TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.919 | Formula: C20H25ClN8O
H donors: 4 H acceptors: 4 LogP: 1.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)[C@H]1[C@@H]2C=C[C@H]([C@H]1Nc1nc(ncc1Cl)Nc1cnn(c1)C[C@H]1CCCN1)C2
InChi: 1S/C20H25ClN8O/c21-15-8-24-20(26-14-7-25-29(10-14)9-13-2-1-5-23-13)28-19(15)27-17-12-4-3-11(6-12)16(17)18(22)30/h3-4,7-8,10-13,16-17,23H,1-2,5-6,9H2,(H2,22,30)(H2,24,26,27,28)/t11-,12+,13-,16+,17-/m1/s1
InChiKey: NZSZVQMHSLFGDA-BBAXIROVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	myosin xvIII	0.0041	0.0197	0.0197
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0186	0.0181
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0614	0.0608
Loa Loa (eye worm)	carboxylesterase	0.0231	0.1603	0.1598
Brugia malayi	putative neuropeptide receptor	0.0041	0.0197	0.0184
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0231	0.1603	0.1603
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.1158	0.6925
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	inositol-1	0.0036	0.0161	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Echinococcus granulosus	neuropeptide receptor A26	0.0041	0.0197	0.0197
Brugia malayi	Serotonin receptor	0.0041	0.0197	0.0184
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.04	0.0394
Echinococcus multilocularis	para nitrobenzyl esterase	0.0231	0.1603	0.1603
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0077	0.0927
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0025	0.0025
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0041	0.0197	0.0184
Brugia malayi	hypothetical protein	0.0231	0.1603	0.1592
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0348	0.0348
Onchocerca volvulus		0.0167	0.1129	0.6739
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0077	0.0927
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0614	0.0602
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	neuropeptide s receptor	0.0041	0.0197	0.0197
Leishmania major	hypothetical protein, conserved	0.0024	0.0077	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0387	0.0381
Onchocerca volvulus		0.0231	0.1603	0.9798
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0219	0.0213
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0041	0.0197	0.0197
Brugia malayi	Carboxylesterase family protein	0.1365	1	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0161	0.3855
Loa Loa (eye worm)	TYRA-2 protein	0.0041	0.0197	0.0191
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0133	0.0656
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0197	0.0197
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	Bromodomain containing protein	0.0077	0.0464	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0097
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.211	0.2105
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.04	0.1939
Echinococcus granulosus	serotonin receptor	0.0041	0.0197	0.0197
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.0264
Brugia malayi	Carboxylesterase family protein	0.0231	0.1603	0.1592
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.04	0.0394
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0041	0.0197	0.0191
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0103	0.1548
Echinococcus multilocularis	allatostatin A receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	dro:myosuppressin receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.1796	0.1796
Brugia malayi	sulfakinin receptor protein	0.0041	0.0197	0.0184
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0041	0.0197	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0025	0.0025
Schistosoma mansoni	zinc finger protein	0.002	0.0044	0.0044
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0231	0.1603	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0197	0.0197
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0283	0.0271
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1173	0.62
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0041	0.0197	0.0184
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0041	0.0197	0.0184
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.008
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0458	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0025	0.0025
Brugia malayi	G-protein coupled receptor	0.0041	0.0197	0.0184
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0257	0.1796	0.1791
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0089	0.1224
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0086	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0041	0.0197	0.0714
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0041	0.0197	0.0197
Echinococcus granulosus	BC026374 protein S09 family	0.0231	0.1603	0.1603
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0197	0.0197
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.04	0.1939
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0123	0.0123
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0458	1
Onchocerca volvulus		0.0041	0.0197	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0458	0.0458
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.04	0.04
Toxoplasma gondii	hypothetical protein	0.0026	0.0089	0.1004
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0161	0.0623
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Brugia malayi	G protein-coupled receptor	0.0041	0.0197	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0432	0.0426
