Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0053 | 0.055 | 0.055 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0096 | 0.1324 | 0.1324 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0053 | 0.055 | 0.0702 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0138 | 0.2665 |
Brugia malayi | mbt repeat family protein | 0.0096 | 0.1324 | 0.3438 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0138 | 0.0266 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0156 | 0.3021 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0149 | 0.2266 | 0.2266 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0256 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.2015 | 0.3884 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.3383 | 0.6521 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0379 | 0.6347 | 0.8103 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.011 | 0.156 | 0.1992 |
Onchocerca volvulus | 0.0242 | 0.3904 | 1 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0149 | 0.2266 | 0.5884 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0136 | 0.0174 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0053 | 0.055 | 0.0702 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0256 | 0.5645 |
Trypanosoma cruzi | ISWI complex protein | 0.0047 | 0.0454 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0096 | 0.1324 | 0.3116 |
Brugia malayi | PHD-finger family protein | 0.008 | 0.1044 | 0.2712 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 0.7834 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0138 | 0.3039 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0083 | 0.109 | 0.1391 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0111 | 0.1583 | 0.2021 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.3488 | 0.6724 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0239 | 0.3851 | 0.7422 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0096 | 0.1324 | 0.169 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0096 | 0.1324 | 0.1324 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0379 | 0.6347 | 0.8103 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0517 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0064 | 0.0752 | 0.0752 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.2369 | 0.2369 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.2369 | 0.6153 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0149 | 0.2266 | 0.2266 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.3904 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0256 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0064 | 0.0752 | 0.096 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0149 | 0.2266 | 0.2266 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0323 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.0454 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0256 | 0.0256 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0149 | 0.2266 | 0.2892 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0138 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1717 | 0.3309 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0156 | 0.0199 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0256 | 0.7923 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0188 | 0.2949 | 0.3765 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0138 | 0.2665 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 0.7834 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1911 | 0.3683 |
Schistosoma mansoni | bromodomain containing protein | 0.0199 | 0.3145 | 0.3145 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0156 | 0.3021 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0138 | 0.4265 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0256 | 0.0656 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.011 | 0.156 | 0.1992 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0256 | 0.0256 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0039 | 0.01 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0256 | 0.0493 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0149 | 0.2266 | 0.2892 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.007 | 0.085 | 0.1085 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0517 | 0.1324 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0149 | 0.2266 | 0.2892 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0256 | 0.5645 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0039 | 0.01 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0039 | 0.121 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0138 | 0.0176 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0096 | 0.1324 | 0.1324 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.007 | 0.085 | 0.085 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0083 | 0.109 | 0.1391 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0256 | 0.0656 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1324 | 0.2552 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.011 | 0.156 | 0.156 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0156 | 0.0156 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.2369 | 0.3024 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0149 | 0.2266 | 0.4367 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.007 | 0.085 | 0.1085 |
Brugia malayi | Bromodomain containing protein | 0.0122 | 0.1777 | 0.4615 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0096 | 0.1324 | 0.2552 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0064 | 0.0746 | 0.1437 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0314 | 0.5188 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0256 | 0.5645 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.2369 | 0.4567 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0517 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0156 | 0.0406 |
Brugia malayi | follicle stimulating hormone receptor | 0.0239 | 0.3851 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0039 | 0.01 |
Brugia malayi | mbt repeat family protein | 0.0096 | 0.1324 | 0.3438 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 0.7834 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.011 | 0.156 | 0.1992 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0454 | 0.0454 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0096 | 0.1324 | 0.169 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0188 | 0.2949 | 0.3765 |
Echinococcus granulosus | snurportin 1 | 0.0314 | 0.5188 | 0.6623 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.3383 | 0.8786 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0053 | 0.055 | 0.055 |
Trypanosoma cruzi | ISWI complex protein | 0.0047 | 0.0454 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.011 | 0.156 | 0.4052 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0083 | 0.109 | 0.109 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0039 | 0.0862 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0256 | 0.0327 |
Brugia malayi | Bromodomain containing protein | 0.0235 | 0.3787 | 0.9834 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0256 | 0.0327 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0517 | 0.066 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.11 | 0.2857 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0256 | 0.0665 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0156 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0746 | 0.0746 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0256 | 0.5 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0039 | 0.0862 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0517 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0256 | 0.4951 |
Onchocerca volvulus | 0.0096 | 0.1324 | 0.3116 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0096 | 0.1324 | 0.169 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0058 | 0.0647 | 0.1248 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0111 | 0.1583 | 0.2021 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0138 | 0.0176 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0144 | 0.2166 | 0.2765 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0323 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0047 | 0.0454 | 0.0454 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.5188 | 0.5188 |
Echinococcus granulosus | neuropeptide s receptor | 0.0463 | 0.7834 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.011 | 0.156 | 0.3008 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.011 | 0.156 | 0.1992 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.109 | 0.2101 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0256 | 0.5645 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0517 | 0.1324 |
Echinococcus multilocularis | zinc finger protein | 0.0064 | 0.0752 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.156 | 0.3008 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0083 | 0.109 | 0.109 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0323 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0138 | 0.3039 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0149 | 0.2266 | 0.2892 |
Trypanosoma brucei | ISWI complex protein | 0.0047 | 0.0454 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0314 | 0.5188 | 0.6623 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0096 | 0.1324 | 0.169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 11 % | Inhibition of BACE1 at 25 uM by FRET assay | ChEMBL. | 22727644 |
Inhibition (binding) | = 54 % | Inhibition of BACE1 at 50 uM by FRET assay | ChEMBL. | 22727644 |
Inhibition (binding) | = 83 % | Inhibition of BACE1 at 100 uM by FRET assay | ChEMBL. | 22727644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.