Detailed information for compound 166353

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 266.333 | Formula: C15H22O4
  • H donors: 2 H acceptors: 3 LogP: 5.03 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCOc1cccc(c1C(=O)O)O
  • InChi: 1S/C15H22O4/c1-2-3-4-5-6-7-11-19-13-10-8-9-12(16)14(13)15(17)18/h8-10,16H,2-7,11H2,1H3,(H,17,18)
  • InChiKey: GUTZZGLHYZZGTE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0071 0.0161 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0073 0.0093
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0085 0.0267
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0085 0.0324
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0227 0.0448
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0088 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0077 0.0247
Schistosoma mansoni cpg binding protein 0.011 0.029 0.0573
Echinococcus granulosus Niemann Pick C1 protein 0.0128 0.0348 0.0416
Echinococcus granulosus serine:threonine protein kinase PLK1 0.017 0.0488 0.0583
Trypanosoma brucei prostaglandin f synthase 0.0034 0.0041 0.0559
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0077 0.0092
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0363 0.1118 0.1337
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0028 0.002 0.0075
Brugia malayi Pax transcription activation domain interacting protein 0.0028 0.002 0.0065
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Brugia malayi RNA binding protein 0.0189 0.055 0.1774
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0092 0.0109
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0363 0.1118 0.2212
Chlamydia trachomatis replicative DNA helicase 0.0351 0.1078 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0047 0.0082 0.0163
Brugia malayi hypothetical protein 0.0181 0.0523 0.1685
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Loa Loa (eye worm) RNA binding protein 0.0189 0.055 0.1769
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0092 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0056 0.0067
Plasmodium falciparum replication factor C subunit 1, putative 0.0028 0.002 0.0075
Onchocerca volvulus Peroxidase homolog 0.0031 0.0031 0.0093
Schistosoma mansoni Replicative DNA helicase 0.0351 0.1078 0.2132
Echinococcus granulosus adam 0.01 0.0258 0.0308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0167 0.02
Loa Loa (eye worm) twinkle helicase 0.01 0.0258 0.0825
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0206 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0062 0.0194
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0056 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0077 0.0247
Plasmodium falciparum importin beta, putative 0.0026 0.0016 0.006
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus multilocularis apoptotic protease activating factor 1 0.0025 0.0012 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0007 0.0009
Plasmodium vivax importin-beta 2, putative 0.0026 0.0016 0.006
Brugia malayi isocitrate dehydrogenase 0.0048 0.0088 0.0282
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0233 0.0693 0.1371
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.0167 0.054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0045 0.0172
Brugia malayi glutathione reductase 0.004 0.0062 0.02
Loa Loa (eye worm) brahma associated protein 0.0071 0.0161 0.0514
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0031 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trypanosoma cruzi DNA repair protein, putative 0.003 0.0028 0.0319
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0222 0.0266
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0027 0.0017 0.0092
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0818 0.2608 1
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0194 0.0626
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0056 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0056 0.0207
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0232 0.0232
Echinococcus multilocularis expressed conserved protein 0.0084 0.0204 0.0244
Brugia malayi YY1-associated factor 2 0.0025 0.0012 0.0039
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.034 0.1041 0.206
Schistosoma mansoni hypothetical protein 0.0027 0.0019 0.0037
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0055 0.0066
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0055 0.0066
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0017 0.0092
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Echinococcus multilocularis stromal cell derived factor 2 0.0756 0.2405 0.2875
Echinococcus multilocularis chromobox protein 1 0.0111 0.0292 0.0349
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0088 0.0326
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0047 0.0085 0.0101
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0034 0.0041 0.0122
Echinococcus granulosus tumor protein p63 0.1186 0.3814 0.456
Brugia malayi MH2 domain containing protein 0.0726 0.2306 0.7437
Schistosoma mansoni Smad4 0.0022 0.0002 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0088 0.0326
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0146 0.0408 0.0488
Giardia lamblia Aldose reductase 0.0034 0.0041 0.0438
Echinococcus granulosus nibrin 0.0028 0.002 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Chlamydia trachomatis DNA ligase 0.0028 0.002 0.0186
Echinococcus multilocularis GPCR, family 2 0.0081 0.0194 0.0232
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0088 0.0282
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0028 0.002 0.0013
Onchocerca volvulus 0.0818 0.2608 0.8408
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0077 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0077 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0077 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0077 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0077 0.0247
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0105 0.0392
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0088 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Echinococcus granulosus jumonji domain containing protein 0.0075 0.0174 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0818 0.2608 0.5158
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0055 0.0172
Schistosoma mansoni zinc finger protein 0.0025 0.0012 0.0024
