Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.1813 | 0.4093 | 0.4901 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3598 | 0.8347 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3598 | 0.8347 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0098 | 0.0004 | 0.0004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1712 | 0.3851 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0435 | 0.0809 | 0.0969 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1813 | 0.4093 | 0.4903 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4291 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1813 | 0.4093 | 0.4901 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1712 | 0.3851 | 0.3849 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1813 | 0.4093 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0435 | 0.0809 | 0.0969 |
Brugia malayi | hypothetical protein | 0.1712 | 0.3851 | 0.4611 |
Brugia malayi | thymidylate synthase | 0.3598 | 0.8347 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4291 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1712 | 0.3851 | 0.4613 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0435 | 0.0809 | 1 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0098 | 0.0004 | 0.0004 |
Brugia malayi | Dihydrofolate reductase | 0.1813 | 0.4093 | 0.4901 |
Onchocerca volvulus | 0.3598 | 0.8347 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4291 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1813 | 0.4093 | 0.4901 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0098 | 0.0004 | 0.0004 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3598 | 0.8347 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4291 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1813 | 0.4093 | 0.4903 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4291 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3598 | 0.8347 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.3598 | 0.8347 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1813 | 0.4093 | 0.4901 |
Schistosoma mansoni | dihydrofolate reductase | 0.1813 | 0.4093 | 0.4901 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0098 | 0.0004 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.3598 | 0.8347 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1813 | 0.4093 | 0.4903 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0098 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | thymidylate synthase | 0.3598 | 0.8347 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Antiallergic activity by rat passive cutaneous anaphylaxis (PCA) assay when administered iv; ND means no data | ChEMBL. | 6876084 |
ED50 (functional) | > 30 mg kg-1 | Antiallergic activity by rat passive cutaneous anaphylaxis (PCA) assay when administered per orally | ChEMBL. | 6876084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.