Detailed information for compound 166330

Basic information

Technical information
  • TDR Targets ID: 166330
  • Name: 1-(4-fluorophenyl)-4-[2-methyl-4-(4-methylphe nyl)sulfonylpiperazin-1-yl]butan-1-one
  • MW: 418.525 | Formula: C22H27FN2O3S
  • H donors: 0 H acceptors: 3 LogP: 3.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCN(C(C1)C)CCCC(=O)c1ccc(cc1)F
  • InChi: 1S/C22H27FN2O3S/c1-17-5-11-21(12-6-17)29(27,28)25-15-14-24(18(2)16-25)13-3-4-22(26)19-7-9-20(23)10-8-19/h5-12,18H,3-4,13-16H2,1-2H3
  • InChiKey: VNSVPXVUMOXEFH-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(4-fluorophenyl)-4-[2-methyl-4-(p-tolylsulfonyl)piperazin-1-yl]butan-1-one
  • 1-(4-fluorophenyl)-4-[2-methyl-4-(p-tolylsulfonyl)-1-piperazinyl]-1-butanone
  • 1-(4-fluorophenyl)-4-[2-methyl-4-(4-methylphenyl)sulfonyl-piperazin-1-yl]butan-1-one
  • 1-(4-fluorophenyl)-4-(2-methyl-4-tosyl-piperazino)butan-1-one
  • 1-(4-fluorophenyl)-4-[2-methyl-4-(4-methylphenyl)sulfonyl-1-piperazinyl]butan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum chorismate synthase 0.2623 1 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.01 0.0159
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0425 0.1571 0.705
Echinococcus multilocularis chromobox protein 1 0.0097 0.0313 0.0497
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.001 0.0016
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0053 0.0845
Brugia malayi hypothetical protein 0.0179 0.0629 0.2822
Onchocerca volvulus 0.0029 0.0053 0.0605
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0053 0.0223
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0354 0.1505
Loa Loa (eye worm) G protein alpha subunit 3 0.0018 0.001 0.0045
Schistosoma mansoni hypothetical protein 0.0022 0.0027 0.0042
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0053 0.0223
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0088 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0319 0.1164 0.1132
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0018 0.001 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0322 0.5302
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0088 0.0139
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0038 0.0159
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0053 0.0223
Echinococcus multilocularis Chromo domain 0.0016 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0073 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0038 0.0159
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0085 0.0266 0.0542
Schistosoma mansoni chromobox protein 0.0016 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.001 0.0016
Schistosoma mansoni hypothetical protein 0.0049 0.0127 0.0202
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0038 0.0168
Trypanosoma cruzi Aminopeptidase M1, putative 0.0072 0.0216 0.0919
Plasmodium vivax importin-beta 2, putative 0.004 0.0093 0.0093
Trichomonas vaginalis chromobox protein, putative 0.0097 0.0313 0.515
Echinococcus granulosus expressed protein 0.0267 0.0963 0.1529
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0024 0.0034 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0036 0.0058
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0036 0.0058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0054 0.0149 0.1751
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0053 0.0084
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0038 0.0159
Leishmania major DNA polymerase kappa, putative 0.0042 0.01 0.0427
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.001 0.0016
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0038 0.006
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0024 0.0034 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0322 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.1013
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Echinococcus granulosus mixed lineage leukemia protein mll 0.0035 0.0073 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0127 0.0571
Schistosoma mansoni chromobox protein 0.0097 0.0313 0.0497
Brugia malayi TAR-binding protein 0.0064 0.0186 0.0835
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0017 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0038 0.006
Mycobacterium ulcerans 6-phosphofructokinase 0.0065 0.0188 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0056 0.0156 0.255
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0017 0.0007 0.0098
Echinococcus granulosus tar DNA binding protein 0.0064 0.0186 0.0295
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0322 0.1445
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0047 0.0753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0188 0.3086
Brugia malayi hypothetical protein 0.0025 0.0038 0.0168
Brugia malayi Associated with TFs and helicases family protein 0.0016 0.0002 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.0154 0.0531 0.2382
Entamoeba histolytica phosphofructokinase, putative 0.0065 0.0188 0.3086
Loa Loa (eye worm) heterochromatin protein 1 0.0097 0.0313 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Echinococcus granulosus 6 phosphofructokinase 0.0065 0.0188 0.0299
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0036 0.0074
Echinococcus granulosus dna polymerase eta 0.0042 0.01 0.0159
Onchocerca volvulus 0.0025 0.0036 0.0411
Trypanosoma brucei unspecified product 0.0042 0.01 0.0427
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0063 0.01
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Onchocerca volvulus 0.0029 0.0053 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1558 0.2473
Echinococcus multilocularis acetylcholinesterase 0.0148 0.0507 0.0804
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.001 0.0141
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.001 0.0045
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.001 0.0016
Brugia malayi Peptidase family M1 containing protein 0.0072 0.0216 0.0971
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Mycobacterium ulcerans beta-lactamase 0.0026 0.0039 0.0003