Giardia lamblia Histone acetyltransferase GCN5 0.0098 0.025 0.4916
Echinococcus granulosus geminin 0.0466 0.1455 0.174
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0071 0.0161 0.06
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0351 0.1078 0.4134
Schistosoma mansoni importin beta-1 0.0026 0.0016 0.0032
Leishmania major DNA polymerase eta, putative 0.0034 0.0042 0.059
Schistosoma mansoni Smad4 0.0049 0.0092 0.0181
Trichomonas vaginalis mannosyltransferase, putative 0.0414 0.1284 0.1901
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0077 0.0152
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0085 0.1422
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Brugia malayi MH2 domain containing protein 0.0049 0.0092 0.0295
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0077 0.0152
Echinococcus granulosus replication factor c subunit 1 0.0028 0.002 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni topbp1 0.0028 0.002 0.004
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0027 0.0019 0.0054
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0151 0.0425 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0077 0.0247
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0692 0.1017
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0255 0.0766 0.2464
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0176 0.0506 0.0605
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Brugia malayi topoisomerase 0.0028 0.002 0.0065
Loa Loa (eye worm) hypothetical protein 0.0175 0.0501 0.1611
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0009 0.0034
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0092 0.0289
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Schistosoma mansoni hypothetical protein 0.0027 0.0019 0.0037
Brugia malayi hypothetical protein 0.01 0.0258 0.0831
Brugia malayi SWIB/MDM2 domain containing protein 0.0071 0.0161 0.052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0077 0.0241
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Schistosoma mansoni smad 0.0022 0.0002 0.0004
Trypanosoma brucei polo-like protein kinase 0.017 0.0488 0.9321
Brugia malayi Augmenter of liver regeneration 0.0037 0.005 0.0161
Loa Loa (eye worm) blistered cuticle protein 3 0.0031 0.0031 0.0093
Loa Loa (eye worm) matrix metalloproteinase 0.0047 0.0082 0.0259
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0232 0.0699
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0085 0.0284
Loa Loa (eye worm) hypothetical protein 0.0092 0.0231 0.0739
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.035 0.1075 0.3461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0021 0.0025
Onchocerca volvulus 0.0818 0.2608 0.8408
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0232 0.0232
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Brugia malayi serine/threonine-protein kinase plk-2 0.017 0.0488 0.1573
Leishmania major hypothetical protein, conserved 0.0181 0.0523 1
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0161 0.052
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0019 0.0023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0139 0.0386 0.124
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0056 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Onchocerca volvulus 0.0818 0.2608 0.8408
Mycobacterium ulcerans hypothetical protein 0.0047 0.0084 0.0321
Loa Loa (eye worm) TAR-binding protein 0.0189 0.055 0.1769
Loa Loa (eye worm) spectraplakin 0.0027 0.0019 0.0054
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Plasmodium falciparum glutathione reductase 0.004 0.0062 0.0231
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0056 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0056 0.0856
Schistosoma mansoni hypothetical protein 0.0466 0.1455 0.2878
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0092 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Schistosoma mansoni TRABID protein (C64 family) 0.0025 0.0012 0.0024
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0057 0.0116 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0077 0.0241
Loa Loa (eye worm) hypothetical protein 0.0054 0.0105 0.0334
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0092 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Onchocerca volvulus Papilin homolog 0.011 0.0291 0.0933
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0045 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Echinococcus granulosus stromal cell derived factor 2 0.0756 0.2405 0.2875
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0107 0.0279 0.1038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0174 0.0498 0.1601
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2576 0.8364 1
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Onchocerca volvulus Chorion peroxidase homolog 0.0031 0.0031 0.0093
Giardia lamblia PHD finger protein 15 0.0054 0.0105 0.1826
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Echinococcus multilocularis nibrin 0.0028 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus granulosus tar DNA binding protein 0.0189 0.055 0.0658
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Echinococcus multilocularis tumor protein p63 0.1186 0.3814 0.456
Echinococcus granulosus chromobox protein 1 0.0111 0.0292 0.0349
Toxoplasma gondii ATPase, AAA family protein 0.0028 0.002 0.0075
Mycobacterium leprae Probable lipase LipE 0.0039 0.0056 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0077 0.0247
Trichomonas vaginalis replication factor C large subunit, putative 0.0028 0.002 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0025 0.0012 0.0045
Schistosoma mansoni hypothetical protein 0.0054 0.0105 0.0209
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0149 0.0481
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0056 0.0168
Onchocerca volvulus 0.0034 0.0041 0.0124
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Leishmania major hypothetical protein, conserved 0.0037 0.005 0.0739
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.0167 0.0534
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.034 0.1041 0.1245
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0088 0.0326
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Echinococcus multilocularis Smad4 0.0049 0.0092 0.0109
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0351 0.1078 0.3251
