1193 0.4525
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.0998
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0182 0.1522
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.039 0.0271
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.066 0.5205 0.6547
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.039 0.0358
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0166 0.1193 0.4525
Loa Loa (eye worm) hypothetical protein 0.0181 0.1315 0.146
Brugia malayi Methyltransferase-like protein 4 0.0199 0.1462 0.1418
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0067 0.0395 0.0625
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0182 0.0131
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.039 0.0271
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.0395 0.2431
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0182 0.1522
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0182 0.0921
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.039 0.0271
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0056 0.0017
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.039 0.0271
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0187 0.0536
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0531 0.4158 0.5183
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0971 0.3643
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.039 0.0271
Onchocerca volvulus 0.1149 0.917 0.9648
Entamoeba histolytica hypothetical protein 0.0026 0.0056 0.0127
Onchocerca volvulus 0.0067 0.039 0.0358
Brugia malayi N-terminal motif family protein 0.0181 0.1315 0.127
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0188 0.0969
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.039 0.134
Echinococcus multilocularis AMP dependent ligase 0.0067 0.039 0.134
Leishmania major quinone oxidoreductase, putative 0.0041 0.0182 0.1241
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0188 0.0249
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0182 0.1522
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.039 0.034
Loa Loa (eye worm) hypothetical protein 0.0058 0.0317 0.0329
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0166 0.0807
Mycobacterium ulcerans acyl carrier protein 0.0067 0.039 0.0271
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0175
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.067 0.0637
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.066 0.5205 0.6547
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0182 0.0921
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1003 0.0956
Echinococcus granulosus AMP dependent ligase 0.0067 0.039 0.134
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0056 0.047
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0531 0.4158 0.5183
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0701 0.5537 0.6981
Treponema pallidum acyl carrier protein 0.0067 0.039 0.5
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0182 0.0515
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0182 0.0237
Mycobacterium ulcerans hypothetical protein 0.0067 0.039 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0531 0.4158 0.5183
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0166 0.1193 1
Plasmodium vivax acyl carrier protein, putative 0.0067 0.039 0.2962
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0027 0.0227
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0187 0.0536
Loa Loa (eye worm) hypothetical protein 0.0101 0.067 0.0729
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0025 0.0052 0.0353

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.2 uM Activity against bovine Farnesyltransferase ChEMBL. 9301658
IC50 (binding) = 2.2 uM Activity against bovine Farnesyltransferase ChEMBL. 9301658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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