Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein kinase, putative | 0.2949 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2949 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2949 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2949 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.0573 | 0.0043 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2949 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.0532 | 0.0005 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2949 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2949 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2949 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2949 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2949 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.0087 | 0.0087 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2949 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.0087 | 0.0087 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2949 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.0087 | 0.0087 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2949 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2949 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2949 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2949 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2949 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2949 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2949 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2949 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 27 uM | Cytotoxicity against human HepG2 cells after 72 hrs by luminescence analysis | ChEMBL. | 22324546 |
IC50 (functional) | = 0.1 uM | Antagonist activity at human TRalpha assessed as inhibition of interaction with SRC2-2 by fluorescence polarisation assay | ChEMBL. | 22324546 |
IC50 (functional) | = 0.66 uM | Antagonist activity at human TRbeta assessed as inhibition of interaction with SRC2-2 after 3 hrs by fluorescence polarisation assay | ChEMBL. | 22324546 |
IC50 (functional) | > 60 uM | Antagonist activity at human PPAR-gamma assessed as inhibition of interaction with DRIP-2 by fluorescence polarisation assay | ChEMBL. | 22324546 |
Inhibition (functional) | = 2.3 % | Antagonist activity at human TRbeta expressed in HEK293 cells assessed as inhibition of T3-mediated response at 5 uM after 18 hrs by luciferase reporter gene assay | ChEMBL. | 22324546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.