TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 277.36 | Formula: C19H19NO
H donors: 1 H acceptors: 1 LogP: 5.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1ccc(cc1)c1cc(=O)c2c([nH]1)cccc2
InChi: 1S/C19H19NO/c1-2-3-6-14-9-11-15(12-10-14)18-13-19(21)16-7-4-5-8-17(16)20-18/h4-5,7-13H,2-3,6H2,1H3,(H,20,21)
InChiKey: IUAHTDMRRTZBNE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0034	0.0034
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.2638	0.2612
Entamoeba histolytica	cysteine proteinase 1, putative	0.0028	0.1025	0.1089
Echinococcus granulosus	cysteine protease	0.0028	0.1025	0.0994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.1538	0.5396
Onchocerca volvulus		0.0054	0.2638	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.2638	0.3277
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1007	0.2004
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.1025	0.1025
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.1007	0.1038
Echinococcus multilocularis	musashi	0.0031	0.1241	0.1211
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0657	0.0688
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.1025	0.2049
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.2638	0.631
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0077	0.4035	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0411	0.0411
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.1538	0.2609
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.2638	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0657	0.1707
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Brugia malayi	ecdysteroid receptor	0.0012	0.0034	0.0034
Plasmodium vivax	vivapain-2	0.0054	0.2638	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1538	0.1509
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1007	1
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0411	0.0427
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0657	1
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0579	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0034	0.0034
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0077	0.4035	0.4014
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0657	0.1077
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0034	0.0034
Brugia malayi	cathepsin L-like precursor	0.0036	0.1538	0.1538
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.1025	0.1247
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.2018	0.7405
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.2638	1
Onchocerca volvulus		0.0031	0.1241	0.4634
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1007	0.0977
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0242	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0207	0.0173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1007	0.1007
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.2018	0.199
Plasmodium vivax	vivapain-2	0.0054	0.2638	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.01	0.5486	0.8837
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0657	0.1077
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0579	0.138
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0657	0.1707
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0034	0.0034
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0657	0.5376
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0034	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.1025	0.2049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0034	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Echinococcus multilocularis	lamin dm0	0.0031	0.1241	0.1211
Plasmodium falciparum	glutathione reductase	0.0044	0.2018	0.7405
Brugia malayi	nuclear hormone receptor	0.0012	0.0034	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Schistosoma mansoni	cathepsin s	0.0018	0.0411	0.0474
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0034	0.0034
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1025	0.1089
Echinococcus multilocularis	cathepsin L	0.0028	0.1025	0.0994
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0077	0.4035	0.4035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.2018	0.4673
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0034	0.0034
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0657	0.0625
Plasmodium vivax	unspecified product	0.0018	0.0411	0.0677
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.2638	0.2612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.2638	1
Mycobacterium tuberculosis	Probable reductase	0.01	0.5486	0.8837
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1025	0.1089
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0249	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0034	0.0034
Toxoplasma gondii	exonuclease III APE	0.0022	0.0657	0.1707
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.2638	0.3277
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0411	0.0378
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.1025	0.2049
Schistosoma mansoni	ap endonuclease	0.0022	0.0657	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0111	0.6175	1
Onchocerca volvulus		0.0054	0.2638	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0657	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.2638	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1007	1
Schistosoma mansoni	lamin	0.0031	0.1241	0.1519
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0242	0.0209
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0509	0.0439
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0657	0.1707
Schistosoma mansoni	ap endonuclease	0.0022	0.0657	0.0784
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0579	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1007	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0579	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1538	0.1509
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0111	0.6175	1
Plasmodium vivax	vivapain-3	0.0028	0.1025	0.3247
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.2045	0.2018
Brugia malayi	steroid hormone receptor	0.0012	0.0034	0.0034
Brugia malayi	Cathepsin L-like precursor	0.0036	0.1538	0.1538
Onchocerca volvulus		0.0054	0.2638	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0249	0.0216
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Loa Loa (eye worm)	fibroinase	0.0054	0.2638	0.2612
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.1025	0.2049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.2638	0.631
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0579	0.0546
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0411	0.0411
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0249	0.0249
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0509	0.0439
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.1241	0.1211
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.1007	1
Plasmodium vivax	glutathione reductase, putative	0.0044	0.2018	0.7405
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.01	0.5486	0.8837
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0034	0.0034
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.0411	0.0427
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.1007	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0579	0.138
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.2638	0.2612
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.1538	0.1893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1025	0.3247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0077	0.4035	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0111	0.6175	1
Plasmodium vivax	vivapain-1	0.0028	0.1025	0.3247
Brugia malayi	intermediate filament protein	0.0031	0.1241	0.1241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0034	0.0034
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0657	0.1077
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0345	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.2638	1
Entamoeba histolytica	cysteine protease, putative	0.0054	0.2638	0.5864
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.1007	0.128
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.1241	0.1241
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.2638	0.631
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0249	0.027
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0077	0.4035	0.4014
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.01	0.5486	0.8667
