Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0671 | 0.0701 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0671 | 0.0671 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0671 | 0.1372 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0671 | 0.0671 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0671 | 0.0671 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0671 | 0.1372 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9567 | 0.9567 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.3972 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0671 | 0.0701 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0671 | 0.1372 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0671 | 0.1689 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0671 | 0.1372 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0671 | 0.1372 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.489 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9567 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0671 | 0.1372 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.3972 | 0.8123 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.9567 | 0.9567 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0671 | 0.0701 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.489 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.3972 | 0.8123 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.9515 | 0.9946 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 27 uM | Cytotoxicity against human HepG2 cells after 72 hrs by luminescence analysis | ChEMBL. | 22324546 |
IC50 (functional) | = 1.4 uM | Antagonist activity at human TRbeta assessed as inhibition of interaction with SRC2-2 after 3 hrs by fluorescence polarisation assay | ChEMBL. | 22324546 |
IC50 (functional) | = 1.6 uM | Antagonist activity at human TRalpha assessed as inhibition of interaction with SRC2-2 by fluorescence polarisation assay | ChEMBL. | 22324546 |
IC50 (functional) | > 60 uM | Antagonist activity at human PPAR-gamma assessed as inhibition of interaction with DRIP-2 by fluorescence polarisation assay | ChEMBL. | 22324546 |
Inhibition (binding) | Displacement of [125I]T3 from human TRbeta up to 60 uM | ChEMBL. | 22324546 | |
Inhibition (functional) | Antagonist activity at human TRbeta expressed in HEK293 cells assessed as inhibition of T3-mediated response at 5 uM after 18 hrs by luciferase reporter gene assay | ChEMBL. | 22324546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.