Detailed information for compound 166594

Basic information

Technical information
  • TDR Targets ID: 166594
  • Name: 4-decylquinolin-8-ol
  • MW: 285.424 | Formula: C19H27NO
  • H donors: 1 H acceptors: 2 LogP: 6.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCc1ccnc2c1cccc2O
  • InChi: 1S/C19H27NO/c1-2-3-4-5-6-7-8-9-11-16-14-15-20-19-17(16)12-10-13-18(19)21/h10,12-15,21H,2-9,11H2,1H3
  • InChiKey: BVPDQHBXLLRDRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-decyl-8-quinolinol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.053 0.1382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0014 0.0031
Plasmodium vivax vivapain-2 0.0051 0.053 0.312
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0283 0.1152
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0033 0.0246 0.0622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Brugia malayi steroid hormone receptor 0.0019 0.0014 0.0031
Onchocerca volvulus 0.0051 0.053 0.1197
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0101 0.1327 0.5705
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0132 0.183 0.169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0014 0.0031
Echinococcus multilocularis cathepsin L 0.0028 0.0168 0.0413
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.211 0.1975
Brugia malayi STAT protein, DNA binding domain containing protein 0.0265 0.3969 0.8974
Echinococcus multilocularis cathepsin b 0.0149 0.211 0.5616
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0246 0.0556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0598 0.1597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0033 0.0246 0.0079
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0033 0.0246 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0014 0.0031
Mycobacterium tuberculosis Conserved protein 0.0043 0.0407 0.061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0014 0.0031
Plasmodium falciparum glyoxalase I 0.0043 0.0407 0.2394
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0014 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.053 0.1197
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.053 0.1197
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0294 0.4423 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0014 0.0031
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0283 0.0756
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0033 0.0246 0.0622
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Loa Loa (eye worm) cysteine protease 0.0051 0.053 0.1197
Echinococcus multilocularis plexin a4 0.0021 0.0052 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0202 0.2955 0.7881
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0033 0.0246 0.0079
Giardia lamblia Cathepsin B precursor 0.0055 0.0598 0.1007
Loa Loa (eye worm) CBP-B 0.0166 0.2383 0.5387
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0014 0.0037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0014 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Leishmania major cysteine peptidase A (CPA) 0.0051 0.053 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0218 0.3216 0.7271
Onchocerca volvulus Cathepsin L homolog 0.0051 0.053 0.1197
Brugia malayi NAD-dependent deacetylase SIRT1 0.0252 0.3746 0.8468
Schistosoma mansoni gynecophoral canal protein 0.0043 0.0407 0.1087
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0101 0.1327 0.3239
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0246 0.0672
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0642 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.053 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0283 0.0322
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.3746 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0033 0.0246 0.078
Toxoplasma gondii cathepsin CPL 0.0051 0.053 0.1497
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0014 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0283 0.0322
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Loa Loa (eye worm) cathepsin B 0.0055 0.0598 0.1353
Echinococcus multilocularis cathepsin b 0.0149 0.211 0.5616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0014 0.0031
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0168 0.0449
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0043 0.0407 0.061
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.2292 0.216
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0014 0.0031
Echinococcus multilocularis chromatin regulatory protein sir2 0.0033 0.0246 0.0622
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Echinococcus multilocularis CREB binding protein 0.0166 0.2369 0.631
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0246 0.0556
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0033 0.0246 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.211 0.5632
Onchocerca volvulus 0.0051 0.053 0.1197
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0014 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.053 0.362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0598 0.1202
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0246 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Onchocerca volvulus Cathepsin F homolog 0.0051 0.053 0.1197
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0246 0.0556
Onchocerca volvulus 0.0051 0.053 0.1197
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0101 0.1327 0.5705
Echinococcus granulosus cathepsin l1 0.0035 0.0283 0.0722
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0033 0.0246 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0014 0.0031
Loa Loa (eye worm) ctsf protein 0.0051 0.053 0.1197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Toxoplasma gondii glyoxalase I, putative 0.0043 0.0407 0.0851
