Detailed information for compound 1663939

Basic information

Technical information
  • TDR Targets ID: 1663939
  • Name: 3-[(1S,2R,3R,6S)-3-ethenyl-2-isocyano-3-methy l-6-prop-1-en-2-ylcyclohexyl]-1H-indole
  • MW: 304.429 | Formula: C21H24N2
  • H donors: 1 H acceptors: 0 LogP: 5.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [C-]#[N+][C@@H]1[C@@H]([C@H](CC[C@]1(C)C=C)C(=C)C)c1c[nH]c2c1cccc2
  • InChi: 1S/C21H24N2/c1-6-21(4)12-11-15(14(2)3)19(20(21)22-5)17-13-23-18-10-8-7-9-16(17)18/h6-10,13,15,19-20,23H,1-2,11-12H2,3-4H3/t15-,19+,20-,21+/m1/s1
  • InChiKey: KGWATBYKCMCFLC-QAJUQPOASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1S,2R,3R,6S)-2-isocyano-6-isopropenyl-3-methyl-3-vinyl-cyclohexyl]-1H-indole
  • 3-[(1S,2R,3R,6S)-2-isocyano-6-isopropenyl-3-methyl-3-vinylcyclohexyl]-1H-indole
  • 3-[(1S,2R,3R,6S)-3-ethenyl-2-isocyano-3-methyl-6-prop-1-en-2-yl-cyclohexyl]-1H-indole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0038 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0081 0.0082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0719 0.2107
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0064 0.0637
Loa Loa (eye worm) hypothetical protein 0.0052 0.0126 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Echinococcus granulosus chromobox protein 1 0.0079 0.0213 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0064 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0112 0.0112
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0037
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0172 0.0515 0.052
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0008 0.0008
Echinococcus granulosus GPCR family 2 0.0172 0.0515 0.052
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0077 0.0225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi chromobox protein homolog 3 0.0044 0.0101 0.0102
Echinococcus granulosus sodium channel protein 0.005 0.012 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0064 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0064 0.0065
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0293 0.0904 0.0912
Echinococcus multilocularis tumor protein p63 0.0383 0.1195 0.1206
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0064 0.0065
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.009 0.0084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0172 0.0515 0.052
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0101 0.1013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi MH2 domain containing protein 0.0044 0.0099 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0064 0.0065
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0031 0.0031
Onchocerca volvulus 0.0037 0.0077 0.0769
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0136 0.0397 0.0401
Onchocerca volvulus 0.0015 0.0007 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0035 0.0072 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0077 0.0225
Schistosoma mansoni cpg binding protein 0.0029 0.0053 0.0053
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0123 0.0124
Brugia malayi latrophilin 2 splice variant baaae 0.0373 0.1162 0.1172
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0432 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0101 0.0101
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0049 0.0117 0.0118
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.073 0.2317 0.2338
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0077 0.0225
Brugia malayi Pax transcription factor protein 2 0.0255 0.0781 0.0788
Schistosoma mansoni smad 0.002 0.0021 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0126 0.0119
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0021 0.0021
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.005 0.012 0.0121
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0064 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0159 0.0161
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0077 0.0078
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Mycobacterium ulcerans lipase LipD 0.0037 0.0077 0.0071
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0134 0.0134
Echinococcus multilocularis chromobox protein 1 0.0079 0.0213 0.0215
Echinococcus multilocularis snurportin 1 0.0326 0.101 0.1019
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0126 0.0367
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.308 0.9911 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0084
Brugia malayi steroid hormone receptor 0.0033 0.0064 0.0065
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0083 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0064 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0172 0.0515 0.052
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0123 0.0124
Loa Loa (eye worm) hypothetical protein 0.0093 0.0258 0.026
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0008 0.0008
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0029 0.0053 0.0521
Schistosoma mansoni hypothetical protein 0.0172 0.0515 0.052
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.308 0.9911 1
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0041
Trypanosoma cruzi ISWI complex protein 0.0034 0.0067 0.006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0079 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0037 0.0077 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0064 0.0065
Schistosoma mansoni 6-phosphogluconolactonase 0.0028 0.0048 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0642 0.2031 0.2049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0453 0.0457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Schistosoma mansoni bromodomain containing protein 0.0144 0.0423 0.0427
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0099 0.01
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0079 0.008
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.3108 1 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0126 0.0127
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0432 0.0436
Schistosoma mansoni smad 0.0044 0.0099 0.01
Brugia malayi CHD4 protein 0.0019 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0225
Brugia malayi MH1 domain containing protein 0.0044 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Brugia malayi RNA, U transporter 1 0.0087 0.0238 0.0241
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0126 0.0119
Brugia malayi beta-lactamase family protein 0.0037 0.0077 0.0078
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0134 0.0104
Echinococcus granulosus transcription factor eb 0.0603 0.1907 0.1924
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0028 0.0048 0.3411
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0021 0.0021
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.0453 0.0457
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0064 0.0065
Schistosoma mansoni hypothetical protein 0.073 0.2317 0.2338
Loa Loa (eye worm) hypothetical protein 0.0044 0.0101 0.0102
Echinococcus multilocularis 6 phosphogluconolactonase 0.0028 0.0048 0.0048
