Detailed information for compound 1667221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 592.644 | Formula: C33H32N6O5
  • H donors: 1 H acceptors: 7 LogP: 1.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ncnc(c1)N1C(=O)N(C(=O)C21CCN(CC2)Cc1ncccc1C)c1ccc(cc1)c1ccc(c(c1)C)C(=O)O
  • InChi: 1S/C33H32N6O5/c1-21-5-4-14-34-27(21)19-37-15-12-33(13-16-37)31(42)38(32(43)39(33)28-18-29(44-3)36-20-35-28)25-9-6-23(7-10-25)24-8-11-26(30(40)41)22(2)17-24/h4-11,14,17-18,20H,12-13,15-16,19H2,1-3H3,(H,40,41)
  • InChiKey: DACGAATZKIWONI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens egl-9 family hypoxia-inducible factor 2 Starlite/ChEMBL References
Homo sapiens egl-9 family hypoxia-inducible factor 3 Starlite/ChEMBL References
Homo sapiens egl-9 family hypoxia-inducible factor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131326 All targets in OG5_131326
Neospora caninum 2OG-Fe(II) oxygenase family protein, putative Get druggable targets OG5_131326 All targets in OG5_131326
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein Get druggable targets OG5_146305 All targets in OG5_146305
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0097 0.0262 0.7737
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0087 0.0231 0.6829
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Onchocerca volvulus 0.0016 0.0012 0.0189
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0095 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.009 0.2653
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.009 0.2653
Entamoeba histolytica protein kinase rad3, putative 0.0023 0.0034 0.0997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0183 0.5406
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Schistosoma mansoni smad1 5 8 and 0.0043 0.0095 0.0095
Echinococcus multilocularis geminin 0.0134 0.0377 0.0377
Schistosoma mansoni smad 0.0019 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.0019 0.0022 0.0115
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Onchocerca volvulus 0.0019 0.0021 0.0322
Echinococcus multilocularis cysteine protease 0.0019 0.0021 0.0021
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0058 0.52
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0044 0.1296
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Entamoeba histolytica hypothetical protein 0.0087 0.0231 0.6829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0089 0.1394
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0044 0.1296
Onchocerca volvulus 0.0129 0.0361 0.5665
Loa Loa (eye worm) hypothetical protein 0.0358 0.1068 0.5601
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0122 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0149
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0026 0.0042 0.014
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.006 0.0149 0.0149
Brugia malayi cathepsin L-like precursor 0.0013 0.0001 0.0007
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Echinococcus multilocularis musashi 0.0129 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0052 0.0125 0.0654
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0026 0.0044 0.0147
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0021 0.0605
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0121 0.0336 0.0336
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0087 0.0231 0.0231
Schistosoma mansoni cpg binding protein 0.0026 0.0044 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0121 0.0336 0.1762
Echinococcus multilocularis lysosomal alpha glucosidase 0.0118 0.0329 0.0329
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0058 0.014 0.4148
Echinococcus multilocularis protein jagged 1 0.0016 0.0012 0.0012
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.007 0.0178 0.0178
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0121 0.0336 0.1762
Onchocerca volvulus 0.0019 0.0021 0.0322
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0095 0.0095
Echinococcus granulosus protein jagged 1 0.0016 0.0012 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0044 0.1296
Leishmania major cathepsin L-like protease 0.0019 0.0021 0.0605
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0051 0.0119 0.3509
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0039 0.0084 0.044
Entamoeba histolytica cysteine protease, putative 0.0019 0.0021 0.0605
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0023 0.0034 0.0034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0041 0.0089 0.0089
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.009 1
Echinococcus granulosus slit 2 protein 0.0016 0.0012 0.0012
Schistosoma mansoni ferritin 0.0017 0.0015 0.0015
Echinococcus multilocularis sterol regulatory element binding protein 0.0039 0.0083 0.0083
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.0044 0.1296
Echinococcus granulosus Niemann Pick C1 protein 0.009 0.0242 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0187 0.2943
Mycobacterium ulcerans hypothetical protein 0.0041 0.009 0.6659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0089 0.1394
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0017 0.0088
Loa Loa (eye worm) Notch2 0.0016 0.0012 0.0063
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0021 0.0021
Brugia malayi Trypsin-like protease protein 5 0.0025 0.004 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Loa Loa (eye worm) nuclear factor I 0.0024 0.0036 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0207 0.3248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.022
Echinococcus multilocularis neurogenic locus notch protein 4 0.0016 0.0012 0.0012
Echinococcus granulosus lysosomal alpha glucosidase 0.0118 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0044 0.01 0.01
Brugia malayi AMP-binding enzyme family protein 0.0041 0.009 0.0471
Echinococcus multilocularis protein dispatched 1 0.0044 0.0099 0.0099
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.006 0.0149 0.0783
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.007 0.0178 0.5251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0185 0.2908
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0041 0.0089 0.0089
Toxoplasma gondii cathepsin CPL 0.0019 0.0021 0.0069
Schistosoma mansoni smad 0.0043 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0177
