Detailed information for compound 1666291

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 578.451 | Formula: C24H29Cl2N9O4
  • H donors: 5 H acceptors: 4 LogP: -0.13 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cl/C=C\C(=O)Nc1cc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)NCCC(=N)N.Cl
  • InChi: 1S/C24H28ClN9O4.ClH/c1-32-12-15(9-17(32)22(36)28-7-5-20(26)27)30-24(38)19-10-16(13-34(19)3)31-23(37)18-8-14(11-33(18)2)29-21(35)4-6-25;/h4,6,8-13H,5,7H2,1-3H3,(H3,26,27)(H,28,36)(H,29,35)(H,30,38)(H,31,37);1H/b6-4-;
  • InChiKey: PLLVYNHVCSADBM-YHSAGPEESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Brugia malayi Hemopexin family protein 0.0263 0.0251 0.0581
Echinococcus granulosus endothelin converting enzyme 1 0.0183 0.0168 0.114
Plasmodium falciparum peptide deformylase 0.9731 1 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0336 0.0326 0.0323
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3713 0.3803 1
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0045 0.0026 0.0053
Toxoplasma gondii peptidase family M13 protein 0.0183 0.0168 0.0162
Echinococcus granulosus TGF beta signal transducer SmadC 0.0036 0.0017 0.0095
Brugia malayi MH2 domain containing protein 0.0036 0.0017 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0016 0.0088
Mycobacterium ulcerans hydrolase 0.0226 0.0212 0.021
Loa Loa (eye worm) hypothetical protein 0.0183 0.0168 0.039
Echinococcus multilocularis disintegrin and metalloproteinase 0.0042 0.0023 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0007 0.001
Loa Loa (eye worm) reprolysin 0.0042 0.0023 0.0053
Plasmodium falciparum amino acid transporter, putative 0.0037 0.0018 0.0011
Toxoplasma gondii hypothetical protein 0.9731 1 1
Mycobacterium tuberculosis Possible exported protein 0.1491 0.1515 0.1512
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0013 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0013 0.0024
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0119 0.0276
Loa Loa (eye worm) hypothetical protein 0.0056 0.0037 0.0086
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0018 0.0104
Entamoeba histolytica hypothetical protein 0.0077 0.0059 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0092 0.0075 0.0167
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0199 0.0184 0.0421
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3713 0.3803 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0007 0.001
Schistosoma mansoni sodium/chloride dependent transporter 0.0219 0.0205 0.047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0027
Leishmania major hypothetical protein, conserved 0.0026 0.0007 0.001
Schistosoma mansoni sodium-dependent amino acid transporter 0.0037 0.0018 0.0035
Echinococcus granulosus serotonin transporter 0.0219 0.0205 0.1397
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0016 0.0088
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0199 0.0184 0.0427
Echinococcus multilocularis GPCR, family 2 0.0035 0.0016 0.0088
Loa Loa (eye worm) matrix metalloproteinase 0.0186 0.0171 0.0396
Brugia malayi Peptidase family M13 containing protein 0.0183 0.0168 0.039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0215 0.0498
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0013 0.0073
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0016 0.0036
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Onchocerca volvulus 0.0037 0.0018 0.0118
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0037 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.0145 0.0374
Echinococcus multilocularis mothers against decapentaplegic 5 0.0036 0.0017 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0031
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0219 0.0205 0.0476
Loa Loa (eye worm) glutaminase 0.4207 0.4312 1
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0048 0.012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0018 0.0035
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0045 0.029
Loa Loa (eye worm) serotonin transporter b 0.0219 0.0205 0.0476
Brugia malayi hypothetical protein 0.0037 0.0018 0.0042
Brugia malayi Matrixin family protein 0.0186 0.0171 0.0396
Leishmania major cathepsin L-like protease 0.0067 0.0048 0.012
Toxoplasma gondii hypothetical protein 0.0055 0.0036 0.0029
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.9731 1 1
Brugia malayi Smad1 0.0036 0.0017 0.0038
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0183 0.0168 0.0384
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0037 0.0235
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0026 0.0053
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.0329 0.0858
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0183 0.0168 0.039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0219 0.0206 0.1398
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0018 0.0011
Onchocerca volvulus Matrilysin homolog 0.0412 0.0404 1
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0023 0.0046
