TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 671.776 | Formula: C39H45NO9
H donors: 2 H acceptors: 3 LogP: 3.9 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: NCCOc1ccc(cc1OC)CC(=O)OCC1=C[C@H]2C3OC4(OC2([C@H]2[C@@](C1)(O)C(=O)C(=C2)C)[C@@H](C[C@]3(O4)C(=C)C)C)Cc1ccccc1
InChi: 1S/C39H45NO9/c1-23(2)37-19-25(4)39-29(35(37)47-38(48-37,49-39)21-26-9-7-6-8-10-26)16-28(20-36(43)32(39)15-24(3)34(36)42)22-46-33(41)18-27-11-12-30(45-14-13-40)31(17-27)44-5/h6-12,15-17,25,29,32,35,43H,1,13-14,18-22,40H2,2-5H3/t25-,29+,32-,35?,36-,37+,38?,39?/m1/s1
InChiKey: VRILWIFMYGGDHR-PEQKXJPMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0008	0.0023	0.007
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.1593	0.1593
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0008	0.0023	0.007
Echinococcus granulosus	TRP transient receptor potential channel	0.0008	0.0023	0.007
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0008	0.0023	0.007
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Loa Loa (eye worm)	voltage-gated calcium channel	0.0008	0.0023	0.0023
Brugia malayi	voltage-dependent calcium channel	0.0008	0.0023	0.0023
Brugia malayi	ion channel NompC	0.0008	0.0023	0.0023
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0052	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2498	0.2498
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0023	0.007
Echinococcus granulosus	short transient receptor potential channel 6	0.0008	0.0023	0.007
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.021	1	1
Echinococcus granulosus	ryanodine receptor 44f	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0008	0.0023	0.0023
Echinococcus multilocularis	shaker cognate	0.0008	0.0023	0.007
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0542	0.1656
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0008	0.0023	0.007
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	potassium large conductance calcium activated	0.0008	0.0023	0.007
Schistosoma mansoni	hypothetical protein	0.0018	0.0542	0.1656
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0008	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	voltage-gated potassium channel	0.0008	0.0023	0.0023
Loa Loa (eye worm)	ion channel NompC	0.0008	0.0023	0.0023
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0012	0.0247	0.0753
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0012	0.0247	1
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0008	0.0023	0.0023
Echinococcus granulosus	two pore calcium channel protein 2	0.0008	0.0023	0.007
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0146	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Schistosoma mansoni	vesicular amine transporter	0.0008	0.0023	0.007
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0542	0.1656
Brugia malayi	Transient-receptor-potential like protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	ryanodine receptor	0.0008	0.0023	0.0023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0542	0.1656
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0247	0.0753
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0008	0.0023	0.0023
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0023	0.007
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0052	0.0159
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0008	0.0023	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.3273	1
Echinococcus multilocularis	sodium channel protein	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0247	0.0753
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0052	0.0159
Echinococcus multilocularis	voltage dependent calcium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0146	0.0447
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0542	0.0542
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.3273	0.3273
Leishmania major	hypothetical protein, unknown function	0.0008	0.0023	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0146	0.0146
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0008	0.0023	0.007
Echinococcus multilocularis	transient receptor potential gamma protein	0.0008	0.0023	0.007
Schistosoma mansoni	hypothetical protein	0.0018	0.0542	0.1656
Schistosoma mansoni	voltage-dependent calcium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0012	0.0247	0.0753
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.3273	0.3273
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0012	0.0247	0.0247
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0023	0.007
Schistosoma mansoni	voltage-gated ion channel	0.0008	0.0023	0.007
Echinococcus multilocularis	two pore calcium channel protein 1	0.0008	0.0023	0.007
Echinococcus granulosus	sodium leak channel non selective protein	0.0008	0.0023	0.007
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.3273	1
Entamoeba histolytica	hypothetical protein	0.0007	0	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0146	0.0146
Brugia malayi	cation channel family protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0146	0.0447
Echinococcus multilocularis	conserved hypothetical protein	0.0008	0.0023	0.007
Leishmania major	hypothetical protein, conserved	0.0008	0.0023	0.5
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0023	0.007
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0146	0.0146
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0023	0.007
Echinococcus multilocularis	voltage gated potassium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0247	0.0753
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0008	0.0023	0.0023
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus multilocularis	sodium leak channel non selective protein	0.0008	0.0023	0.007
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0542	0.1656
