Detailed information for compound 166343

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.641 | Formula: C26H37NO4S
  • H donors: 1 H acceptors: 3 LogP: 7.42 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CS(=O)(=O)Nc1c(cccc1C(C)C)C(C)C)Oc1c(cccc1C(C)C)C(C)C
  • InChi: 1S/C26H37NO4S/c1-16(2)20-11-9-12-21(17(3)4)25(20)27-32(29,30)15-24(28)31-26-22(18(5)6)13-10-14-23(26)19(7)8/h9-14,16-19,27H,15H2,1-8H3
  • InChiKey: PQLMHSCAWDDKIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Acyl-CoA:cholesterol acyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl-CoA:cholesterol acyltransferase   305 aa 278 aa 21.9 %
Neospora caninum sterol O-acyltransferase, putative Acyl-CoA:cholesterol acyltransferase   305 aa 258 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0047 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0039 0.0871
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Onchocerca volvulus 0.003 0.006 0.2675
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0016 0.0037
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0026 0.006
Brugia malayi MBOAT family protein 0.0026 0.0047 0.0112
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0039 0.1218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0262 0.0262
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0083 0.1837
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Schistosoma mansoni hypothetical protein 0.0076 0.0191 0.0442
Echinococcus multilocularis Niemann Pick C1 protein 0.0331 0.0916 0.0915
Brugia malayi hypothetical protein 0.002 0.0031 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0206 0.0492
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0189
Leishmania major 0.1478 0.4183 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0039 0.1218
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0039 0.1218
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0039 0.0871
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Onchocerca volvulus 0.002 0.0031 0.1197
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0206 0.0476
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0083
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0042 0.0121
Echinococcus granulosus Niemann Pick C1 protein 0.0473 0.132 0.3154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0262 0.0611
Echinococcus multilocularis sterol regulatory element binding protein 0.0142 0.0378 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0206 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0047 0.0111
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0039 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0191 0.0191
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0083 0.1872
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0007 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.008 0.02 0.9712
Plasmodium falciparum pyruvate kinase 0.0039 0.0083 0.5154
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0007 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0157 0.036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0093 0.4062
Echinococcus granulosus Protein patched homolog 1 0.0142 0.0378 0.0902
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0039 0.1218
Brugia malayi protein C24B5.3 0.002 0.0031 0.0073
Onchocerca volvulus 0.0082 0.0206 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0047 0.0095
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Toxoplasma gondii fructose-bisphospatase II 0.1478 0.4183 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0026 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0039 0.0871
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0042 0.0982
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0042 0.1373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0262 0.0611
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0016 0.0015
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0047 0.0047
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0083 0.0183
Brugia malayi MBOAT family protein 0.0026 0.0047 0.0112
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0039 0.0871
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0083 0.5154
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0136 0.031
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0039 0.1218
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0039 0.0076
Onchocerca volvulus 0.0024 0.0042 0.1755
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0083 0.0199
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.055 0.1539 0.3655
Echinococcus granulosus tumor protein p63 0.0391 0.1087 0.2597
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0262 0.0626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0016
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0047 0.0111
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0095 0.2985
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0007 0.0007
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0039 0.1218
Brugia malayi Cytochrome P450 family protein 0.008 0.02 0.0479
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0093 0.0221
Echinococcus multilocularis Niemann Pick C1 protein 0.0473 0.132 0.1319
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.0725 0.0725
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0039 0.0871
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0016 0.002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0004 0.0011
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0039 0.0871
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0206 0.7152
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0047 0.3991
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0047 0.2345
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0042 0.1373
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0721
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0042 0.1373
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Schistosoma mansoni hypothetical protein 0.0018 0.0026 0.0045
Loa Loa (eye worm) hhat protein 0.0026 0.0047 0.0111
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Toxoplasma gondii patched family protein 0.002 0.0031 0.0036
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0264 0.0725 0.1733
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0093 0.0205
Brugia malayi nuclear hormone receptor 0.0012 0.0007 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.006 0.0143
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.0753 0.0752
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0042 0.0041
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0047 0.2381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0982
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0191 0.0456