Brugia malayi MH1 domain containing protein 0.0043 0.0095 0.0499
Schistosoma mansoni alpha-glucosidase 0.0102 0.0278 0.0278
Echinococcus granulosus geminin 0.0134 0.0377 0.0377
Brugia malayi Smad1 0.0043 0.0095 0.0499
Brugia malayi Cathepsin L-like precursor 0.0013 0.0001 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0021 0.1848
Loa Loa (eye worm) trypsin family protein 0.0025 0.004 0.0208
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.007 0.0178 0.0595
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0097 0.0262 0.7737
Echinococcus multilocularis Niemann Pick C1 protein 0.0129 0.0362 0.0362
Echinococcus multilocularis glycoprotein Antigen 5 0.0049 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.007 0.0178 0.0932
Echinococcus granulosus tumor protein p63 0.1357 0.4158 0.4158
Echinococcus multilocularis tumor protein p63 0.1357 0.4158 0.4158
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.3891
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Echinococcus granulosus Mastin 0.0049 0.0114 0.0114
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Echinococcus granulosus notch 0.0016 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Echinococcus multilocularis fibrillin 1 0.0033 0.0066 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.3891
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0044 0.069
Leishmania major cathepsin L-like protease 0.0071 0.0183 0.5406
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Schistosoma mansoni hypothetical protein 0.0134 0.0377 0.0377
Echinococcus granulosus expressed conserved protein 0.0085 0.0225 0.0225
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0021 0.0021
Schistosoma mansoni apoferritin-2 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Echinococcus multilocularis fat cadherin tumor suppressor 0.0016 0.0012 0.0012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0122 0.0339 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0021 0.0322
Brugia malayi AMP-binding enzyme family protein 0.0041 0.009 0.0471
Schistosoma mansoni hypothetical protein 0.0025 0.004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0049 0.0049
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0122 0.0339 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0206
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Echinococcus multilocularis lysosomal alpha glucosidase 0.0118 0.0329 0.0329
Echinococcus granulosus protein jagged 1 0.0016 0.0012 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0041 0.0089 0.2621
Onchocerca volvulus Slit protein homolog 0.0016 0.0012 0.0189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0198 0.0576 0.0576
Echinococcus granulosus protein jagged 2 0.0016 0.0012 0.0012
Echinococcus multilocularis smad 0.0043 0.0095 0.0095
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0122 0.0339 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0089 0.1394
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0121 0.0336 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.0658
Onchocerca volvulus 0.0025 0.004 0.0624
Onchocerca volvulus 0.0048 0.0111 0.1743
Leishmania major phosphatidylinositol 3-kinase, putative 0.0041 0.0089 0.2621
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.007 0.0178 0.0595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.009 0.0242 0.7145
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0183 0.5406
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0041 0.0089 0.2621
Brugia malayi Calcitonin receptor-like protein seb-1 0.0382 0.1143 0.5993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0166 0.2603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0115
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0021 0.0108
Schistosoma mansoni hypothetical protein 0.0048 0.0111 0.0111
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0041 0.009 0.6659
Schistosoma mansoni hypothetical protein 0.0121 0.0336 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0187 0.2943
Brugia malayi Cadherin domain containing protein 0.0016 0.0012 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0021 0.0021
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0023 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0365 0.1092 0.1092
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0041 0.0089 0.2621
Onchocerca volvulus 0.0028 0.0049 0.0772
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0744 0.2264 0.2264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0135 1
Echinococcus multilocularis Tolloid protein 1 0.0033 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0044 0.069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0087 0.0231 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0149
Trichomonas vaginalis set domain proteins, putative 0.0218 0.0637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0998
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0044 0.023
Brugia malayi Protein kinase domain containing protein 0.0048 0.0111 0.0582
Echinococcus granulosus Tolloid protein 1 0.0033 0.0066 0.0066
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0015 0.1136
Loa Loa (eye worm) hypothetical protein 0.0198 0.0576 0.3021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0155 0.0811
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0015 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.007 0.0178 0.0932
Echinococcus multilocularis protein jagged 2 0.0016 0.0012 0.0012
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.007 0.0178 0.0595
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0345
Echinococcus multilocularis Mastin 0.0049 0.0114 0.0114
Echinococcus multilocularis tissue type plasminogen activator 0.0048 0.0111 0.0111
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0122 0.0339 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0345
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0044 0.069
Onchocerca volvulus 0.0026 0.0044 0.0693
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0118 0.0329 0.1724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0089 0.1394
Brugia malayi notch-like transmembrane receptor 0.0016 0.0012 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0041 0.009 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0262 0.4112