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0034 0.0081
Echinococcus granulosus GPCR family 2 0.0035 0.0016 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0016
Onchocerca volvulus 0.0219 0.0205 0.4921
Echinococcus granulosus adam 0.0073 0.0055 0.0359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0039 0.0096
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0036 0.0017 0.0038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0045 0.029
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0675 0.0675 0.4632
Loa Loa (eye worm) hypothetical protein 0.0186 0.0171 0.0396
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0029 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0145 0.0374
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0037 0.0018 0.0104
Loa Loa (eye worm) hypothetical protein 0.0186 0.0171 0.0396
Trypanosoma brucei Peptide deformylase 2 0.3713 0.3803 1
Leishmania major cathepsin L-like protease 0.0067 0.0048 0.012
Loa Loa (eye worm) Smad1 0.0036 0.0017 0.0038
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0264 0.0251 0.1714
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0057 0.0133
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0037 0.0018 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0013 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0135 0.0119 0.0276
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0186 0.0171 0.039
Plasmodium vivax amine transporter, putative 0.0037 0.0018 0.0011
Brugia malayi hypothetical protein 0.0026 0.0007 0.0016
Loa Loa (eye worm) solute carrier family 6 member 4 0.0219 0.0205 0.0476
Schistosoma mansoni hypothetical protein 0.0263 0.0251 0.0575
Loa Loa (eye worm) zinc metallopeptidase 4 0.0045 0.0026 0.0059
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0042 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Loa Loa (eye worm) matrixin family protein 0.0449 0.0442 0.1025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0036 0.0017 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0219 0.0205 0.0476
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0219 0.0206 0.1398
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Toxoplasma gondii hypothetical protein 0.0037 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Brugia malayi Disintegrin family protein 0.0042 0.0023 0.0053
Echinococcus multilocularis smad 0.0036 0.0017 0.0095
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0037 0.0018 0.0104
Echinococcus granulosus adam 17 protease 0.0463 0.0456 0.3124
Mycobacterium ulcerans peptide deformylase 0.9731 1 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0027
Trypanosoma brucei Polypeptide deformylase 1 0.3713 0.3803 1
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0036 0.0017 0.0032
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0037 0.0018 0.0104
Loa Loa (eye worm) MBCTL1 0.0063 0.0045 0.0104
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0042
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Leishmania major polypeptide deformylase-like protein, putative 0.3713 0.3803 1
Onchocerca volvulus 0.0091 0.0073 0.153
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0042 0.0023 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0003 0.0006
Giardia lamblia DINP protein human, muc B family 0.0023 0.0003 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.0329 0.0858
Loa Loa (eye worm) hypothetical protein 0.0219 0.0205 0.0476
Schistosoma mansoni hypothetical protein 0.0076 0.0057 0.0127
Plasmodium vivax SET domain protein, putative 0.0033 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0007 0.001
Schistosoma mansoni smad1 5 8 and 0.0036 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0045 0.0098
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0016 0.0036
Brugia malayi peptidase family M13 containing protein 0.0045 0.0026 0.0059
Brugia malayi Matrixin family protein 0.0449 0.0442 0.1025
Brugia malayi MH2 domain containing protein 0.0526 0.0522 0.121
Schistosoma mansoni glutaminase 0.4207 0.4312 1
Entamoeba histolytica hypothetical protein 0.0077 0.0059 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0018 0.0104
Brugia malayi mbt repeat family protein 0.0056 0.0037 0.0086
Schistosoma mansoni dihydroceramide desaturase 0.0042 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0186 0.0171 0.0396
Loa Loa (eye worm) hypothetical protein 0.0219 0.0205 0.0476
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0023 0.0046
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0092 0.0075 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0183 0.0168 0.039
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0029 0.0068
Onchocerca volvulus 0.0263 0.0251 0.6081
Brugia malayi Matrixin family protein 0.0186 0.0171 0.0396
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0018 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0013 0.0024
Leishmania major cathepsin L-like protease 0.0067 0.0048 0.012
