Detailed information for compound 166324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.488 | Formula: C24H27N3O6
  • H donors: 3 H acceptors: 6 LogP: 0.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H](N[C@H](C(=O)N1[C@@H](CN(C1=O)Cc1ccccc1)C(=O)O)C)CCc1ccccc1
  • InChi: 1S/C24H27N3O6/c1-16(25-19(22(29)30)13-12-17-8-4-2-5-9-17)21(28)27-20(23(31)32)15-26(24(27)33)14-18-10-6-3-7-11-18/h2-11,16,19-20,25H,12-15H2,1H3,(H,29,30)(H,31,32)/t16-,19-,20-/m0/s1
  • InChiKey: JUKHDGIMURKPAP-VDGAXYAQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin I converting enzyme Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0021 0.0012 0.0012
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0155 0.0575
Echinococcus multilocularis importin subunit beta 1 0.0092 0.0241 0.0241
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0039 0.0069 0.0069
Brugia malayi beta-lactamase 0.0072 0.0176 0.0176
Leishmania major 4-coumarate:coa ligase-like protein 0.0222 0.0664 0.2459
Echinococcus multilocularis neuroligin 0.0524 0.1643 0.1643
Schistosoma mansoni 6-phosphofructokinase 0.0061 0.014 0.014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0082 0.021 0.0343
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0124 0.042
Echinococcus granulosus expressed protein 0.0069 0.0167 0.0167
Brugia malayi Csnk2b protein 0.0031 0.0045 0.0045
Loa Loa (eye worm) oxidoreductase 0.0065 0.0155 0.0155
Echinococcus granulosus chromobox protein 1 0.0091 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0155 0.0226
Brugia malayi Flap endonuclease-1 0.0037 0.0063 0.0063
Echinococcus granulosus transmembrane protease serine 3 0.002 0.0008 0.0008
Plasmodium falciparum casein kinase II beta chain 0.0031 0.0045 0.0047
Onchocerca volvulus 0.0524 0.1643 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0031 0.0045 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0091 0.024 0.1458
Echinococcus multilocularis microtubule associated protein 2 0.075 0.2374 0.2374
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Onchocerca volvulus 0.0072 0.0176 0.1073
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0073 0.0224
Onchocerca volvulus 0.002 0.0008 0.0046
Entamoeba histolytica serine/threonine protein kinase, putative 0.0053 0.0117 0.0361
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0222 0.0664 0.0678
Entamoeba histolytica phosphofructokinase, putative 0.0061 0.014 0.0434
Entamoeba histolytica acyl-CoA synthetase, putative 0.0222 0.0664 0.2054
Mycobacterium tuberculosis Conserved protein 0.0072 0.0176 0.0271
Brugia malayi Ets-domain containing protein 0.0079 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.211 0.6779 0.6779
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Onchocerca volvulus 0.0072 0.0176 0.1073
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Mycobacterium ulcerans chorismate synthase 0.3008 0.9689 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0053 0.0117 0.0117
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0124 0.0124
Leishmania major DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0049 0.005
Echinococcus granulosus para nitrobenzyl esterase 0.0524 0.1643 0.1643
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1938 0.6223 0.6223
Leishmania major DNA repair protein, putative 0.0133 0.0373 0.1382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0055 0.0121 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0176 0.0176
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0122 0.034 0.1259
Schistosoma mansoni importin beta-1 0.0092 0.0241 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0157 0.0453 0.0859
Echinococcus granulosus dna polymerase eta 0.0056 0.0124 0.0124
Onchocerca volvulus 0.0524 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0122 0.034 0.034
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Echinococcus multilocularis dna polymerase eta 0.0056 0.0124 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0067 0.0408
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0065 0.0155 0.0226
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0199 0.0199
Mycobacterium tuberculosis Conserved protein 0.0072 0.0176 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0222 0.0664 0.1309
Schistosoma mansoni importin-beta 2 0.0017 0.0000083029 0.0000083029
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0851 0.27 1
Plasmodium vivax casein kinase II beta chain, putative 0.0031 0.0045 0.0047
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0538 0.0547
Plasmodium vivax casein kinase II beta chain, putative 0.0031 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0133 0.0373 0.1382
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0031 0.0045 0.0125
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.0183 0.0286
Echinococcus multilocularis chromobox protein 1 0.0091 0.024 0.024
Echinococcus multilocularis snurportin 1 0.098 0.312 0.312
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0055 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0524 0.1643 0.1643
Trichomonas vaginalis spcc417.12 protein, putative 0.0524 0.1643 1
Entamoeba histolytica hypothetical protein 0.0075 0.0188 0.058
Trypanosoma cruzi ISWI complex protein 0.0023 0.0019 0.0026
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.3104 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0068 0.0253
Toxoplasma gondii propionate-CoA ligase 0.0065 0.0155 0.016
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.0241 0.0893
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0065 0.0155 0.0153
Onchocerca volvulus 0.0065 0.0155 0.0945
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Echinococcus multilocularis dnaJ subfamily B 0.211 0.6779 0.6779
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0076 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus GPCR family 2 0.0024 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0079 0.0479
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0039 0.0069 0.0072
Loa Loa (eye worm) hypothetical protein 0.0558 0.1751 0.1751
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0065 0.0155 0.0226
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.014 0.0855
Brugia malayi chromobox protein homolog 3 0.0051 0.011 0.011
Loa Loa (eye worm) phosphofructokinase 0.0061 0.014 0.014
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0056 0.0124 0.0161
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0025 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0222 0.0664 0.1265
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0065 0.0155 0.016
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0117 0.0322 0.0581
Brugia malayi Importin beta-1 subunit 0.0092 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0039 0.0071 0.0218
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.0241 0.0893
