Detailed information for compound 166264

Basic information

Technical information
  • TDR Targets ID: 166264
  • Name: 1-(dimethylamino)-3-[4-[[4-(4-methoxyanilino) pyrimidin-2-yl]amino]phenoxy]propan-2-ol
  • MW: 409.481 | Formula: C22H27N5O3
  • H donors: 3 H acceptors: 3 LogP: 3.32 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Nc1ccnc(n1)Nc1ccc(cc1)OCC(CN(C)C)O
  • InChi: 1S/C22H27N5O3/c1-27(2)14-18(28)15-30-20-10-6-17(7-11-20)25-22-23-13-12-21(26-22)24-16-4-8-19(29-3)9-5-16/h4-13,18,28H,14-15H2,1-3H3,(H2,23,24,25,26)
  • InChiKey: ACISHMVGWWWZAU-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(dimethylamino)-3-[4-[[4-(4-methoxyanilino)-2-pyrimidinyl]amino]phenoxy]-2-propanol
  • 1-(dimethylamino)-3-[4-[[4-[(4-methoxyphenyl)amino]pyrimidin-2-yl]amino]phenoxy]propan-2-ol
  • 1-(dimethylamino)-3-[4-[[4-(p-anisidino)pyrimidin-2-yl]amino]phenoxy]propan-2-ol
  • 1-dimethylamino-3-[4-[[4-[(4-methoxyphenyl)amino]pyrimidin-2-yl]amino]phenoxy]propan-2-ol
  • 1-dimethylamino-3-[4-[[4-[(4-methoxyphenyl)amino]-2-pyrimidinyl]amino]phenoxy]propan-2-ol
  • 2,4-bis anilino pyrimidine deriv. 9

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0201 0.0769 0.1529
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0027 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0745 1
Trypanosoma cruzi oxidoreductase, putative 0.004 0.0118 0.1388
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0066 0.0221 0.3225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0061 0.0679
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0027 0.0135
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.004 0.0118 0.0242
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.055 0.1087
Leishmania major cathepsin L-like protease 0.0051 0.0162 0.1982
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0027 0.0024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Echinococcus multilocularis GPCR, family 2 0.0078 0.0271 0.0257
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0026 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0187 0.0426
Brugia malayi jmjC domain containing protein 0.0015 0.0017 0.0006
Echinococcus granulosus NADH dehydrogenase 0.0066 0.0221 0.0372
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.004 0.0118 0.0252
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0115 0.1221
Echinococcus granulosus cysteine protease 0.0026 0.0061 0.0086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0079 0.0179
Entamoeba histolytica hypothetical protein 0.0025 0.0054 0.0697
Toxoplasma gondii quinone oxidoreductase, putative 0.004 0.0118 0.0428
Entamoeba histolytica hypothetical protein 0.0107 0.0389 0.9331
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Schistosoma mansoni smad1 5 8 and 0.0033 0.0087 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0106 0.0187
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.004 0.0118 0.1388
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0061 0.0608
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Mycobacterium ulcerans Type I modular polyketide synthase 0.065 0.259 0.6631
Plasmodium vivax vivapain-2 0.0051 0.0162 0.242
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0027 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0148
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0033 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0325 0.056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0026 0.0012
Brugia malayi PAS domain containing protein 0.0016 0.002 0.0012
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0106 0.0167
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.004 0.0118 0.0252
Mycobacterium tuberculosis Polyketide synthase Pks12 0.069 0.2754 0.7057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0061 0.0823
Schistosoma mansoni rotamase 0.0034 0.0093 0.0143
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.065 0.259 0.6634
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0031 0.0017
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0017 0.0006
Plasmodium vivax vivapain-1 0.0026 0.0061 0.074
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0014 0.0032
Schistosoma mansoni intermediate filament proteins 0.0107 0.0388 0.0673
Schistosoma mansoni lamin 0.0107 0.0388 0.0673
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0162 0.0148
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0054 0.0508
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0032 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.0267
Brugia malayi hypothetical protein 0.0119 0.0438 0.0859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0199 0.0452
Onchocerca volvulus 0.0023 0.0048 0.0073
Brugia malayi nuclear hormone receptor 0.0037 0.0106 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0162 0.1982
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0079 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Brugia malayi Phosphopantetheine attachment site family protein 0.0066 0.0221 0.0419
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0148
Loa Loa (eye worm) fibroinase 0.0051 0.0162 0.0369
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0066 0.0221 0.0517
Echinococcus granulosus geminin 0.0852 0.3407 0.611
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0244
Loa Loa (eye worm) transcription factor SMAD2 0.0481 0.1905 0.4345
Mycobacterium ulcerans fatty acid synthase Fas 0.0204 0.0782 0.1959
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0048 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0748 0.8281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) hypothetical protein 0.0105 0.038 0.0866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0035 0.0038
Trichomonas vaginalis rotamase, putative 0.0033 0.009 0.0994
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0162 0.242
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0162 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0069
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0027 0.0013
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.015 0.2212
Brugia malayi nuclear receptor NHR-88 0.0037 0.0106 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.3392 0.3382
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.002 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0106 0.0187
Trichomonas vaginalis alcohol dehydrogenase, putative 0.004 0.0118 0.1307
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0222
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0614 0.2444 0.5573
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0106 0.0243
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.069 0.2754 0.7057
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0222
Brugia malayi Pre-SET motif family protein 0.0206 0.0789 0.1571
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0163 0.0616 0.8224
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0038 0.0107 0.0189
Brugia malayi nuclear receptor RXR 0.0018 0.0026 0.0025
Leishmania major DNA polymerase eta, putative 0.002 0.0037 0.0266
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.0638 0.1264
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0055
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0415 0.5469
Mycobacterium ulcerans hypothetical protein 0.0066 0.0221 0.0507
Toxoplasma gondii cathepsin CPL 0.0051 0.0162 0.0587
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0106 0.0167
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0162 0.199
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.004 0.0316
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0189 0.0176
