Detailed information for compound 1665806

Basic information

Technical information
  • TDR Targets ID: 1665806
  • Name: [(E,5R,6R,7R,8R)-6,7-dihydroxy-8-methoxy-2-me thyl-9-oxo-9-[[(3S)-2-oxoazepan-3-yl]amino]no n-3-en-5-yl] tetradecanoate
  • MW: 568.786 | Formula: C31H56N2O7
  • H donors: 4 H acceptors: 5 LogP: 6.81 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]([C@@H]([C@H]([C@H](C(=O)N[C@H]1CCCCNC1=O)OC)O)O)/C=C/C(C)C
  • InChi: 1S/C31H56N2O7/c1-5-6-7-8-9-10-11-12-13-14-15-19-26(34)40-25(21-20-23(2)3)27(35)28(36)29(39-4)31(38)33-24-18-16-17-22-32-30(24)37/h20-21,23-25,27-29,35-36H,5-19,22H2,1-4H3,(H,32,37)(H,33,38)/b21-20+/t24-,25+,27-,28+,29+/m0/s1
  • InChiKey: ZVRFWGNDDYSRLF-MCRXVNGLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(E,1R)-1-[(1R,2R,3R)-1,2-dihydroxy-3-methoxy-4-oxo-4-[[(3S)-2-oxoazepan-3-yl]amino]butyl]-4-methyl-pent-2-enyl] tetradecanoate
  • tetradecanoic acid [(E,1R)-1-[(1R,2R,3R)-1,2-dihydroxy-3-methoxy-4-oxo-4-[[(3S)-2-oxo-3-azepanyl]amino]butyl]-4-methylpent-2-enyl] ester
  • myristic acid [(E,1R)-1-[(1R,2R,3R)-1,2-dihydroxy-4-keto-4-[[(3S)-2-ketoazepan-3-yl]amino]-3-methoxy-butyl]-4-methyl-pent-2-enyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0042 0.0252 0.0252
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0187 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0252 0.0252
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0252 0.0252
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0252 0.0252
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0252 0.0252
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.108 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0133
Schistosoma mansoni biogenic amine receptor 0.0042 0.0252 0.0252
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0252 0.0252
Echinococcus granulosus orexin receptor type 2 0.0042 0.0252 0.0252
Echinococcus granulosus mitogen activated protein kinase 0.108 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0252 0.0252
Brugia malayi G-protein coupled receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0252 0.0252
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni neuropeptide receptor 0.0042 0.0252 0.0252
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0252 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0252 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0252 0.0252
Schistosoma mansoni amine GPCR 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.008 0.0021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0252 0.0252
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0252 0.0252
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.108 1 1
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Entamoeba histolytica hypothetical protein 0.0035 0.0187 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0252 0.0252
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0252 0.0252
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.108 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine receptor 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.008 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0297 0.0297
Entamoeba histolytica hypothetical protein 0.0035 0.0187 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0252 0.0252
Echinococcus granulosus snurportin 1 0.0317 0.2836 0.2836
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.108 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0252 0.0252
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0252 0.0252
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0252 0.0252
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0252 0.0252
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0059 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0187 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.2836 0.2836
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0252 0.0252
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0252 0.0252
Brugia malayi Serotonin receptor 0.0042 0.0252 0.0252
Brugia malayi G protein-coupled receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis importin subunit beta 1 0.003 0.0133 0.0133
Onchocerca volvulus 0.0042 0.0252 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0252 0.0252
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0252 0.0252
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0252 0.0252
Brugia malayi Dopamine receptor protein 1 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0035 0.0187 0.0187
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0297 0.0297
Brugia malayi AKH receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi Melatonin receptor type 1A 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0252 0.0252
Schistosoma mansoni ran 0.0022 0.0059 0.0059
Schistosoma mansoni importin beta-1 0.003 0.0133 0.0133
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0252 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Schistosoma mansoni neuropeptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0297 0.0297
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0252 0.0252
Plasmodium vivax importin-beta 2, putative 0.003 0.0133 1
Schistosoma mansoni myosin xvIII 0.0042 0.0252 0.0252
Schistosoma mansoni amine GPCR 0.0042 0.0252 0.0252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0316 0.0316
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0252 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0252 0.0252
Echinococcus granulosus allatostatin A receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0252 0.0252
Entamoeba histolytica hypothetical protein 0.0035 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi neuropeptide F receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine receptor 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0317 0.2836 0.2836
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0252 0.0252
Brugia malayi Dopamine receptor 0.0042 0.0252 0.0252
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.008 0.0021
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0252 0.0252
Schistosoma mansoni opsin-like receptor 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0297 0.0297
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.108 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0252 0.0252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0252 0.0252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0252 0.0252
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.108 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.108 1 1
Schistosoma mansoni neuropeptide receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis mitogen activated protein kinase 0.108 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0297 0.0297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Entamoeba histolytica hypothetical protein 0.0035 0.0187 1