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0008	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Echinococcus granulosus	hyperpolarization activated cyclic	0.0012	0.0247	0.0753
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0008	0.0023	0.0023
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0023	0.007
Schistosoma mansoni	two-pore calcium channel	0.0008	0.0023	0.007
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0008	0.0023	0.007
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0146	0.0447
Brugia malayi	hypothetical protein	0.001	0.0146	0.0146
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0023	0.007
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0247	0.0753
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0012	0.0247	1
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0146	0.0447
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Echinococcus granulosus	sodium channel protein	0.0008	0.0023	0.007
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0146	0.0447
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0146	0.0447
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	RNA binding protein	0.0074	0.3273	0.3273
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0012	0.0247	0.0247
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0008	0.0023	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0542	0.1656
Echinococcus granulosus	transient receptor potential gamma protein	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0023	0.007
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0542	0.1656
Echinococcus multilocularis	calcium activated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	shaker cognate	0.0008	0.0023	0.007
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0023	0.007
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0012	0.0247	0.0753
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0008	0.0023	0.0023
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0247	0.0753
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0023	0.007
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0008	0.0023	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0008	0.0023	0.007
Brugia malayi	hypothetical protein	0.001	0.0146	0.0146
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0146	0.0146
Brugia malayi	TAR-binding protein	0.0074	0.3273	0.3273
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0008	0.0023	0.007
Echinococcus granulosus	voltage dependent calcium channel	0.0008	0.0023	0.007
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0012	0.0247	0.0753
Schistosoma mansoni	hypothetical protein	0.004	0.1593	0.4866
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.3273	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0012	0.0247	0.0753
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0023	0.007
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0008	0.0023	0.007
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0012	0.0247	0.0753
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0008	0.0023	0.007
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0008	0.0023	0.007
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0008	0.0023	0.0023
Onchocerca volvulus		0.001	0.0146	0.0146
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.3273	1
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0008	0.0023	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0052	0.0052
Echinococcus multilocularis	transient receptor potential cation channel	0.0008	0.0023	0.007
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0146	0.0447
Brugia malayi	cation channel family protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	short transient receptor potential channel 6	0.0008	0.0052	0.0159
Echinococcus granulosus	voltage dependent calcium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	ryanodine receptor 44f	0.0008	0.0023	0.007
Echinococcus multilocularis	transfer RNA-Gly	0.0008	0.0023	0.007
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0012	0.0247	0.0753
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	voltage-gated potassium channel	0.0008	0.0023	0.0023
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0247	0.0753
Schistosoma mansoni	calcium-activated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	hyperpolarization activated cyclic	0.0012	0.0247	0.0753
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0023	0.007
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0008	0.0023	0.0023
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0146	0.0447
Schistosoma mansoni	transient receptor potential channel 4	0.0008	0.0023	0.007
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0247	0.0753
Brugia malayi	DIX domain containing protein	0.001	0.0146	0.0146
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0008	0.0023	0.007
Echinococcus multilocularis	short transient receptor potential channel 6	0.0008	0.0023	0.007
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0052	0.0159
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0247	0.0753
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0008	0.0023	0.007
Brugia malayi	olfactory channel protein osm-9	0.0008	0.0052	0.0052
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0023	0.007
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.3273	0.3273
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.2498	0.2498
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0247	0.0753
Echinococcus multilocularis	voltage dependent calcium channel	0.0008	0.0023	0.007
Brugia malayi	RNA binding protein	0.0074	0.3273	0.3273
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0247	0.0247
Echinococcus granulosus	calcium activated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.2498	0.2498
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0008	0.0023	0.007
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0247	0.0753