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0063 0.0063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0088 0.0372
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0195 0.0688 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0038 0.0038
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.001 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0298 0.1083 0.46
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Echinococcus multilocularis Chromobox protein 3 0.0016 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0043 0.0106 0.0168
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0038 0.0038
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0088 0.0139
Onchocerca volvulus 0.0019 0.0013 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0531 0.2382
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0322 0.1445
Brugia malayi RNA binding protein 0.0064 0.0186 0.0835
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0195 0.0688 0.0681
Echinococcus granulosus expressed protein 0.0018 0.001 0.0016
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0036 0.0058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.0322 0.0657
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0053 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0263 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0536
Echinococcus granulosus acetylcholinesterase 0.0148 0.0507 0.0804
Trypanosoma brucei importin beta-1 subunit, putative 0.004 0.0093 0.0396
Loa Loa (eye worm) carboxylesterase 0.0025 0.0036 0.0163
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0036 0.0058
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0053 0.0084
Loa Loa (eye worm) RNA binding protein 0.0064 0.0186 0.0835
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0088 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1558 0.2473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0174 0.0606 1
Mycobacterium ulcerans hypothetical protein 0.0099 0.0322 0.0287
Leishmania major DNA polymerase eta, putative 0.0042 0.01 0.0427
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.0043 0.0192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0192 0.0677 0.1074
Brugia malayi Muscleblind-like protein 0.0597 0.2228 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0016 0.0002 0.0002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0088 0.0372
Schistosoma mansoni rotamase 0.0026 0.0041 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.01 0.0427
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0065 0.0188 0.0306
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0026 0.0039 0.0166
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0017 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0058 0.0926
Brugia malayi Protein kinase domain containing protein 0.0027 0.0043 0.0192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0322 0.0287
Echinococcus multilocularis geminin 0.0339 0.124 0.1969
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0039 0.0167
Onchocerca volvulus 0.0026 0.0039 0.0447
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0188 0.3086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0017 0.0027
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0047 0.0119 0.0507
Onchocerca volvulus 0.0018 0.001 0.0101
Brugia malayi TATA binding protein associated factor 0.0025 0.0038 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0155 0.0533 0.2393
Mycobacterium ulcerans hypothetical protein 0.0026 0.0039 0.0003
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0036 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0024 0.0034 0.0144
Loa Loa (eye worm) hypothetical protein 0.0126 0.0423 0.19
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.01 0.0427
Brugia malayi RNA, U transporter 1 0.0113 0.0375 0.1682
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.001 0.0016
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.01 0.1636
Brugia malayi G-protein alpha subunit 0.0018 0.001 0.0045
Entamoeba histolytica G protein alpha subunit, putative 0.0018 0.001 0.0141
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0026 0.0039 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0188 0.3086
Brugia malayi beta-lactamase family protein 0.0026 0.0039 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0024 0.0034 0.0534
Echinococcus granulosus tissue type plasminogen activator 0.0027 0.0043 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0295 0.1071 0.1701
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.0322 0.0287
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0047 0.0119 0.019
Echinococcus multilocularis expressed protein 0.0026 0.0041 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0188 0.3086
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0038 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1558 0.2473
Brugia malayi hypothetical protein 0.0025 0.0036 0.0163
Echinococcus multilocularis chromobox protein 2 0.0016 0.0002 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0322 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0344 0.1544
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0047 0.0753
Toxoplasma gondii HEAT repeat-containing protein 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Trichomonas vaginalis importin beta-1, putative 0.0032 0.0064 0.104
Loa Loa (eye worm) transcription factor SMAD2 0.0155 0.0533 0.2393
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.01 0.0451
Echinococcus multilocularis snurportin 1 0.0425 0.1571 0.2494
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0027 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0002 0.0002
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0038 0.0038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0174 0.0606 1
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0039 0.0167
Giardia lamblia DINP protein human, muc B family 0.0042 0.01 0.1592
