TDR Targets

Basic information

Technical information

TDR Targets ID: 166175
Name: [(E,2R)-5-(3-formyl-2,6-dihydroxy-4-methylphe nyl)-3-methyl-1-[(1S,2R,6R)-1,2,6-trimethyl-3 -oxocyclohexyl]pent-3-en-2-yl] propanoate
MW: 444.56 | Formula: C26H36O6
H donors: 2 H acceptors: 5 LogP: 5.53 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)O[C@@H](/C(=C/Cc1c(O)cc(c(c1O)C=O)C)/C)C[C@@]1(C)[C@H](C)CCC(=O)[C@@H]1C
InChi: 1S/C26H36O6/c1-7-24(30)32-23(13-26(6)17(4)9-11-21(28)18(26)5)15(2)8-10-19-22(29)12-16(3)20(14-27)25(19)31/h8,12,14,17-18,23,29,31H,7,9-11,13H2,1-6H3/b15-8+/t17-,18+,23-,26+/m1/s1
InChiKey: VLFRJRBSRCFKPU-AXNCTASFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methyl-phenyl)-2-methyl-1-[[(1S,2R,6R)-1,2,6-trimethyl-3-oxo-cyclohexyl]methyl]but-2-enyl] propanoate
propanoic acid [(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methylphenyl)-2-methyl-1-[[(1S,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]methyl]but-2-enyl] ester
[(E,2R)-5-(2,6-dihydroxy-3-methanoyl-4-methyl-phenyl)-3-methyl-1-[(1S,2R,6R)-1,2,6-trimethyl-3-oxo-cyclohexyl]pent-3-en-2-yl] propanoate
propionic acid [(E,1R)-4-(3-formyl-2,6-dihydroxy-4-methyl-phenyl)-1-[[(1S,2R,6R)-3-keto-1,2,6-trimethyl-cyclohexyl]methyl]-2-methyl-but-2-enyl] ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Protein farnesyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Methyltransferase like 2	0.0199	0.1462	1
Onchocerca volvulus	Putative alcohol dehydrogenase	0.0041	0.0182	0.0137
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0474	0.3696	0.4581
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.0971	0.3643
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.0166	0.1193	0.4525
Trypanosoma brucei	Trans-2-enoyl-ACP reductase 2, putative	0.0041	0.0182	0.1138
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0041	0.0182	0.0131
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0169	0.0118
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0166	0.0451
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0701	0.5537	0.6981
Toxoplasma gondii	type I fatty acid synthase, putative	0.047	0.3661	0.658
Leishmania major	acyl carrier protein, putative	0.0067	0.039	0.2666
Mycobacterium ulcerans	hypothetical protein	0.0067	0.039	0.0271
Mycobacterium tuberculosis	Probable polyketide synthase Pks17	0.0161	0.1157	0.1272
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0701	0.5537	0.6981
Schistosoma mansoni	[ACP] S-malonyltransferase	0.0042	0.0187	0.0536
Echinococcus multilocularis	serine protein kinase ATM	0.0026	0.0056	0.0017
Mycobacterium tuberculosis	Acyl carrier protein (ACP) MbtL	0.0067	0.039	0.0271
Mycobacterium ulcerans	acyl-CoA synthetase	0.0067	0.039	0.0271
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.016	0.316
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0049	0.0247	0.1707
Entamoeba histolytica	NADP-dependent alcohol dehydrogenase, putative	0.0041	0.0182	0.3787
Loa Loa (eye worm)	hypothetical protein	0.0101	0.067	0.0729
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0067	0.039	0.9861
Trypanosoma cruzi	nuclear receptor binding factor, putative	0.0041	0.0182	0.1522
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	0.097	0.1069
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0067	0.039	0.0271
Toxoplasma gondii	quinone oxidoreductase, putative	0.0041	0.0182	0.0237
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0074	0.0448	0.0347
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0166	0.1193	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0039	0.0166	0.3321
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0166	0.1193	0.1319
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0026	0.0056	0.0017
Echinococcus multilocularis	NADH dehydrogenase	0.0067	0.039	0.134
Loa Loa (eye worm)	acyl carrier protein	0.0304	0.2312	0.2591
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0067	0.0395	0.3004
Echinococcus granulosus	geminin	0.0336	0.2574	1
Onchocerca volvulus		0.1149	0.917	0.9648
Leishmania major	nuclear receptor binding factor-like protein	0.0041	0.0182	0.1241
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0267	0.2015	0.2389
Plasmodium vivax	malonyl CoA-acyl carrier protein transacylase precursor, putative	0.0042	0.0187	0.1185
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0166	0.1193	0.1319
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0317	0.0329
Mycobacterium tuberculosis	Meromycolate extension acyl carrier protein AcpM	0.0067	0.039	0.0271
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0188	0.0969
