Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0684 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0684 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0684 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0684 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0684 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0684 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0684 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0684 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0684 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0684 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0684 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0684 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0684 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0684 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0684 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0684 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to syndecan 4 in mouse NIH/3T3 cells assessed as induction of cell proliferation at 25 to 50 ug/ml after 2 days by MTT assay | ChEMBL. | 22776297 | |
Activity (binding) | Binding affinity to syndecan 4 in mouse NIH/3T3 cells assessed as stimulation of beta 1 integrin-mediated cell adhesion at 50 ug/ml after 2 hrs by microscopic analysis | ChEMBL. | 22776297 | |
Activity (binding) | Binding affinity to syndecan 4 in mouse NIH/3T3 cells assessed as stimulation of beta 1 integrin-mediated cell spreading at 50 ug/ml after 2 hrs by microscopic analysis | ChEMBL. | 22776297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.