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	carboxylesterase 5A	0.1365	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0041	0.0197	0.0184
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0025	0.0025
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0197	0.0191
Echinococcus granulosus	7tm_1 domain containing protein	0.0041	0.0197	0.0197
Entamoeba histolytica	protein kinase, putative	0.0068	0.04	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0041	0.0197	0.0197
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0197	0.0197
Onchocerca volvulus		0.0041	0.0197	0.0714
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Echinococcus granulosus	acetylcholinesterase	0.1365	1	1
Schistosoma mansoni	gliotactin	0.0231	0.1603	0.1603
Brugia malayi	Dopamine receptor protein 1	0.0853	0.6209	0.6204
Onchocerca volvulus		0.0041	0.0197	0.0714
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0231	0.1603	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0264	0.1489
Loa Loa (eye worm)	acetylcholinesterase 1	0.1365	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0123	0.011
Mycobacterium ulcerans	glutaminase	0.0266	0.1862	1
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0264	0.0264
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0086	0.1077
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.0264
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0123	0.0117
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0264	0.479
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0161	0.3214
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0614	0.0608
Schistosoma mansoni	protein kinase	0.0068	0.04	0.04
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1173	0.62
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.1247	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0041	0.0197	0.0197
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0086	0.0356
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0086	0.0264
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Echinococcus multilocularis	acetylcholinesterase	0.1365	1	1
Brugia malayi	GnHR receptor homolog	0.0041	0.0197	0.0184
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0074
Echinococcus granulosus	neuropeptide s receptor	0.0041	0.0197	0.0197
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0614	0.0602
Echinococcus multilocularis	zinc finger protein	0.002	0.0044	0.0044
Schistosoma mansoni	neuropeptide f receptor 76f	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0025	0.0025
Echinococcus granulosus	acetylcholinesterase	0.1365	1	1
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Brugia malayi	neuropeptide F receptor	0.0041	0.0197	0.0184
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0231	0.1603	0.8573
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0161	0.0161
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0123	0.0117
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0161	0.3855
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0197	0.0197
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0041	0.0197	0.0197
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.04	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0197	0.0191
Echinococcus multilocularis	neuroligin	0.0231	0.1603	0.1603
Onchocerca volvulus		0.0041	0.0197	0.0714
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0048	0.0245
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.04	0.0394
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0161	0.3855
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0066	0.0066
Brugia malayi	Carboxylesterase family protein	0.0231	0.1603	0.1592
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0041	0.0197	0.0197
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.192
Echinococcus multilocularis	serotonin receptor	0.0041	0.0197	0.0197
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Echinococcus multilocularis	acetylcholinesterase	0.1365	1	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0161	0.0623
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0161	0.0623
Leishmania major	GTP-binding protein, putative	0.0021	0.0048	0.0945
Echinococcus granulosus	dro:myosuppressin receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	importin beta-1	0.0028	0.0103	0.0103
Echinococcus granulosus	zinc finger protein	0.002	0.0044	0.0044
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0041	0.0197	0.0197
Brugia malayi	Carboxylesterase family protein	0.0231	0.1603	0.1592
Onchocerca volvulus		0.0041	0.0197	0.0714
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	hypothetical protein	0.0299	0.211	0.211
Onchocerca volvulus		0.0041	0.0197	0.0714
Trichomonas vaginalis	spcc417.12 protein, putative	0.0231	0.1603	0.8573
Onchocerca volvulus		0.0231	0.1603	0.9798
Onchocerca volvulus		0.0041	0.0197	0.0714
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0197	0.0197
Echinococcus granulosus	g-protein coupled receptor	0.0041	0.0197	0.0197
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0048	0.0945
Onchocerca volvulus		0.0041	0.0197	0.0714
Schistosoma mansoni	ran	0.0021	0.0048	0.0048
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0025	0.0019
Onchocerca volvulus		0.0041	0.0197	0.0714
Echinococcus granulosus	fmrfamide receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0197	0.0197
Echinococcus multilocularis	aurora kinase A	0.0068	0.04	0.04
Loa Loa (eye worm)	glutaminase	0.0266	0.1862	0.1857
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0048	0.0945