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0437	0.339	0.4183
Mycobacterium tuberculosis	Conserved protein	0.0199	0.1462	0.1669
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0701	0.5537	0.6981
Echinococcus multilocularis	mitochondrial trans 2 enoyl coenzyme A reductase	0.0041	0.0182	0.0515
Toxoplasma gondii	3-oxoacyl-acyl-carrier protein synthase I/II, putative	0.0166	0.1193	0.2081
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.066	0.5205	0.6547
Schistosoma mansoni	zinc binding dehydrogenase	0.0041	0.0182	0.0515
Toxoplasma gondii	Zn-containing alcohol dehydrogenase	0.0041	0.0182	0.0237
Toxoplasma gondii	acyl carrier protein ACP	0.0067	0.039	0.0616
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0166	0.0451
Trypanosoma brucei	oxidoreductase, putative	0.0041	0.0182	0.1138
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0188	0.0542
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0101	0.067	0.0637
Mycobacterium ulcerans	Type I modular polyketide synthase	0.066	0.5205	0.6547
Mycobacterium ulcerans	acyl carrier protein	0.0067	0.039	0.0271
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0052	0.0433
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0701	0.5537	0.6981
Trypanosoma brucei	acyl transferase-like protein	0.0042	0.0187	0.1185
Mycobacterium ulcerans	acyl carrier protein	0.0067	0.039	0.0271
Mycobacterium tuberculosis	Hypothetical protein	0.0199	0.1462	0.1669
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.055	0.4312	0.5384
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0052	0.0028
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0052	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0199	0.1462	1
Mycobacterium ulcerans	polyketide synthase MbtC	0.0166	0.1193	0.1319
Entamoeba histolytica	hypothetical protein	0.0026	0.0056	0.0127
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	0.097	0.1069
Entamoeba histolytica	NADP-dependent alcohol dehydrogenase, putative	0.0041	0.0182	0.3787
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0052	0.0433
Entamoeba histolytica	NADP-dependent alcohol dehydrogenase	0.0041	0.0182	0.3787
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.0448	0.3752
Chlamydia trachomatis	acyl carrier protein	0.0067	0.039	0.2016
Leishmania major	hypothetical protein, conserved	0.0042	0.0187	0.1278
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0067	0.039	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0182	0.0175
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	0.0067	0.039	0.0271
Mycobacterium leprae	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	0.0207	0.1531	0.1759
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0188	0.0249
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0067	0.0395	0.1359
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0067	0.039	0.0271
Mycobacterium tuberculosis	Probable thioesterase TesA	0.055	0.4312	0.5384
Leishmania major	NADP-dependent alcohol dehydrogenase, putative	0.0041	0.0182	0.1241
Echinococcus granulosus	ubiquitin specific protease 41	0.0039	0.0166	0.0451
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0067	0.0395	0.2431
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0437	0.339	0.4183
Trypanosoma brucei	oxidoreductase, putative	0.0041	0.0182	0.1138
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.0448	0.3752
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0067	0.039	0.9861
Mycobacterium ulcerans	thioesterase	0.055	0.4312	0.5384
Leishmania major	quinone oxidoreductase, putative	0.0041	0.0182	0.1241
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.066	0.5205	0.6547
Trypanosoma cruzi	acyl transferase-like protein, putative	0.0042	0.0187	0.1567
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0101	0.067	0.0637
Leishmania major	zinc-binding dehydrogenase-like protein	0.0041	0.0182	0.1241
Onchocerca volvulus		0.0067	0.039	0.0358
Trypanosoma cruzi	NADP-dependent alcohol hydrogenase, putative	0.0041	0.0182	0.1522
Echinococcus multilocularis	geminin	0.0336	0.2574	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0041	0.0182	0.0921
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.0166	0.1193	0.4525
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0041	0.0182	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0166	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0166	0.0157
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0067	0.0395	0.0625
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0188	0.0249
