Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | deoxyuridine triphosphatase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | VIR protein | deoxyuridine triphosphatase | 252 aa | 229 aa | 18.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2776 | 0.4146 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0091 | 0.2776 | 0.2776 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0094 | 0.286 | 0.286 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0362 | 0.0362 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.1092 | 0.3819 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0091 | 0.2776 | 0.9707 |
Brugia malayi | dUTP diphosphatase | 0.0091 | 0.2776 | 0.2776 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0296 | 1 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2776 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0094 | 0.286 | 0.286 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.0032 | 0.0673 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1233 | 0.1842 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2776 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.1233 | 0.1842 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0091 | 0.2776 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.6695 | 0.6695 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0094 | 0.286 | 1 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2776 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.286 | 0.4271 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0362 | 0.0362 |
Entamoeba histolytica | hypothetical protein | 0.006 | 0.1657 | 0.4682 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.286 | 0.4271 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0091 | 0.2776 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.6695 | 1 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2776 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0094 | 0.286 | 0.286 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0091 | 0.2776 | 0.9707 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0091 | 0.2776 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0362 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0362 | 0.5 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.0032 | 0.0673 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.1092 | 0.3819 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2776 | 1 |
Entamoeba histolytica | hypothetical protein | 0.006 | 0.1657 | 0.4682 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2776 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0094 | 0.286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.286 | 0.286 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0362 | 0.0362 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0362 | 0.5 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2776 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.286 | 0.4271 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 1 | 1 |
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.0032 | 0.0673 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2776 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2776 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0094 | 0.286 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2776 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.286 | 0.4271 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0091 | 0.2776 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0296 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0362 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0094 | 0.286 | 1 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0032 | 0.0673 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.0792 | 0.0792 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0202 | 0.6695 | 0.6695 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0889 | 0.0889 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0044 | 0.1092 | 0.1092 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0094 | 0.286 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0094 | 0.286 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2776 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 260 nM | BindingDB_Patents: Inhibition Assay. The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-3H]deoxyuridine triphosphate. | ChEMBL. | No reference |
IC50 (binding) | = 260 nM | BindingDB_Patents: Inhibition Assay. The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-3H]deoxyuridine triphosphate. | ChEMBL. | No reference |
IC50 (binding) | = 0.035 uM | Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysis | ChEMBL. | 22339362 |
IC50 (binding) | = 0.035 uM | Inhibition of human dUTPase-mediated formation of [5-3H]dUMP expressed in Escherichia coli BL21 (DE3) after 15 mins by HPLC analysis | ChEMBL. | 22607122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.