Brugia malayi hypothetical protein 0.0031 0.0031 0.0099
Echinococcus multilocularis Spectrin alpha actinin 0.0027 0.0019 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0019 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0167 0.02
Schistosoma mansoni serine/threonine protein kinase 0.017 0.0488 0.0965
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0151 0.0425 0.1281
Leishmania major hypothetical protein, conserved 0.0039 0.0056 0.0856
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0019 0.0023
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0056 0.0056
Echinococcus granulosus smad 0.0049 0.0092 0.0109
Loa Loa (eye worm) nuclear factor I 0.0027 0.0019 0.0055
Echinococcus granulosus snurportin 1 0.0282 0.0853 0.102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0085 0.0085
Onchocerca volvulus 0.0031 0.0031 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.0766 0.2464
Trypanosoma brucei unspecified product 0.0033 0.0037 0.0479
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Toxoplasma gondii LsmAD domain-containing protein 0.0181 0.0523 0.1943
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Loa Loa (eye worm) apoptosis regulator protein 0.034 0.1041 0.3354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Loa Loa (eye worm) hypothetical protein 0.011 0.0291 0.0933
Onchocerca volvulus 0.0039 0.0056 0.0173
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0028 0.002 0.0157
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0016 0.0081
Brugia malayi RNA, U transporter 1 0.0075 0.0176 0.0566
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.017 0.0485 0.0579
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Schistosoma mansoni chromobox protein 0.0111 0.0292 0.0577
Schistosoma mansoni smad 0.0049 0.0092 0.0181
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0034 0.0041 0.0559
Brugia malayi hypothetical protein 0.0028 0.002 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0092 0.0289
Schistosoma mansoni peroxidasin 0.0031 0.0031 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0217 0.0641 0.2382
Schistosoma mansoni DNA polymerase eta 0.0067 0.0149 0.0295
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0692 0.1017
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0025 0.0012 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0084 0.0321
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Schistosoma mansoni hypothetical protein 0.1566 0.5056 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.0054 0.0105 0.0126
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.002 0.0157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0021 0.0025
Echinococcus multilocularis chromobox protein 1 0.0111 0.0292 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0194 0.0232
Echinococcus multilocularis tar DNA binding protein 0.0189 0.055 0.0658
Mycobacterium ulcerans hypothetical protein 0.0414 0.1284 0.4923
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.017 0.0488 0.9321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Brugia malayi chromobox protein homolog 3 0.0062 0.0133 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Brugia malayi hypothetical protein 0.0024 0.0007 0.0023
Brugia malayi ADAMTS-like protease 0.0107 0.0281 0.0906
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0009 0.0034
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0028 0.002 0.0065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0718 0.2281 0.4511
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0107 0.0279 0.1038
Loa Loa (eye worm) hypothetical protein 0.0062 0.0133 0.0422
Brugia malayi Thioredoxin reductase 0.004 0.0062 0.02
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Mycobacterium tuberculosis Probable aminotransferase 0.0151 0.0425 0.0425
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Schistosoma mansoni hypothetical protein 0.0175 0.0501 0.0991
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0088 0.148
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0002 0.0002
Brugia malayi hypothetical protein 0.0024 0.0007 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0107 0.0279 0.0334
Echinococcus multilocularis peregrin 0.0063 0.0135 0.0161
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0042 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0843 0.269 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0077 0.0152
Onchocerca volvulus 0.0039 0.0056 0.0173
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0133 0.0182
Schistosoma mansoni rotamase 0.0027 0.0019 0.0037
Onchocerca volvulus 0.0071 0.0161 0.0514
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0033 0.0032
Brugia malayi MIR domain containing protein 0.0756 0.2405 0.7754
Echinococcus multilocularis ryanodine receptor 44f 0.0756 0.2405 0.2875
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0016 0.006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0007 0.0017
Brugia malayi PHD-finger family protein 0.0054 0.0105 0.034
Mycobacterium leprae Conserved membrane protein 0.0414 0.1284 0.3872
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0756 0.2405 0.4756
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.055 0.1769
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Trichomonas vaginalis bromodomain-containing protein, putative 0.0107 0.0279 0.04
Loa Loa (eye worm) hypothetical protein 0.0034 0.0041 0.0124
Onchocerca volvulus 0.0025 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0267
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0194 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0077 0.0247
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0146 0.0408 0.0488
Echinococcus multilocularis snurportin 1 0.0282 0.0853 0.102
Onchocerca volvulus 0.0034 0.0041 0.0124
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0047 0.0085 0.0101
Schistosoma mansoni chromosome transmission fidelity factor 0.0028 0.002 0.004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0085 0.0085
Plasmodium vivax cytochrome b 0.0843 0.269 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0222 0.0266
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.005 0.0739
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0232 0.0232
Leishmania major DNA polymerase eta, putative 0.0067 0.0149 0.2684
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.005 0.0185