Mycobacterium ulcerans hypothetical protein 0.0025 0.004 0.2944
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0025 0.004 0.004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0058 0.4276
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Echinococcus multilocularis cpg binding protein 0.0028 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Echinococcus multilocularis expressed conserved protein 0.0085 0.0225 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0261 0.077 0.4035
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.1297
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0056 0.0137 0.2154
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) fibroinase 0.0019 0.0021 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0165 0.2598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0089 0.1394
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0135 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0049 0.0049
Echinococcus granulosus protein jagged 2 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0017 0.0017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0049 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0262 0.4112
Echinococcus granulosus neutral alpha glucosidase AB 0.0026 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0262 0.4112
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.007 0.0178 0.5251
Onchocerca volvulus Putative cubilin 0.0016 0.0012 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0166 0.2603
Schistosoma mansoni ferritin 0.0017 0.0015 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0044 0.069
Echinococcus multilocularis Niemann Pick C1 protein 0.009 0.0242 0.0242
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0021 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0034 0.0177
Brugia malayi Kringle domain containing protein 0.0048 0.0111 0.0582
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0122 0.0339 0.0339
Onchocerca volvulus 0.0199 0.0577 0.9059
Brugia malayi TAR-binding protein 0.0039 0.0084 0.044
Schistosoma mansoni intermediate filament proteins 0.0129 0.0361 0.0361
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.007 0.0178 0.5251
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0208
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0135 0.0135
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0021 0.1848
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0303
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0043 0.0095 0.0499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.009 0.6659
Echinococcus multilocularis transmembrane protease serine 3 0.0025 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0078
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0021 0.0108
Onchocerca volvulus 0.0016 0.0012 0.0189
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0574
Toxoplasma gondii FATC domain-containing protein 0.0023 0.0034 0.0113
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.0044 0.023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0021 0.0021
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0033 0.0066 0.0345
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.009 0.2653
Schistosoma mansoni Smad4 0.0019 0.0022 0.0022
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0044 0.069
Loa Loa (eye worm) phosphatidylinositol 3 0.0122 0.0339 0.1776
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Brugia malayi hypothetical protein 0.0015 0.001 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Loa Loa (eye worm) latrophilin receptor protein 2 0.0121 0.0336 0.1762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Trypanosoma cruzi target of rapamycin kinase 3 0.0097 0.0262 0.7737
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.001 0.0281
Brugia malayi MH2 domain containing protein 0.0043 0.0095 0.0499
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0339 0.5321
Echinococcus granulosus GPCR family 2 0.0121 0.0336 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0121 0.0336 0.0336
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0017 0.0017
Brugia malayi hypothetical protein 0.0025 0.004 0.0208
Schistosoma mansoni microtubule-associated protein tau 0.3246 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0242 0.1269
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0188
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0208
Brugia malayi hypothetical protein 0.0217 0.0634 0.3322
Brugia malayi Trypsin family protein 0.0025 0.004 0.0208
Loa Loa (eye worm) Smad1 0.0043 0.0095 0.0499
Echinococcus multilocularis Smad4 0.0043 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Toxoplasma gondii EGF family domain-containing protein 0.0016 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0078
Schistosoma mansoni laminin gamma-3 chain 0.0016 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0023 0.0034 0.0997
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0471
Loa Loa (eye worm) hypothetical protein 0.006 0.0147 0.0773
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0021 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0215 0.3376
Leishmania major cathepsin L-like protease 0.0019 0.0021 0.0605
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0111 0.0582
Brugia malayi intermediate filament protein 0.0129 0.0361 0.1891
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0084 0.0084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0129 0.0361 0.1891
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0303
Giardia lamblia GTOR 0.0122 0.0339 1
Onchocerca volvulus 0.0129 0.0361 0.5665
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0208
Schistosoma mansoni microsomal glutathione s-transferase 0.0057 0.0138 0.0138
Echinococcus granulosus neurogenic locus notch protein 4 0.0016 0.0012 0.0012
Echinococcus granulosus delta-like protein 1 0.0016 0.0012 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0217 0.0634 0.0634
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.009 0.2653
Plasmodium falciparum cysteine repeat modular protein 1 0.0048 0.0111 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0022 0.0022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0118 0.0329 0.1724
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0089 0.0465
