TDR Targets

Basic information

Technical information

TDR Targets ID: 1664612
Name: [2-(1,3-benzothiazol-2-yl)piperidin-1-yl]-[3- (tetrazol-1-yl)phenyl]methanone
MW: 390.462 | Formula: C20H18N6OS
H donors: 0 H acceptors: 5 LogP: 3.55 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCCCC1c1nc2c(s1)cccc2)c1cccc(c1)n1cnnn1
InChi: 1S/C20H18N6OS/c27-20(14-6-5-7-15(12-14)26-13-21-23-24-26)25-11-4-3-9-17(25)19-22-16-8-1-2-10-18(16)28-19/h1-2,5-8,10,12-13,17H,3-4,9,11H2
InChiKey: VWJQPKQTWAPVTK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-(1,3-benzothiazol-2-yl)-1-piperidyl]-[3-(tetrazol-1-yl)phenyl]methanone
[2-(1,3-benzothiazol-2-yl)-1-piperidinyl]-[3-(1-tetrazolyl)phenyl]methanone
[2-(1,3-benzothiazol-2-yl)piperidin-1-yl]-[3-(1,2,3,4-tetrazol-1-yl)phenyl]methanone
T5548280

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0023
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0217	0.0545
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0376	0.1011
Echinococcus multilocularis	GPCR, family 2	0.0054	0.0963	0.0954
Echinococcus granulosus	GPCR family 2	0.0054	0.0963	0.0954
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0122	0.0123
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0094	0.2071	0.584
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0207	0.0203
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0596	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0285	0.0304
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.0144	0.3446	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0217	0.2525
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.094	0.093
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0376	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0217	0.0229
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0217	0.2525
Schistosoma mansoni	zinc finger protein	0.0022	0.0089	0.0078
Schistosoma mansoni	ran	0.0024	0.014	0.013
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0217	0.0229
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0596	0.0587
Echinococcus multilocularis	zinc finger protein	0.0022	0.0089	0.0078
Loa Loa (eye worm)	MH2 domain-containing protein	0.0273	0.6994	0.7738
Leishmania major	hypothetical protein, conserved	0.0029	0.0285	0.0439
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0144	0.3446	1
Entamoeba histolytica	hypothetical protein	0.0026	0.0207	0.8684
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0963	0.1056
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.1334	0.1325
Echinococcus granulosus	snurportin 1	0.0347	0.9035	0.9034
Brugia malayi	MH2 domain containing protein	0.0273	0.6994	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0285	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0672	0.0733
Plasmodium falciparum	importin beta, putative	0.0033	0.0376	0.1011
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0285	0.0744
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.094	0.093
Schistosoma mansoni	bromodomain containing protein	0.0071	0.1445	0.1436
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0285	0.0439
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.094	0.093
Loa Loa (eye worm)	hypothetical protein	0.008	0.1676	0.1846
Schistosoma mansoni	hypothetical protein	0.0054	0.0963	0.0954
Brugia malayi	latrophilin 2 splice variant baaae	0.0116	0.2683	0.3837
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.005	0.0856	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0273	0.6994	0.7738
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0746	0.0815
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0376	0.0715
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0217	1
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0144	0.3446	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0217	0.0545
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.014	0.0319
Brugia malayi	Pax transcription factor protein 2	0.0271	0.6951	0.9939
Schistosoma mansoni	hypothetical protein	0.0054	0.0963	0.0954
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0217	0.031
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.1334	0.1325
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	1
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0144	0.3446	0.4927
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.017	0.4165	0.4604
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0285	0.0744
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0376	0.0715
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.094	0.093
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0031	0.0351
Schistosoma mansoni	hypothetical protein	0.0054	0.0963	0.0954
Schistosoma mansoni	hypothetical protein	0.0023	0.0122	0.0111
Brugia malayi	PHD-finger family protein	0.0028	0.0254	0.0364
Loa Loa (eye worm)	hypothetical protein	0.017	0.4165	0.4604
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.014	0.0319
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0054	0.0963	0.0954
Echinococcus multilocularis	geminin	0.0382	1	1
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0029	0.0021
Schistosoma mansoni	hypothetical protein	0.0054	0.0963	0.0954
Brugia malayi	hypothetical protein	0.0029	0.0285	0.0407
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0054	0.0963	0.1377
Echinococcus multilocularis	snurportin 1	0.0347	0.9035	0.9034
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	0.5
Schistosoma mansoni	hypothetical protein	0.0382	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0217	0.031
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0217	0.0545
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	1
Schistosoma mansoni	hypothetical protein	0.0116	0.2683	0.2676
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0217	0.0545
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0054	0.0963	0.0954
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0181	0.0171
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0217	0.031
Schistosoma mansoni	ran	0.0024	0.014	0.013
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0217	0.0545
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0217	0.0233
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0217	1
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0094	0.2071	0.5973
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0181	0.0171
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.014	0.02
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.014	0.013
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.014	0.0143
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.094	0.1344
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0048	0.0795	0.1981
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.094	0.103
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0217	0.0545
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0023
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0217	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0217	0.5
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.0144	0.3446	1
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0376	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0805	0.088
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0217	0.0229
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0144	0.3446	1
Brugia malayi	Latrophilin receptor protein 2	0.0054	0.0963	0.1377
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0285	0.0744
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0217	0.0233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.094	0.093
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0181	0.0171
Schistosoma mansoni	hypothetical protein	0.0382	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.094	0.093
Brugia malayi	RNA, U transporter 1	0.0092	0.2026	0.2897
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.017	0.4165	0.5956
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0207	0.0203
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0054	0.0963	0.1056
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0376	0.0366
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.094	0.093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0376	0.0405
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	0.3439
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0207	0.0203
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0217	1
Echinococcus granulosus	zinc finger protein	0.0022	0.0089	0.0078
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0207	0.0203
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0144	0.3446	0.3439
Brugia malayi	Bromodomain containing protein	0.0085	0.1809	0.2587
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0207	0.0203
Onchocerca volvulus		0.0271	0.6951	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0347	0.9035	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2683	0.2962
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0144	0.3446	0.3807
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0217	0.0545
Schistosoma mansoni	importin beta-1	0.0033	0.0376	0.0366
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0023
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.0144	0.3446	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0217	0.0545
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0285	0.0439
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0285	0.0439
Loa Loa (eye worm)	hypothetical protein	0.002	0.0031	0.0023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.017	0.4165	0.5956
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.014	0.013
Brugia malayi	Importin beta-1 subunit	0.0033	0.0376	0.0538
Schistosoma mansoni	hypothetical protein	0.0347	0.9035	0.9034
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0046	0.0757	0.1866
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0054	0.0963	0.0954
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0054	0.0963	0.0954
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0144	0.3446	0.3439
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0144	0.3446	1
Brugia malayi	Bromodomain containing protein	0.0043	0.067	0.0958
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0217	0.0233
Loa Loa (eye worm)	pax transcription factor protein 2	0.0271	0.6951	0.7691
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0144	0.3446	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2098296

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1664612