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.043 0.1697 0.433
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0026 0.0025
Leishmania major d-xylulose reductase, putative 0.004 0.0118 0.1382
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0055
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0093 0.103
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0072 0.0248 0.0578
Loa Loa (eye worm) mucolipin 1 0.0064 0.0215 0.049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0142 0.053 0.1045
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0027 0.0098
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0037 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0271 0.052
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0114 0.0415 0.0723
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0087 0.0132
Echinococcus granulosus cathepsin L 0.0026 0.0061 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0359
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0224 0.5086
Schistosoma mansoni hypothetical protein 0.0066 0.0221 0.0372
Leishmania major cathepsin L-like protease 0.0051 0.0162 0.1982
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.013 0.1435
Brugia malayi Alcohol dehydrogenase class III 0.004 0.0118 0.0211
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0079 0.0285
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0027 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0415 0.4596
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0032 0.0074
Schistosoma mansoni DNA polymerase eta 0.002 0.0037 0.0041
Brugia malayi cathepsin L-like precursor 0.0034 0.0093 0.0161
Schistosoma mansoni zinc finger protein 0.0018 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0244
Echinococcus granulosus cathepsin l1 0.0051 0.0162 0.0267
Loa Loa (eye worm) hypothetical protein 0.0181 0.069 0.1574
Leishmania major oxidoreductase, putative 0.004 0.0118 0.1382
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0114 0.0415 0.0723
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0037 0.0041
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0041 0.0121 0.1514
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0019 0.0005
Loa Loa (eye worm) fatty acid synthase 0.0641 0.2555 0.5825
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.004 0.0118 0.2348
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0029
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.065 0.259 0.6635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.01 0.0359 0.0873
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.0213
Mycobacterium ulcerans acyl carrier protein 0.0066 0.0221 0.0507
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0114 0.0415 0.4596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0106 0.0167
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0027 0.0138
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0054 0.0072
Loa Loa (eye worm) hypothetical protein 0.0054 0.0173 0.0394
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0024 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0364 0.5786
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0148
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0162 0.03
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0061
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0114 0.0415 0.5383
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0035 0.0042
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.004 0.0118 0.1468
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.009 0.0994
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0037 0.0404
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.002 0.004
Mycobacterium ulcerans quinone oxidoreductase 0.004 0.0118 0.0242
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0055
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.015 0.2007
Mycobacterium ulcerans dehydrogenase 0.004 0.0118 0.0242
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0087 0.0199
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0163 0.0616 0.1529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Schistosoma mansoni hypothetical protein 0.0168 0.0638 0.1123
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.004 0.0118 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0106 0.0167
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0162 0.0148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0048 0.0061
Brugia malayi Cathepsin L-like precursor 0.0034 0.0093 0.0161
Echinococcus granulosus lamin dm0 0.0107 0.0388 0.0673
Toxoplasma gondii type I fatty acid synthase, putative 0.0691 0.2757 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Mycobacterium tuberculosis Possible dehydrogenase 0.004 0.0118 0.0252
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0163 0.0616 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0069
Echinococcus multilocularis expressed protein 0.0034 0.0093 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Brugia malayi N-terminal motif family protein 0.0181 0.069 0.137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0222
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.015 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0106 0.0187
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0079
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0163 0.0616 0.1404
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0114 0.0415 0.0723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0032 0.0021
Trichomonas vaginalis alcohol dehydrogenase, putative 0.004 0.0118 0.1307
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0221 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0106 0.0187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0027 0.0361
Brugia malayi MH2 domain containing protein 0.0033 0.0087 0.0149
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.013 0.047
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.069 0.2754 0.7054
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.004 0.0118 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0325 0.0311
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0059 0.0193 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Onchocerca volvulus 0.008 0.028 0.0566
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0163 0.0616 0.122
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0523 0.2075 0.53
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0026 0.006
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0033 0.0035
Echinococcus granulosus intermediate filament protein 0.0107 0.0388 0.0673
Onchocerca volvulus 0.0018 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0162 0.0267
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0017 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.065 0.259 0.6635
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0106 0.0167
Trypanosoma cruzi acyl transferase-like protein, putative 0.0041 0.0121 0.1425
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.004 0.0118 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Echinococcus granulosus lamin 0.0107 0.0388 0.0673
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0222
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0325 0.063
Onchocerca volvulus 0.0051 0.0162 0.0316
Echinococcus multilocularis lamin 0.0107 0.0388 0.0375
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.004 0.0118 0.2348
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0061
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0041
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0269