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1124 0.425 0.6747
Echinococcus multilocularis neuroligin 0.0025 0.0036 0.0058
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0072 0.0216 0.0919
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.0226 0.0226
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0088 0.1422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1558 0.2473
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0186 0.0835
Echinococcus granulosus cpg binding protein 0.0147 0.0504 0.08
Brugia malayi CXXC zinc finger family protein 0.0139 0.0474 0.2126
Brugia malayi MH2 domain containing protein 0.0155 0.0533 0.2393
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.021 0.0429
Leishmania major ATP-dependent phosphofructokinase 0.0065 0.0188 0.0799
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0036 0.0058
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0038 0.0038
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0038 0.0168
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0024 0.0034 0.0144
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0017 0.0005 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.028 0.1189
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0063 0.0063
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0053 0.0027
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0053 0.0016
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.001 0.0045
Mycobacterium ulcerans lipase LipD 0.0026 0.0039 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.0216
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.01 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.0099 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0041 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0088 0.1422
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0026 0.0041 0.0186
Brugia malayi Carboxylesterase family protein 0.0148 0.0507 0.2274
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0053 0.0107
Loa Loa (eye worm) beta-lactamase 0.0026 0.0039 0.0176
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0422 0.1558 0.6992
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0195 0.0688 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0195 0.0688 0.5
Onchocerca volvulus 0.0026 0.0039 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0295
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.01 0.0064
Brugia malayi Importin beta-1 subunit 0.004 0.0093 0.0419
Loa Loa (eye worm) carboxylesterase 0.0148 0.0507 0.2274
Brugia malayi hypothetical protein 0.0072 0.0216 0.0971
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0053 0.0223
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0018 0.001 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Brugia malayi Peptidase family M1 containing protein 0.0072 0.0216 0.0971
Trichomonas vaginalis rotamase, putative 0.0026 0.0039 0.0621
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0536
Brugia malayi Protein cec-1. 0.0016 0.0002 0.0007
Schistosoma mansoni ran 0.0017 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0419
Mycobacterium tuberculosis Conserved protein 0.0026 0.0039 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0393
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0053 0.0223
Schistosoma mansoni chromobox protein 0.0016 0.0002 0.0002
Toxoplasma gondii kringle domain-containing protein 0.0027 0.0043 0.0043
Schistosoma mansoni myst-related protein 0.0016 0.0004 0.0006
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0038 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0174 0.0606 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0536
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0018 0.001 0.0141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0226 0.019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0122 0.1998
Brugia malayi Heterochromatin protein 1 0.0097 0.0313 0.1404
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0124 0.0417 0.0777
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0036 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Plasmodium falciparum importin beta, putative 0.004 0.0093 0.0093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0026 0.0039 0.008
Mycobacterium ulcerans esterase/lipase LipP 0.0026 0.0039 0.0003
Trichomonas vaginalis helicase, putative 0.0032 0.0061 0.099
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0319 0.1164 0.1157
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0053 0.0107
Onchocerca volvulus 0.0025 0.0036 0.0411
Onchocerca volvulus 0.0026 0.0039 0.0447
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0039 0.0166
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0037 0.0076
Chlamydia trachomatis dehyroquinate synthase 0.0124 0.0417 0.041
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.001 0.0016
Loa Loa (eye worm) acetylcholinesterase 1 0.0148 0.0507 0.2274
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.001 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0322 0.0287
Echinococcus granulosus carboxylesterase 5A 0.0148 0.0507 0.0804
Toxoplasma gondii chorismate synthase, putative 0.2623 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0026 0.0039 0.0166
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.001 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0322 0.0287
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.001 0.0141
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0192 0.0677 0.1074
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0072 0.0216 0.3552
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0322 0.0582
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.001 0.0045
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.01 0.0427
Schistosoma mansoni hypothetical protein 0.0105 0.0344 0.0546
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.001 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0629 0.2354 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0133 0.0133
