Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0149 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0517 | 0.5703 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0149 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0517 | 0.5703 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0149 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.3399 | 0.5961 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0149 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0517 | 0.5703 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0517 | 0.5703 | 0.9453 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0149 | 0 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0769 | 0.9598 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0149 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0517 | 0.5703 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0149 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0517 | 0.5703 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0149 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0149 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0517 | 0.5703 | 0.9453 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0517 | 0.5703 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0517 | 0.5703 | 1 |
Brugia malayi | Serotonin receptor | 0.0539 | 0.6033 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0149 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0149 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0517 | 0.5703 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0149 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0149 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 25 nM | Displacement of [3H]-Nalpha-methylhistamine from human histamine H3 receptor expressed in CHO cells after 4 hrs by scintillation proximity assay | ChEMBL. | 22578490 |
Ki (binding) | = 34 nM | Displacement of [3H]-Nalpha-methylhistamine from rat histamine H3 receptor expressed in CHO-A3 cells after 4 hrs by scintillation proximity assay | ChEMBL. | 22578490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.