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.004 0.0118 0.0252
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0106 0.0167
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0533 0.0936
Brugia malayi Coelomocyte uptake defective protein 5 0.0064 0.0215 0.0407
Echinococcus multilocularis serotonin transporter 0.0059 0.0193 0.0179
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0224 0.0528
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0038 0.0108 0.0191
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1232 0.495 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0423
Brugia malayi steroid hormone receptor 0.0037 0.0106 0.0187
Schistosoma mansoni hypothetical protein 0.0078 0.0271 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0106 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0106 0.0243
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0048 0.0061
Schistosoma mansoni sodium/chloride dependent transporter 0.0059 0.0193 0.0322
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0106 0.0093
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0162 0.242
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0093 0.0212
Brugia malayi Pre-SET motif family protein 0.0031 0.0079 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.0954 0.2175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0054 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0189 0.0176
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.004 0.0118 0.0253
Echinococcus granulosus acyl carrier protein mitochondrial 0.0066 0.0221 0.0372
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0106 0.0167
Schistosoma mansoni mucolipin 0.0064 0.0215 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) hypothetical protein 0.0107 0.0388 0.0884
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0163 0.0616 0.8189
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Schistosoma mansoni hypothetical protein 0.0142 0.053 0.0928
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.002 0.0222
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0189 0.0316
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0041 0.0121 0.0249
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0163 0.0616 0.8224
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.069 0.2754 0.7057
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.004 0.0118 0.0242
Schistosoma mansoni hypothetical protein 0.0852 0.3407 0.611
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0224 0.0517
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.015 0.0542
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0026 0.0012
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0041 0.0121 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0106 0.0243
Loa Loa (eye worm) hypothetical protein 0.0059 0.0193 0.0439
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0027 0.0361
Leishmania major zinc binding dehydrogenase-like protein 0.004 0.0118 0.1382
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0163 0.0616 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0106 0.0243
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0054 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Trypanosoma brucei unspecified product 0.002 0.0037 0.049
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.004 0.0118 0.0242
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0066 0.0221 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.0954 0.1904
Echinococcus granulosus expressed protein 0.0034 0.0093 0.0143
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.009 0.1618
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0121 0.0107
Loa Loa (eye worm) norepinephrine transporter 0.0059 0.0193 0.0439
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0072 0.0248 0.0588
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0162 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0106 0.0187
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0114 0.0415 0.0813
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.004 0.0118 0.1388
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0106 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.0267
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0329 0.129 0.4679
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.009 0.1205
Mycobacterium ulcerans Type I modular polyketide synthase 0.065 0.259 0.6631
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0093 0.0143
Loa Loa (eye worm) hypothetical protein 0.0364 0.1431 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0061 0.0886
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0026 0.0012
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0121 0.0193
Echinococcus granulosus cpg binding protein 0.0063 0.021 0.0352
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0027 0.0361
Loa Loa (eye worm) MH2 domain-containing protein 0.0481 0.1905 0.4345
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0271 0.0257
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0019 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0114 0.0415 0.0723
Onchocerca volvulus 0.006 0.0196 0.0388
Plasmodium vivax unspecified product 0.0017 0.0023 0.01
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0364 0.5786
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0061 0.0086
Schistosoma mansoni mucolipin 0.0059 0.0193 0.0323
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0106 0.0093
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0027 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Entamoeba histolytica hypothetical protein 0.0107 0.0389 0.9331
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0162 0.1793
Plasmodium vivax acyl carrier protein, putative 0.0066 0.0221 0.3399
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.013 0.188
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0026 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0087 0.0199
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0271 0.0462
Leishmania major cathepsin L-like protease 0.0051 0.0162 0.1982
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0026 0.006
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0027 0.0024
Loa Loa (eye worm) acyl carrier protein 0.0299 0.1166 0.2659
Echinococcus multilocularis cysteine protease 0.0051 0.0162 0.0148
Schistosoma mansoni cpg binding protein 0.0063 0.021 0.0352
Echinococcus multilocularis cpg binding protein 0.0063 0.021 0.0196
Loa Loa (eye worm) hypothetical protein 0.1093 0.4386 1
Leishmania major acyl carrier protein, putative 0.0066 0.0221 0.2784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0325 0.056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.069 0.2754 0.7057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0114 0.0415 0.0402
Loa Loa (eye worm) hypothetical protein 0.0246 0.0954 0.2175
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0106 0.0197
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0037 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0136
Onchocerca volvulus 0.0234 0.0904 0.1897
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0072 0.0248 0.0588
Brugia malayi nuclear receptor NHR-67 0.0018 0.0026 0.0025
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0035 0.0079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0178 0.0677 0.9058
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0037 0.0267
Entamoeba histolytica hypothetical protein 0.0107 0.0389 0.9331
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.002 0.0222
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0017 0.0003