Schistosoma mansoni hypothetical protein 0.0018 0.0026 0.0045
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0083
Onchocerca volvulus 0.002 0.0031 0.1197
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0047 0.0094
Brugia malayi Patched related family protein 10 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0082 0.0206 0.0491
Loa Loa (eye worm) patched family protein 0.002 0.0031 0.0073
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0251 0.8726
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.0042 0.1373
Schistosoma mansoni hypothetical protein 0.0018 0.0026 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0282 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0204
Onchocerca volvulus 0.002 0.0031 0.1197
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0982
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0111
Schistosoma mansoni hypothetical protein 0.0056 0.0132 0.0301
Entamoeba histolytica hypothetical protein 0.0076 0.0191 0.1711
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0083 0.3563
Brugia malayi protein C24B5.3 0.002 0.0031 0.0073
Onchocerca volvulus 0.002 0.0031 0.1197
Echinococcus multilocularis pyruvate kinase 0.0039 0.0083 0.0083
Brugia malayi hypothetical protein 0.0076 0.0191 0.0457
Echinococcus granulosus sterol regulatory element binding protein 0.0142 0.0378 0.0902
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0047 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0016
Schistosoma mansoni pyruvate kinase 0.0039 0.0083 0.0183
Echinococcus granulosus expressed conserved protein 0.0311 0.0858 0.2051
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Mycobacterium tuberculosis Probable reductase 0.0097 0.0251 0.8837
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0093 0.5876
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0026 0.006
Giardia lamblia Pyruvate kinase 0.0039 0.0083 0.8771
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0042 0.0982
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Brugia malayi Thioredoxin reductase 0.0043 0.0095 0.0227
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0016 0.0037
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0206 0.0492
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0016
Trypanosoma cruzi GUP1, putative 0.0026 0.0047 0.0095
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0095 0.0226
Onchocerca volvulus 0.0056 0.0132 0.6309
Brugia malayi CHE-14 protein 0.0142 0.0378 0.0903
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0083 0.3848
Brugia malayi fructose-1,6-bisphosphatase 0.1478 0.4183 1
Loa Loa (eye worm) cytochrome P450 0.0023 0.0039 0.0092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0016
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0047 0.0111
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0039 0.0076
Onchocerca volvulus 0.0026 0.0047 0.2016
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0206 0.0476
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0039 0.0871
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0083 0.3848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0138 0.4587
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0007
Onchocerca volvulus 0.002 0.0031 0.1197
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0206 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.055 0.1539 0.3668
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0042 0.0063
Plasmodium vivax patched family protein, putative 0.002 0.0031 0.1141
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0262 0.0626
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0047 0.0095
Trypanosoma cruzi GUP1, putative 0.0026 0.0047 0.0095
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0251 0.8837
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0042 0.01
Echinococcus granulosus GPCR family 2 0.0018 0.0026 0.006
Echinococcus granulosus pyruvate kinase 0.0039 0.0083 0.0199
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0206 0.1879
Plasmodium vivax glutathione reductase, putative 0.0043 0.0095 0.6038
Schistosoma mansoni cpg binding protein 0.0032 0.0065 0.0139
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0039 0.1218
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Brugia malayi Patched related family protein 12 0.002 0.0031 0.0073
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0047 0.0047
Mycobacterium ulcerans hypothetical protein 0.0082 0.0206 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0016
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0047 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0206 0.7152
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0007 0.0007
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0047 0.0095
Echinococcus multilocularis pyruvate kinase 0.0039 0.0083 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0039 0.0871
Brugia malayi Cytochrome P450 family protein 0.0023 0.0039 0.0093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.0262 0.0626
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0042 0.1986
Loa Loa (eye worm) hypothetical protein 0.0174 0.0469 0.112
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0047 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0206 0.1879
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0206 0.0492
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0047 0.0852
Brugia malayi ecdysteroid receptor 0.0012 0.0007 0.0016
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0047 0.011
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0039 0.1218
Plasmodium falciparum pyruvate kinase 2 0.002 0.003 0.1087
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0047 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0039 0.0871
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0147 0.0351
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0042 0.1373
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0721
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0206 0.1879
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0206 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0865
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0147 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0039 0.0871
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0083 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0026 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0093 0.0205
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1478 0.4183 1
Onchocerca volvulus 0.0024 0.0042 0.1755
Echinococcus granulosus pyruvate kinase 0.002 0.003 0.0071
Echinococcus granulosus pyruvate kinase 0.002 0.003 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0093 0.0221
Schistosoma mansoni pyruvate kinase 0.002 0.003 0.0055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0206 0.688