Loa Loa (eye worm) Smad1 0.0049 0.0092 0.0289
Onchocerca volvulus Cell death protein 3 homolog 0.0025 0.0012 0.0033
Echinococcus granulosus ring and YY1 binding protein 0.0025 0.0012 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0077 0.0247
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0077 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0077 0.0241
Onchocerca volvulus 0.0025 0.0012 0.0032
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0045 0.0167
Treponema pallidum replicative DNA helicase (dnaB) 0.0351 0.1078 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0056 0.0214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0077 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0194 0.062
Brugia malayi Cell death protein 3 precursor 0.0025 0.0012 0.0039
Brugia malayi angiogenesis inhibito 0.0107 0.0281 0.0906
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.017 0.0488 0.1568
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0028 0.002 0.0077
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.005 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0085 0.0273
Echinococcus granulosus cytochrome B 0.0843 0.269 0.3215
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0266 0.0266
Brugia malayi jmjC domain containing protein 0.0071 0.0163 0.0526
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0025 0.0012 0.0045
Onchocerca volvulus Peroxidase homolog 0.0031 0.0031 0.0093
Leishmania major DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni cpg binding protein 0.0116 0.031 0.0613
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trypanosoma cruzi aldo/keto reductase, putative 0.0034 0.0041 0.0559
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.01 0.0258 0.051
Echinococcus granulosus zinc finger protein Ran binding 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0083 0.0263
Onchocerca volvulus 0.0066 0.0146 0.0465
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0077 0.0247
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0149 0.2684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0056 0.0067
Brugia malayi Matrixin family protein 0.0113 0.0299 0.0963
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0077 0.0152
Toxoplasma gondii ran binding protein 0.0025 0.0012 0.0045
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0054 0.0105 0.0209
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0293 0.0938
Entamoeba histolytica acetyltransferase, GNAT family 0.0098 0.025 0.0977
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0025 0.0012 0.0014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0085 0.011
Loa Loa (eye worm) matrixin family protein 0.0103 0.0268 0.0859
Loa Loa (eye worm) cytochrome b 0.0843 0.269 0.8672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0019 0.0023
Trichomonas vaginalis mannosyltransferase 1, putative 0.0756 0.2405 0.3575
Echinococcus multilocularis caspase 2 0.0025 0.0012 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0163 0.0322
Schistosoma mansoni cellular tumor antigen P53 0.0174 0.0498 0.0985
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Onchocerca volvulus 0.0034 0.0041 0.0124
Loa Loa (eye worm) acetyltransferase 0.0363 0.1118 0.3602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.007 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0084 0.0084
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0007 0.0023
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.2576 0.8364 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Loa Loa (eye worm) hypothetical protein 0.034 0.1041 0.3354
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0007 0.0014
Schistosoma mansoni pol-related 0.0034 0.0041 0.008
Loa Loa (eye worm) hypothetical protein 0.0089 0.0222 0.071
Echinococcus granulosus PHD finger protein rhinoceros 0.0054 0.0105 0.0126
Chlamydia trachomatis recombinase RecA 0.0098 0.025 0.2322
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus granulosus SWI:SNF matrix associated 0.0071 0.0161 0.0193
Brugia malayi hypothetical protein 0.033 0.1011 0.326
Brugia malayi acetyltransferase, GNAT family protein 0.0363 0.1118 0.3606
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0028 0.002 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0172
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0726 0.2306 0.7436
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Brugia malayi cation channel family protein 0.0756 0.2405 0.7754
Loa Loa (eye worm) hypothetical protein 0.0049 0.0089 0.028
Echinococcus granulosus ryanodine receptor 44f 0.0756 0.2405 0.2875
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0167 0.02
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0142 0.017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0077 0.0247
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0222 0.086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0084 0.0321
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Echinococcus multilocularis peroxidasin 0.0031 0.0031 0.0037
Chlamydia trachomatis DNA topoisomerase I 0.0071 0.0161 0.1496
Treponema pallidum recombinase A 0.0098 0.025 0.2176
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Brugia malayi TspO/MBR family protein 0.0818 0.2608 0.8409
Echinococcus granulosus dnaJ subfamily B 0.1566 0.5056 0.6045
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0009 0.0011
Schistosoma mansoni brg-1 associated factor 0.0071 0.0161 0.0319
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Echinococcus multilocularis translocator protein 0.0818 0.2608 0.3118
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0266 0.0801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0056 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0161 0.0224
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Trypanosoma brucei aldo-keto reductase, putative 0.0034 0.0041 0.0559
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0009 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0523 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0056 0.0056
Brugia malayi CHD4 protein 0.0024 0.0009 0.003
Trichomonas vaginalis rotamase, putative 0.0027 0.0019 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Brugia malayi MH2 domain containing protein 0.0022 0.0002 0.0006
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0098 0.025 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni DNA ligase IV 0.0028 0.002 0.004