Plasmodium falciparum	malonyl CoA-acyl carrier protein transacylase	0.0042	0.0187	0.1185
Onchocerca volvulus		0.0617	0.4853	0.508
Schistosoma mansoni	[ACP] S-malonyltransferase	0.0042	0.0187	0.0536
Mycobacterium ulcerans	polyketide synthase	0.066	0.5205	0.6547
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0987	0.7853	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0531	0.4158	0.5183
Plasmodium vivax	acyl carrier protein, putative	0.0067	0.039	0.2962
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0701	0.5537	0.6981
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0187	0.0181
Trypanosoma cruzi	NADP-dependent alcohol hydrogenase, putative	0.0041	0.0182	0.1522
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0227	0.169	0.1966
Echinococcus multilocularis	ubiquitin specific protease 41	0.0039	0.0166	0.0451
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0395	0.2431
Mycobacterium leprae	conserved hypothetical protein	0.0067	0.039	0.0271
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0531	0.4158	0.5183
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0701	0.5537	0.6981
Leishmania major	farnesyltransferase beta subunit	0.0067	0.0395	0.2698
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0166	0.0451
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.016	0.0768
Toxoplasma gondii	type I fatty acid synthase	0.0101	0.067	0.1128
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0334	0.2556	0.4564
Brugia malayi	Methyltransferase-like protein 4	0.0199	0.1462	0.1418
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.0395	0.3307
Loa Loa (eye worm)	alcohol dehydrogenase class III	0.0041	0.0182	0.0175
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0052	0.0433
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0166	0.0114
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.0166	0.1193	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0531	0.4158	0.5183
Mycobacterium ulcerans	polyketide synthase MbtD	0.0203	0.1495	0.1713
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.1003	0.0956
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0166	0.0998
Echinococcus granulosus	mitochondrial trans 2 enoyl coenzyme A reductase	0.0041	0.0182	0.0515
Trypanosoma brucei	beta-ketoacyl-ACP synthase	0.0166	0.1193	1
Leishmania major	d-xylulose reductase, putative	0.0041	0.0182	0.1241
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0987	0.7853	1
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0067	0.0395	1
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.064	0.504	0.6333
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0375	0.2894	0.3535
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0056	0.047
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0169	0.0161
Echinococcus granulosus	NADH dehydrogenase	0.0067	0.039	0.134
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.0166	0.1193	0.4525
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0067	0.039	0.0271
Trypanosoma cruzi	NADP-dependent alcohol hydrogenase, putative	0.0041	0.0182	0.1522
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.016	0.0949
Brugia malayi	Phosphopantetheine attachment site family protein	0.0067	0.039	0.034
Schistosoma mansoni	hypothetical protein	0.0067	0.039	0.134
Brugia malayi	AMP-binding enzyme family protein	0.0203	0.1495	0.1451
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.054	0.4229	0.5275
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0041	0.0182	0.0921
Echinococcus multilocularis	Acyl carrier protein, mitochondrial	0.0067	0.039	0.134
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0617	0.4853	0.5472
Trypanosoma cruzi	oxidoreductase, putative	0.0041	0.0182	0.1522
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0052	0.0433
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.1003	0.3771
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0166	0.1193	1
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	0.0101	0.067	0.0637
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0067	0.039	0.0271
Mycobacterium ulcerans	malonyl CoA-acyl carrier protein transacylase FabD	0.0042	0.0187	0.0007
Schistosoma mansoni	alcohol dehydrogenase	0.0041	0.0182	0.0515
Schistosoma mansoni	hypothetical protein	0.0336	0.2574	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0166	0.0807
Mycobacterium ulcerans	Type I modular polyketide synthase	0.066	0.5205	0.6547
Mycobacterium ulcerans	polyketide synthase Pks13	0.0987	0.7853	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0188	0.0969