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0039 0.0871
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0007 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0093 0.5876
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0047 0.0047
Schistosoma mansoni patched 1 0.0142 0.0378 0.0888
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0199
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0251 0.8837
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1478 0.4183 1
Chlamydia trachomatis pyruvate kinase 0.0039 0.0083 0.5154
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.055 0.1539 0.3668
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0032 0.0625
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.055 0.1539 0.3655
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0251 0.8837
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0095 0.0211
Brugia malayi hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0331 0.0916 0.2188
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0095 0.6038
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0039 0.0076
Plasmodium falciparum glutathione reductase 0.0043 0.0095 0.6038
Brugia malayi Cytochrome P450 family protein 0.0023 0.0039 0.0093
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0206 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0047 0.0047
Onchocerca volvulus Protein patched homolog 0.002 0.0031 0.1197
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.0296 0.0815 0.1949
Leishmania major cytochrome p450-like protein 0.008 0.02 0.0463
Brugia malayi steroid hormone receptor 0.0012 0.0007 0.0016
Entamoeba histolytica hypothetical protein 0.0076 0.0191 0.1711
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0047 0.0096
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0039 0.0871
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0191 0.0442
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1478 0.4183 0.4183
Echinococcus granulosus pyruvate kinase 0.0039 0.0083 0.0199
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0042 0.1373
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0026 0.0025
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0047 0.0111
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0047 0.0095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0138 0.0329
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0047 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0093 0.0205
Leishmania major glycerol uptake protein, putative 0.0026 0.0047 0.0095
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0093 1
Brugia malayi hypothetical protein 0.0273 0.0753 0.1799
Onchocerca volvulus 0.002 0.0031 0.1197
Entamoeba histolytica hypothetical protein 0.0076 0.0191 0.1711
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0026 0.0061
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0042 0.0982
Echinococcus multilocularis expressed conserved protein 0.0311 0.0858 0.0858
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0047 0.0059
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.003 0.0034
Toxoplasma gondii patched family protein 0.002 0.0031 0.0036
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0093 0.0586
Loa Loa (eye worm) hhat protein 0.0026 0.0047 0.0111
Schistosoma mansoni cpg binding protein 0.0032 0.0065 0.0139
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0251 0.8837
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0042 0.0982
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0042 0.0063
Loa Loa (eye worm) hypothetical protein 0.0058 0.0138 0.0329
Schistosoma mansoni cytochrome P450 0.0023 0.0039 0.0077
Brugia malayi nuclear receptor NHR-88 0.0012 0.0007 0.0016
Brugia malayi Cytochrome P450 family protein 0.008 0.02 0.0479
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0086 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.01
Brugia malayi glutathione reductase 0.0043 0.0095 0.0227
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0047 0.0059
Trichomonas vaginalis porcupine, putative 0.0026 0.0047 0.0865
Brugia malayi hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Niemann-Pick C1 protein precursor 0.0331 0.0916 0.2188
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.005 0.0119
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.01
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0047 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0016
Onchocerca volvulus 0.0024 0.0042 0.1755
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.0725 0.172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0138 0.4587
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0039 0.0871
Toxoplasma gondii fructose-bisphospatase I 0.055 0.1539 0.3655
Loa Loa (eye worm) CYP4Cod1 0.008 0.02 0.0478
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0007 0.0016
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0047 0.0075
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0016
Echinococcus multilocularis cpg binding protein 0.0032 0.0065 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0282 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0024 0.0042 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Leishmania major glycerol uptake protein, putative 0.0026 0.0047 0.0095
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0047 0.0111
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.003 0.1087
Loa Loa (eye worm) hypothetical protein 0.0057 0.0135 0.0322
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0083 0.3848
Schistosoma mansoni hypothetical protein 0.0018 0.0026 0.0045
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0083 0.0163
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0039 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0039 0.1218
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0047 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0206 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0047 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0138 0.4587
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0004 0.0011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0982
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0016 0.002
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0039 0.1218
Schistosoma mansoni hypothetical protein 0.0137 0.0363 0.0853
Plasmodium falciparum lipid/sterol:H+ symporter 0.002 0.0031 0.1141
Brugia malayi Patched related family protein 4 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.0142 0.0378 0.0902
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0047 0.0059
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0047 0.0111
Schistosoma mansoni cpg binding protein 0.003 0.006 0.0128