Echinococcus granulosus somatostatin receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Brugia malayi RNA, U transporter 1 0.0085 0.0648 0.0648
Trichomonas vaginalis importin beta-1, putative 0.0024 0.008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus importin subunit beta 1 0.003 0.0133 0.0133
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0252 0.0252
Brugia malayi GnHR receptor homolog 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.017 0.017
Brugia malayi putative neuropeptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.108 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0252 0.0252
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0252 0.0252
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0297 0.0297
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni ran 0.0022 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0252 0.0252
Schistosoma mansoni neuropeptide receptor 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0252 0.0252
Echinococcus granulosus fmrfamide receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0252 0.0252
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0297 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0297 0.0297
Brugia malayi G-protein coupled receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni histamine h1 receptor 0.0042 0.0252 0.0252
Echinococcus granulosus g protein coupled receptor 0.0042 0.0252 0.0252
Echinococcus granulosus g protein coupled receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0252 0.0252
Echinococcus granulosus hypothetical protein 0.0042 0.0252 0.0252
Leishmania major importin beta-1 subunit, putative 0.0024 0.008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni amine GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0252 0.0252
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0252 0.0252
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0252 0.0252
Brugia malayi neuropeptide F receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0252 0.0252
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.108 1 1
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0252 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0059 0.0059
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0252 0.0252
Schistosoma mansoni opsin-like receptor 0.0042 0.0252 0.0252
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0252 0.0252
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0799 0.7366 0.7366
Trichomonas vaginalis CMGC family protein kinase 0.108 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.108 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0252 0.0252
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0252 0.0252
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi Serotonin receptor 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0252 0.0252
Echinococcus granulosus serotonin receptor 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0167 0.1424 0.1424
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0252 0.0252
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0035 0.0187 0.0187
Echinococcus multilocularis serotonin receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi ORL1-like opioid receptor 0.0042 0.0252 0.0252
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0034 0.017 0.017
Echinococcus granulosus geminin 0.0167 0.1424 0.1424
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0252 0.0252
Echinococcus granulosus sex peptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Entamoeba histolytica hypothetical protein 0.0024 0.008 0.1639
Brugia malayi larval opioid receptor 0.0042 0.0252 0.0252
Echinococcus granulosus mitogen activated protein kinase 3 0.108 1 1
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0133 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.108 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0133 0.0074
Echinococcus multilocularis sex peptide receptor 0.0042 0.0252 0.0252
Schistosoma mansoni opsin-like receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0252 0.0252
Echinococcus multilocularis serotonin receptor 0.0042 0.0252 0.0252
Brugia malayi Dopamine receptor protein 2 0.0042 0.0252 0.0252
Brugia malayi RE15519p 0.0042 0.0252 0.0252
Echinococcus granulosus g protein coupled receptor 0.0042 0.0252 0.0252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0316 0.0316
Onchocerca volvulus 0.0042 0.0252 0.5
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Trichomonas vaginalis CMGC family protein kinase 0.108 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0252 0.0252
Brugia malayi Importin beta-1 subunit 0.003 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Schistosoma mansoni amine GPCR 0.0042 0.0252 0.0252
Plasmodium falciparum importin beta, putative 0.003 0.0133 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0133 0.0074
Trypanosoma brucei protein kinase, putative 0.108 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0252 0.0252
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0252 0.0252
Giardia lamblia Kinase, CMGC MAPK 0.108 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0252 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Echinococcus multilocularis snurportin 1 0.0317 0.2836 0.2836
Brugia malayi sulfakinin receptor protein 0.0042 0.0252 0.0252
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0167 0.1424 0.1424
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.108 1 1
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.108 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0252 0.0252
Echinococcus multilocularis somatostatin receptor 0.0042 0.0252 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0252 0.0252
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0042 0.0252 0.0252
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0252 0.0252
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0252 0.0252
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0252 0.0252
Onchocerca volvulus 0.0042 0.0252 0.5
Onchocerca volvulus 0.0042 0.0252 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0187 0.0187
Echinococcus multilocularis geminin 0.0167 0.1424 0.1424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0042 0.0252 0.0252
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0252 0.0252
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0049 0.0316 0.0316
Onchocerca volvulus 0.0042 0.0252 0.5
Schistosoma mansoni adenoreceptor 0.0042 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.0252

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.73 uM Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay ChEMBL. 22705020

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22705020

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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