Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4774 | 0.4774 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.009 | 0.616 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4774 | 0.762 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.2045 | 0.2045 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.009 | 0.616 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4774 | 0.762 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4774 | 0.4774 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0338 | 0.0338 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4774 | 0.4774 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0338 | 0.0338 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.009 | 0.616 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0059 | 0.3647 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0338 | 0.0338 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4774 | 0.762 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0059 | 0.3647 | 0.4744 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4774 | 0.4774 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4774 | 0.762 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4774 | 0.762 |
Brugia malayi | Probable ClpP-like protease | 0.009 | 0.616 | 0.616 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.009 | 0.616 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0059 | 0.3647 | 0.5684 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2045 | 0.2932 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0059 | 0.3647 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.616 | 0.616 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4774 | 0.762 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0338 | 0.0338 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4774 | 0.4774 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0059 | 0.3647 | 0.5684 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3516 | 0.3516 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4774 | 0.762 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2045 | 0.2045 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4774 | 0.4774 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3516 | 0.3516 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.616 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.009 | 0.616 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.89 uM | DNDI | DNDI. | No reference |
IC50 | = 7.85 uM | DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | |||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.