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0072 0.0216 0.3552
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0088 0.0139
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0038 0.0038
Trypanosoma cruzi aminopeptidase, putative 0.0072 0.0216 0.0919
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.0216
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.0005 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0066 0.1072
Onchocerca volvulus 0.0236 0.0845 1
Leishmania major hypothetical protein, conserved 0.005 0.0133 0.0564
Trypanosoma brucei Aminopeptidase M1, putative 0.0072 0.0216 0.0919
Plasmodium falciparum cysteine repeat modular protein 1 0.0027 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0054 0.0149 0.067
Echinococcus multilocularis cpg binding protein 0.0147 0.0504 0.08
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0072 0.0216 0.0343
Loa Loa (eye worm) aminopeptidase N 0.0072 0.0216 0.0971
Loa Loa (eye worm) 6-phosphofructokinase 0.0065 0.0188 0.0844
Loa Loa (eye worm) proteasome 26S subunit 0.0024 0.0034 0.0152
Schistosoma mansoni chromobox protein 0.0097 0.0313 0.0497
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0629 0.2354 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0186 0.0835
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0032 0.0064 0.104
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0017 0.0007 0.0098
Brugia malayi Carboxylesterase family protein 0.0025 0.0036 0.0163
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0053 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0127 0.0571
Brugia malayi Carboxylesterase family protein 0.0148 0.0507 0.2274
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0039 0.0624
Plasmodium falciparum heterochromatin protein 1 0.0016 0.0002 0.0002
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0088 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0322 0.0287
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0038 0.006
Trypanosoma brucei polo-like protein kinase 0.0056 0.0156 0.0661
Echinococcus granulosus leukotriene A 4 hydrolase 0.0025 0.0038 0.006
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0072 0.0216 0.0919
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.001 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0531 0.2382
Schistosoma mansoni ran 0.0017 0.0005 0.0007
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0088 0.0393
Brugia malayi SET domain containing protein 0.0019 0.0013 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0053 0.0107
Brugia malayi hypothetical protein 0.0032 0.0065 0.029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.01 0.0159
Echinococcus granulosus aminopeptidase N 0.0072 0.0216 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0039 0.0624
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.001 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.01 0.0064
Schistosoma mansoni cpg binding protein 0.0147 0.0504 0.08
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.001 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0165 0.2706
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0017 0.0005 0.002
Echinococcus multilocularis tissue type plasminogen activator 0.0027 0.0043 0.0068
Trypanosoma brucei importin beta-1 subunit, putative 0.004 0.0093 0.0396
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0065 0.0188 0.2655
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0124 0.0417 0.0851
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.01 0.0451
Onchocerca volvulus 0.0072 0.0216 0.2545
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.021 0.0429
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.001 0.0045
Echinococcus granulosus GTP binding nuclear protein Ran 0.0017 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0322 0.1445
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0027 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0103 0.0464
Schistosoma mansoni myst-related protein 0.0016 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.0016 0.0004 0.0033
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.01 0.1636
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0036 0.0574
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.01 0.0427
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0035 0.0073 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0322 0.1368
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0027 0.0042
Onchocerca volvulus 0.0018 0.001 0.0101
Brugia malayi Valyl-tRNA synthetase 0.0016 0.0002 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0024 0.0034 0.0534
Echinococcus multilocularis GPCR, family 2 0.0049 0.0127 0.0202
Mycobacterium tuberculosis Carboxylesterase LipT 0.0025 0.0036 0.0074
Plasmodium vivax heterochromatin protein 1, putative 0.0016 0.0002 0.0002
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0053 0.0107
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0026 0.0039 0.008
Trichomonas vaginalis rotamase, putative 0.0026 0.0041 0.066
Onchocerca volvulus 0.0179 0.0629 0.7433
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0063 0.01
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0295
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0038 0.0038
Schistosoma mansoni tsg101-related 0.0034 0.0072 0.0115
Plasmodium vivax 6-phosphofructokinase, putative 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0041 0.0099 0.0444
Toxoplasma gondii peptidylprolyl isomerase 0.0026 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0045
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0047 0.0119 0.019
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.1013
Schistosoma mansoni 6-phosphofructokinase 0.0065 0.0188 0.0299
Mycobacterium tuberculosis Probable lipase LipD 0.0026 0.0039 0.008
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.001 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Trypanosoma brucei unspecified product 0.0029 0.0051 0.0216
