Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intracellular kinase | 0.0058 | 0.083 | 0.1198 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.001 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0036 | 0.0245 | 0.0358 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0053 | 0.0688 | 0.0729 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.083 | 0.121 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0697 | 0.082 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0874 | 0.0928 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.083 | 0.0977 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.083 | 0.088 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.083 | 0.0999 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0073 | 0.1219 | 0.121 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0073 | 0.1219 | 0.121 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0289 | 0.6855 | 0.6852 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.004 | 0.0353 | 0.0343 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.014 | 0.2962 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5344 | 0.6357 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0161 | 0.0151 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.006 | 0.0872 | 0.1062 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1219 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0353 | 0.0409 |
Echinococcus multilocularis | tumor protein p63 | 0.041 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0318 | 0.0451 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.083 | 0.121 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0273 | 0.6418 | 0.7637 |
Trypanosoma cruzi | ISWI complex protein | 0.0036 | 0.0245 | 0.0358 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0697 | 0.0738 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0058 | 0.083 | 0.082 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.014 | 0.2962 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1918 | 0.2275 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0245 | 0.0253 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.006 | 0.0872 | 0.1272 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.083 | 0.0999 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0231 | 0.5344 | 0.7793 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.001 | 0.0014 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0096 | 0.181 | 0.264 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0041 | 0.039 | 0.0453 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0697 | 0.0738 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.8401 | 0.9014 |
Brugia malayi | Pax transcription factor protein 2 | 0.0273 | 0.6418 | 0.9361 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0245 | 0.0358 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0231 | 0.5344 | 0.6357 |
Schistosoma mansoni | zinc finger protein | 0.0036 | 0.0245 | 0.0253 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0131 | 0.2724 | 0.3966 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0161 | 0.0162 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0046 | 0.0507 | 0.0497 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0697 | 0.0688 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.083 | 0.128 | |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0093 | 0.1737 | 0.2534 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0231 | 0.5344 | 0.7793 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.013 | 0.2708 | 0.3215 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.001 | 0.0014 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.004 | 0.0353 | 0.0368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0697 | 0.0738 |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.0872 | 0.1272 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.004 | 0.0353 | 0.0343 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.004 | 0.0353 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1657 | 0.1963 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0289 | 0.6855 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1219 | 0.1298 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.004 | 0.0353 | 0.0343 |
Onchocerca volvulus | 0.006 | 0.0874 | 0.1349 | |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3435 | 0.4082 |
Brugia malayi | PHD-finger family protein | 0.0058 | 0.0833 | 0.1203 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.3435 | 0.3679 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.083 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.083 | 1 |
Brugia malayi | hypothetical protein | 0.006 | 0.0872 | 0.1259 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0073 | 0.1219 | 0.121 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0058 | 0.083 | 0.082 |
Echinococcus multilocularis | geminin | 0.0384 | 0.9319 | 0.9318 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0084 | 0.1508 | 0.1499 |
Schistosoma mansoni | bromodomain containing protein | 0.0148 | 0.3181 | 0.3406 |
Echinococcus granulosus | zinc finger protein | 0.0046 | 0.0507 | 0.0497 |
Echinococcus granulosus | protein kinase shaggy | 0.0058 | 0.083 | 0.082 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0274 | 0.6458 | 0.7685 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.004 | 0.0353 | 0.0368 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0289 | 0.6855 | 0.8158 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0073 | 0.1219 | 0.1441 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.083 | 0.0999 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.001 | 0.0116 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.006 | 0.0872 | 0.1062 |
Trypanosoma brucei | ISWI complex protein | 0.0036 | 0.0245 | 0.0126 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.001 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0073 | 0.1219 | 0.1766 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0697 | 0.0688 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0289 | 0.6855 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0053 | 0.0688 | 0.0679 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0189 | 0.4237 | 0.609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0697 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0872 | 0.1027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.083 | 0.121 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0289 | 0.6855 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0084 | 0.1508 | 0.1499 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0161 | 0.0221 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.083 | 0.0999 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.006 | 0.0872 | 0.1062 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0073 | 0.1219 | 0.1766 |
Schistosoma mansoni | zinc finger protein | 0.0046 | 0.0507 | 0.0534 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.004 | 0.0353 | 0.0368 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0289 | 0.6855 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.083 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.083 | 0.0977 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.083 | 0.121 |
Echinococcus multilocularis | GPCR, family 2 | 0.0073 | 0.1219 | 0.121 |
Schistosoma mansoni | hypothetical protein | 0.0384 | 0.9319 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0349 | 0.8401 | 0.8399 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0349 | 0.8401 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0349 | 0.8401 | 0.8399 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.001 | 0.0014 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1219 | 0.1298 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.004 | 0.0353 | 0.0343 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0161 | 0.0151 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0158 | 0.3435 | 0.5003 |
Echinococcus multilocularis | protein kinase shaggy | 0.0058 | 0.083 | 0.082 |
Echinococcus granulosus | transcription factor eb | 0.0131 | 0.2724 | 0.2717 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1219 | 0.1441 |
Echinococcus multilocularis | transcription factor eb | 0.0131 | 0.2724 | 0.2717 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.006 | 0.0872 | 0.1272 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1219 | 0.1298 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0274 | 0.6458 | 0.7685 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.006 | 0.0872 | 0.1062 |
Brugia malayi | RNA, U transporter 1 | 0.0093 | 0.1731 | 0.2515 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0289 | 0.6855 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0697 | 0.1005 |
Brugia malayi | Bromodomain containing protein | 0.0176 | 0.3897 | 0.5679 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0289 | 0.6855 | 0.6852 |
Echinococcus granulosus | GPCR family 2 | 0.0073 | 0.1219 | 0.121 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.001 | 0.0116 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0289 | 0.6855 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0289 | 0.6855 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0697 | 0.0688 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0048 | 0.0572 | 0.067 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0073 | 0.1219 | 0.121 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0572 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0161 | 0.018 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0289 | 0.6855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0874 | 0.103 |
Onchocerca volvulus | 0.0273 | 0.6418 | 1 | |
Brugia malayi | Bromodomain containing protein | 0.009 | 0.1652 | 0.24 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0289 | 0.6855 | 0.7353 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.001 | 0.0116 |
Schistosoma mansoni | hypothetical protein | 0.0384 | 0.9319 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.006 | 0.0872 | 0.1062 |
Brugia malayi | MH2 domain containing protein | 0.0274 | 0.6458 | 0.942 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0053 | 0.0688 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2708 | 0.3215 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.3636 | 0.4321 |
Echinococcus granulosus | geminin | 0.0384 | 0.9319 | 0.9318 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.01 | 0.1927 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0189 | 0.4237 | 0.6176 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1801 | 0.2135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 31.3 % | Antagonist activity at human P2Y1R expressed in human 1321N1 cells assessed as inhibition of 2-MeSADP-induced increase in intracellular calcium mobilization at 10 uM | ChEMBL. | 22831801 |
Ki (binding) | = 42 uM | Displacement of [125I]MRS2500 from human P2Y1R expressed in Sf9 cell membrane | ChEMBL. | 22831801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.