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0168 0.0449
Trichomonas vaginalis bromodomain-containing protein, putative 0.0101 0.1327 0.3239
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.053 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Brugia malayi Cathepsin L-like precursor 0.0035 0.0283 0.064
Echinococcus granulosus cathepsin b 0.0149 0.211 0.5616
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.3746 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.053 0.1382
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0407 0.5
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0252 0.3746 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0444 0.683 0.675
Trypanosoma brucei SIR2-like protein 4, putative 0.0033 0.0246 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.183 0.169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Giardia lamblia Cathepsin B precursor 0.0055 0.0598 0.1007
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0014 0.0037
Echinococcus granulosus chromatin regulatory protein sir2 0.0033 0.0246 0.0622
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.053 0.1197
Toxoplasma gondii hypothetical protein 0.0151 0.2141 1
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0014 0.0037
Echinococcus multilocularis cysteine protease 0.0051 0.053 0.1382
Schistosoma mansoni chromatin regulatory protein sir2 0.0252 0.3746 1
Onchocerca volvulus 0.0019 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0051 0.053 0.1197
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0132 0.183 0.169
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0246 0.0556
Entamoeba histolytica cysteine protease, putative 0.0051 0.053 0.362
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0202 0.2955 0.7889
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0043 0.0407 0.0165
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0043 0.0407 0.0243
Plasmodium vivax glyoxalase I, putative 0.0043 0.0407 0.2063
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0197 0.2875 0.7676
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0168 0.0413
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0168 0.038
Echinococcus multilocularis cysteine protease 0.0051 0.053 0.1382
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.053 0.0368
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0014 0.0031
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0043 0.0407 0.0921
Entamoeba histolytica acetyltransferase, GNAT family 0.0091 0.1167 1
Schistosoma mansoni coup transcription factor 0.0019 0.0014 0.0037
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.053 0.1382
Plasmodium vivax vivapain-2 0.0051 0.053 0.312
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.053 0.1382
Loa Loa (eye worm) hypothetical protein 0.0051 0.053 0.1197
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Mycobacterium tuberculosis Conserved protein TB27.3 0.0043 0.0407 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0246 0.078
Echinococcus granulosus CREB binding protein 0.0159 0.2257 0.6012
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0246 0.0556
Onchocerca volvulus Bile acid receptor homolog 0.0176 0.2533 0.5726
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0014 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0246 0.078
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0444 0.683 0.6776
Brugia malayi cathepsin L-like precursor 0.0035 0.0283 0.064
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.053 0.362
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Giardia lamblia Histone acetyltransferase GCN5 0.0091 0.1167 0.2631
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0149 0.211 0.5632
Echinococcus granulosus cathepsin L 0.0028 0.0168 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Schistosoma mansoni CREB-binding protein 2 0.0197 0.2875 0.7676
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Loa Loa (eye worm) hypothetical protein 0.0149 0.211 0.4769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0014 0.0031
Brugia malayi nuclear receptor NHR-88 0.0019 0.0014 0.0031
Brugia malayi cathepsin B-like cysteine proteinase 0.0149 0.211 0.4769
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0246 0.0556
Brugia malayi Cathepsin L-like precursor 0.0035 0.0283 0.064
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Echinococcus granulosus cathepsin b 0.0149 0.211 0.5616
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0168 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.053 0.0368
Brugia malayi plexin A 0.0021 0.0052 0.0117
Brugia malayi acetyltransferase, GNAT family protein 0.0202 0.2955 0.668
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0101 0.1327 0.3519
Onchocerca volvulus Putative protein 0.0294 0.4423 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0055 0.0598 0.0438
Brugia malayi lactoylglutathione lyase 0.0043 0.0407 0.0921
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0033 0.0246 0.078
Echinococcus granulosus cathepsin l1 0.0051 0.053 0.1382
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Onchocerca volvulus 0.0035 0.0283 0.064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0014 0.0031
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.053 0.0368
Loa Loa (eye worm) fibroinase 0.0051 0.053 0.1197
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.211 0.5632
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.183 0.169
Echinococcus granulosus plexin a4 0.0021 0.0052 0.0102
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0294 0.4423 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0252 0.3746 1
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.053 0.0368
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.064
