Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0375 | 0.7529 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.7529 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0063 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.7529 | 1 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0375 | 0.7529 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0884 | 0.0884 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0375 | 0.7529 | 0.7529 |
Loa Loa (eye worm) | carboxylesterase | 0.0375 | 0.7529 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0375 | 0.7529 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0375 | 0.7529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.7529 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0375 | 0.7529 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0884 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.7529 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0375 | 0.7529 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0063 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0375 | 0.7529 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0063 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 1.506 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 1.506 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.