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0222
Mycobacterium leprae Probable polyketide synthase Pks1 0.069 0.2754 0.7057
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0745 1
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0162 0.0316
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0052 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0106 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0115 0.2268
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0032 0.0143
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.004 0.0118 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.004 0.0118 0.0428
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0048 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.0267
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0106 0.0093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.0916 0.2088
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0026 0.0022
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.065 0.259 0.6634
Toxoplasma gondii exonuclease III APE 0.0019 0.0032 0.0118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0244
Loa Loa (eye worm) alcohol dehydrogenase class III 0.004 0.0118 0.0269
Mycobacterium tuberculosis Hypothetical protein 0.0196 0.0748 0.1879
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0106 0.0167
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.004 0.0118 0.0242
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0061 0.0886
Trypanosoma cruzi oxidoreductase, putative 0.004 0.0118 0.1388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0048 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0037 0.0041
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0061 0.0608
Schistosoma mansoni alcohol dehydrogenase 0.004 0.0118 0.0188
Mycobacterium ulcerans oxidoreductase FadB5 0.004 0.0118 0.0242
Leishmania major hypothetical protein, conserved 0.0041 0.0121 0.1418
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.063 0.2509 0.6426
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0052 0.0164 0.027
Mycobacterium ulcerans polyketide synthase 0.069 0.2754 0.7054
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0072 0.0248 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0248 0.0578
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0325 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0061 0.0823
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Onchocerca volvulus 0.0018 0.0026 0.0026
Onchocerca volvulus 0.0051 0.0162 0.0316
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.069 0.2754 0.7057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.02 0.0765 0.1922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0061 0.0608
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0415 0.5469
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0174 0.0397
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0163 0.0616 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0106 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0039
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0072 0.0248 0.0578
Brugia malayi follicle stimulating hormone receptor 0.0237 0.0916 0.1827
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0061 0.0608
Brugia malayi hypothetical protein 0.0107 0.0389 0.0761
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0106 0.0197
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0162 0.0267
Leishmania major oxidoreductase-like protein 0.004 0.0118 0.1382
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0061 0.0096
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0072 0.0248 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0026 0.0022
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0072 0.0248 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0106 0.0187
Echinococcus granulosus cathepsin l1 0.0034 0.0093 0.0143
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0422 0.1664 0.6035
Chlamydia trachomatis acyl carrier protein 0.0066 0.0221 0.3367
Mycobacterium leprae Probable oxidireductase 0.004 0.0118 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0106 0.0093
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0269
Echinococcus granulosus Smad4 0.0033 0.0087 0.0132
Trypanosoma cruzi cruzipain precursor, putative 0.0195 0.0745 1
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.004 0.0118 0.0242
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0106 0.0167
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0114 0.0415 0.5446
Mycobacterium ulcerans short-chain dehydrogenase 0.0048 0.015 0.0324
Mycobacterium tuberculosis Possible dehydrogenase 0.004 0.0118 0.0252
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.013 0.1435
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0199 0.0461
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0026 0.0022
Giardia lamblia Methyltransferase like 2 0.0196 0.0748 1
Mycobacterium ulcerans polyketide synthase MbtC 0.0163 0.0616 0.1529
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0026 0.0022
Mycobacterium tuberculosis Probable thioesterase TesA 0.0542 0.2151 0.55
Echinococcus granulosus dna polymerase kappa 0.002 0.0037 0.0041
Trypanosoma cruzi major cysteine proteinase, putative 0.0153 0.0576 0.7676
Schistosoma mansoni nuclear receptor 0.0018 0.0026 0.0022
Echinococcus granulosus phd:f box containing protein 0.0015 0.0017 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0037 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0017 0.0062
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0033 0.0076
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0106 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0026 0.0022
Onchocerca volvulus Huntingtin homolog 0.0119 0.0438 0.0904
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0027 0.0135
Brugia malayi hypothetical protein 0.0018 0.0026 0.0025
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0037 0.049
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0035 0.0042
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0017 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0415 0.5573
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.0954 0.1904
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.065 0.259 0.6634
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0203 0.0341
Brugia malayi nuclear receptor NHR-88 0.0018 0.0026 0.0025
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.0174 0.016
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.015 0.0542
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0026 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Loa Loa (eye worm) ctsf protein 0.0051 0.0162 0.0369
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0048 0.0061
Trypanosoma cruzi acyl transferase-like protein 0.0041 0.0121 0.1425
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0017 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0023 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Giardia lamblia DINP protein human, muc B family 0.002 0.0037 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.1385 0.5568 1
Brugia malayi jmjC domain containing protein 0.0015 0.0017 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0087 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.049
Brugia malayi hypothetical protein 0.0038 0.0108 0.0191
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0523 0.2075 0.5305
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0023 0.0053
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0017 0.0006
Entamoeba histolytica hypothetical protein 0.0107 0.0389 0.9331
