Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fk506 binding protein | 0.0065 | 0.5731 | 0.5731 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0065 | 0.5731 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0065 | 0.5731 | 0.5731 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.5731 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.5731 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.5731 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.4622 | 0.4622 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.5731 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0065 | 0.5731 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0065 | 0.5731 | 0.5731 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0035 | 0.1973 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0065 | 0.5731 | 0.714 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.5731 | 0.2062 |
Echinococcus granulosus | phospholipase D1 | 0.01 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0065 | 0.5731 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.5731 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0065 | 0.5731 | 0.714 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.5731 | 0.5731 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.5731 | 0.5731 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.5702 | 0.7103 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.5702 | 0.7103 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.5731 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0065 | 0.5731 | 0.5731 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.4622 | 0.5759 |
Onchocerca volvulus | Putative phospholipase D | 0.0019 | 0 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.5731 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.4622 | 0.4622 |
Entamoeba histolytica | phospholipase D, putative | 0.01 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.5731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.8027 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0065 | 0.5731 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0065 | 0.5731 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.5731 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.5731 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.5731 | 0.5 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0035 | 0.1973 | 0.1973 |
Schistosoma mansoni | phospholipase D | 0.01 | 1 | 1 |
Entamoeba histolytica | phospholipase D active site domain-containing protein | 0.0084 | 0.8027 | 0.5378 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.5731 | 0.2062 |
Echinococcus multilocularis | phospholipase D1 | 0.01 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0088 | 0.8562 | 0.8562 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.8027 | 1 |
Echinococcus granulosus | phospholipase D | 0.0088 | 0.8562 | 0.8562 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0065 | 0.5731 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0065 | 0.5731 | 0.2062 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.5731 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.01 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | Binding affinity to FKBP12 by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
IC50 (binding) | > 100 uM | Binding affinity to FKBP51 FK1 domain by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
IC50 (binding) | > 100 uM | Binding affinity to FKBP52 FK1 domain by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.