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0077 0.0092
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0756 0.2405 0.4756
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Schistosoma mansoni coup transcription factor 0.0045 0.0077 0.0152
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Brugia malayi ADAM-TS Spacer 1 family protein 0.035 0.1075 0.3465
Mycobacterium ulcerans hypothetical protein 0.0151 0.0425 0.1628
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Loa Loa (eye worm) hypothetical protein 0.0139 0.0386 0.124
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0028 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0107 0.0279 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Mycobacterium tuberculosis Conserved membrane protein 0.0181 0.0521 0.0521
Onchocerca volvulus Matrilysin homolog 0.0047 0.0082 0.0259
Schistosoma mansoni cytochrome b 0.0843 0.269 0.5319
Trypanosoma cruzi FHA domain containing protein, putative 0.0028 0.002 0.0157
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0025 0.0012 0.0032
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0151 0.0425 0.0617
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0077 0.0092
Onchocerca volvulus Dual oxidase homolog 0.0031 0.0031 0.0093
Echinococcus granulosus hypothetical protein 0.0034 0.0041 0.0049
Onchocerca volvulus Matrilysin homolog 0.0103 0.0268 0.0859
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0028 0.002 0.0013
Mycobacterium ulcerans beta-lactamase 0.0039 0.0056 0.0214
Echinococcus granulosus Spectrin alpha actinin 0.0027 0.0019 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Onchocerca volvulus 0.0049 0.0089 0.028
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Onchocerca volvulus 0.0034 0.0041 0.0124
Plasmodium vivax ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Brugia malayi MH2 domain containing protein 0.0049 0.0092 0.0295
Echinococcus granulosus apoptotic protease activating factor 1 0.0025 0.0012 0.0015
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0045 0.0416
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0017 0.0092
Echinococcus granulosus aldehyde reductase 0.0024 0.0008 0.001
Onchocerca volvulus Serine\/threonine kinase homolog 0.017 0.0488 0.1568
Echinococcus multilocularis zinc finger protein Ran binding 0.0025 0.0012 0.0014
Brugia malayi nuclear hormone receptor 0.0045 0.0077 0.0247
Plasmodium vivax glutathione reductase, putative 0.004 0.0062 0.0231
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.017 0.0488 0.0583
Loa Loa (eye worm) heterochromatin protein 1 0.0111 0.0292 0.0935
Leishmania major trypanothione reductase 0.004 0.0062 0.0981
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0097 0.0313
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Schistosoma mansoni topbp1 0.0028 0.002 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Echinococcus multilocularis smad 0.0049 0.0092 0.0109
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0098 0.025 0.0931
Loa Loa (eye worm) PHD-finger family protein 0.0054 0.0105 0.0334
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Onchocerca volvulus Alhambra homolog 0.0054 0.0105 0.0334
Loa Loa (eye worm) MIR domain-containing protein 0.0756 0.2405 0.7752
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0282 0.0853 0.2747
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.0735 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Mycobacterium ulcerans hydrolase 0.0057 0.0116 0.0443
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Onchocerca volvulus 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0133 0.0182
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Plasmodium falciparum cytochrome b 0.0843 0.269 1
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.062
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0475
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0085 0.0101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0092 0.0181
Entamoeba histolytica serine/threonine protein kinase, putative 0.017 0.0488 0.1973
Leishmania major aldo-keto reductase-like protein 0.0034 0.0041 0.0559
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Plasmodium falciparum thioredoxin reductase 0.004 0.0062 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.0501 0.1616
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.055 0.1774
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0071 0.0161 0.06
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0008 0.0025
Echinococcus multilocularis protein patched 0.0038 0.0055 0.0066
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0105 0.0392
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0077 0.0241
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Brugia malayi Heterochromatin protein 1 0.0111 0.0292 0.0941
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0084 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Onchocerca volvulus 0.0045 0.0077 0.0241
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.2823 0.9172 0.9172
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0088 0.0326
Echinococcus granulosus expressed conserved protein 0.0084 0.0204 0.0244
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0047 0.0085 0.0168
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0071 0.0161 0.0193
Loa Loa (eye worm) hypothetical protein 0.0181 0.0523 0.168
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0062 0.0981
Loa Loa (eye worm) hypothetical protein 0.01 0.0258 0.0826
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0077 0.0092
Trichomonas vaginalis chromobox protein, putative 0.0111 0.0292 0.0419
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0756 0.2405 0.7754
Plasmodium vivax replication factor C subunit 1, putative 0.0028 0.002 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0194 0.0232
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0088 0.0088
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0077 0.0247
Echinococcus multilocularis expressed protein 0.0027 0.0019 0.0022
Echinococcus granulosus caspase 2 0.0025 0.0012 0.0015
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0077 0.0092
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus granulosus peroxidasin 0.0031 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0222 0.0716