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.0415 0.0415
Echinococcus granulosus tankyrase 0.0075 0.0188 0.0188
Brugia malayi Carboxylesterase family protein 0.0524 0.1643 0.1643
Schistosoma mansoni chromobox protein 0.0091 0.024 0.024
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0033 0.0033
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0233 0.0699 0.0699
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0039 0.0069 0.0422
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0031 0.0045 0.014
Trypanosoma brucei unspecified product 0.0056 0.0124 0.0461
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0096 0.0099
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0176 0.0271
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0044 0.0269
Mycobacterium ulcerans beta-lactamase 0.0072 0.0176 0.0174
Loa Loa (eye worm) acetylcholinesterase 1 0.3104 1 1
Brugia malayi Heterochromatin protein 1 0.0091 0.024 0.024
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0069 0.0167 0.0167
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0524 0.1643 0.1643
Onchocerca volvulus 0.0065 0.0155 0.0945
Trichomonas vaginalis antibiotic synthetase, putative 0.0065 0.0155 0.0945
Echinococcus multilocularis dna polymerase kappa 0.0056 0.0124 0.0124
Echinococcus granulosus poly (ADP ribose) polymerase 0.0158 0.0455 0.0455
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0155 0.0226
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0122 0.0743
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0039 0.0069 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0157 0.0453 0.0859
Toxoplasma gondii thioredoxin reductase 0.0032 0.0049 0.005
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0065 0.0155 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.3104 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0039 0.0069 0.0072
Trypanosoma cruzi DNA polymerase eta, putative 0.0056 0.0124 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.011 0.0667
Toxoplasma gondii ck2 beta subunit 0.0031 0.0045 0.0047
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0039 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.022 0.0656 0.0656
Toxoplasma gondii proteasome regulatory subunit 0.003 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Brugia malayi Protein kinase domain containing protein 0.0027 0.003 0.003
Giardia lamblia Casein kinase II beta chain 0.0031 0.0045 0.0602
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Brugia malayi Carboxylesterase family protein 0.0524 0.1643 0.1643
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.003 0.0041 0.0042
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0033 0.0033
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0018 0.0001 0.0001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0061 0.014 0.052
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0061 0.014 0.0195
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.001 0.001
Leishmania major acetyl-CoA synthetase, putative 0.0065 0.0155 0.0575
Plasmodium falciparum chorismate synthase 0.3008 0.9689 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0039 0.0069 0.0072
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0021 0.0012 0.0012
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0065 0.0155 0.016
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0158 0.0155
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0082 0.021 0.0294
Leishmania major hypothetical protein, conserved 0.0047 0.0096 0.0357
Onchocerca volvulus 0.002 0.0008 0.0046
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0044 0.0121
Trypanosoma brucei unspecified product 0.0038 0.0068 0.0253
Schistosoma mansoni gabp alpha 0.0079 0.0199 0.0199
Brugia malayi WGR domain containing protein 0.0558 0.1751 0.1751
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0176 0.0174
Brugia malayi CXXC zinc finger family protein 0.022 0.0656 0.0656
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0053 0.0117 0.0117
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0023 0.0018 0.0108
Echinococcus multilocularis geminin 0.0546 0.1714 0.1714
Trichomonas vaginalis helicase, putative 0.005 0.0105 0.064
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0065 0.0155 0.0155
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.034 0.1221
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.034 0.034
Echinococcus multilocularis carboxylesterase 5A 0.3104 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.0096
Schistosoma mansoni cell adhesion molecule 0.0018 0.0001 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0124 0.0124
Schistosoma mansoni myst-related protein 0.0026 0.0028 0.0028
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0044 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.005 0.005
Onchocerca volvulus 0.002 0.0008 0.0046
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0082 0.021 0.0343
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.0008 0.0008
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Loa Loa (eye worm) glutathione reductase 0.0032 0.0049 0.0049
Onchocerca volvulus 0.0025 0.0025 0.0152
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0403 0.1248 0.4623
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0044 0.0163
Giardia lamblia Fructose-bisphosphate aldolase 0.0163 0.0473 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0158 0.0158
Trypanosoma brucei polo-like protein kinase 0.0053 0.0117 0.0432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0076 0.0189 0.0189
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.003 0.003
Chlamydia trachomatis chorismate synthase 0.3008 0.9689 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0124 0.0124
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0155 0.0226
Schistosoma mansoni hypothetical protein 0.0024 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0044 0.0269
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0049 0.0139
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0176 0.0271
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0987 0.3141 0.3141
Loa Loa (eye worm) tnks protein 0.0075 0.0188 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0158 0.0158
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.1429 0.2936
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.001 0.001
Brugia malayi Fibronectin type III domain containing protein 0.0018 0.0001 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0071 0.007
Brugia malayi Trypsin family protein 0.002 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0176 0.0176
Loa Loa (eye worm) carboxylesterase 0.0524 0.1643 0.1643
Echinococcus granulosus mixed lineage leukemia protein mll 0.0055 0.0121 0.0121
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0069 0.0167 0.0167
