TDR Targets

Basic information

Technical information

TDR Targets ID: 166235
Name: 4-(3-fluoro-5,5,8,8-tetramethyl-6,7-dihydrona phthalene-2-carbonyl)benzoic acid
MW: 354.415 | Formula: C22H23FO3
H donors: 1 H acceptors: 3 LogP: 6.02 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cc2c(cc1C(=O)c1ccc(cc1)C(=O)O)C(C)(C)CCC2(C)C
InChi: 1S/C22H23FO3/c1-21(2)9-10-22(3,4)17-12-18(23)15(11-16(17)21)19(24)13-5-7-14(8-6-13)20(25)26/h5-8,11-12H,9-10H2,1-4H3,(H,25,26)
InChiKey: WWPNKNDRIFQGQU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(7-fluoro-1,1,4,4-tetramethyl-tetralin-6-carbonyl)benzoic acid
4-[(7-fluoro-1,1,4,4-tetramethyl-6-tetralinyl)-oxomethyl]benzoic acid
4-[(3-fluoro-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonyl]benzoic acid
4-(3-fluoro-5,5,8,8-tetramethyl6,7-dihydronaphthalene-2-carbonyl)benzoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	retinoic acid receptor, alpha	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, gamma	Starlite/ChEMBL	References
Mus musculus	retinoid X receptor gamma	Starlite/ChEMBL	References
Homo sapiens	retinoid X receptor, alpha	Starlite/ChEMBL	References
Mus musculus	retinoid X receptor beta	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	Get druggable targets OG5_130073	All targets in OG5_130073
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	Get druggable targets OG5_131607	All targets in OG5_131607
Loa Loa (eye worm)	nuclear receptor nhr-7B	Get druggable targets OG5_131607	All targets in OG5_131607
Echinococcus granulosus	retinoic acid receptor rxr beta a	Get druggable targets OG5_130073	All targets in OG5_130073
Brugia malayi	nuclear hormone receptor	Get druggable targets OG5_131607	All targets in OG5_131607
Schistosoma japonicum	ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative	Get druggable targets OG5_130073	All targets in OG5_130073
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131607	All targets in OG5_131607
Schistosoma mansoni	retinoic acid receptor RXR	Get druggable targets OG5_130073	All targets in OG5_130073