Schistosoma mansoni	amine GPCR	0.0041	0.0197	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Plasmodium falciparum	importin beta, putative	0.0028	0.0103	0.1548
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0064	0.0086
Onchocerca volvulus		0.0041	0.0197	0.0714
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Echinococcus granulosus	para nitrobenzyl esterase	0.0231	0.1603	0.1603
Schistosoma mansoni	hypothetical protein	0.0021	0.0052	0.0052
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Echinococcus granulosus	roundabout 2	0.0018	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0103	0.1336
Brugia malayi	ORL1-like opioid receptor	0.0041	0.0197	0.0184
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0387	0.0374
Brugia malayi	Probable ClpP-like protease	0.0076	0.0458	0.0446
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.008
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0077	0.0699
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0041	0.0197	0.0184
Brugia malayi	Pax transcription factor protein 2	0.0235	0.1634	0.1624
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0197	0.0197
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0077	0.1683
Onchocerca volvulus		0.0235	0.1634	1
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Brugia malayi	Dopamine receptor protein 2	0.0041	0.0197	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0006	0.0006
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.04	0.1939
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Schistosoma mansoni	amine GPCR	0.0041	0.0197	0.0197
Brugia malayi	Serotonin receptor	0.0041	0.0197	0.0184
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0041	0.0197	0.0191
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0052	0.0046
Echinococcus granulosus	twitchin	0.0015	0.0004	0.0004
Echinococcus multilocularis	sex peptide receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus granulosus	GPCR family 2	0.0031	0.0123	0.0123
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.04	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0041	0.0197	0.0184
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0161	0.0161
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1365	1	1
Echinococcus multilocularis	roundabout 2	0.0018	0.0027	0.0027
Echinococcus granulosus	snurportin 1	0.0299	0.211	0.211
Echinococcus multilocularis	g-protein coupled receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Onchocerca volvulus		0.0052	0.0283	0.1273
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0231	0.1603	0.1603
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0077	0.1683
Brugia malayi	Bromodomain containing protein	0.0039	0.0186	0.0173
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	snurportin 1	0.0299	0.211	0.211
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0041	0.0197	0.0714
Onchocerca volvulus		0.0231	0.1603	0.9798
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0023	0.0064	0.0442
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0048	0.0042
Schistosoma mansoni	amine GPCR	0.0041	0.0197	0.0197
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0231	0.1603	0.1603
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0103	0.0103
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Onchocerca volvulus		0.0041	0.0197	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0074
Schistosoma mansoni	hypothetical protein	0.0031	0.0123	0.0123
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0086	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0204	0.0199
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	orexin receptor type 2	0.0041	0.0197	0.0197
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.04	0.8615
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0077	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0161	0.0161
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0086	0.0264
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0458	0.0458
Brugia malayi	hypothetical protein	0.0024	0.0077	0.0064
Brugia malayi	larval opioid receptor	0.0041	0.0197	0.0184
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0249	0.1742	0.1738
Trypanosoma brucei	aurora B kinase	0.0068	0.04	1
Onchocerca volvulus		0.0231	0.1603	0.9798
Echinococcus multilocularis	neuropeptide receptor A26	0.0041	0.0197	0.0197
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.0264
Trichomonas vaginalis	glutaminase, putative	0.0266	0.1862	1
Echinococcus granulosus	hypothetical protein	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0032
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0089	0.0088
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0064	0.1345
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.192
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0231	0.1603	0.1603
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0064	0.1345
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0038	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Entamoeba histolytica	protein kinase , putative	0.0068	0.04	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0041	0.0197	0.0197
Onchocerca volvulus		0.0231	0.1603	0.9798
Schistosoma mansoni	adenoreceptor	0.0041	0.0197	0.0197
Schistosoma mansoni	amine GPCR	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0048	0.0036
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0048	0.0945
Loa Loa (eye worm)	carboxylesterase	0.1365	1	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0231	0.1603	0.8581
Onchocerca volvulus		0.0041	0.0197	0.0714