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0068 0.0164 0.0164
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0091 0.024 0.1458
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0466 0.1455 0.1455
Echinococcus granulosus chromobox protein 1 0.0091 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Schistosoma mansoni tankyrase 0.0075 0.0188 0.0188
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0067 0.0162 0.0598
Loa Loa (eye worm) hypothetical protein 0.0053 0.0115 0.0115
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0163 0.0473 0.1461
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0061 0.014 0.0145
Schistosoma mansoni ets-related 0.0239 0.0718 0.0718
Onchocerca volvulus 0.022 0.0656 0.3994
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0524 0.1643 0.1643
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0031 0.0044 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0077 0.0194 0.0194
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.03 0.0916 0.0877
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.0008 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.075 0.2374 0.2374
Loa Loa (eye worm) 6-phosphofructokinase 0.0061 0.014 0.014
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.0145 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0056 0.0126 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0157 0.0453 0.0859
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.1015 0.3234 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0176 0.0182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.0183 0.0286
Schistosoma mansoni hypothetical protein 0.0039 0.0071 0.0071
Brugia malayi phosphofructokinase 0.0061 0.014 0.014
Echinococcus multilocularis Immunoglobulin 0.0018 0.0001 0.0001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0065 0.0155 0.0155
Trichomonas vaginalis rotamase, putative 0.0067 0.0162 0.0983
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Trichomonas vaginalis DNA polymerase eta, putative 0.0056 0.0124 0.0757
Schistosoma mansoni kinase 0.0027 0.0033 0.0033
Brugia malayi CHD4 protein 0.0027 0.0033 0.0033
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0061 0.014 0.146
Loa Loa (eye worm) hypothetical protein 0.3104 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0012 0.0012
Echinococcus multilocularis Mastin 0.002 0.0008 0.0008
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0073 0.0441
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0222 0.0664 0.0664
Brugia malayi Muscleblind-like protein 0.0987 0.3141 0.3141
Loa Loa (eye worm) hypothetical protein 0.0222 0.0664 0.0664
Brugia malayi serine/threonine-protein kinase plk-2 0.0053 0.0117 0.0117
Echinococcus granulosus Immunoglobulin 0.0018 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0851 0.27 1
Brugia malayi Fli-1 protein 0.0239 0.0718 0.0718
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0073 0.0441
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0073 0.0441
Brugia malayi hypothetical protein 0.002 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.003 0.0185
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0172 0.0501 0.1549
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.008 0.0202 0.0326
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0072 0.0176 0.0652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0176 0.1072
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0031 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Schistosoma mansoni casein kinase II beta subunit 0.0031 0.0045 0.0045
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Echinococcus granulosus neuroligin 0.0524 0.1643 0.1643
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0023 0.0018 0.0018
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0039 0.0069 0.1134
Schistosoma mansoni hypothetical protein 0.0024 0.0023 0.0023
Echinococcus granulosus acetylcholinesterase 0.3104 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0124 0.0461
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0061 0.0372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0124 0.0124
Brugia malayi Protein kinase domain containing protein 0.0122 0.034 0.034
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0181 0.0529 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0037 0.0063 0.0234
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0155 0.0534
Entamoeba histolytica phosphofructokinase, putative 0.0061 0.014 0.0434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0065 0.0155 0.0155
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0023 0.0018 0.0108
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.0117 0.0391
Loa Loa (eye worm) hypothetical protein 0.0172 0.0501 0.0501
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0073 0.0073
Schistosoma mansoni z-protein (S1r protein) 0.002 0.001 0.001
Schistosoma mansoni tsg101-related 0.0032 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0158 0.0455 0.1406
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0166 0.0482 0.0426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0448 0.1396 0.2866
Onchocerca volvulus 0.0169 0.0491 0.2986
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0065 0.0155 0.0575
Brugia malayi 6-phosphofructokinase 0.0061 0.014 0.014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0222 0.0664 0.0678
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0065 0.0155 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0416 0.1505
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0039 0.0069 0.0257
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Loa Loa (eye worm) hypothetical protein 0.0121 0.0337 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0076 0.0189 0.0189
Entamoeba histolytica phosphofructokinase, putative 0.0061 0.014 0.0434
Mycobacterium tuberculosis Probable reductase 0.0074 0.0183 0.0286
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0056 0.0124 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0077 0.0194 0.0194
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.04 0.124 0.124
Brugia malayi Trypsin-like protease protein 5 0.002 0.0008 0.0008
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0073 0.0441
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.098 0.312 0.312
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0031 0.0045 0.0125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0076 0.0189 0.0189
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0018 0.0001 0.0001
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0031 0.0045 0.014
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0073 0.0073
Schistosoma mansoni myst-related protein 0.0026 0.0028 0.0028
Brugia malayi 6-phosphofructokinase 0.0061 0.014 0.014