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0032 0.0038
Plasmodium vivax vivapain-2 0.0051 0.0162 0.242
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0523 0.2075 0.53
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0061 0.0096
Schistosoma mansoni smad1 5 8 and 0.0033 0.0087 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Brugia malayi Methyltransferase-like protein 4 0.0196 0.0748 0.1488
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0017 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0271 0.0257
Onchocerca volvulus Putative alcohol dehydrogenase 0.004 0.0118 0.0222
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0038 0.0108 0.017
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.0174 0.0288
Onchocerca volvulus Huntingtin homolog 0.0119 0.0438 0.0904
Leishmania major cathepsin L-like protease 0.0051 0.0162 0.1982
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Schistosoma mansoni hypothetical protein 0.0078 0.0271 0.0462
Loa Loa (eye worm) hypothetical protein 0.0114 0.0415 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Plasmodium falciparum acyl carrier protein 0.0066 0.0221 0.3399
Onchocerca volvulus 0.004 0.0118 0.0222
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0032 0.0211
Loa Loa (eye worm) intermediate filament protein 0.0107 0.0388 0.0884
Loa Loa (eye worm) solute carrier family 6 member 4 0.0059 0.0193 0.0439
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0079 0.0065
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0373
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0106 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0325 0.056
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.049
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0162 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0048 0.0072
Treponema pallidum acyl carrier protein 0.0066 0.0221 1
Onchocerca volvulus Fatty acid synthase homolog 0.1172 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0359 0.0818
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0106 0.0187
Brugia malayi jmjC domain containing protein 0.0015 0.0017 0.0006
Brugia malayi MH1 domain containing protein 0.0033 0.0087 0.0149
Onchocerca volvulus 0.004 0.0118 0.0222
Echinococcus granulosus serotonin transporter 0.0059 0.0193 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Brugia malayi MH1 domain containing protein 0.0033 0.0087 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0745 1
Plasmodium vivax unspecified product 0.0026 0.0061 0.074
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0023 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.004 0.0118 0.0252
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0066 0.0221 0.2961
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0389 0.0376
Brugia malayi MH2 domain containing protein 0.0033 0.0087 0.0149
Onchocerca volvulus 0.0051 0.0162 0.0316
Onchocerca volvulus 0.0051 0.0162 0.0316
Echinococcus multilocularis Smad4 0.0033 0.0087 0.0074
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0121 0.0193
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0204 0.0782 0.1968
Brugia malayi ecdysone receptor 0.0018 0.0026 0.0025
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0027 0.0013
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.004 0.0118 0.0242
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0162 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0026 0.0026
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0106 0.0093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0389 0.0676
Loa Loa (eye worm) hypothetical protein 0.0059 0.0193 0.0439
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0024 0.001
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0163 0.0616 0.0603
Leishmania major hypothetical protein, conserved 0.0196 0.0748 1
Toxoplasma gondii acyl transferase domain-containing protein 0.0041 0.0121 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Brugia malayi intermediate filament protein 0.0107 0.0388 0.0758
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0032 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0136
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0061 0.0886
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0467 0.1848 0.4718
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0022 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0032 0.0212
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0199 0.0452
Brugia malayi nuclear hormone receptor 0.0018 0.0026 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0089 0.0314 0.7396
Leishmania major protein kinase, putative 0.0017 0.0022 0.0071
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0026 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0027 0.0136
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0087 0.0132
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0162 0.0369
Brugia malayi hypothetical protein 0.002 0.0035 0.0042
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0034
Entamoeba histolytica cysteine protease, putative 0.0051 0.0162 0.3478
Loa Loa (eye worm) hypothetical protein 0.0107 0.0389 0.0888
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.004 0.0118 0.0253
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0106 0.0167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.009 0.0999
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.004 0.0118 0.1382
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0079
Onchocerca volvulus 0.0107 0.0388 0.0797
Loa Loa (eye worm) Smad1 0.0033 0.0087 0.0199
Brugia malayi Smad1 0.0033 0.0087 0.0149
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.004 0.0118 0.0252
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0204 0.0782 0.1967
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0019 0.0009
Loa Loa (eye worm) cysteine protease 0.0051 0.0162 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0026 0.0012
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0115 0.1636
Loa Loa (eye worm) hypothetical protein 0.0051 0.0162 0.0369
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0189 0.0316
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.055 0.0966
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0072 0.0248 0.0588
Onchocerca volvulus 0.0037 0.0106 0.0197
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.0213
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0066 0.0221 0.2796
Loa Loa (eye worm) hypothetical protein 0.0119 0.0438 0.0998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0026 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.043 0.1697 0.4324
Leishmania major cathepsin L-like protease 0.0051 0.0162 0.1982
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0109
Schistosoma mansoni cathepsin s 0.0017 0.0023 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0106 0.0167
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0355
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0061 0.0886
Toxoplasma gondii acyl carrier protein ACP 0.0066 0.0221 0.08
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0027 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.065 0.259 0.6631
Brugia malayi Cathepsin L-like precursor 0.0017 0.0023 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0048 0.015 0.0275
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.004 0.0118 0.0242
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Schistosoma mansoni methyltransferase-related 0.0196 0.0748 0.1322
Schistosoma mansoni smad1 5 8 and 0.0033 0.0087 0.0132
Schistosoma mansoni hypothetical protein 0.0852 0.3407 0.611