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0067	0.0395	0.0345
Echinococcus granulosus	serine protein kinase ATM	0.0026	0.0056	0.0017
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0428	0.3323	0.5964
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0067	0.039	0.0271
Trypanosoma cruzi	oxidoreductase, putative	0.0041	0.0182	0.1522
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0067	0.0395	0.2431
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0067	0.039	0.0271
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0067	0.0395	0.3004
Brugia malayi	MH2 domain containing protein	0.0138	0.097	0.0923
Toxoplasma gondii	type I fatty acid synthase, putative	0.0701	0.5537	1
Toxoplasma gondii	acyl transferase domain-containing protein	0.0042	0.0187	0.0247
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0067	0.039	0.0271
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0166	0.1193	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0166	0.0451
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0067	0.039	0.0271
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.066	0.5205	0.6547
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0166	0.1388
Schistosoma mansoni	hypothetical protein	0.0336	0.2574	1
Onchocerca volvulus		0.0041	0.0182	0.0137
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0188	0.1197
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0039	0.0166	0.1132
Echinococcus granulosus	AMP dependent ligase	0.0067	0.039	0.134
Mycobacterium ulcerans	polyketide synthase Pks9	0.0437	0.339	0.4183
Brugia malayi	Alcohol dehydrogenase class III	0.0041	0.0182	0.0131
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.0166	0.1193	1
Trypanosoma cruzi	Acyl carrier protein, mitochondrial, putative	0.0067	0.039	0.3267
Echinococcus granulosus	Malonyl coenzyme A acyl carrier protein transacylase	0.0042	0.0187	0.0536
Mycobacterium ulcerans	fatty acid synthase Fas	0.0207	0.1531	0.1759
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0181	0.1315	0.1337
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0701	0.5537	0.6981
Schistosoma mansoni	acyl carrier protein	0.0067	0.039	0.134
Trypanosoma cruzi	NADP-dependent alcohol hydrogenase, putative	0.0041	0.0182	0.1522
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0166	0.0451
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0317	0.0267
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.066	0.5205	0.6547
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0166	0.0451
Plasmodium falciparum	acyl carrier protein	0.0067	0.039	0.2962
Trypanosoma brucei	lanosterol synthase	0.0074	0.0448	0.3469
Brugia malayi	AMP-binding enzyme family protein	0.0617	0.4853	0.4826
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0067	0.039	0.0271
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0041	0.0182	0.0131
Plasmodium vivax	hypothetical protein, conserved	0.0095	0.0616	0.4948
Trypanosoma brucei	Acyl carrier protein, mitochondrial	0.0067	0.039	0.2962
Loa Loa (eye worm)	acyl carrier protein	0.0067	0.039	0.0411
Leishmania major	hypothetical protein, conserved	0.0199	0.1462	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0025	0.0052	0.0353
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0203	0.1495	0.1713
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0395	0.2431
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.064	0.504	0.6333
Echinococcus multilocularis	AMP dependent ligase	0.0067	0.039	0.134
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	0.0101	0.067	0.0637
Trypanosoma cruzi	acyl transferase-like protein	0.0042	0.0187	0.1567
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.066	0.5205	0.6547
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0052	0.0028
Leishmania major	oxidoreductase-like protein	0.0041	0.0182	0.1241
Onchocerca volvulus		0.0041	0.0182	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0056	0.0031
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0026	0.0056	0.0004
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0395	0.2431
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	0.0101	0.067	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0317	0.0329
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0052	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0182	0.0175
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0067	0.0395	0.0417
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0041	0.0182	0.0921
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0067	0.0395	0.2431