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0117 0.0322 0.0534
Brugia malayi AMP-binding enzyme family protein 0.0222 0.0664 0.0664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Echinococcus granulosus snurportin 1 0.098 0.312 0.312
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0538 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.0183 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0096 0.0315
Echinococcus granulosus nibrin 0.004 0.0073 0.0073
Schistosoma mansoni regulator of G protein signaling 0.002 0.001 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0176 0.0271
Echinococcus multilocularis acetylcholinesterase 0.3104 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0166 0.0482 0.0497
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0158 0.0231
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0071 0.0071
Echinococcus granulosus expressed protein 0.0251 0.0756 0.0756
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Brugia malayi Ets-domain containing protein 0.0079 0.0199 0.0199
Mycobacterium ulcerans 6-phosphofructokinase 0.0061 0.014 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0046 0.0046
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0199 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Echinococcus granulosus defective proboscis extension response 0.0018 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.012 0.0331 0.1189
Entamoeba histolytica protein kinase, putative 0.0122 0.034 0.1051
Echinococcus granulosus dual specificity 0.0122 0.034 0.034
Trichomonas vaginalis importin beta-1, putative 0.0074 0.0185 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0524 0.1643 0.1643
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0538 0.0483
Schistosoma mansoni acetyl-CoA synthetase 0.0065 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.098 0.312 0.312
Brugia malayi Trypsin family protein 0.002 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0072 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0166 0.0482 0.0482
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0076 0.0189 0.0189
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0077 0.0194 0.0194
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0065 0.0155 0.0226
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0065 0.0155 0.0153
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0071 0.007
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0073 0.0067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0185 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0068 0.0253
Plasmodium falciparum glutathione reductase 0.0032 0.0049 0.005
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0073 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0417 0.1294 0.1335
Entamoeba histolytica hypothetical protein 0.0074 0.0185 0.0572
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0199 0.0199
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0044 0.0044
Loa Loa (eye worm) trypsin family protein 0.002 0.0008 0.0008
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0033 0.0033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0044 0.0121
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.003 0.0041 0.0041
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0065 0.0155 0.0534
Brugia malayi 26S proteasome regulatory subunit rpn11 0.003 0.0041 0.0041
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0018 0.0001 0.0001
Schistosoma mansoni vesicular amine transporter 0.0018 0.0001 0.0001
Plasmodium falciparum flap endonuclease 1 0.0037 0.0063 0.0065
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0039 0.0069 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.0183 0.0286
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.003 0.0185
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.001 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0222 0.0664 0.0678
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0031 0.0044 0.0136
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0025 0.0025
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.003 0.0041 0.0127
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0176 0.0271
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0031 0.0044 0.0579
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0155 0.0445 0.271
Loa Loa (eye worm) hypothetical protein 0.0121 0.0337 0.0337
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Brugia malayi RNA, U transporter 1 0.0261 0.079 0.079
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0181 0.0529 0.0529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0018 0.0001 0.0001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Brugia malayi Carboxylesterase family protein 0.3104 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.014 0.0855
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0023 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0441
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0012 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0077 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0167 0.1015
Loa Loa (eye worm) hypothetical protein 0.0092 0.0241 0.0241
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0039 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Brugia malayi topoisomerase 0.004 0.0073 0.0073
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1483 0.4749 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0172 0.0501 0.1549
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0068 0.0164 0.0164
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.237 0.237
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.011 0.0667
Echinococcus multilocularis acetylcholinesterase 0.3104 1 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Echinococcus granulosus muscleblind protein 0.0987 0.3141 0.3141
Trypanosoma cruzi DNA repair protein, putative 0.0133 0.0373 0.1345
Onchocerca volvulus 0.002 0.0008 0.0046
Schistosoma mansoni hypothetical protein 0.0053 0.0115 0.0115
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0065 0.0155 0.0177
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0483 0.1507 0.1507
Entamoeba histolytica hypothetical protein 0.0122 0.034 0.1051
Leishmania major trypanothione reductase 0.0032 0.0049 0.0181
Plasmodium falciparum thioredoxin reductase 0.0032 0.0049 0.005
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0065 0.0155 0.0153
Leishmania major acetyl-CoA synthetase, putative 0.0065 0.0155 0.0575
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0181 0.0529 0.0529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Loa Loa (eye worm) proteasome 26S subunit 0.0023 0.0018 0.0018
Echinococcus multilocularis muscleblind protein 1 0.0987 0.3141 0.3141
Mycobacterium ulcerans hypothetical protein 0.0222 0.0664 0.0678