Onchocerca volvulus Protein cycle homolog 0.0038 0.0108 0.0201
Trypanosoma cruzi nuclear receptor binding factor, putative 0.004 0.0118 0.1388
Mycobacterium tuberculosis Conserved protein 0.0196 0.0748 0.1879
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0061 0.0886
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0038 0.0108 0.0247
Echinococcus multilocularis cysteine protease 0.0051 0.0162 0.0148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Mycobacterium ulcerans hypothetical protein 0.0023 0.0048 0.0061
Echinococcus multilocularis NADH dehydrogenase 0.0066 0.0221 0.0207
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0614 0.2444 0.6258
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0162 0.1793
Onchocerca volvulus 0.0051 0.0162 0.0316
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0041 0.0121 0.1691
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0106 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Leishmania major quinone oxidoreductase, putative 0.004 0.0118 0.1382
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0064
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0021 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.037 0.1453 0.3698
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0121 0.0193
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0114 0.0415 0.0402
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0163 0.0616 0.2234
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0106 0.0167
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0258
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0061 0.0086
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0048 0.0071
Leishmania major protein kinase, putative 0.0021 0.0038 0.0288
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0072 0.0248 0.0578
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.0267
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Loa Loa (eye worm) nuclear factor I 0.0018 0.0028 0.0064
Onchocerca volvulus 0.0614 0.2444 0.518
Schistosoma mansoni lamin 0.0107 0.0388 0.0673
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0024 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0093 0.1033
Echinococcus granulosus smad 0.0033 0.0087 0.0132
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0019 0.0005
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0066 0.0221 0.0419
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0199 0.0185
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0119 0.0438 0.0998
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0106 0.0243
Leishmania major nuclear receptor binding factor-like protein 0.004 0.0118 0.1382
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.013 0.047
Brugia malayi nuclear receptor RXR 0.002 0.0035 0.0042
Loa Loa (eye worm) acetyltransferase 0.0147 0.055 0.1255
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0033 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0162 0.242
Trichomonas vaginalis helicase, putative 0.0013 0.0009 0.0101
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0022 0.0072
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0048 0.0542
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.0388 0.0758
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0106 0.0167
Schistosoma mansoni cpg binding protein 0.0063 0.021 0.0352
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0061 0.074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0035 0.0021
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0041 0.0121 0.1732
Brugia malayi hypothetical protein 0.002 0.0035 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.015 0.0136
Loa Loa (eye worm) hypothetical protein 0.0695 0.2774 0.6325
Echinococcus multilocularis mucolipin 3 0.0064 0.0215 0.0201
Echinococcus multilocularis ubiquitin specific protease 41 0.0114 0.0415 0.0402
Echinococcus granulosus AMP dependent ligase 0.0067 0.0224 0.0379
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0359
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0027 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0101
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0017 0.0006
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0038 0.0108 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0163 0.0616 0.1529
Schistosoma mansoni hypothetical protein 0.0848 0.3392 0.6081
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0026 0.0025
Schistosoma mansoni smad 0.0033 0.0087 0.0132
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0163 0.0616 0.8265
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0021 0.0013
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0066 0.0221 0.0441
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0017 0.0003
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.004 0.0118 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0037 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0061 0.0608
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Loa Loa (eye worm) DR-78 0.0018 0.0026 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0106 0.0187
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0093 0.016
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.004 0.0118 0.0188
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0163 0.0616 0.1084
Echinococcus multilocularis geminin 0.0852 0.3407 0.3398
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0163 0.0616 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0114 0.0415 0.4596
Echinococcus multilocularis musashi 0.0107 0.0388 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0271 0.052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0106 0.0093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0106 0.0197
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0121 0.0193
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0389 0.0676
Leishmania major zinc-binding dehydrogenase-like protein 0.004 0.0118 0.1382
Schistosoma mansoni acyl carrier protein 0.0066 0.0221 0.0372
Onchocerca volvulus 0.0051 0.0162 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.049
Mycobacterium ulcerans thioesterase 0.0542 0.2151 0.5496
Echinococcus granulosus mucolipin 3 0.0064 0.0215 0.0362
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.2007
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0187 0.035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0072 0.0248 0.0578
Echinococcus multilocularis lamin dm0 0.0107 0.0388 0.0375
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0542 0.2151 0.5501
Brugia malayi ecdysteroid receptor 0.0037 0.0106 0.0187
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0032 0.0077
Schistosoma mansoni cpg binding protein 0.006 0.0196 0.0328
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0106 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0695 0.2774 0.4969
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0093 0.0161
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0224 0.0211
Leishmania major cathepsin L-like protease 0.0195 0.0745 0.9957
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.015 0.0244
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0168 0.0382
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0037 0.0266
Mycobacterium leprae Polyketide synthase Pks13 0.0972 0.3893 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0193 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0222
Mycobacterium ulcerans polyketide synthase Pks9 0.043 0.1697 0.4324
Onchocerca volvulus 0.0054 0.0173 0.0339
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0027 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0106 0.0243
