Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast growth factor 2 (basic) | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor 1 (acidic) | Starlite/ChEMBL | References |
Homo sapiens | heparanase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Treponema pallidum | integrase/recombinase (codV) | fibroblast growth factor 1 (acidic) | 155 aa | 132 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0077 | 0.3839 | 1 |
Giardia lamblia | Hypothetical protein | 0.0065 | 0.284 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.3839 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.3839 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Schistosoma mansoni | hypothetical protein | 0.015 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.284 | 0.7398 |
Echinococcus multilocularis | geminin | 0.015 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.015 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.3839 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.3839 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.3839 | 0.3839 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.284 | 0.7398 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.3839 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Antiangiogenic activity in FGF1-stimulated HUVEC cells after 72 hrs by CellTiter assay | ChEMBL. | 22458531 |
Kd (binding) | = 270 nM | Binding affinity to FGF-1 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Kd (binding) | = 1570 nM | Binding affinity to FGF-2 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Ki (binding) | = 22.3 nM | Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assay | ChEMBL. | 22458531 |
Time (ADMET) | = 25.5 s | Anticoagulant activity in pooled human plasma assessed as prolongation of the recalcification time at 0.1 mg/ml by Heptest assay | ChEMBL. | 22458531 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22458531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.