Schistosoma mansoni hypothetical protein 0.0282 0.0853 0.1688
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0077 0.0241
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0019 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0042 0.059
Schistosoma mansoni hypothetical protein 0.0081 0.0196 0.0387
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0077 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0021 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0007 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0056 0.0067
Brugia malayi ecdysteroid receptor 0.0045 0.0077 0.0247
Brugia malayi beta-lactamase family protein 0.0039 0.0056 0.018
Schistosoma mansoni hypothetical protein 0.0066 0.0146 0.0289
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0161 0.052
Onchocerca volvulus 0.0025 0.0012 0.0032
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0007 0.0008
Loa Loa (eye worm) metalloprotease 0.0047 0.0085 0.0267
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0085 0.0101
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Echinococcus multilocularis adam 0.01 0.0258 0.0308
Echinococcus multilocularis jumonji domain containing protein 0.0075 0.0174 0.0208
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Brugia malayi CXXC zinc finger family protein 0.011 0.029 0.0934
Brugia malayi beta-lactamase family protein 0.0039 0.0056 0.018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0055
Toxoplasma gondii thioredoxin reductase 0.004 0.0062 0.0231
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0009 0.0011
Schistosoma mansoni fusion 0.0025 0.0012 0.0024
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Onchocerca volvulus 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0073 0.0093
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0148 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0055 0.0066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus granulosus translocator protein 0.0818 0.2608 0.3118
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0085 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus multilocularis replication factor c subunit 1 0.0028 0.002 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0084 0.0321
Brugia malayi MH1 domain containing protein 0.0027 0.0019 0.0062
Brugia malayi Blistered cuticle protein 3 0.0031 0.0031 0.0099
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.003 0.0028 0.0319
Loa Loa (eye worm) histone methyltransferase 0.0034 0.0041 0.0126
Echinococcus granulosus expressed protein 0.0027 0.0019 0.0022
Onchocerca volvulus 0.0025 0.0012 0.0033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0077 0.0092
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0028 0.002 0.0061
Brugia malayi DKFZp564C0469 protein 0.0028 0.002 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0194 0.0232
Brugia malayi hypothetical protein 0.0025 0.0012 0.0039
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0057 0.0116 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Giardia lamblia Kinase, PLK 0.017 0.0488 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis chromobox protein, putative 0.0111 0.0292 0.0419
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0084 0.0281
Echinococcus multilocularis aldehyde reductase 0.0024 0.0008 0.001
Schistosoma mansoni patched 1 0.0038 0.0055 0.0109
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.011 0.029 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.034 0.1041 0.3358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Mycobacterium ulcerans lipase LipD 0.0039 0.0056 0.0214
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0028 0.002 0.0157
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0146 0.0408 0.0807
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0007 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0167 0.02
Trypanosoma cruzi polo-like protein kinase, putative 0.017 0.0488 0.9321
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0077 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0056 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Brugia malayi Reprolysin 0.0047 0.0085 0.0273
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Schistosoma mansoni hypothetical protein 0.0466 0.1455 0.2878
Brugia malayi steroid hormone receptor 0.0045 0.0077 0.0247
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) angiogenesis inhibito 0.0054 0.0108 0.0341
Brugia malayi VAB-10A protein 0.0027 0.0019 0.0061
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0007 0.0009
Mycobacterium leprae PROBABLE HYDROLASE 0.0057 0.0116 0.0349
Mycobacterium tuberculosis Probable reductase 0.0092 0.0232 0.0232
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0084 0.0253
Brugia malayi Hemopexin family protein 0.0066 0.0146 0.0471
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0232 0.0232
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0056 0.0173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Trypanosoma brucei PAB1-binding protein , putative 0.0181 0.0523 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Onchocerca volvulus Matrix metalloproteinase homolog 0.0103 0.0268 0.0859
Onchocerca volvulus 0.0756 0.2405 0.7752
Mycobacterium ulcerans hypothetical protein 0.0039 0.0056 0.0214
Schistosoma mansoni chromobox protein 0.0111 0.0292 0.0577
Giardia lamblia DINP protein human, muc B family 0.0047 0.0085 0.138
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0002 0.0002
Schistosoma mansoni peroxidasin 0.0031 0.0031 0.0061
Echinococcus multilocularis dnaJ subfamily B 0.1566 0.5056 0.6045
Loa Loa (eye worm) matrixin family protein 0.0113 0.0299 0.0957
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.005 0.0185
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0028 0.002 0.0075
Echinococcus multilocularis cpg binding protein 0.0116 0.031 0.0371
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0088 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0027 0.0023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0084 0.0253
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0085 0.011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Onchocerca volvulus 0.0039 0.0056 0.0173
Echinococcus multilocularis geminin 0.0466 0.1455 0.174
Mycobacterium ulcerans oxidoreductase 0.0034 0.0041 0.0156
Onchocerca volvulus 0.0969 0.3101 1