Entamoeba histolytica hypothetical protein 0.0075 0.0188 0.058
Loa Loa (eye worm) hypothetical protein 0.0169 0.0491 0.0491
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Echinococcus granulosus flap endonuclease 1 0.0037 0.0063 0.0063
Onchocerca volvulus 0.0524 0.1643 1
Echinococcus granulosus twitchin 0.0018 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0073 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0124 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0025 0.005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0067 0.0162 0.0558
Trichomonas vaginalis hypothetical protein 0.0027 0.003 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.014 0.0855
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0124 0.0124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0023 0.0023
Brugia malayi kap beta 3 protein 0.0017 0.0000083029 0.0000083029
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0176 0.0271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0023 0.0023
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0065 0.0155 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0155 0.0226
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0012 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0851 0.27 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Onchocerca volvulus 0.0065 0.0155 0.0945
Echinococcus granulosus dna polymerase kappa 0.0056 0.0124 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0524 0.1643 1
Onchocerca volvulus 0.004 0.0074 0.0449
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0403 0.1248 0.4623
Echinococcus granulosus cpg binding protein 0.0232 0.0697 0.0697
Echinococcus granulosus ubiquitin specific protease 41 0.0031 0.0044 0.0044
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0524 0.1643 0.3391
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0037 0.0063 0.0192
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0403 0.1248 0.46
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0117 0.0117
Leishmania major DNA polymerase eta, putative 0.0056 0.0124 0.0461
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0073 0.0075
Echinococcus multilocularis roundabout 2 0.0018 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0076 0.0189 0.0189
Plasmodium vivax chorismate synthase 0.3008 0.9689 1
Echinococcus multilocularis flap endonuclease 1 0.0037 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.03 0.0916 0.0938
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0031 0.0045 0.0167
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0222 0.0664 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Loa Loa (eye worm) hypothetical protein 0.0166 0.0482 0.0482
Trypanosoma brucei poly(adp-ribose) polymerase 0.0558 0.1751 0.6485
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0044 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0222 0.0664 0.1309
Schistosoma mansoni flap endonuclease-1 0.0033 0.0052 0.0052
Loa Loa (eye worm) carboxylesterase 0.3104 1 1
Loa Loa (eye worm) carboxylesterase 0.0524 0.1643 0.1643
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0023 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0074
Brugia malayi hypothetical protein 0.004 0.0073 0.0073
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0073 0.0227
Leishmania major GTP-binding protein, putative 0.0039 0.0069 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0122 0.034 0.1259
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0023 0.0018 0.0066
Brugia malayi N-terminal motif family protein 0.0155 0.0445 0.0445
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0096 0.0099
Schistosoma mansoni neuroligin 3 (S09 family) 0.0524 0.1643 0.1643
Onchocerca volvulus 0.0524 0.1643 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0524 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0024 0.0023 0.0023
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0067 0.0162 0.0598
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Brugia malayi beta-lactamase family protein 0.0072 0.0176 0.0176
Trypanosoma brucei ISWI complex protein 0.0023 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0065 0.0155 0.0153
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0055 0.0122 0.0744
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0044 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Echinococcus granulosus 6 phosphofructokinase 0.0061 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0155 0.0534
Loa Loa (eye worm) CXXC zinc finger family protein 0.022 0.0656 0.0656
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0065 0.0154 0.0935
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0166 0.0482 0.049
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0031 0.0044 0.0044
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0558 0.1751 0.647
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0124 0.0461
Mycobacterium leprae Probable lipase LipE 0.0072 0.0176 0.0222
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0558 0.1751 0.1751
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0065 0.0155 0.0153
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Brugia malayi WGR domain containing protein 0.1015 0.3234 0.3234
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0124 0.0124
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.014 0.0855
Mycobacterium ulcerans carboxylesterase, LipT 0.0524 0.1643 0.1689
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0122 0.0743
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Entamoeba histolytica hypothetical protein 0.0026 0.0028 0.0086
Entamoeba histolytica hypothetical protein 0.0075 0.0188 0.058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.011 0.0667
Schistosoma mansoni 6-phosphofructokinase 0.0061 0.014 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0031 0.0045 0.0276
Echinococcus granulosus neuroglian 0.0018 0.0001 0.0001
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0025 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0157 0.0453 0.0859
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0524 0.1643 0.3391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0176 0.0176
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0176 0.0176
Trypanosoma brucei DNA polymerase beta thumb, putative 0.012 0.0331 0.1227
Echinococcus granulosus WGR domain containing protein 0.0315 0.0966 0.0966
Toxoplasma gondii hypothetical protein 0.0137 0.0388 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0073 0.0227
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0176 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0001 0.0001
Echinococcus granulosus importin subunit beta 1 0.0092 0.0241 0.0241