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1294 0.4901 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0038 0.0595
Brugia malayi M-phase phosphoprotein, mpp8 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0179 0.0629 0.2822
Trichomonas vaginalis hypothetical protein 0.0017 0.0005 0.0064
Echinococcus multilocularis acetylcholinesterase 0.0148 0.0507 0.0804
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.021 0.0429
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0097 0.0313 0.515
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0127 0.0571
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.1013
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0053 0.0016
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0126 0.0423 0.6978
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0072 0.0216 0.0343
Trypanosoma brucei Aminopeptidase M1, putative 0.0072 0.0216 0.0919
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.1013
Trichomonas vaginalis esterase, putative 0.0026 0.0039 0.0624
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0036 0.0058
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0053 0.0845
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0053 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Schistosoma mansoni hypothetical protein 0.0339 0.124 0.1969
Loa Loa (eye worm) carboxylesterase 0.0025 0.0036 0.0163
Schistosoma mansoni 3-dehydroquinate synthase 0.0124 0.0417 0.0662
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0133 0.0133
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0038 0.0159
Onchocerca volvulus 0.0027 0.0043 0.0488
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0122 0.1998
Schistosoma mansoni hypothetical protein 0.0049 0.0127 0.0202
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.0107
Loa Loa (eye worm) phosphofructokinase 0.0065 0.0188 0.0844
Entamoeba histolytica aminopeptidase, putative 0.0072 0.0216 0.3552
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0036 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0468
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0085 0.0266 0.023
Schistosoma mansoni hypothetical protein 0.0339 0.124 0.1969
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0186 0.0295
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.0322 0.5302
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0053 0.0845
Trichomonas vaginalis ran, putative 0.0017 0.0005 0.0052
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0038 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0127 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0045
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0053 0.0223
Mycobacterium ulcerans aminopeptidase N PepN 0.0072 0.0216 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0088 0.0139
Leishmania major importin beta-1 subunit, putative 0.0032 0.0064 0.0274
Echinococcus granulosus GPCR family 2 0.0049 0.0127 0.0202
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.01 0.0205
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0053 0.0053
Onchocerca volvulus 0.0139 0.0474 0.5596
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0156 0.0247
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0053 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0088 0.1422
Schistosoma mansoni importin beta-1 0.004 0.0093 0.0148
Loa Loa (eye worm) hypothetical protein 0.0042 0.01 0.0451
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0065 0.0188 0.0384
Toxoplasma gondii 6-phosphofructokinase 0.0017 0.0007 0.0007
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0053 0.0053
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0298 0.1083 0.46
Loa Loa (eye worm) hypothetical protein 0.0105 0.0344 0.1544
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0595
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0018 0.001 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0053 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.028 0.1189
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.0322 0.0287
Mycobacterium ulcerans chorismate synthase 0.2623 1 1
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0053 0.0223
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0016 0.0002 0.0002
Brugia malayi hypothetical protein 0.0016 0.0002 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0026 0.0039 0.008
Echinococcus multilocularis carboxylesterase 5A 0.0148 0.0507 0.0804
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0088 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0053 0.0236
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.0107
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.01 0.1636
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1558 0.2473
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0032 0.0143
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.01 0.0427
Leishmania major hypothetical protein, conserved 0.0027 0.0043 0.0182
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0018 0.001 0.0045
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0041 0.0099 0.0157
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.01 0.0427
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0074 0.0226 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0149 0.2444
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0168
Onchocerca volvulus 0.0025 0.0036 0.0411
Onchocerca volvulus 0.0099 0.0322 0.3798
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0319 0.1164 0.1164
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0039 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0322 0.5302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1558 0.2473
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0322 0.0657
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0038 0.0038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Schistosoma mansoni DNA polymerase eta 0.0042 0.01 0.0159
Echinococcus granulosus Chromobox protein 3 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0017 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0322 0.1445