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0028 0.0048 0.0041
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0134 0.0135
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.009 0.0084
Echinococcus granulosus zinc finger protein 0.0048 0.0113 0.0114
Leishmania major mitochondrial DNA polymerase beta 0.029 0.0897 0.0898
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0064 0.0065
Schistosoma mansoni zinc finger protein 0.0034 0.0067 0.0067
Brugia malayi hypothetical protein 0.011 0.0313 0.0316
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0007 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0064 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0453 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0293 0.0904 0.0912
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0083 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Plasmodium vivax ataxin-2 like protein, putative 0.011 0.0313 0.0313
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0007 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0064 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0112 0.0112
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0019 0.0019
Trypanosoma brucei protein kinase, putative 0.0054 0.0134 0.0128
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.3108 1 1
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0044 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0077 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0134 0.0369
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0037
Trypanosoma brucei 6-phosphogluconolactonase 0.0028 0.0048 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0172 0.0515 0.052
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Brugia malayi nuclear receptor NHR-88 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Schistosoma mansoni Smad4 0.002 0.0021 0.0022
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0134 0.0128
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0079 0.008
Entamoeba histolytica hypothetical protein 0.0324 0.1004 0.2763
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0126 0.0119
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.3108 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.029 0.0897 0.0898
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0126 0.0367
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.308 0.9911 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0057 0.0057
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.308 0.9911 1
Onchocerca volvulus 0.0255 0.0781 0.7955
Echinococcus granulosus protein kinase shaggy 0.0054 0.0134 0.0135
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0028 0.0048 0.0017
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0044 0.0013
Onchocerca volvulus 0.0056 0.0139 0.1402
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.1069 0.3411 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0007 0.0007
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0134 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0059 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis GPCR, family 2 0.0172 0.0515 0.052
Onchocerca volvulus Glucosylceramidase homolog 0.0192 0.0579 0.5889
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0082 0.0082
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0064 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.0153 0.0453 0.1325
Echinococcus multilocularis zinc finger protein 0.0048 0.0113 0.0114
Schistosoma mansoni bromodomain containing protein 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0155 0.0459 0.0463
Echinococcus multilocularis sodium channel protein 0.005 0.012 0.0121
Brugia malayi nuclear receptor RXR 0.0015 0.0008 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0137 0.0402 0.0399
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0134 0.0104
Brugia malayi hypothetical protein 0.0317 0.0981 0.099
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0064 0.0065
Mycobacterium leprae Probable lipase LipE 0.0037 0.0077 0.5915
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0612 0.0612
Trypanosoma brucei PAB1-binding protein , putative 0.011 0.0313 0.0308
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0031 0.0031
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.308 0.9911 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0019 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0064 0.0065
Onchocerca volvulus 0.0033 0.0064 0.0637
Echinococcus multilocularis cpg binding protein 0.0035 0.0072 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0014 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0126 0.0119
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0082 0.0051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0064 0.0065
Brugia malayi nuclear receptor NHR-67 0.0015 0.0008 0.0008
Schistosoma mansoni importin beta-1 0.003 0.0057 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0126 1
Brugia malayi nuclear hormone receptor 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0077 0.0225
Onchocerca volvulus 0.0015 0.0008 0.0064
Brugia malayi SET domain containing protein 0.0014 0.0002 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0064 0.0065
Echinococcus multilocularis mothers against decapentaplegic 6 0.002 0.0021 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.011 0.011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0064 0.0065
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Brugia malayi ecdysteroid receptor 0.0033 0.0064 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0073 0.0073
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0019 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0077 0.5915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0064 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.029 0.0897 0.0898
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0126 0.0127
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0403 0.0407
Giardia lamblia DNA repair protein RAD52 0.1137 0.3633 0.3613
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0172 0.0515 0.052
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.3108 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0064 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0008 0.0064
Echinococcus granulosus mothers against decapentaplegic 2 0.002 0.0021 0.0022
Onchocerca volvulus Mothers against decapentaplegic homolog 0.002 0.0021 0.0197
Echinococcus multilocularis importin subunit beta 1 0.003 0.0057 0.0057
Schistosoma mansoni cpg binding protein 0.0035 0.0072 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0612 0.0612
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0007 0.002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0073 0.0067
Echinococcus granulosus cpg binding protein 0.0035 0.0072 0.0073
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.308 0.9911 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0007 0.002
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0007 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0064 0.0065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.101 0.1019