Schistosoma mansoni kinase 0.0087 0.0213 0.0422
Toxoplasma gondii cytochrome b 0.0843 0.269 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.0514
Echinococcus granulosus chromobox protein 1 0.0111 0.0292 0.0349
Onchocerca volvulus 0.0034 0.0041 0.0124
Brugia malayi beta-lactamase 0.0039 0.0056 0.018
Toxoplasma gondii peptidylprolyl isomerase 0.0027 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0366
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Brugia malayi MH1 domain containing protein 0.0049 0.0092 0.0295
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0077 0.0152
Brugia malayi hypothetical protein 0.0117 0.0312 0.1007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0353 0.1085 0.1297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0081 0.0196 0.0234
Brugia malayi metalloprotease 0.0047 0.0085 0.0273
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.034 0.1041 0.1245
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0077 0.0152
Echinococcus granulosus dna polymerase kappa 0.0047 0.0085 0.0101
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0007 0.0008
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0009 0.0019
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0351 0.1078 0.4008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0077 0.0092
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0064 0.0076
Brugia malayi hypothetical protein 0.0028 0.002 0.0065
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0062 0.0133 0.0422
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0163 0.052
Trypanosoma brucei unspecified product 0.0033 0.0037 0.0479
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0088 0.0105
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0056 0.0856
Schistosoma mansoni hypothetical protein 0.0028 0.0021 0.0041
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0726 0.2306 0.7436
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0064 0.0076
Brugia malayi Pax transcription factor protein 2 0.0969 0.3101 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0194 0.0626
Loa Loa (eye worm) beta-lactamase 0.0039 0.0056 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0056 0.018
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0056 0.0856
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.0766 0.2469
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0049
Echinococcus multilocularis ring and YY1 binding protein 0.0025 0.0012 0.0014
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Entamoeba histolytica MIR domain protein 0.0756 0.2405 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0002 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.005 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.005 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0062 0.0231
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0025 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Onchocerca volvulus 0.0028 0.002 0.0058
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0047 0.0085 0.0168
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0107 0.0279 0.1038
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0266 0.0266
Brugia malayi Smad1 0.0049 0.0092 0.0295
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0163 0.0195
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Onchocerca volvulus 0.011 0.029 0.0928
Trypanosoma cruzi DNA repair protein, putative 0.003 0.0028 0.0319
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Brugia malayi Importin beta-1 subunit 0.0026 0.0016 0.0052
Brugia malayi PHD-finger family protein 0.0024 0.0008 0.0025
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0081 0.0196 0.0234
Brugia malayi CHE-14 protein 0.0038 0.0055 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0055 0.0066
Schistosoma mansoni caspase-7 (C14 family) 0.0025 0.0012 0.0024
Schistosoma mansoni cpg binding protein 0.0116 0.031 0.0613
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Brugia malayi jmjC domain containing protein 0.0176 0.0506 0.163
Brugia malayi MH1 domain containing protein 0.0027 0.0019 0.0062
Echinococcus granulosus cpg binding protein 0.0116 0.031 0.0371
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0028 0.002 0.0013
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.0024
Schistosoma mansoni RNA binding protein 0.0025 0.0012 0.0024
Giardia lamblia Aldose reductase 0.0034 0.0041 0.0438
Brugia malayi N-terminal motif family protein 0.0139 0.0386 0.1246
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0077 0.0152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.0766 0.2469
Schistosoma mansoni jumonji domain containing protein 0.014 0.0387 0.0766
Echinococcus multilocularis Niemann Pick C1 protein 0.0128 0.0348 0.0416
Echinococcus granulosus Zinc finger RanBP2 type 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0232 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0077 0.0241
Trypanosoma brucei trypanothione reductase 0.004 0.0062 0.0981
Plasmodium falciparum histone acetyltransferase GCN5 0.0098 0.025 0.093
Loa Loa (eye worm) hypothetical protein 0.0053 0.0103 0.0325
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0084 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Brugia malayi nuclear receptor RXR 0.0024 0.0007 0.0023
Brugia malayi MH1 domain containing protein 0.0049 0.0092 0.0295
Onchocerca volvulus 0.0818 0.2608 0.8408
Toxoplasma gondii apocytochrome b, putative 0.0843 0.269 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0062 0.0062
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma cruzi aldo-keto reductase 0.0034 0.0041 0.0559
Echinococcus granulosus dna polymerase eta 0.0067 0.0149 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.002 0.0157
Brugia malayi nuclear receptor NHR-88 0.0045 0.0077 0.0247
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0084 0.0281
Toxoplasma gondii aldose reductase, putative 0.0034 0.0041 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Plasmodium falciparum phd finger protein, putative 0.0054 0.0105 0.0392
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0054
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0067 0.0148 0.0472
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Schistosoma mansoni Smad4 0.0022 0.0002 0.0004
Trichomonas vaginalis esterase, putative 0.0039 0.0056 0.0067
Schistosoma mansoni ryanodine receptor related 0.0756 0.2405 0.4756