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0053 0.0016
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0016 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0088 0.1422
Brugia malayi hypothetical protein 0.005 0.0133 0.0595
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0038 0.0159
Echinococcus multilocularis dnaJ subfamily B 0.1658 0.6299 1
Onchocerca volvulus 0.0029 0.0053 0.0605
Toxoplasma gondii phosphofructokinase PFKII 0.0017 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0017 0.0007 0.0046
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.0226 0.046
Toxoplasma gondii hypothetical protein 0.0102 0.033 0.033
Onchocerca volvulus 0.0072 0.0216 0.2545
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0295
Echinococcus multilocularis 6 phosphofructokinase 0.0065 0.0188 0.0299
Mycobacterium tuberculosis Conserved protein 0.0026 0.0039 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0422 0.1558 0.6992
Brugia malayi Carboxylesterase family protein 0.0025 0.0036 0.0163
Schistosoma mansoni hypothetical protein 0.1658 0.6299 1
Echinococcus multilocularis expressed protein 0.0267 0.0963 0.1529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0039 0.0062
Plasmodium vivax 6-phosphofructokinase, putative 0.0017 0.0007 0.0007
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.0226 0.0226
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0088 0.0139
Echinococcus granulosus snurportin 1 0.0425 0.1571 0.2494
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0168
Schistosoma mansoni acetylcholinesterase 0.0025 0.0036 0.0058
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0032 0.0051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0186 0.0835
Echinococcus granulosus geminin 0.0339 0.124 0.1969
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0226 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0053 0.0016
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018 0.001 0.0016
Entamoeba histolytica phosphofructokinase, putative 0.0065 0.0188 0.3086
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.001 0.0045
Schistosoma mansoni cpg binding protein 0.0139 0.0474 0.0752
Loa Loa (eye worm) oxidoreductase 0.0029 0.0053 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0039 0.0624
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0127 0.0202
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0133 0.0133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.0322 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0024 0.0034 0.0485
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0088 0.1377
Echinococcus multilocularis aminopeptidase N 0.0072 0.0216 0.0343
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1294 0.4901 1
Echinococcus multilocularis importin subunit beta 1 0.004 0.0093 0.0148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0164 0.0571 0.1165
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0032 0.0064 0.104
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0085 0.0266 0.0466
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0026 0.0039 0.0621
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0043 0.0106 0.0168
Loa Loa (eye worm) 6-phosphofructokinase 0.0065 0.0188 0.0844
Entamoeba histolytica phosphofructokinase, putative 0.0065 0.0188 0.3086
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0295
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0053 0.0016
Toxoplasma gondii ABC1 family protein 0.0026 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0149 0.2444
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.001 0.0016
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0053 0.0016
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.001 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0019 0.0013 0.0021
Loa Loa (eye worm) histone methyltransferase 0.0043 0.0106 0.0474
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0163
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0053 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0133 0.0564
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0053 0.0223
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0016 0.0002 0.0002
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0017 0.0007 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0127 0.0202
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.01 0.0205
Mycobacterium ulcerans hypothetical protein 0.0332 0.1212 0.118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.01 0.0159
Brugia malayi CHD4 protein 0.0024 0.0032 0.0143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0026 0.0039 0.0176
Echinococcus multilocularis expressed protein 0.0018 0.001 0.0016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0002 0.0002
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0063 0.0063
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Echinococcus granulosus Chromo domain 0.0016 0.0002 0.0002
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0018 0.001 0.0045
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0133 0.0564
Echinococcus granulosus dna polymerase kappa 0.0042 0.01 0.0159
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0124 0.0417 0.0382
Onchocerca volvulus 0.0025 0.0038 0.0427
Leishmania major GTP-binding protein, putative 0.0017 0.0005 0.002
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0076 0.0231 0.0366
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0018 0.001 0.0045
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0319 0.1164 0.2314
Echinococcus granulosus chromobox protein 1 0.0097 0.0313 0.0497
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.01 0.0427
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0063 0.0283
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.001 0.0016
Brugia malayi chromobox protein homolog 3 0.0054 0.0149 0.067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0026 0.0039 0.0062
Brugia malayi phosphofructokinase 0.0065 0.0188 0.0844