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.1025	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1007	0.0977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.1538	0.5396
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.2638	0.631
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1538	0.1509
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.1007	0.128
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1007	0.2004
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1007	1
Brugia malayi	Thioredoxin reductase	0.0044	0.2018	0.2018
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.1025	0.2049
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0077	0.4035	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0411	0.0411
Onchocerca volvulus		0.0054	0.2638	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2638	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Onchocerca volvulus		0.0054	0.2638	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Echinococcus multilocularis	muscleblind protein	0.0173	1	1
Echinococcus multilocularis	cysteine protease	0.0054	0.2638	0.2612
Plasmodium falciparum	thioredoxin reductase	0.0044	0.2018	0.7405
Echinococcus granulosus	cathepsin L	0.0028	0.1025	0.0994
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.2638	0.5864
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0034	0.0034
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Brugia malayi	glutathione reductase	0.0044	0.2018	0.2018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0509	0.0439
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.01	0.5486	0.8837
Mycobacterium tuberculosis	Probable oxidoreductase	0.0111	0.6175	1
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.2638	1
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.2638	0.5864
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0411	0.0378
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1007	0.1007
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1007	0.1007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0034	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.1025	0.3247
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1025	0.1089
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.1025	0.1025
Echinococcus multilocularis	muscleblind protein 1	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0207	0.0173
Plasmodium vivax	unspecified product	0.0028	0.1025	0.3247
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0657	1
Loa Loa (eye worm)	cysteine protease	0.0054	0.2638	0.2612
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.2638	0.2612
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.1241	0.1211
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0657	0.1077
Echinococcus granulosus	intermediate filament protein	0.0031	0.1241	0.1211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.1025	0.2049
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0509	0.0439
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Loa Loa (eye worm)	ctsf protein	0.0054	0.2638	0.2612
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0657	0.0625
Echinococcus granulosus	lamin	0.0031	0.1241	0.1211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1205	0.1175
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0242	0.0209
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.1025	0.1247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0077	0.4035	0.5035
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.01	0.5486	0.8837
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.1007	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0579	0.0546
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1007	0.2004
Onchocerca volvulus		0.0031	0.1241	0.4634
Echinococcus granulosus	cathepsin L cysteine protease	0.0028	0.1025	0.0994
Loa Loa (eye worm)	glutathione reductase	0.0044	0.2018	0.199
Leishmania major	cathepsin L-like protease	0.0054	0.2638	0.631
Echinococcus multilocularis	cysteine protease	0.0054	0.2638	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0579	0.0546
Onchocerca volvulus		0.0036	0.1538	0.5776
Echinococcus multilocularis	lamin	0.0031	0.1241	0.1211
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Brugia malayi	Cathepsin L-like precursor	0.0036	0.1538	0.1538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0077	0.4035	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.2638	0.631
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0579	0.4346
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0077	0.4035	0.4014
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0657	0.1707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Leishmania major	trypanothione reductase	0.0044	0.2018	0.4673
Toxoplasma gondii	cathepsin CPL	0.0054	0.2638	1
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.2045	0.2018
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.1025	0.2049
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.2638	1
Onchocerca volvulus		0.0054	0.2638	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.1007	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.1007	1
Onchocerca volvulus		0.0054	0.2638	1
Onchocerca volvulus		0.0027	0.1007	0.3738
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.1007	0.1038
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0657	0.0657
Schistosoma mansoni	intermediate filament proteins	0.0031	0.1241	0.1519
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0044	0.2018	0.2985
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.2638	0.2612
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.2638	0.2612
Echinococcus granulosus	cathepsin l1	0.0054	0.2638	0.2612
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0077	0.4035	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.2638	0.631
Echinococcus granulosus	thioredoxin glutathione reductase	0.0044	0.2054	0.2027
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0044	0.2054	0.2027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Brugia malayi	Cathepsin L-like precursor	0.0054	0.2638	0.2638
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.2638	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0411	0.0378
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0657	0.0625
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0579	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0345	0.0312
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1025	0.1089
Echinococcus granulosus	cathepsin l1	0.0036	0.1538	0.1509
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0034	0.0034
Toxoplasma gondii	thioredoxin reductase	0.0044	0.2018	0.7405
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0034	0.0034
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.2638	0.2612
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0034	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1025	0.3247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1241	0.1211
Entamoeba histolytica	cysteine proteinase 2	0.0028	0.1025	0.1089
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.1007	0.1038
Echinococcus granulosus	muscleblind protein	0.0173	1	1
Schistosoma mansoni	lamin	0.0031	0.1241	0.1519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.2638	0.631
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.2638	0.2638
Echinococcus granulosus	lamin dm0	0.0031	0.1241	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0411	0.0378
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.2638	0.2612
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0036	0.1538	0.3405
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1
Trypanosoma brucei	trypanothione reductase	0.0044	0.2018	0.4673
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.1538	0.1538
Mycobacterium tuberculosis	Probable dehydrogenase	0.01	0.5486	0.8837
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1025	0.1089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.2638	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.6 uM	Inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis	ChEMBL.	22591648
IC50 (binding)	= 5.2 uM	Inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by fluorometric analysis	ChEMBL.	22591648
Ki (binding)	= 0.8 uM	Noncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysis	ChEMBL.	22591648
Ki (binding)	= 1.5 uM	Noncompetitive inhibition of human recombinant cathepsin L expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysis	ChEMBL.	22591648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2042446

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1665586