Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.032 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.032 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.032 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.032 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0133 | 0.2766 | 0.2766 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0194 | 0.5141 | 0.5141 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0129 | 0.2597 | 0.2597 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0104 | 0.1657 | 0.1657 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0133 | 0.2766 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0194 | 0.5141 | 0.5141 |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.5141 | 0.5141 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0121 | 0.0121 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0129 | 0.2597 | 0.2597 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0194 | 0.5141 | 0.5082 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0129 | 0.2597 | 0.2597 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0104 | 0.1657 | 0.1657 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0065 | 0.0121 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0194 | 0.5141 | 0.5141 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0133 | 0.2766 | 0.2766 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0194 | 0.5141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2766 | 0.2766 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0194 | 0.5141 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0194 | 0.5141 | 0.5141 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0104 | 0.1657 | 0.1657 |
Echinococcus multilocularis | cysteine protease | 0.0194 | 0.5141 | 0.5082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Echinococcus granulosus | cathepsin b | 0.032 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0129 | 0.2597 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.032 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.032 | 1 | 1 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0065 | 0.0121 | 0.0121 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0194 | 0.5141 | 0.5082 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0194 | 0.5141 | 0.5141 |
Giardia lamblia | Cathepsin B precursor | 0.0129 | 0.2597 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0065 | 0.0121 | 0.0121 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0133 | 0.2766 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0129 | 0.2597 | 0.2697 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0194 | 0.5141 | 0.5082 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0194 | 0.5141 | 0.5082 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0133 | 0.2766 | 0.2766 |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0194 | 0.5141 | 0.5141 |
Onchocerca volvulus | Cathepsin F homolog | 0.0194 | 0.5141 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0194 | 0.5141 | 0.5082 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0194 | 0.5141 | 0.5141 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0104 | 0.1657 | 0.306 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0121 | 0.0121 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Plasmodium vivax | vivapain-1 | 0.0104 | 0.1657 | 0.3224 |
Brugia malayi | cathepsin L-like precursor | 0.0133 | 0.2766 | 0.2766 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.032 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0194 | 0.5141 | 0.5082 |
Plasmodium vivax | vivapain-2 | 0.0194 | 0.5141 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0104 | 0.1657 | 0.1657 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0104 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2766 | 0.2766 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0104 | 0.1657 | 0.1657 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0133 | 0.2766 | 0.2766 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0194 | 0.5141 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0104 | 0.1657 | 0.1555 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0194 | 0.5141 | 0.5141 |
Echinococcus multilocularis | cathepsin b | 0.032 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0104 | 0.1657 | 0.3224 |
Onchocerca volvulus | Cathepsin L homolog | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Plasmodium vivax | metal transporter, putative | 0.0065 | 0.0121 | 0.0236 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Onchocerca volvulus | 0.0133 | 0.2766 | 0.5268 | |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0133 | 0.2766 | 0.2766 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2766 | 0.2766 |
Echinococcus granulosus | cysteine protease | 0.0104 | 0.1657 | 0.1555 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0194 | 0.5141 | 0.5141 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0194 | 0.5141 | 0.5141 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0133 | 0.2766 | 0.3182 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0104 | 0.1657 | 0.1657 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Leishmania major | cathepsin L-like protease | 0.0194 | 0.5141 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0133 | 0.2766 | 0.2677 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0194 | 0.5141 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0194 | 0.5141 | 1 |
Onchocerca volvulus | 0.0194 | 0.5141 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0194 | 0.5141 | 0.5141 |
Echinococcus granulosus | cathepsin L | 0.0104 | 0.1657 | 0.1555 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Plasmodium vivax | vivapain-3 | 0.0104 | 0.1657 | 0.3224 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0129 | 0.2597 | 0.2697 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0194 | 0.5141 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0104 | 0.1657 | 0.1657 |
Trypanosoma cruzi | cysteine protease, putative | 0.0104 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0194 | 0.5141 | 0.5141 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0194 | 0.5141 | 0.5141 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Toxoplasma gondii | cathepsin B | 0.0129 | 0.2597 | 0.4932 |
Echinococcus granulosus | cathepsin l1 | 0.0194 | 0.5141 | 0.5082 |
Plasmodium vivax | vivapain-2 | 0.0194 | 0.5141 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0129 | 0.2597 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0065 | 0.0121 | 0.0121 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0194 | 0.5141 | 0.5141 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0194 | 0.5141 | 0.5082 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0194 | 0.5141 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0104 | 0.1657 | 0.1555 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0194 | 0.5141 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0104 | 0.1657 | 0.1657 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.