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Brugia malayi Thioredoxin reductase 0.0032 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Trichomonas vaginalis esterase, putative 0.0072 0.0176 0.1072
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0176 0.1072
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0176 0.1072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0124 0.042
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0074 0.0185 0.0645
Schistosoma mansoni hypothetical protein 0.0024 0.0023 0.0023
Plasmodium falciparum zinc finger protein, putative 0.0026 0.0028 0.0029
Mycobacterium tuberculosis Conserved protein 0.0072 0.0176 0.0271
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0039 0.0071 0.0071
Onchocerca volvulus 0.0222 0.0664 0.4043
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.0415 0.0415
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0049 0.0049
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0163 0.0473 0.1461
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0176 0.1072
Schistosoma mansoni tsg101-related 0.0026 0.0029 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Brugia malayi hypothetical protein 0.0039 0.007 0.007
Echinococcus multilocularis tankyrase 0.0075 0.0188 0.0188
Giardia lamblia Replication factor C, subunit 1 0.004 0.0073 0.1203
Brugia malayi Tnks protein 0.0075 0.0188 0.0188
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0023 0.0023
Giardia lamblia Flap structure-specific endonuclease 0.0037 0.0063 0.0998
Schistosoma mansoni ran 0.0039 0.0069 0.0069
Brugia malayi Trypsin family protein 0.002 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0222 0.0664 0.0664
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0158 0.0163
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0124 0.0161
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0072 0.0176 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0073 0.0227
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0065 0.0155 0.0226
Echinococcus multilocularis GPCR, family 2 0.0024 0.0023 0.0023
Chlamydia trachomatis dehyroquinate synthase 0.0117 0.0322 0.026
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0065 0.0155 0.0177
Schistosoma mansoni hypothetical protein 0.0546 0.1714 0.1714
Loa Loa (eye worm) hypothetical protein 0.0051 0.011 0.011
Schistosoma mansoni nephrin 0.0018 0.0001 0.0001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0124 0.0385
Giardia lamblia DINP protein human, muc B family 0.0056 0.0124 0.2343
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0031 0.0045 0.0276
Treponema pallidum fructose-bisphosphate aldolase 0.0163 0.0473 0.8604
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.008 0.0202 0.0277
Onchocerca volvulus 0.0524 0.1643 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0076 0.0189 0.0189
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0166 0.0482 0.0922
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0065 0.0155 0.0226
Echinococcus granulosus poly adp ribose polymerase 2 0.0558 0.1751 0.1751
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0023 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0023 0.0023
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0065 0.0155 0.0575
Loa Loa (eye worm) hypothetical protein 0.0166 0.0482 0.0482
Schistosoma mansoni topbp1 0.004 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0155 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0067 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Onchocerca volvulus Tankyrase homolog 0.0075 0.0188 0.1143
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0061 0.014 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Onchocerca volvulus 0.002 0.0008 0.0046
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0117 0.0322 0.0581
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0155 0.0177
Toxoplasma gondii chorismate synthase, putative 0.3008 0.9689 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.0664 0.0664
Echinococcus granulosus GTP binding nuclear protein Ran 0.0039 0.0069 0.0069
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0122 0.034 0.1221
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0068 0.0253
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0158 0.0158
Plasmodium falciparum casein kinase II beta chain 0.0031 0.0045 0.0047
Echinococcus granulosus BC026374 protein S09 family 0.0524 0.1643 0.1643
Trichomonas vaginalis flap endonuclease-1, putative 0.0037 0.0063 0.0385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0096 0.0357
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.021 0.0343
Schistosoma mansoni cpg binding protein 0.0232 0.0697 0.0697
Brugia malayi F/Y-rich N-terminus family protein 0.0067 0.0161 0.0161
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0025 0.0025
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.0117 0.0391
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0065 0.0155 0.0534
Echinococcus granulosus Mastin 0.002 0.0008 0.0008
Echinococcus granulosus casein kinase ii subunit beta 0.0031 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Loa Loa (eye worm) hypothetical protein 0.0166 0.0482 0.0482
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0023 0.0018 0.0108
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Leishmania major importin beta-1 subunit, putative 0.0074 0.0185 0.0685
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0065 0.0154 0.0935
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Brugia malayi hypothetical protein 0.0047 0.0096 0.0096
Plasmodium falciparum importin beta, putative 0.0092 0.0241 0.0249
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.0183 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0096 0.0099
Echinococcus multilocularis dual specificity 0.0122 0.034 0.034
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0023 0.0023
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0222 0.0664 0.0678
Trypanosoma brucei DNA repair protein, putative 0.0133 0.0373 0.1382
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Leishmania major hypothetical protein, conserved 0.0025 0.0025 0.0092
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.034 0.1051
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0096 0.0315
Schistosoma mansoni acetylcholinesterase 0.0524 0.1643 0.1643
Loa Loa (eye worm) fli-1 protein 0.0239 0.0718 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.012 0.0331 0.1189
Onchocerca volvulus 0.002 0.0008 0.0046
Plasmodium vivax glutathione reductase, putative 0.0032 0.0049 0.005
Trypanosoma brucei trypanothione reductase 0.0032 0.0049 0.0181
Mycobacterium tuberculosis Carboxylesterase LipT 0.0524 0.1643 0.3391
Echinococcus granulosus enteropeptidase 0.002 0.0008 0.0008
Echinococcus granulosus poly ADP ribose polymerase 1 0.1015 0.3234 0.3234
Mycobacterium ulcerans acetyl-CoA synthetase 0.0065 0.0155 0.0153