Onchocerca volvulus 0.0015 0.0007 0.0055
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0044 0.0044
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0028 0.0048 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0077 0.0077
Brugia malayi intracellular kinase 0.0054 0.0134 0.0135
Loa Loa (eye worm) hypothetical protein 0.0545 0.1719 0.1735
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0008 0.0008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.011 0.0111
Loa Loa (eye worm) hypothetical protein 0.06 0.1897 0.1914
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0073 0.0067
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0073 0.0067
Plasmodium falciparum flap endonuclease 1 0.0027 0.0044 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0076 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0064 0.0065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0077 0.0225
Loa Loa (eye worm) acetyltransferase 0.0147 0.0432 0.0436
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0028 0.0048 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0073 0.0074
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0077 0.0078
Schistosoma mansoni flap endonuclease-1 0.0024 0.0036 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0172 0.0515 0.052
Schistosoma mansoni ran 0.0022 0.0031 0.0031
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.029 0.0897 0.0898
Loa Loa (eye worm) beta-lactamase 0.0037 0.0077 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Echinococcus granulosus muscleblind protein 0.0296 0.0915 0.0924
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0123 0.0124
Brugia malayi ecdysone receptor 0.0015 0.0008 0.0008
Brugia malayi CXXC zinc finger family protein 0.0029 0.0053 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0064 0.0637
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0099 0.01
Schistosoma mansoni chromobox protein 0.0079 0.0213 0.0215
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0432 0.0436
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0126 0.0346
Trichomonas vaginalis ran, putative 0.0022 0.0031 0.0031
Brugia malayi Heterochromatin protein 1 0.0079 0.0213 0.0215
Loa Loa (eye worm) DR-78 0.0015 0.0008 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0064 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0064 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0073 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0126 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.308 0.9911 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2527 0.8122 0.8196
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) Smad1 0.0044 0.0099 0.01
Brugia malayi PHD-finger family protein 0.006 0.0151 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Onchocerca volvulus 0.0015 0.0007 0.0055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.0453 0.0457
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0025 0.0038 0.0105
Entamoeba histolytica protein kinase, putative 0.0054 0.0134 0.0369
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.308 0.9911 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0545 0.1719 0.1735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0064 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0012 0.0012
Brugia malayi tailless protein 0.0015 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0064 0.0065
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0099 0.01
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0077 0.0225
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0073 0.0074
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Schistosoma mansoni smad1 5 8 and 0.0044 0.0099 0.01
Echinococcus multilocularis mothers against decapentaplegic 2 0.002 0.0021 0.0022
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0073 0.0074
Brugia malayi hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0014 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.009 0.0084
Brugia malayi MH1 domain containing protein 0.0044 0.0099 0.01
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0134 0.0135
Plasmodium vivax importin-beta 2, putative 0.003 0.0057 0.0057
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0048
Echinococcus granulosus smad 0.0044 0.0099 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0008 0.0008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0064 0.0637
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Brugia malayi 6-phosphogluconolactonase family protein 0.0028 0.0048 0.0048
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0134 0.0135
Leishmania major importin beta-1 subunit, putative 0.0025 0.0038 0.0031
Schistosoma mansoni zinc finger protein 0.0015 0.0008 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0213 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0134 0.0134
Echinococcus granulosus flap endonuclease 1 0.0027 0.0044 0.0045
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0099 0.01
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0064 0.0065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0038 0.0038
Brugia malayi Bromodomain containing protein 0.0169 0.0506 0.051
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0077 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0064 0.0065
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0603 0.1907 0.1924
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0067
Echinococcus multilocularis Smad4 0.0044 0.0099 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0545 0.1719 0.1735
Schistosoma mansoni chromobox protein 0.0079 0.0213 0.0215
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0064 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0021 0.0022
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.3108 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0007 0.002
Entamoeba histolytica Ran family GTPase 0.0022 0.0031 0.0085
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0326 0.101 0.1019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0081 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0642 0.2031 0.2049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0064 0.0065
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0073 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0073 0.0074
Schistosoma mansoni nuclear receptor 0.0015 0.0008 0.0008
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0324 0.1004 0.2763
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0073 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0084
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0134 0.0135
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0031
Leishmania major GTP-binding protein, putative 0.0022 0.0031 0.0024
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.308 0.9911 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0064 0.0065
Brugia malayi Muscleblind-like protein 0.0296 0.0915 0.0924