Onchocerca volvulus Matrix metalloproteinase homolog 0.0412 0.0404 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0075 0.0167
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0093 0.0217
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0018 0.0104
Brugia malayi Pre-SET motif family protein 0.0033 0.0013 0.0031
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0016 0.0088
Brugia malayi MH1 domain containing protein 0.0036 0.0017 0.0038
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0073 0.0055 0.0121
Brugia malayi Matrixin family protein 0.0186 0.0171 0.0396
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0884 0.089 0.2063
Toxoplasma gondii hypothetical protein 0.0037 0.0018 0.0011
Echinococcus multilocularis Smad4 0.0036 0.0017 0.0095
Mycobacterium ulcerans glutaminase 0.4207 0.4312 0.431
Onchocerca volvulus 0.0056 0.0037 0.0605
Echinococcus multilocularis tumor protein p63 0.0347 0.0337 0.2301
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0042 0.0023 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0036
Onchocerca volvulus 0.0037 0.0018 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0053
Schistosoma mansoni hypothetical protein 0.0077 0.0059 0.0131
Entamoeba histolytica hypothetical protein 0.0077 0.0059 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0226 0.0212 0.0493
Loa Loa (eye worm) hypothetical protein 0.0076 0.0057 0.0133
Brugia malayi glutaminase DH11.1 0.4207 0.4312 1
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0037 0.0086
Plasmodium falciparum transporter, putative 0.0037 0.0018 0.0011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.0526 0.0522 0.121
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0045 0.029
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.9731 1 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0036 0.0017 0.0095
Brugia malayi mbt repeat family protein 0.0056 0.0037 0.0086
Schistosoma mansoni neprilysin-2 (M13 family) 0.0092 0.0075 0.0167
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0018 0.0104
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0145 0.0374
Trypanosoma cruzi Peptide deformylase 2, putative 0.3713 0.3803 1
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.0329 0.0858
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0016 0.0088
Schistosoma mansoni hypothetical protein 0.0339 0.0328 0.0755
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0119 0.0276
Onchocerca volvulus 0.0051 0.0032 0.0475
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0048 0.012
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.9731 1 1
Echinococcus granulosus smad 0.0036 0.0017 0.0095
Brugia malayi hypothetical protein 0.0077 0.0059 0.0137
Trichomonas vaginalis set domain proteins, putative 0.026 0.0247 0.0567
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0032 0.0067
Onchocerca volvulus 0.026 0.0247 0.5993
Loa Loa (eye worm) hypothetical protein 0.0111 0.0093 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0032 0.0074
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0045 0.0104
Echinococcus multilocularis adam 0.0073 0.0055 0.0359
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0037 0.0079
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0226 0.0212 0.021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0059 0.0388
Loa Loa (eye worm) hypothetical protein 0.0226 0.0212 0.0493
Echinococcus granulosus disintegrin and metalloproteinase 0.0042 0.0023 0.0138
Brugia malayi MH2 domain containing protein 0.0036 0.0017 0.0038
Schistosoma mansoni smad1 5 8 and 0.0036 0.0017 0.0032
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0421 0.0413 0.0951
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0059 0.0388
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Schistosoma mansoni hypothetical protein 0.0048 0.0029 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0037 0.0018 0.0042
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0037 0.0018 0.0104
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0037 0.0235
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0029 0.0068
Loa Loa (eye worm) hypothetical protein 0.0063 0.0045 0.0104
Schistosoma mansoni neprilysin 0.0048 0.0029 0.006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0029 0.006
Schistosoma mansoni microtubule-associated protein tau 0.1431 0.1453 0.3366
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0013 0.0073
Loa Loa (eye worm) MH1 domain-containing protein 0.0036 0.0017 0.0038
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0075 0.0167
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0045 0.029
Schistosoma mansoni smad1 5 8 and 0.0036 0.0017 0.0032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0042
Schistosoma mansoni smad 0.0036 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0135 0.0119 0.0276
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Brugia malayi ADAMTS-like protease 0.0031 0.0012 0.0027