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0026 0.0041 0.0186
Mycobacterium tuberculosis Conserved hypothetical protein 0.0332 0.1212 0.2473
Onchocerca volvulus Serine\/threonine kinase homolog 0.0056 0.0156 0.1827
Onchocerca volvulus 0.0043 0.0104 0.1217
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0045
Schistosoma mansoni 6-phosphofructokinase 0.0065 0.0188 0.0299
Onchocerca volvulus 0.0025 0.0036 0.0411
Brugia malayi Pax transcription factor protein 2 0.0236 0.0845 0.3794
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0024 0.0034 0.0144
Brugia malayi Carboxylesterase family protein 0.0025 0.0036 0.0163
Loa Loa (eye worm) hypothetical protein 0.0049 0.0127 0.0571
Loa Loa (eye worm) hypothetical protein 0.0597 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0507 0.2274
Schistosoma mansoni tsg101-related 0.0034 0.0072 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0063 0.0283
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0053 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0629 0.2354 1
Onchocerca volvulus 0.0018 0.001 0.0101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0127 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0531 0.2382
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0056 0.0156 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Schistosoma mansoni hypothetical protein 0.0049 0.0127 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.021 0.0429
Brugia malayi serine/threonine-protein kinase plk-2 0.0056 0.0156 0.0699
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0032 0.0051
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0059 0.0165 0.1939
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0295
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0063 0.0283
Echinococcus granulosus chromobox protein 1 0.0097 0.0313 0.0497
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.0107
Echinococcus granulosus chromobox protein 2 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Echinococcus granulosus expressed protein 0.0026 0.0041 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0236
Loa Loa (eye worm) hypothetical protein 0.0099 0.0322 0.1445
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.01 0.0159
Brugia malayi Carboxylesterase family protein 0.0025 0.0036 0.0163
Trypanosoma cruzi polo-like protein kinase, putative 0.0056 0.0156 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0002 0.0002
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.001 0.0141
Loa Loa (eye worm) hypothetical protein 0.0148 0.0507 0.2274
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0017 0.0005 0.0005
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.001 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0053 0.0016
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0056 0.0156 0.0247
Trypanosoma brucei unspecified product 0.0029 0.0051 0.0216
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0018 0.001 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0088 0.1436
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0028 0.0048 0.0774
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0053 0.0053
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0056 0.0156 0.0699
Loa Loa (eye worm) CXXC zinc finger family protein 0.0139 0.0474 0.2126
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0017 0.0005 0.0021
Echinococcus multilocularis muscleblind protein 1 0.0597 0.2228 0.3538
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.01 0.0427
Loa Loa (eye worm) hypothetical protein 0.0597 0.2228 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0133 0.0133
Echinococcus multilocularis dna polymerase eta 0.0042 0.01 0.0159
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0053 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0322 0.1368
Echinococcus multilocularis chromobox protein 1 0.0097 0.0313 0.0497
Leishmania major hypothetical protein, conserved 0.0026 0.0039 0.0167
Onchocerca volvulus 0.0025 0.0036 0.0411
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.01 0.0159
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0053 0.0016
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0298 0.1083 0.46
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0056 0.0156 0.0661
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0036 0.0574
Schistosoma mansoni cpg binding protein 0.0147 0.0504 0.08
Mycobacterium tuberculosis Conserved protein 0.0026 0.0039 0.008
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0072 0.0216 0.0919
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0165 0.2706
Echinococcus granulosus importin subunit beta 1 0.004 0.0093 0.0148
Brugia malayi 6-phosphofructokinase 0.0065 0.0188 0.0844
Brugia malayi beta-lactamase family protein 0.0026 0.0039 0.0176
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0065 0.0188 0.0799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0174 0.0606 1
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0039 0.0624
Schistosoma mansoni hypothetical protein 0.0425 0.1571 0.2494
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0043 0.0182
Schistosoma mansoni tsg101-related 0.0028 0.0048 0.0077
Brugia malayi beta-lactamase 0.0026 0.0039 0.0176
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0018 0.001 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0026 0.0039 0.008
Echinococcus granulosus dnaJ subfamily B 0.1658 0.6299 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0025 0.0038 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0065 0.0188 0.0799
Brugia malayi 6-phosphofructokinase 0.0065 0.0188 0.0844
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0025 0.0038 0.0168
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0192 0.0677 0.1074
Echinococcus granulosus beta LACTamase domain containing family member 0.0026 0.0039 0.0062
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.01 0.0427
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.028 0.1189