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0047 0.0096
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0042 0.0099
Echinococcus multilocularis pyruvate kinase 0.003 0.006 0.006
Echinococcus multilocularis protein dispatched 1 0.0162 0.0435 0.0435
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0251 0.8837
Loa Loa (eye worm) hypothetical protein 0.0082 0.0206 0.0491
Loa Loa (eye worm) hypothetical protein 0.0057 0.0136 0.0325
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0039 0.0871
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0047 0.0094
Toxoplasma gondii exonuclease III APE 0.0042 0.0093 0.0185
Echinococcus multilocularis pyruvate kinase 0.002 0.003 0.003
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0047 0.2345
Brugia malayi Patched protein homolog 1 0.002 0.0031 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0042 0.0982
Toxoplasma gondii thioredoxin reductase 0.0043 0.0095 0.0191
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0097 0.023
Loa Loa (eye worm) patched family protein 0.002 0.0031 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1478 0.4183 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0206 0.688
Loa Loa (eye worm) hypothetical protein 0.0061 0.0147 0.0351
Toxoplasma gondii hypothetical protein 0.002 0.0031 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0282 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0047 0.0111
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0083 0.2548
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0042 0.01
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0026 0.006
Leishmania major hypothetical protein, conserved 0.0026 0.0047 0.0095
Brugia malayi hypothetical protein 0.002 0.0031 0.0073
Leishmania major trypanothione reductase 0.0043 0.0095 0.0211
Loa Loa (eye worm) hypothetical protein 0.0238 0.0652 0.1557
Schistosoma mansoni pyruvate kinase 0.0039 0.0083 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1478 0.4183 1
Brugia malayi MBOAT family protein 0.0026 0.0047 0.0112
Schistosoma mansoni hypothetical protein 0.0137 0.0363 0.0853
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0099
Leishmania major glycerol uptake protein, putative 0.0026 0.0047 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0026 0.0025
Brugia malayi MBOAT family protein 0.0026 0.0047 0.0112
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Schistosoma mansoni hypothetical protein 0.0137 0.0363 0.0853
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0083 0.0199
Loa Loa (eye worm) patched family protein 0.002 0.0031 0.0073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0083
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.006
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.02 0.0478
Leishmania major cytochrome p450-like protein 0.0023 0.0039 0.0076
Leishmania major pyruvate kinase 0.0039 0.0083 0.0183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0331 0.0916 1
Echinococcus granulosus muscleblind protein 0.0296 0.0815 0.1949
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0083 0.1872
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0083 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0016
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0047 0.011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0093 1
Onchocerca volvulus 0.002 0.0031 0.1197
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0042 0.1373
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Plasmodium falciparum thioredoxin reductase 0.0043 0.0095 0.6038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0007 0.0016
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0119
Loa Loa (eye worm) hypothetical protein 0.0061 0.0147 0.0351
Trypanosoma brucei cytochrome P450, putative 0.008 0.02 0.0443
Brugia malayi cytochrome P450 0.0023 0.0039 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0016
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.005 0.0096
Echinococcus multilocularis protein patched 0.0142 0.0378 0.0377
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0042 0.1373
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0047 0.0111
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0047 0.0096
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0206 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0047 0.2381
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0138 0.0292
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0039 0.1218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0138 0.0329
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.01
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0047 0.0111
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0042 0.0982
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0047 0.0047
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0007 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0007 0.0016
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0042 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0378 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0083
Trichomonas vaginalis chaperonin, putative 0.0026 0.0047 0.0852
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0093 0.2134
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1478 0.4183 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0039 0.0871
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0282 1
Toxoplasma gondii patched family protein 0.002 0.0031 0.0036
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0039 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0865
Onchocerca volvulus 0.0024 0.0042 0.1755
Loa Loa (eye worm) patched family protein 0.002 0.0031 0.0073
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0982
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0331 0.0916 0.2188
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Giardia lamblia Pyruvate kinase 0.002 0.003 0.185
Schistosoma mansoni hypothetical protein 0.0137 0.0363 0.0853
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0093 0.2134
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0039 0.0871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0016 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0016
Schistosoma mansoni ap endonuclease 0.0042 0.0093 0.0206
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0007 0.0016
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0042 0.1986
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0047 0.0111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0132 0.0317
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus multilocularis pyruvate kinase 0.002 0.003 0.003
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0047 0.4051
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0042 0.0982