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Brugia malayi MH2 domain containing protein 0.0044 0.0099 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0077 0.0225
Brugia malayi nuclear hormone receptor 0.0033 0.0064 0.0065
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0021 0.0022
Leishmania major 6-phosphogluconolactonase 0.0028 0.0048 0.0041
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1137 0.3633 1
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0037
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0131
Onchocerca volvulus 0.0317 0.0981 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0134 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0064 0.0065
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0008 0.0008
Brugia malayi hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0134 0.0135
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.002
Trypanosoma cruzi ISWI complex protein 0.0034 0.0067 0.006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0099 0.01
Echinococcus granulosus chromobox protein 1 0.0079 0.0213 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0081 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0119 0.0113
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.2012 0.6458 0.6514
Loa Loa (eye worm) hypothetical protein 0.0052 0.0126 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0064 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0059 0.0059
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0007 0.0007
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0064 0.0065
Brugia malayi hypothetical protein 0.0017 0.0014 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0313 0.0308
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0044 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.2012 0.6458 0.6458
Leishmania major hypothetical protein, conserved 0.0034 0.0067 0.006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0044 0.0099 0.01
Brugia malayi Importin beta-1 subunit 0.003 0.0057 0.0057
Brugia malayi Flap endonuclease-1 0.0027 0.0044 0.0045
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0057 0.005
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0313 0.0308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0453 0.0457
Onchocerca volvulus 0.0052 0.0126 0.1263
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0076 0.0223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0038 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0077 0.0071
Schistosoma mansoni Smad4 0.002 0.0021 0.0022
Loa Loa (eye worm) nuclear factor I 0.0024 0.0036 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0077 0.0077
Schistosoma mansoni ran 0.0022 0.0031 0.0031
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0134 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0064 0.0065
Schistosoma mansoni Smad4 0.0044 0.0099 0.01
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0064 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.0402 0.0399
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.011 0.0313 0.0308
Echinococcus granulosus geminin 0.073 0.2317 0.2338
Mycobacterium ulcerans hypothetical protein 0.0037 0.0077 0.0071
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0073 0.0074
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0082 0.0224
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0073 0.0067
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0077 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.0579 0.0579
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0099 0.01
Mycobacterium ulcerans hypothetical protein 0.0153 0.0453 0.045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0136 0.0397 0.0401
Echinococcus multilocularis transcription factor eb 0.0603 0.1907 0.1924
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.06 0.1897 0.1914
Loa Loa (eye worm) hypothetical protein 0.011 0.0313 0.0316
Trypanosoma brucei ISWI complex protein 0.0034 0.0067 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.0904 0.0904
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0134 0.0134
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0064 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0057 0.005
Onchocerca volvulus 0.0054 0.0134 0.1349
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0134 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0126 0.0119
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0126 0.0346
Loa Loa (eye worm) hypothetical protein 0.0084 0.023 0.0232
Schistosoma mansoni zinc finger protein 0.0048 0.0113 0.0114
Trichomonas vaginalis esterase, putative 0.0037 0.0077 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0064 0.0065
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0008 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0008 0.0064
Echinococcus multilocularis geminin 0.073 0.2317 0.2338
Mycobacterium ulcerans hypothetical protein 0.0052 0.0126 0.0119
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0064 0.0065
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0064 0.0065
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.011 0.011
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0094 0.0095
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0213 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0064 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.0071
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.002
Echinococcus granulosus importin subunit beta 1 0.003 0.0057 0.0057
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0077 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0453 0.0457
Schistosoma mansoni hypothetical protein 0.0172 0.0515 0.052
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0073 0.0074
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0007 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0064 0.0065
Echinococcus granulosus Smad4 0.0044 0.0099 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0172 0.0515 0.052
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi Bromodomain containing protein 0.0087 0.0241 0.0243
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0296 0.0915 0.0924
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0031
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0028 0.0048 0.0041
Echinococcus granulosus mothers against decapentaplegic 6 0.002 0.0021 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0373 0.1162 0.1172
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0007 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0083 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0083 0.0083
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.011 0.011
Echinococcus multilocularis smad 0.0044 0.0099 0.01
Onchocerca volvulus 0.0035 0.007 0.0697
Schistosoma mansoni hypothetical protein 0.0373 0.1162 0.1172
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.011 0.011
Loa Loa (eye worm) pax transcription factor protein 2 0.0255 0.0781 0.0788
Loa Loa (eye worm) latrophilin receptor protein 2 0.0172 0.0515 0.052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0213 0.0214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0064 0.0065