Brugia malayi nuclear hormone receptor 0.0019 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0033 0.0246 0.078
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Onchocerca volvulus 0.0051 0.053 0.1197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.3746 1
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0407 0.061
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0283 0.064
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0014 0.0031
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.053 0.362
Echinococcus granulosus CREB binding protein 0.0197 0.2875 0.7668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Toxoplasma gondii glyoxalase family protein 0.0043 0.0407 0.0851
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0252 0.3746 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0014 0.0037
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0642 1 1
Onchocerca volvulus 0.0051 0.053 0.1197
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0035 0.0283 0.0117
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0246 0.0657
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0246 0.078
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0246 0.078
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0252 0.3746 0.8468
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.053 0.362
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0014 0.0031
Mycobacterium tuberculosis Conserved protein 0.0043 0.0407 0.061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0014 0.0031
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0033 0.0246 0.0622
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0014 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Brugia malayi ecdysteroid receptor 0.0176 0.2533 0.5726
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0168 0.038
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0033 0.0246 0.0622
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Plasmodium vivax NAD-dependent deacetylase, putative 0.0033 0.0246 0.0672
Mycobacterium ulcerans hypothetical protein 0.0198 0.2886 1
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0043 0.0407 0.1087
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Onchocerca volvulus 0.0051 0.053 0.1197
Giardia lamblia Cathepsin B precursor 0.0055 0.0598 0.1007
Plasmodium falciparum histone acetyltransferase GCN5 0.0091 0.1167 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0014 0.0037
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.053 0.1414
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0014 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0407 0.0921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0101 0.1327 1
Loa Loa (eye worm) plexin A 0.0021 0.0052 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0014 0.0031
Onchocerca volvulus 0.0051 0.053 0.1197
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0014 0.0037
Brugia malayi TAZ zinc finger family protein 0.0197 0.2875 0.6501
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0033 0.0246 0.0622
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0246 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0191 0.2776 0.7401
Leishmania major cathepsin L-like protease 0.0051 0.053 0.0291
Loa Loa (eye worm) hypothetical protein 0.0176 0.2533 0.5726
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0407 0.0668
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0642 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.053 0.362
Loa Loa (eye worm) hypothetical protein 0.0047 0.0473 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0407 0.0668
Toxoplasma gondii cathepsin B 0.0055 0.0598 0.1859
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0043 0.0407 0.061
Mycobacterium ulcerans hypothetical protein 0.0043 0.0407 0.061
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0407 0.061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0014 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0014 0.0031
Plasmodium falciparum glyoxalase I 0.0043 0.0407 0.2394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0014 0.0031
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.3746 1
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0043 0.0407 0.0243
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.211 0.5632
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0407 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.053 0.0368
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0444 0.683 0.6776
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0055 0.0598 0.0361
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0246 0.0079
Loa Loa (eye worm) acetyltransferase 0.0202 0.2955 0.668
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Loa Loa (eye worm) sirtuin 4 0.0033 0.0246 0.0556
Loa Loa (eye worm) STAT protein 0.0265 0.3969 0.8974
Mycobacterium tuberculosis Conserved hypothetical protein 0.0198 0.2886 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0055 0.0598 0.0438
Plasmodium vivax glyoxalase I, putative 0.0043 0.0407 0.2063
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.053 0.1382
Echinococcus granulosus cysteine protease 0.0028 0.0168 0.0413
Brugia malayi Cathepsin L-like precursor 0.0051 0.053 0.1197
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.053 0.0368
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.053 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.053 0.1011
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0014 0.0037

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) NA 0 % Compound was evaluated in vitro for the inhibition of 5-lipoxygenase; NS means no significant inhibition ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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