Onchocerca volvulus	Fatty acid synthase homolog	0.119	0.9503	1
Schistosoma mansoni	[ACP] S-malonyltransferase	0.0042	0.0187	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0182	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0182	0.0175
Mycobacterium ulcerans	Type I modular polyketide synthase	0.066	0.5205	0.6547
Leishmania major	zinc binding dehydrogenase-like protein	0.0041	0.0182	0.1241
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.066	0.5205	0.518
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.0395	0.3307
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.066	0.5205	0.6547
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0701	0.5537	0.6981
Wolbachia endosymbiont of Brugia malayi	acyl carrier protein	0.0067	0.039	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1315	0.146
Brugia malayi	ADP-specific Phosphofructokinase/Glucokinase conserved region family protein	0.0042	0.0187	0.0136
Leishmania major	lanosterol synthase, putative	0.0056	0.03	0.2049
Mycobacterium ulcerans	polyketide synthase	0.0701	0.5537	0.6981
Loa Loa (eye worm)	hypothetical protein	0.037	0.2849	0.32
Wolbachia endosymbiont of Brugia malayi	ACP S-malonyltransferase	0.0042	0.0187	0.0053
Trypanosoma cruzi	oxidoreductase, putative	0.0041	0.0182	0.1522
Mycobacterium leprae	Polyketide synthase Pks13	0.0987	0.7853	1
Brugia malayi	N-terminal motif family protein	0.0181	0.1315	0.127
Loa Loa (eye worm)	phosphopantetheine attachment site family protein	0.0067	0.039	0.0411
Echinococcus multilocularis	Malonyl coenzyme A acyl carrier protein transacylase	0.0042	0.0187	0.0536
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.1003	0.3771
Leishmania major	beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative	0.0166	0.1193	0.816
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0095	0.0616	0.4948
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0026	0.0056	0.0038
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0067	0.039	0.0271
Brugia malayi	acyl carrier protein, mitochondrial precursor, putative	0.0067	0.039	0.034
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0166	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0101	0.067	0.0729
Trypanosoma cruzi	nuclear receptor binding factor, putative	0.0041	0.0182	0.1522
Leishmania major	oxidoreductase, putative	0.0041	0.0182	0.1241
Mycobacterium ulcerans	thioesterase TesA	0.055	0.4312	0.5384
Echinococcus granulosus	acyl carrier protein mitochondrial	0.0067	0.039	0.134
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0617	0.4853	0.6089
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0039	0.0166	0.0807
Loa Loa (eye worm)	beta-ketoacyl synthase domain-containing protein	0.0166	0.1193	0.1322
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0166	0.1193	0.1147
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0207	0.1531	0.1759
Schistosoma mansoni	hypothetical protein	0.0039	0.0169	0.0465
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative	0.0166	0.1193	1
Treponema pallidum	acyl carrier protein	0.0067	0.039	0.5
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0166	0.1388
Giardia lamblia	Prenyltransferase	0.0067	0.0395	0.2431
Onchocerca volvulus	Acyl carrier protein, mitochondrial homolog	0.0067	0.039	0.0358
Loa Loa (eye worm)	fatty acid synthase	0.0651	0.5133	0.579
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0027	0.0227
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0317	0.0267
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0067	0.039	0.0271
Mycobacterium tuberculosis	Probable acyl carrier protein AcpA (ACP)	0.0067	0.039	0.0271
Toxoplasma gondii	FATC domain-containing protein	0.0026	0.0056	0.0008
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0067	0.039	0.034
Loa Loa (eye worm)	acetyltransferase	0.0142	0.1003	0.1107
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0067	0.0395	0.1359
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0067	0.0395	0.3004
Loa Loa (eye worm)	hypothetical protein	0.1109	0.8846	1
Schistosoma mansoni	methyltransferase-related	0.0199	0.1462	0.5591
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0067	0.039	0.0271
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0067	0.0395	0.1359

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.2 uM	Activity against bovine Farnesyltransferase	ChEMBL.	9301658
IC50 (binding)	= 2.2 uM	Activity against bovine Farnesyltransferase	ChEMBL.	9301658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 10456134

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 166175