Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Get druggable targets OG5_133042 | All targets in OG5_133042 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | 388 aa | 314 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.1278 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1278 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1278 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1278 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1278 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1278 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1278 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1278 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1278 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1278 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1278 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1278 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1278 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1278 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1278 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1278 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1278 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1278 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1278 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1278 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.4 | Agonist activity at human 5HT4C receptor expressed at 100 fold physiological-level in HEK293 cells assessed as cAMP accumulation | ChEMBL. | 22683222 |
Inhibition (binding) | = 9 % | Inhibition of human ERG expressed in CHO cells at 3 uM | ChEMBL. | 22683222 |
Intrinsic activity (functional) | = 88 % | Intrinsic activity at human 5HT4C receptor expressed at 100 fold physiological-level in HEK293 cells assessed as cAMP accumulation relative to 5HT | ChEMBL. | 22683222 |
Ki (binding) | = 7.9 | Displacement of [3H]GR113808 from human recombinant 5HT4C receptor expressed in HEK293 cells | ChEMBL. | 22683222 |
Kp (ADMET) | = 31 ucm/s | Permeability across human Caco2 cells | ChEMBL. | 22683222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.