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	retinoid X receptor, alpha	435 aa	352 aa	23.9 %
Brugia malayi	ecdysteroid receptor	retinoid X receptor gamma	340 aa	338 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.012	0.018
Schistosoma mansoni	nuclear hormone receptor	0.008	0.0634	0.1047
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0249	0.0249
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.008	0.0634	0.0656
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0063	0.0053
Brugia malayi	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.008	0.0634	0.0656
Onchocerca volvulus		0.0038	0.012	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.008	0.0634	0.0656
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.008	0.0634	0.1066
Schistosoma mansoni	zinc finger protein	0.0038	0.012	0.018
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.0175	0.0294
Echinococcus multilocularis	FTZ F1 alpha	0.008	0.0634	0.1146
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.008	0.0634	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0063	0.0053
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0013	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0038	0.012	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0171
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.012	0.018
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.012	0.0113
Brugia malayi	photoreceptor-specific nuclear receptor	0.008	0.0634	0.0656
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0249	0.0249
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0038	0.012	0.0113
Brugia malayi	Steroid receptor seven-up type 2	0.008	0.0634	0.0656
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0038	0.012	0.018
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.1346	0.5
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0516	0.5949	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.008	0.0634	0.1066
Schistosoma mansoni	RAR-like nuclear receptor	0.008	0.0634	0.1047
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.008	0.0634	0.1047
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.008	0.0634	0.1047
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor-like 1	0.008	0.0634	0.0656
Echinococcus granulosus	FTZ F1 alpha	0.008	0.0634	0.1066
Echinococcus multilocularis	thyroid hormone receptor alpha	0.008	0.0634	0.1146
Schistosoma mansoni	thyroid hormone receptor	0.008	0.0634	0.1047
Brugia malayi	steroid hormone receptor	0.008	0.0634	0.0656
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.008	0.0634	0.1047
Echinococcus granulosus	ecdysone induced protein 78C	0.008	0.0634	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.008	0.0634	0.0656
Onchocerca volvulus	Protein ultraspiracle homolog	0.008	0.0634	0.0622
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1424	0.149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.012	0.0197
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.008	0.0634	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0171
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Schistosoma mansoni	nuclear receptor	0.0038	0.012	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.008	0.0634	0.0656
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Brugia malayi	hypothetical protein	0.0042	0.0175	0.0171
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.012	0.0202
Echinococcus multilocularis	muscleblind protein	0.0145	0.1424	0.2603
Brugia malayi	Muscleblind-like protein	0.0145	0.1424	0.149
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.3111	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0038	0.012	0.0202
Brugia malayi	ecdysteroid receptor	0.008	0.0634	0.0656
Onchocerca volvulus		0.008	0.0634	0.0622
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.008	0.0634	0.0656
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.008	0.0634	0.1146
Brugia malayi	nuclear receptor RXR	0.0038	0.012	0.0113
Brugia malayi	orphan nuclear receptor NR2E1	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0249	0.0249
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0038	0.012	0.018
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0807	0.9486	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Onchocerca volvulus	Bile acid receptor homolog	0.008	0.0634	0.0622
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Brugia malayi	nuclear receptor NHR-67	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.008	0.0634	0.0656
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2117	0.2222
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Brugia malayi	nuclear receptor RXR	0.0042	0.0175	0.0171
Onchocerca volvulus		0.0038	0.012	0.0107
Brugia malayi	nuclear hormone receptor	0.0807	0.9486	1
Onchocerca volvulus		0.023	0.2457	0.2447
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.008	0.0634	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0171
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.012	0.0197
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0038	0.012	0.0197
Brugia malayi	hypothetical protein	0.0038	0.012	0.0113
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.0175	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0171
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.008	0.0634	0.1066
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0038	0.012	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.008	0.0634	0.1146
Brugia malayi	Pre-SET motif family protein	0.0202	0.2117	0.2222
Schistosoma mansoni	nuclear receptor	0.0038	0.012	0.018
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.012	0.0113
Brugia malayi	ecdysone receptor	0.0038	0.012	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.008	0.0634	0.0656
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0175	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0171
Loa Loa (eye worm)	nuclear hormone receptor	0.0038	0.012	0.0113
Brugia malayi	conserved hypotetical protein	0.0038	0.012	0.0113
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0175	0.0273
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.008	0.0634	0.1066
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0013	0.0022
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.008	0.0634	0.1146
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.008	0.0634	0.1146
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1424	0.149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.008	0.0634	0.1146
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.0175	0.0171
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Plasmodium vivax	SET domain protein, putative	0.0029	0.0013	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.008	0.0634	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.008	0.0634	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0769	0.9026	0.9515
Schistosoma mansoni	hypothetical protein	0.0033	0.0063	0.0084
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.008	0.0634	0.1047
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0038	0.012	0.018
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.3111	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0038	0.012	0.0202
Loa Loa (eye worm)	DR-78	0.0038	0.012	0.0113
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.008	0.0634	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.008	0.0634	0.0656
Schistosoma mansoni	steroid hormone receptor ad4bp	0.008	0.0634	0.1047
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.1346	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.012	0.0197
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Treponema pallidum	fructose-bisphosphate aldolase	0.0283	0.3111	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0516	0.5949	1
Schistosoma mansoni	coup transcription factor	0.008	0.0634	0.1047
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0038	0.012	0.0107
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.012	0.0113
Echinococcus multilocularis	ecdysone induced protein 78C	0.008	0.0634	0.1146
Loa Loa (eye worm)	hypothetical protein	0.008	0.0634	0.0656
Brugia malayi	hypothetical protein	0.0042	0.0175	0.0171
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.008	0.0634	0.0656
Brugia malayi	nuclear receptor NHR-88	0.0038	0.012	0.0113
Echinococcus granulosus	thyroid hormone receptor alpha	0.0038	0.012	0.0202
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.008	0.0634	0.1066
Schistosoma mansoni	thyroid hormone receptor	0.008	0.0634	0.1047
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.008	0.0634	0.1047
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.0175	0.0299
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.012	0.0202
Giardia lamblia	Fructose-bisphosphate aldolase	0.0283	0.3111	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0038	0.012	0.0113
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0474	0.5435	1
Brugia malayi	nuclear hormone receptor	0.008	0.0634	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.008	0.0634	0.0656
Brugia malayi	tailless protein	0.0038	0.012	0.0113
Loa Loa (eye worm)	steroid hormone receptor	0.008	0.0634	0.0656
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.008	0.0634	0.0656
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0038	0.012	0.0113
Echinococcus granulosus	muscleblind protein	0.0145	0.1424	0.2394
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.1424	0.2603
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.012	0.0202
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0175	0.0171
Brugia malayi	nuclear receptor NHR-88	0.008	0.0634	0.0656
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.1346	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.3111	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 395 nM	Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 395 nM	Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1016 nM	Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1016 nM	Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1820 nM	Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1820 nM	Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1976 nM	Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 1976 nM	Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 2246 nM	Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 2246 nM	Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 2856 nM	Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells	ChEMBL.	8071941
EC50 (binding)	= 2856 nM	Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells	ChEMBL.	8071941
Kd (binding)	= 706 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha	ChEMBL.	8071941
Kd (binding)	= 706 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha	ChEMBL.	8071941
Kd (binding)	= 902 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta	ChEMBL.	8071941
Kd (binding)	= 902 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta	ChEMBL.	8071941
Kd (binding)	= 911 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma	ChEMBL.	8071941
Kd (binding)	= 911 nM	Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta	ChEMBL.	8071941
Kd (binding)	> 1000 nM	Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus	ChEMBL.	8071941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL419166
PubChem: 10450790

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 166235