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0126 0.0119
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0225
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0028 0.0048 0.0048
Onchocerca volvulus 0.0037 0.0077 0.0769
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0166 0.0166
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0213 0.0213
Brugia malayi glucose-6-phosphate dehydrogenase 0.308 0.9911 1
Brugia malayi mothers against decapentaplegic homolog 3 0.002 0.0021 0.0022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0073 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0172 0.0515 0.052
Leishmania major calcium channel protein, putative,ion transporter, putative 0.005 0.012 0.0113
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0225
Schistosoma mansoni smad1 5 8 and 0.0044 0.0099 0.01
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0083 0.0036
Brugia malayi hypothetical protein 0.0071 0.0187 0.0189
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0038 0.0031
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.1021 0.3256 0.328
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0104 0.0105
Brugia malayi nuclear receptor NHR-88 0.0033 0.0064 0.0065
Toxoplasma gondii ABC1 family protein 0.0037 0.0077 0.0077
Leishmania major hypothetical protein, conserved 0.0037 0.0077 0.0071
Brugia malayi conserved hypotetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus 6 phosphogluconolactonase 0.0028 0.0048 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0545 0.1719 0.1735
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0008 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0313 0.0313
Schistosoma mansoni coup transcription factor 0.0033 0.0064 0.0065
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.308 0.9911 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0453 0.0457
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.001 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0008 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0077 0.0078
Plasmodium falciparum importin beta, putative 0.003 0.0057 0.0057
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0028 0.0048 0.0041
Schistosoma mansoni nuclear receptor 0.0015 0.0008 0.0008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0112 0.1124
Echinococcus multilocularis muscleblind protein 0.0296 0.0915 0.0924
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0071
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0028 0.0048 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0076 0.0223
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0099 0.01
Echinococcus multilocularis chromobox protein 1 0.0079 0.0213 0.0215
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0126 0.0127
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0007 0.002
Onchocerca volvulus 0.0015 0.0007 0.0055
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0139 0.0141
Onchocerca volvulus 0.0037 0.0077 0.0769
Toxoplasma gondii hypothetical protein 0.0047 0.011 0.011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0137 0.0402 0.0399
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0453 0.0457
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0064 0.0065
Loa Loa (eye worm) oxidoreductase 0.0015 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.011 0.011
Echinococcus granulosus snurportin 1 0.0326 0.101 0.1019
Brugia malayi beta-lactamase 0.0037 0.0077 0.0078
Brugia malayi hypothetical protein 0.0015 0.0008 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0077 0.0071
Brugia malayi Smad1 0.0044 0.0099 0.01
Schistosoma mansoni hypothetical protein 0.0172 0.0515 0.052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0076 0.0223
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0064 0.0065
Toxoplasma gondii LsmAD domain-containing protein 0.011 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0099 0.0277 0.0279
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0045 0.0104 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0064 0.0065
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0073 0.0074
Onchocerca volvulus 0.0015 0.0008 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0077 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0313 0.0313
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0044 0.0122
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0007 0.002
Echinococcus multilocularis muscleblind protein 1 0.0296 0.0915 0.0924
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.009 0.0084
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0117 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0064 0.0065
Brugia malayi nuclear receptor RXR 0.0017 0.0014 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0037
Echinococcus granulosus tumor protein p63 0.0383 0.1195 0.1206
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0007 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0126 0.0346
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0139 0.0141
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.3108 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0037 0.0077 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0073 0.0074
Loa Loa (eye worm) hypothetical protein 0.0296 0.0915 0.0924
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0008 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0081 0.0082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Brugia malayi MH2 domain containing protein 0.002 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0081 0.0082
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0317 0.0981 0.099
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0117 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0021 0.0021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0073 0.0073
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0007 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0213 0.0214
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0019 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0073 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0453 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0064 0.0065
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0991 0.316 0.3184
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0126 0.0127
Brugia malayi MH2 domain containing protein 0.0642 0.2031 0.2049
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0007 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0126 0.0119
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0126 0.0119
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0084
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0134 0.0134
Schistosoma mansoni 6-phosphogluconolactonase 0.0028 0.0048 0.0048
Brugia malayi isocitrate dehydrogenase 0.0036 0.0073 0.0074

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 100 uM Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay ChEMBL. 22863526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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