Schistosoma mansoni chromobox protein 0.0091 0.024 0.024
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Mycobacterium ulcerans hypothetical protein 0.0072 0.0176 0.0174
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0073 0.0441
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0065 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0166 0.0482 0.0482
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0121 0.0121
Echinococcus granulosus poly (ADP ribose) polymerase 0.0158 0.0455 0.0455
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Brugia malayi glutathione reductase 0.0032 0.0049 0.0049
Trypanosoma brucei unspecified product 0.0038 0.0068 0.0253
Toxoplasma gondii peptidylprolyl isomerase 0.0067 0.0162 0.0167
Brugia malayi DKFZp564C0469 protein 0.004 0.0073 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0185 0.1126
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0026 0.0029 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0176 0.0222
Loa Loa (eye worm) hypothetical protein 0.0773 0.2448 0.2448
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0031 0.0045 0.014
Echinococcus multilocularis Immunoglobulin 0.0018 0.0001 0.0001
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0073 0.0227
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0023 0.0018 0.0066
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0558 0.1751 0.647
Leishmania major mitochondrial DNA polymerase beta 0.0851 0.27 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0158 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0176 0.0176
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0065 0.0155 0.016
Entamoeba histolytica Ran family GTPase 0.0039 0.0069 0.0215
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0019 0.0006 0.0006
Trichomonas vaginalis hypothetical protein 0.0019 0.0005 0.0031
Loa Loa (eye worm) Csnk2b protein 0.0031 0.0045 0.0045
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.03 0.0916 0.0945
Echinococcus multilocularis 6 phosphofructokinase 0.0061 0.014 0.014
Trichomonas vaginalis antibiotic synthetase, putative 0.0065 0.0155 0.0945
Schistosoma mansoni hypothetical protein 0.0546 0.1714 0.1714
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0061 0.0372
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0222 0.0664 0.0678
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.1055 0.3363 0.347
Onchocerca volvulus 0.0072 0.0176 0.1073
Echinococcus granulosus carboxylesterase 5A 0.3104 1 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.237 0.2369
Mycobacterium ulcerans acyl-CoA synthetase 0.0222 0.0664 0.0678
Echinococcus multilocularis expressed protein 0.0069 0.0167 0.0167
Echinococcus granulosus poly (ADP ribose) polymerase 0.0158 0.0455 0.0455
Echinococcus multilocularis nibrin 0.004 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0019 0.0113
Loa Loa (eye worm) flap endonuclease-1 0.0037 0.0063 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0076 0.0189 0.0189
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0183 0.0538 1
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.003 0.0041 0.0041
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.003 0.0041 0.0041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0158 0.0584
Schistosoma mansoni topbp1 0.004 0.0073 0.0073
Brugia malayi Kringle domain containing protein 0.0025 0.0025 0.0025
Brugia malayi hypothetical protein 0.004 0.0073 0.0073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0065 0.0155 0.0155
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0067 0.0162 0.0558
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0044 0.0163
Entamoeba histolytica acyl-coA synthetase, putative 0.0222 0.0664 0.2054
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0176 0.0612
Brugia malayi hypothetical protein 0.0169 0.0491 0.0491
Entamoeba histolytica hypothetical protein 0.0039 0.0071 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0222 0.0664 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0441
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0031 0.0045 0.0167
Mycobacterium ulcerans lipase LipD 0.0072 0.0176 0.0174
Entamoeba histolytica hypothetical protein 0.004 0.0073 0.0224
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.008 0.0202 0.0201
Onchocerca volvulus 0.004 0.0073 0.0442
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0073 0.0269
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0065 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0075 0.0188 0.058
Entamoeba histolytica hypothetical protein 0.0039 0.0071 0.0218
Echinococcus multilocularis ubiquitin specific protease 41 0.0031 0.0044 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0155 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0008 0.0008
Echinococcus multilocularis chromobox protein 1 0.0091 0.024 0.024
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0025 0.0026
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0073 0.1159
Entamoeba histolytica protein kinase, putative 0.0122 0.034 0.1051
Loa Loa (eye worm) beta-lactamase 0.0072 0.0176 0.0176
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.0008 0.0008
Loa Loa (eye worm) heterochromatin protein 1 0.0091 0.024 0.024
Trichomonas vaginalis casein kinase II beta chain, putative 0.0031 0.0045 0.0275
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0117 0.0322 0.0325
Mycobacterium ulcerans acyl-CoA synthetase 0.0222 0.0664 0.0678
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0065 0.0155 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0076 0.0189 0.0189
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0012 0.0043
Onchocerca volvulus DNA ligase 3 homolog 0.0133 0.0373 0.2272
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0056 0.0124 0.0757
Echinococcus granulosus microtubule associated protein 2 0.075 0.2374 0.2374
Echinococcus multilocularis cpg binding protein 0.0232 0.0697 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.0008 0.0008
Schistosoma mansoni DNA polymerase eta 0.0056 0.0124 0.0124
Schistosoma mansoni ran 0.0039 0.0069 0.0069
Schistosoma mansoni BC026374 protein (S09 family) 0.0524 0.1643 0.1643
Onchocerca volvulus Serine\/threonine kinase homolog 0.0053 0.0117 0.0711
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0133 0.0373 0.1345
Leishmania major ATP-dependent phosphofructokinase 0.0061 0.014 0.052
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0055 0.0121 0.0121
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0037 0.0063 0.0065
Brugia malayi SET domain containing protein 0.002 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0124 0.0121
Schistosoma mansoni rotamase 0.0069 0.0167 0.0167
Echinococcus multilocularis neuroglian 0.0018 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Brugia malayi Trypsin family protein 0.002 0.0008 0.0008