Brugia malayi	RE15519p	0.0041	0.0197	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	hypothetical protein	0.0031	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0077	0.0927
Schistosoma mansoni	hypothetical protein	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Schistosoma mansoni	hypothetical protein	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0032
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0064	0.0086
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0123	0.0123
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	ran	0.0021	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	hypothetical protein	0.0031	0.0123	0.0123
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0086	0.1077
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0197	0.0197
Echinococcus granulosus	7TM GPCR rhodopsin	0.0041	0.0197	0.0197
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0123	0.011
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Brugia malayi	glutaminase DH11.1	0.0266	0.1862	0.1851
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0021
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.04	0.04
Loa Loa (eye worm)	glutaminase 2	0.0266	0.1862	0.1857
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0041	0.0197	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.192
Schistosoma mansoni	hypothetical protein	0.0031	0.0123	0.0123
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0458	1
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.04	0.1939
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0103	0.0103
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.04	0.0388
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0197	0.0197
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	opsin-like receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.1796	0.1796
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0168	0.0168
Echinococcus multilocularis	serotonin receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	neuropeptide FF receptor 2	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	hypothetical protein	0.0066	0.0387	0.0387
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0123	0.0123
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0161	0.3855
Brugia malayi	G protein-coupled receptor F59B2.13	0.0041	0.0197	0.0184
Onchocerca volvulus	Glucosylceramidase homolog	0.0164	0.1107	0.6597
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	0.2304
Brugia malayi	AKH receptor	0.0041	0.0197	0.0184
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0249	0.1742	0.1732
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Echinococcus granulosus	aurora kinase A	0.0068	0.04	0.04
Entamoeba histolytica	protein kinase, putative	0.0068	0.04	1
Schistosoma mansoni	histamine h1 receptor	0.0041	0.0197	0.0197
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.1247	0.1242
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.04	0.04
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0458	0.0458
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0197	0.0197
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0231	0.1603	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Giardia lamblia	Aurora kinase	0.0068	0.04	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0123	0.0123
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0133	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0041	0.0197	0.0191
Schistosoma mansoni	acetylcholinesterase	0.0231	0.1603	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0041	0.0197	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	Carboxylesterase family protein	0.0231	0.1603	0.1592
Brugia malayi	RNA, U transporter 1	0.008	0.0485	0.0473
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	G protein coupled receptor 139	0.0041	0.0197	0.0197
Echinococcus granulosus	neuroligin	0.0231	0.1603	0.1603
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.04	1
Onchocerca volvulus		0.0041	0.0197	0.0714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	G-protein coupled receptor	0.0041	0.0197	0.0184
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0066	0.0066
Brugia malayi	PHD-finger family protein	0.0026	0.0084	0.0072
Onchocerca volvulus		0.0041	0.0197	0.0714
Echinococcus granulosus	carboxylesterase 5A	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0032
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0041	0.0197	0.0197
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1107	0.584
Brugia malayi	hypothetical protein	0.0041	0.0197	0.0184
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0283	0.0283
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0348	0.0348
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0161	0.0676
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0197	0.0191
Toxoplasma gondii	aurora kinase	0.0068	0.04	0.8581
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0458	0.0452
Brugia malayi	Melatonin receptor type 1A	0.0041	0.0197	0.0184
Echinococcus granulosus	somatostatin receptor	0.0041	0.0197	0.0197
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0161	0.2758
Loa Loa (eye worm)	carboxylesterase	0.0231	0.1603	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0032
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0086	0.0264
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0066	0.0066
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0041	0.0197	0.0197
Brugia malayi	Importin beta-1 subunit	0.0028	0.0103	0.009
Echinococcus granulosus	orexin receptor type 2	0.0041	0.0197	0.0197