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0018 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0013 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0135 0.0119 0.0276
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0011
Onchocerca volvulus 0.0186 0.0171 0.4034
Brugia malayi Matrixin family protein 0.0186 0.0171 0.0396
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0037 0.0605
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0135 0.0119 0.0276
Loa Loa (eye worm) matrixin family protein 0.0412 0.0404 0.0936
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.0329 0.0858
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0016 0.0036
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0675 0.0675 0.4632
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0045 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0183 0.0168 0.039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0012 0.0064
Trypanosoma cruzi Peptide deformylase 2, putative 0.3713 0.3803 1
Schistosoma mansoni endothelin-converting enzyme-related 0.0045 0.0026 0.0053
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0199 0.0184 0.125
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Entamoeba histolytica hypothetical protein 0.0077 0.0059 1
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0037 0.0235
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Echinococcus granulosus microtubule associated protein 2 0.1431 0.1453 1
Loa Loa (eye worm) glutaminase 2 0.4207 0.4312 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0526 0.0522 0.121
Echinococcus multilocularis serotonin transporter 0.0219 0.0205 0.1397
Echinococcus multilocularis microtubule associated protein 2 0.1431 0.1453 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0048 0.012
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0183 0.0168 0.0165
Trichomonas vaginalis glutaminase, putative 0.4207 0.4312 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0018 0.0035
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.003
Brugia malayi Pre-SET motif family protein 0.0228 0.0215 0.0498
Brugia malayi hypothetical protein 0.0073 0.0055 0.0127
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0003 0.0006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0026 0.0053
Echinococcus granulosus Smad4 0.0036 0.0017 0.0095
Loa Loa (eye worm) norepinephrine transporter 0.0219 0.0205 0.0476
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0093 0.0217
Mycobacterium ulcerans zinc metalloprotease 0.0183 0.0168 0.0165
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042
Echinococcus multilocularis endothelin converting enzyme 1 0.0183 0.0168 0.114
Onchocerca volvulus Matrilysin homolog 0.0186 0.0171 0.4034
Treponema pallidum polypeptide deformylase (def) 0.9731 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.0163 0.0161
Brugia malayi ADAM-TS Spacer 1 family protein 0.0031 0.0012 0.0027
Mycobacterium ulcerans hypothetical protein 0.0179 0.0163 0.0161
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0029 0.0068
Brugia malayi angiogenesis inhibito 0.0031 0.0012 0.0027
Schistosoma mansoni Smad4 0.0036 0.0017 0.0032
Echinococcus granulosus tumor protein p63 0.0347 0.0337 0.2301
Plasmodium vivax peptide deformylase, putative 0.9731 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0122 0.0283
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0219 0.0205 0.047
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0018 0.0011
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0264 0.0251 0.1714
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0018 0.0104
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0199 0.0184 0.125
Onchocerca volvulus 0.0037 0.0018 0.0118
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0093 0.0217
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0018 0.0104
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0059 0.0131
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0037 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0091 0.0073 0.0169
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0003 0.0006
Brugia malayi MH1 domain containing protein 0.0036 0.0017 0.0038
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0037 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0048 0.012
Echinococcus multilocularis adam 17 protease 0.0421 0.0413 0.2826
Mycobacterium leprae PROBABLE HYDROLASE 0.0226 0.0212 0.0045
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0144 0.0127 0.0289
Mycobacterium ulcerans epoxide hydrolase EphA 0.0336 0.0326 0.0323
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0042

Activities

Activity type Activity value Assay description Source Reference
IPol (functional) > 50000 nM In vitro cytotoxicity of the compound was measured after 4 hr of exposure against L1210 murine leukemia cells ChEMBL. 10866397

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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