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0026 0.0026
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.1819
Schistosoma mansoni hypothetical protein 0.0078 0.0271 0.0462
Mycobacterium ulcerans polyketide synthase Pks13 0.0972 0.3893 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.004 0.0118 0.1388
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0106 0.0167
Onchocerca volvulus 0.0031 0.0079 0.0138
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0269
Trypanosoma cruzi oxidoreductase, putative 0.004 0.0118 0.1388
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0162 0.3478
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0972 0.3893 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.004 0.0118 0.0211
Loa Loa (eye worm) hypothetical protein 0.0078 0.0271 0.0617
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0087 0.0132
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0199 0.2489
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.009 0.0999
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.004 0.0118 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Mycobacterium ulcerans oxidoreductase 0.004 0.0118 0.0242
Schistosoma mansoni single-minded 0.0016 0.002 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0325 0.0311
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0162 0.3478
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.004 0.0118 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0054 0.004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0054 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0027 0.0061
Echinococcus granulosus ubiquitin specific protease 41 0.0114 0.0415 0.0723
Mycobacterium ulcerans quinone oxidoreductase 0.004 0.0118 0.0242
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.069 0.2754 0.7054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.069 0.1441
Brugia malayi jmjC domain containing protein 0.0058 0.0189 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0106 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0325 0.056
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0027 0.0135
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0223 0.086 0.2169
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0027 0.0361
Toxoplasma gondii type I fatty acid synthase, putative 0.0463 0.183 0.6638
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0026 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0125 0.0461 0.0906
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.004 0.0118 0.0252
Mycobacterium ulcerans acyl carrier protein 0.0066 0.0221 0.0507
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0034
Brugia malayi conserved hypotetical protein 0.0018 0.0026 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0106 0.0243
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.015 0.0136
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0125 0.0461 0.0805
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0032 0.0031
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0222
Echinococcus multilocularis survival motor neuron protein 1 0.0695 0.2774 0.2764
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Schistosoma mansoni Smad4 0.0033 0.0087 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0436
Schistosoma mansoni survival motor neuron protein 0.0142 0.053 0.0928
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Echinococcus multilocularis dna polymerase kappa 0.002 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0121 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0027 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0054 0.0598
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0904 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0079
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0026 0.0012
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0024 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0203 0.0341
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0106 0.0093
Brugia malayi MH2 domain containing protein 0.0481 0.1905 0.3832
Schistosoma mansoni hypothetical protein 0.0078 0.0271 0.0462
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.004 0.0118 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0027 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0244
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0114 0.0415 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0423
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0079 0.0117
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0083
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0431 0.1562
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.015 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0148
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0026 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0037 0.0032
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0066 0.0221 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0093 0.1033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0106 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.009 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0117
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0066 0.0221 0.0503
Leishmania major DNA polymerase kappa, putative 0.002 0.0037 0.0266
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.004 0.0118 0.1388
Brugia malayi Cathepsin L-like precursor 0.0051 0.0162 0.03
Echinococcus granulosus dnaJ subfamily B 0.0848 0.3392 0.6081
Brugia malayi hypothetical protein 0.0038 0.0107 0.0189
Echinococcus multilocularis dna polymerase eta 0.002 0.0037 0.0023
Brugia malayi hypothetical protein 0.0018 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Onchocerca volvulus 0.0107 0.0388 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0101
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0162 0.0316
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0087 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.049
Schistosoma mansoni nuclear receptor 0.0018 0.0026 0.0022
Echinococcus granulosus microtubule associated protein 2 0.1385 0.5568 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0532 0.211 0.5394
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0079 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0106 0.0187
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0027 0.0136
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0027 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0037 0.0032
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0014 0.0032
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0199 0.0375
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0059 0.0193 0.0362
Trypanosoma brucei oxidoreductase, putative 0.004 0.0118 0.1585
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0017 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0106 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0061 0.0886
Onchocerca volvulus 0.0059 0.0193 0.0381
Brugia malayi CXXC zinc finger family protein 0.006 0.0196 0.0369
Toxoplasma gondii type I fatty acid synthase 0.01 0.0359 0.1301
Schistosoma mansoni zinc binding dehydrogenase 0.004 0.0118 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0054 0.0196
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0026 0.0025
Mycobacterium ulcerans polyketide synthase MbtD 0.02 0.0765 0.1914
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0019 0.0009
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0199 0.0333