Loa Loa (eye worm) reprolysin 0.0047 0.0085 0.0267
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0149 0.2684
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Leishmania major prostaglandin f synthase, putative 0.0034 0.0041 0.0559
Schistosoma mansoni aldo-keto reductase 0.0034 0.0041 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0206 0.0291
Schistosoma mansoni cytochrome b 0.0843 0.269 0.5319
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0176 0.0506 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0077 0.0247
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Brugia malayi Peroxidasin 0.0031 0.0031 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Echinococcus granulosus importin subunit beta 1 0.0026 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0056 0.0067
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.017 0.0485 0.0579
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.005 0.006
Onchocerca volvulus 0.0034 0.0041 0.0124
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Trypanosoma brucei unspecified product 0.0047 0.0085 0.1422
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0002 0.0002
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0027 0.0019 0.0061
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.005 0.0739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Echinococcus multilocularis protein dispatched 1 0.0044 0.0073 0.0087
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Mycobacterium leprae Conserved hypothetical protein 0.1034 0.3315 1
Chlamydia trachomatis SWIB complex protein 0.0071 0.0161 0.1496
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Brugia malayi Bromodomain containing protein 0.0063 0.0135 0.0434
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.005 0.0739
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0027 0.0019 0.0133
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0085 0.0167
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0047 0.0085 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Onchocerca volvulus 0.0047 0.0084 0.0264
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0027 0.0017 0.0092
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0034 0.0041 0.0559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0077 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Brugia malayi cytochrome b 0.0843 0.269 0.8673
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0027 0.0019 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0148 0.0205
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0085 0.0167
Trichomonas vaginalis rotamase, putative 0.0027 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0077 0.0092
Loa Loa (eye worm) pax transcription factor protein 2 0.0969 0.3101 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0077 0.0241
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0016 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0033 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0077 0.0241
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0077 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0077 0.0241
Echinococcus granulosus Smad4 0.0049 0.0092 0.0109
Echinococcus multilocularis dna polymerase eta 0.0067 0.0149 0.0178
Echinococcus granulosus peregrin 0.0063 0.0135 0.0161
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.005 0.0185
Loa Loa (eye worm) glutathione reductase 0.004 0.0062 0.0194
Trypanosoma cruzi polo-like protein kinase, putative 0.017 0.0488 0.9321
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0077 0.0152
Echinococcus granulosus GPCR family 2 0.0081 0.0194 0.0232
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0077 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0161 0.06
Onchocerca volvulus 0.0047 0.0082 0.0259
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.005 0.0185
Onchocerca volvulus 0.0025 0.0012 0.0032
Onchocerca volvulus 0.0174 0.0498 0.1601
Schistosoma mansoni apoptosis regulator bax 0.034 0.1041 0.206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1603 0.5179 0.6192
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0151 0.0425 0.1628
Brugia malayi TAR-binding protein 0.0189 0.055 0.1774
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0088 0.148
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.007 0.0089
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0084 0.0281
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0163 0.0322
Brugia malayi hypothetical protein 0.0028 0.0021 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0523 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Schistosoma mansoni aldo-keto reductase 0.0034 0.0041 0.008
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0077 0.0152
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0105 0.0392
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0077 0.0247
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0016 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0045 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0085 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Mycobacterium ulcerans recombinase A 0.0098 0.025 0.096
Toxoplasma gondii ABC1 family protein 0.0039 0.0056 0.0207

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 190 uM Ability to inhibit autophosphorylation of KinA and/or Sp0F TCS proteins from Bacillus subtilis ChEMBL. 10571153
IC50 (functional) > 500 uM Ability to inhibit autophosphorylation of NR11 and/or transphosphorylation of NR1 TCS proteins from E. coli ChEMBL. 10571153
IC50 (functional) > 500 uM Ability to inhibit autophosphorylation of NR11 and/or transphosphorylation of NR1 TCS proteins from E. coli ChEMBL. 10571153
MIC (functional) = 64 ug ml-1 In vitro antibacterial activity against against Staphylococcus aureus strain, ATCC29213 ChEMBL. 10571153
MIC (functional) = 64 ug ml-1 In vitro antibacterial activity against against methicillin resistant Staphylococcus aureus (MRSA) strain, OC2089 ChEMBL. 10571153
MIC (functional) = 128 ug ml-1 In vitro antibacterial activity against against E. faecalis strain, OC3041 ChEMBL. 10571153
MIC (functional) = 128 ug ml-1 In vitro antibacterial activity against against E. faecium(VR) strain, OC3312 Van R ChEMBL. 10571153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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