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.03 0.0916 0.1803
Leishmania major 4-coumarate:coa ligase-like protein 0.0222 0.0664 0.2459
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.003 0.0041 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0105 0.064
Loa Loa (eye worm) hypothetical protein 0.0987 0.3141 0.3141
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.0008 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0023 0.0023
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.001 0.001
Echinococcus granulosus replication factor c subunit 1 0.004 0.0073 0.0073
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0053 0.0117 0.0432
Brugia malayi Carboxylesterase family protein 0.0524 0.1643 0.1643
Schistosoma mansoni DNA ligase IV 0.004 0.0073 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0124 0.042
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.003 0.0041 0.0041
Echinococcus multilocularis enteropeptidase 0.002 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0176 0.0271
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0018 0.0003 0.001
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1483 0.4749 1
Toxoplasma gondii ABC1 family protein 0.0072 0.0176 0.0182
Schistosoma mansoni gliotactin 0.0524 0.1643 0.1643
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0065 0.0155 0.0226
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0008 0.0008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.012 0.0331 0.1189
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0008
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1015 0.3234 0.3234
Loa Loa (eye worm) histone methyltransferase 0.0068 0.0164 0.0164
Plasmodium vivax acyl-CoA synthetase, putative 0.0166 0.0482 0.0497
Plasmodium vivax acetyl-CoA synthetase, putative 0.0065 0.0155 0.016
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0096 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0163 0.0473 0.2876
Echinococcus granulosus acetylcholinesterase 0.3104 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.0183 0.0286
Brugia malayi hypothetical protein 0.0524 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0025
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.1015 0.3234 0.3234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0158 0.0155
Toxoplasma gondii HEAT repeat-containing protein 0.0092 0.0241 0.0249
Onchocerca volvulus 0.0065 0.0155 0.0945
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0073
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0073 0.0075
Echinococcus multilocularis para nitrobenzyl esterase 0.0524 0.1643 0.1643
Trichomonas vaginalis rotamase, putative 0.0069 0.0167 0.1015
Entamoeba histolytica zinc finger protein, putative 0.0075 0.0188 0.058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0042 0.0079 0.0479
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0629 0.198 0.198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0222 0.0664 0.2054
Loa Loa (eye worm) 6-phosphofructokinase 0.0061 0.014 0.014
Entamoeba histolytica Flap nuclease, putative 0.0037 0.0063 0.0195
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.0008 0.0008
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0558 0.1751 0.1751
Schistosoma mansoni 3-dehydroquinate synthase 0.0117 0.0322 0.0322
Leishmania major 4-coumarate:coa ligase-like protein 0.0222 0.0664 0.2459
Loa Loa (eye worm) hypothetical protein 0.0524 0.1643 0.1643
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0176 0.0271
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0008
Echinococcus granulosus roundabout 2 0.0018 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0065 0.0154 0.0935
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0044 0.0269
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0008 0.0008
Giardia lamblia Kinase, PLK 0.0053 0.0117 0.2174
Loa Loa (eye worm) hypothetical protein 0.0133 0.0373 0.0373
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0176 0.0176
Brugia malayi latrophilin 2 splice variant baaae 0.0053 0.0115 0.0115
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0067 0.0162 0.05
Brugia malayi hypothetical protein 0.003 0.0042 0.0042
Echinococcus granulosus geminin 0.0546 0.1714 0.1714
Echinococcus granulosus dnaJ subfamily B 0.211 0.6779 0.6779
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0124 0.0461
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0176 0.0652
Schistosoma mansoni cpg binding protein 0.0232 0.0697 0.0697
Plasmodium vivax importin-beta 2, putative 0.0092 0.0241 0.0249
Entamoeba histolytica hypothetical protein 0.0039 0.0071 0.0218
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0039 0.007 0.007
Leishmania major hypothetical protein, conserved 0.0133 0.0373 0.1382
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0124 0.0461
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.071
Echinococcus multilocularis muscleblind protein 0.0987 0.3141 0.3141
Echinococcus multilocularis expressed protein 0.0251 0.0756 0.0756
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0065 0.0155 0.048
Schistosoma mansoni tsg101-related 0.0032 0.0049 0.0049
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0037 0.0063 0.0234
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0053 0.0117 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0176 0.0612
Echinococcus granulosus poly (ADP ribose) polymerase 0.0315 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0176 0.0174
Mycobacterium ulcerans hypothetical protein 0.0448 0.1396 0.1434
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0039 0.007 0.007
Brugia malayi Carboxylesterase family protein 0.0524 0.1643 0.1643
Onchocerca volvulus 0.002 0.0008 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0073 0.0441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0056 0.0124 0.0461
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0073 0.0073
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0524 0.1643 0.1643
Plasmodium vivax flap endonuclease 1, putative 0.0037 0.0063 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0188 0.1143

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0000000017 M Inhibition of Angiotensin I converting enzyme from pig renal cortex, hippurylhistidylleucine as substrate ChEMBL. 2913292
IC50 (binding) = 0.0000000017 M Inhibition of Angiotensin I converting enzyme from pig renal cortex, hippurylhistidylleucine as substrate ChEMBL. 2913292
Inhibition (functional) = 39 % Maximum inhibitory effect on Angiotensin I induced pressor responses in anesthetized normotensive rats with 10 ug/kg dose of compound given intra venously ChEMBL. 2913292

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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