Schistosoma mansoni	opsin-like receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	sex peptide receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0197	0.0197
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0086	0.0356
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.04	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	hypothetical protein	0.0016	0.0012	0.0012
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0197	0.0197
Brugia malayi	neuropeptide F receptor	0.0041	0.0197	0.0184
Schistosoma mansoni	hypothetical protein	0.0052	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0041	0.0197	0.0197
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0077	0.1683
Schistosoma mansoni	glutaminase	0.0266	0.1862	0.1862
Echinococcus granulosus	G protein coupled receptor 139	0.0041	0.0197	0.0197
Onchocerca volvulus		0.0041	0.0197	0.0714
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	pax transcription factor protein 2	0.0235	0.1634	0.1629
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0103	0.2355
Brugia malayi	putative neuropeptide receptor NPR1	0.0041	0.0197	0.0184
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0197	0.0197
Brugia malayi	serine/threonine kinase 12	0.0068	0.04	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0853	0.6209	0.6207
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0197	0.0197
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0086	0.0264
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0123	0.0123
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0458	1
Brugia malayi	Dopamine receptor	0.0041	0.0197	0.0184
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0197	0.0197
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	1
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0197	0.0197
Brugia malayi	follicle stimulating hormone receptor	0.0041	0.0197	0.0184
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0161	0.0161
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.04	0.8615
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.04	0.0388
Schistosoma mansoni	hypothetical protein	0.0041	0.0197	0.0197
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	growth hormone secretagogue receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0029	0.0024
Schistosoma mansoni	amine GPCR	0.0041	0.0197	0.0197
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0264	0.1489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0197	0.0197
Leishmania major	protein kinase, putative	0.0068	0.04	1
Onchocerca volvulus		0.0041	0.0197	0.0714
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0041	0.0197	0.0197
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0231	0.1603	0.1603
Schistosoma mansoni	opsin-like receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	BC026374 protein (S09 family)	0.0231	0.1603	0.1603
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0006	0.0006
Echinococcus multilocularis	somatostatin receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0021
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0375	0.0375
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0458	0.2304
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0025	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Brugia malayi	Inositol-1	0.0036	0.0161	0.0149
Brugia malayi	hypothetical protein	0.0257	0.1796	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.1742	0.9342
Loa Loa (eye worm)	melatonin receptor type 1A	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0103	0.2355
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0197	0.0197
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0089	0.1224
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.04	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0197	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1603	0.1598
Schistosoma mansoni	zinc finger protein	0.0016	0.0012	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0197	0.0197
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0197	0.0197
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0197	0.0197
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0264	0.0264
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0231	0.1603	0.1603
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0064	0.0086
Onchocerca volvulus		0.0041	0.0197	0.0714
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0231	0.1603	1
Echinococcus granulosus	allatostatin A receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0041	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0032
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0197	0.0197
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0025	0.0025

Activities

Activity type	Activity value	Assay description	Source	Reference
EC15 (functional)	= 11 nM	Cell cycle arrest in human NCI-H1299 cells assessed as induction of polyploidy after 48 hrs by Hoechst staining-based fluorescence microscopic analysis	ChEMBL.	22695126
IC50 (binding)	= 15 nM	Inhibition of KDR by HTRF analysis in presence of 1 mM ATP	ChEMBL.	22695126
IC50 (binding)	= 15 nM	Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP	ChEMBL.	22695126
IC50 (binding)	= 49 nM	Inhibition of human KDR autophosphorylation expressed in mouse NIH/3T3 cells	ChEMBL.	22695126
Stability (ADMET)	= 48 %	Metabolic stability of the compound in mouse liver microsomes assessed as compound remaining after 30 mins	ChEMBL.	22695126

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2071277

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1663358