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0012	0.0247	0.0247
Echinococcus multilocularis	two pore calcium channel protein 2	0.0008	0.0023	0.007
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0008	0.0023	0.007
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0008	0.0023	0.0023
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0012	0.0247	0.0753
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	calcium channel	0.0008	0.0023	0.0023
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	GPCR family 2	0.0018	0.0542	0.1656
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0247	0.0753
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0146	0.0447
Echinococcus granulosus	voltage gated potassium channel	0.0008	0.0023	0.007
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0023	0.007
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0008	0.0023	0.0023
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0008	0.0023	0.007
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0542	0.0542
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Echinococcus granulosus	short transient receptor potential channel 6	0.0008	0.0052	0.0159
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Toxoplasma gondii	hypothetical protein	0.001	0.0146	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0008	0.0023	0.0023
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Schistosoma mansoni	dishevelled	0.001	0.0146	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0012	0.0247	0.0753
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0008	0.0023	0.007
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0012	0.0247	0.0753
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0008	0.0023	0.007
Echinococcus granulosus	hypothetical protein	0.0008	0.0023	0.007
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0012	0.0247	0.0247
Schistosoma mansoni	voltage-gated cation channel	0.0008	0.0023	0.007
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0247	0.0753
Schistosoma mansoni	dishevelled	0.001	0.0146	0.0447
Schistosoma mansoni	dep domain containing protein	0.001	0.0146	0.0447
Echinococcus granulosus	tar DNA binding protein	0.0074	0.3273	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0247	0.0753
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0023	0.007
Echinococcus granulosus	two pore calcium channel protein 1	0.0008	0.0023	0.007
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0008	0.0023	0.0023
Onchocerca volvulus		0.0008	0.0023	0.0023
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0146	0.0447
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.3273	1
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0023	0.007
Schistosoma mansoni	hypothetical protein	0.0008	0.0023	0.007
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0	0.5
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0008	0.0023	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0542	0.1656
Schistosoma mansoni	transient receptor potential channel	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0023	0.007
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0008	0.0023	0.007
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0008	0.0023	0.0023
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0008	0.0023	0.0023
Schistosoma mansoni	60S ribosomal protein L21	0.0008	0.0023	0.007
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.3273	1
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.004	0.1593	0.1593
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0023	0.0023
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.0247	0.0247
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0012	0.0247	0.0753
Echinococcus granulosus	transient receptor potential cation channel	0.0008	0.0023	0.007
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0146	0.0447
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0023	0.007
Loa Loa (eye worm)	hypothetical protein	0.021	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0247	0.0247
Echinococcus multilocularis	potassium large conductance calcium activated	0.0008	0.0023	0.007
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0008	0.0023	0.007
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0008	0.0023	0.007
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0247	0.0753
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0012	0.0247	0.0247
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0146	0.0447
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.2498	0.2498
Schistosoma mansoni	ryanodine receptor related	0.0008	0.0023	0.007

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 13.04 nM	Ability to stimulate uptake of Calcium into Dorsal Root Ganglion(DRG) neurons	ChEMBL.	8709128
EC50 (functional)	= 13.04 nM	Ability to stimulate uptake of Calcium into Dorsal Root Ganglion(DRG) neurons	ChEMBL.	8709128
Ki (binding)	= 4.3 nM	Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]-RTX binding assay.	ChEMBL.	8709128
Ki (binding)	= 4.3 nM	Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]-RTX binding assay.	ChEMBL.	8709128
Relative affinity (binding)	= 0.028	Binding affinity against Vanilloid receptor in dorsal root ganglion(DRG)membranes relative to resinferatoxin (RTX); not tested	ChEMBL.	8709128
Relative affinity (binding)	= 0.028	Binding affinity against Vanilloid receptor in dorsal root ganglion(DRG)membranes relative to resinferatoxin (RTX); not tested	ChEMBL.	8709128
Relative Potency (functional)	= 0.123	Relative potency(RTX) against Dorsal Root Ganglion(DRG)membranes using RTX binding assay.	ChEMBL.	8709128
Relative Potency (functional)	= 0.123	Relative potency(RTX) against Dorsal Root Ganglion(DRG)membranes using RTX binding assay.	ChEMBL.	8709128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL317463

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 166180