Loa Loa (eye worm) pax transcription factor protein 2 0.0236 0.0845 0.3794
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0133 0.0564
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.001 0.0045
Trichomonas vaginalis hypothetical protein 0.002 0.0018 0.0268
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0036 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0156 0.255
Loa Loa (eye worm) helicase 0.0016 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.0049 0.0127 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0039 0.0062
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0088 0.0372
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0072 0.0216 0.0919
Brugia malayi hypothetical protein 0.0018 0.001 0.0045
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0124 0.0417 0.0851
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0016 0.0002 0.0002
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.001 0.0141
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0056 0.0156 0.0247
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.001 0.0016
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0041 0.0099 0.0157
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.001 0.0016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0017 0.0007 0.0007
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0063 0.1018
Brugia malayi Kringle domain containing protein 0.0027 0.0043 0.0192
Echinococcus granulosus muscleblind protein 0.0597 0.2228 0.3538
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0026 0.0039 0.0176
Echinococcus granulosus acetylcholinesterase 0.0148 0.0507 0.0804
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.01 0.0427
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0053 0.0053
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0024 0.0034 0.0144
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0045
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0126 0.0423 0.6978
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0122 0.1998
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0073 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1558 0.2473
Mycobacterium tuberculosis Probable esterase LipL 0.0026 0.0039 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0025 0.0038 0.006
Schistosoma mansoni hypothetical protein 0.0027 0.0043 0.0068
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0032 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0322 0.1445
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0016 0.0002 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0061 0.099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0053 0.0236
Mycobacterium tuberculosis Probable lipase LipE 0.0026 0.0039 0.008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0148 0.0507 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0088 0.1436
Giardia lamblia Kinase, PLK 0.0056 0.0156 0.2511
Plasmodium vivax chorismate synthase 0.2623 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.01 0.0427
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0016 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0017 0.0007 0.0098
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0038 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.028 0.1189
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0036 0.0058
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.001 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0039 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0192
Echinococcus granulosus neuroligin 0.0025 0.0036 0.0058
Leishmania major mitochondrial DNA polymerase beta 0.0629 0.2354 1
Schistosoma mansoni kinase 0.0029 0.005 0.0079
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0038 0.0159
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0216 0.0343
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.001 0.0141
Schistosoma mansoni gliotactin 0.0025 0.0036 0.0058
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0039 0.0166
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0053 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0073 0.0116
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0036 0.0058
Trypanosoma cruzi importin beta-1 subunit, putative 0.0032 0.0064 0.0274
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0024 0.0034 0.0054
Echinococcus multilocularis muscleblind protein 0.0597 0.2228 0.3538
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0066 0.1072
Onchocerca volvulus 0.0029 0.0053 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.0216
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0004 0.0004
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0016 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0039 0.0039
Treponema pallidum fructose-bisphosphate aldolase 0.0174 0.0606 0.8799
Entamoeba histolytica Ran family GTPase 0.0017 0.0005 0.0052
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0053 0.0223

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced climbing behavior in mice, after intraperitoneal administration ChEMBL. 8709130
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced climbing behavior in mice, after peroral administration ChEMBL. 8709130
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced Hyperactivity in mice, after Intraperitoneal administration ChEMBL. 8709130
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced hyperactivity in mice after per oral administration ChEMBL. 8709130
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced climbing behavior in mice, after peroral administration ChEMBL. 8709130
ED50 (functional) > 200 mg kg-1 Inhibition of apomorphine-induced Hyperactivity in mice, after Intraperitoneal administration ChEMBL. 8709130
Inhibition (functional) = 8 % Percent inhibition of apomorphine-induced stereotypy in rat after an intraperitoneal dose of 50 mg/kg ChEMBL. 8709130

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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