Toxoplasma gondii patched family protein 0.002 0.0031 0.0036
Loa Loa (eye worm) glutathione reductase 0.0043 0.0095 0.0226
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Onchocerca volvulus 0.0057 0.0136 0.6512
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0093 0.2905
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0047 0.0111
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.0082 0.0206 0.0491
Brugia malayi Myosin head containing protein 0.002 0.0031 0.0073
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0083
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.0273 0.0753 0.1798
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0865
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.0725 0.1733
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0138 0.4587
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1478 0.4183 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0007 0.0016
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0016
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0142 0.0378 0.0902
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0047 0.0059
Echinococcus multilocularis muscleblind protein 1 0.0296 0.0815 0.0815
Leishmania major cytochrome p450-like protein 0.0023 0.0039 0.0076
Entamoeba histolytica hypothetical protein 0.0076 0.0191 0.1711
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0016 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0061 0.0147 0.6912
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0047 0.0095
Echinococcus multilocularis muscleblind protein 0.0296 0.0815 0.0815
Loa Loa (eye worm) oxidoreductase 0.0024 0.0042 0.0099
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0047 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0042 0.1373
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0047 0.0047
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0042 0.0063
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0206 1
Schistosoma mansoni hypothetical protein 0.0026 0.0047 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.02 0.0478
Brugia malayi Muscleblind-like protein 0.0296 0.0815 0.1949
Loa Loa (eye worm) hypothetical protein 0.0061 0.0147 0.0351
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.0753 0.1798
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0061 0.0147 0.4944
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0042 0.0063
Schistosoma mansoni ap endonuclease 0.0042 0.0093 0.0206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.0262 0.0627
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0093 0.0093
Trypanosoma brucei trypanothione reductase 0.0043 0.0095 0.0191
Leishmania major pyruvate kinase 0.0039 0.0083 0.0183
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0083 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0138 0.0329
Echinococcus granulosus cpg binding protein 0.0032 0.0065 0.0155
Leishmania major glycerol uptake protein, putative 0.0026 0.0047 0.0095
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0039 0.0871
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0016
Schistosoma mansoni zinc finger protein 0.0026 0.0047 0.0096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0296 0.0815 0.1949
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0083 0.0199
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0039 0.0871
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0039 0.1218
Brugia malayi CXXC zinc finger family protein 0.003 0.006 0.0144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0111
Schistosoma mansoni survival motor neuron protein 0.0056 0.0132 0.0301
Brugia malayi MBOAT family protein 0.0026 0.0047 0.0112
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0039 0.1218
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0047 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0206 0.0476
Trypanosoma cruzi cytochrome P450, putative 0.008 0.02 0.0463
Brugia malayi Hhat protein 0.0026 0.0047 0.0112
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0083 0.0199
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0083 0.0163
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0336 0.093 0.2211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0007 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0007 0.0016
Loa Loa (eye worm) patched family protein 0.002 0.0031 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0039 0.0871
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0039 0.1218
Echinococcus multilocularis 0.0023 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0061 0.0147 0.0351
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0016 0.002
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0016
Echinococcus multilocularis tumor protein p63 0.0391 0.1087 0.1086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0042 0.1373
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0016 0.002
Entamoeba histolytica hypothetical protein 0.0026 0.0047 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Echinococcus granulosus pyruvate kinase 0.002 0.003 0.0071
Echinococcus multilocularis pyruvate kinase 0.002 0.003 0.003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0061 0.0147 1
Trypanosoma cruzi cytochrome P450, putative 0.008 0.02 0.0463
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0093 0.0185
Onchocerca volvulus Protein patched homolog 0.002 0.0031 0.1197
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Toxoplasma gondii hypothetical protein 0.0026 0.0047 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0262 0.0611
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0047 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi Patched family protein 0.002 0.0031 0.0073
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0047 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0073
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0093 0.0222
Schistosoma mansoni hypothetical protein 0.0023 0.0039 0.0077
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0047 0.0111
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0039 0.0076

Activities

Activity type Activity value Assay description Source Reference
DeltaTC (functional) 0 % In vivo percent change in plasma cholesterol level was measured at a dose of 30 mg/Kg in rat and expressed as deltaTC; ND means not determined ChEMBL. 9871672
IC50 (binding) > 1 uM In vitro inhibition of ACAT by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from cholesterol-fed rabbits. ChEMBL. 9871672
IC50 (binding) > 1 uM In vitro inhibition of ACAT by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from cholesterol-fed rabbits. ChEMBL. 9871672

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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