Echinococcus multilocularis cathepsin L 0.0026 0.0061 0.0048
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.004 0.0118 0.0242
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0159 0.0598 0.1492
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0017 0.0039
Mycobacterium ulcerans oxidoreductase 0.004 0.0118 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0271 0.0617
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0203 0.0463
Entamoeba histolytica cysteine protease, putative 0.0026 0.0061 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0061 0.0679
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0101
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.1812
Trichomonas vaginalis rotamase, putative 0.0034 0.0093 0.103
Plasmodium vivax SET domain protein, putative 0.0031 0.0079 0.1029
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.0213
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0017 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0106 0.0167
Onchocerca volvulus 0.1138 0.4569 0.971
Trypanosoma brucei oxidoreductase, putative 0.004 0.0118 0.1585
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0053
Echinococcus granulosus dna polymerase eta 0.002 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0355
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0022 0.0072
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0263 0.102 0.2581
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0046
Onchocerca volvulus 0.0034 0.0093 0.017
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.065 0.259 0.5219
Treponema pallidum sodium- and chloride- dependent transporter 0.0059 0.0193 0.8508
Mycobacterium ulcerans Type I modular polyketide synthase 0.065 0.259 0.6631
Mycobacterium tuberculosis Polyketide synthase Pks2 0.063 0.2509 0.6426
Echinococcus multilocularis smad 0.0033 0.0087 0.0074
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.004 0.0118 0.0252
Loa Loa (eye worm) nuclear hormone receptor 0.0105 0.0381 0.0868
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0972 0.3893 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.0388 0.0884
Brugia malayi Cathepsin L-like precursor 0.0034 0.0093 0.0161
Onchocerca volvulus 0.0051 0.0162 0.0316
Loa Loa (eye worm) hypothetical protein 0.0168 0.0638 0.1454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0162 0.1793
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0066 0.0221 0.0207
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0017 0.0006
Loa Loa (eye worm) acyl carrier protein 0.0066 0.0221 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Schistosoma mansoni coup transcription factor 0.0037 0.0106 0.0167
Brugia malayi tailless protein 0.0018 0.0026 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0069 0.0099
Mycobacterium ulcerans polyketide synthase 0.065 0.259 0.6631
Loa Loa (eye worm) hypothetical protein 0.01 0.0359 0.0818
Trichomonas vaginalis alcohol dehydrogenase, putative 0.004 0.0118 0.1307
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.004 0.0118 0.0211
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0037 0.0106 0.0243
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.004 0.0118 0.1585
Mycobacterium ulcerans quinone reductase Qor 0.004 0.0118 0.0242
Mycobacterium ulcerans thioesterase TesA 0.0542 0.2151 0.5496
Plasmodium vivax vivapain-3 0.0026 0.0061 0.074
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.015 0.2212
Brugia malayi hypothetical protein 0.0695 0.2774 0.5592
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0017 0.0062
Brugia malayi hypothetical protein 0.0054 0.0173 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0106 0.0187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0022 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0106 0.0167
Brugia malayi jmjC domain containing protein 0.0015 0.0017 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0271 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0325 0.056
Trypanosoma brucei acyl transferase-like protein 0.0041 0.0121 0.1621
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0021 0.0007
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.002 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.015 0.1819
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0093 0.1711
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0026 0.0022
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.002 0.0041
Brugia malayi isocitrate dehydrogenase 0.0048 0.015 0.0275
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0224 0.0517
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0027 0.0027
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.01 0.0359 0.0873
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0037 0.0083
Echinococcus granulosus GPCR family 2 0.0078 0.0271 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0745 1
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.01 0.0359 0.0874
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.013 0.0208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0471 0.0823
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.055 0.0537
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0162 0.0148
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0163 0.0616 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0027 0.0298
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0614 0.2444 0.4924
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0221 0.0518
Echinococcus multilocularis microtubule associated protein 2 0.1385 0.5568 0.5562
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0224 0.0527
Trypanosoma cruzi nuclear receptor binding factor, putative 0.004 0.0118 0.1388
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0041 0.0121 0.1732
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.01 0.0359 0.0873
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0423
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0203 0.0341
Schistosoma mansoni hypothetical protein 0.0107 0.0389 0.0676
Onchocerca volvulus 0.0142 0.053 0.1099
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0017 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0125 0.0461 0.0448
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0162 0.1793
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0789 0.1799
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0199 0.0333
Leishmania major cathepsin L-like protease 0.0195 0.0745 0.9957
Loa Loa (eye worm) serotonin transporter b 0.0059 0.0193 0.0439
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0031 0.0031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0048 0.0061
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0196 0.0446
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.01 0.0359 0.0873
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.004 0.0118 0.0252
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0162 0.0369
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0061
Leishmania major cathepsin L-like protease 0.0195 0.0745 0.9957
Brugia malayi jmjC domain containing protein 0.0061 0.0203 0.0383

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 uM Inhibitory concentration against cyclin-dependent kinase 4 ChEMBL. 12941312
IC50 (binding) = 2 uM Inhibitory concentration against cyclin-dependent kinase 4 ChEMBL. 12941312
IC50 (binding) = 36 uM Inhibitory concentration against cyclin-dependent kinase 2 ChEMBL. 12941312
IC50 (binding) = 36 uM Inhibitory concentration against cyclin-dependent kinase 2 ChEMBL. 12941312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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