Echinococcus granulosus enteropeptidase 0.0049 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0166 0.2603
Schistosoma mansoni alpha glucosidase 0.0026 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0021 0.0322
Echinococcus multilocularis cysteine protease 0.0019 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0165 0.2598
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0022 0.0022
Schistosoma mansoni ferritin light chain 0.0017 0.0015 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0135 0.0451
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0165 0.2598
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0071 0.0183 0.5406
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0049 0.0049
Echinococcus granulosus tar DNA binding protein 0.0039 0.0084 0.0084
Echinococcus multilocularis slit 2 protein 0.0016 0.0012 0.0012
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.007 0.0178 0.0595
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0044 0.1296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0339 0.5321
Onchocerca volvulus 0.0019 0.0021 0.0322
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0167 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0015 0.001 0.093
Echinococcus granulosus tissue type plasminogen activator 0.0048 0.0111 0.0111
Brugia malayi GCC2 and GCC3 family protein 0.0016 0.0012 0.0063
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0012 0.0063
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0021 0.0322
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0031 0.0058 0.5
Echinococcus multilocularis notch 0.0016 0.0012 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0135 0.0135
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0021 0.0021
Plasmodium vivax SET domain protein, putative 0.0028 0.0049 0.4428
Toxoplasma gondii calcium binding egf domain-containing protein 0.0033 0.0066 0.022
Brugia malayi prolyl 4-hydroxylase 0.007 0.0178 0.0932
Echinococcus multilocularis neural cadherin 0.0016 0.0012 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0183 0.5406
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0015 0.5
Brugia malayi hypothetical protein 0.0087 0.0231 0.1213
Brugia malayi CHE-14 protein 0.0039 0.0083 0.0433
Toxoplasma gondii target of rapamycin (TOR), putative 0.009 0.0242 0.081
Schistosoma mansoni transcription factor LCR-F1 0.0087 0.0231 0.0231
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0058 0.52
Toxoplasma gondii calcium binding egf domain-containing protein 0.0033 0.0066 0.022
Echinococcus multilocularis expressed protein 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0217 0.0634 0.3322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0041 0.009 0.6659
Schistosoma mansoni smad1 5 8 and 0.0043 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0044 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.3891
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0129 0.0361 0.1891
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0208
Loa Loa (eye worm) RNA binding protein 0.0039 0.0084 0.044
Schistosoma mansoni cell polarity protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Leishmania major cathepsin L-like protease 0.0071 0.0183 0.5406
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0041 0.009 0.6659
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0039 0.0084 0.044
Schistosoma mansoni smad1 5 8 and 0.0043 0.0095 0.0095
Brugia malayi Trypsin family protein 0.0198 0.0576 0.3021
Schistosoma mansoni patched 1 0.0039 0.0083 0.0083
Echinococcus granulosus neuropeptide receptor A26 0.0365 0.1092 0.1092
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0339 0.1776
Schistosoma mansoni hypothetical protein 0.0134 0.0377 0.0377
Toxoplasma gondii kringle domain-containing protein 0.0048 0.0111 0.0371
Echinococcus granulosus lamin 0.0129 0.0361 0.0361
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0044 0.0231
Echinococcus granulosus intermediate filament protein 0.0129 0.0361 0.0361
Onchocerca volvulus 0.0041 0.009 0.1412
Brugia malayi Fibulin-1 precursor 0.0033 0.0066 0.0345
Loa Loa (eye worm) ctsf protein 0.0019 0.0021 0.0108
Echinococcus granulosus smad 0.0043 0.0095 0.0095
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0087 0.0231 0.0231
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0001 0.0007
Echinococcus multilocularis lamin 0.0129 0.0361 0.0361
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0048 0.0111 1
Schistosoma mansoni hypothetical protein 0.0121 0.0336 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0021 0.1848
Loa Loa (eye worm) hypothetical protein 0.0198 0.0576 0.3021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.0129 0.0362 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0001 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0284 0.4457
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0164 0.4841
Brugia malayi Cathepsin L-like precursor 0.0013 0.0001 0.0007
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.006 0.0149 0.0783
Brugia malayi Trypsin family protein 0.0025 0.004 0.0208
Trypanosoma brucei glucosidase, putative 0.0026 0.0044 0.1296
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0095 0.0499
Onchocerca volvulus 0.0025 0.004 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni ferritin 0.0017 0.0015 0.0015
Onchocerca volvulus Arrow homolog 0.0033 0.0066 0.1035
Echinococcus granulosus cathepsin l1 0.0013 0.0001 0.0001
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.007 0.0178 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0135 1
Echinococcus granulosus serine protein kinase ATM 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.009 0.6659
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0198 0.0576 0.0576
Onchocerca volvulus 0.0019 0.0021 0.0322
Trypanosoma brucei PAB1-binding protein , putative 0.0015 0.001 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0345
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Onchocerca volvulus 0.0016 0.0012 0.0189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0053 0.3891
Echinococcus multilocularis laminin 0.0033 0.0066 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0095 0.0095
Brugia malayi Calcium binding EGF domain containing protein 0.0033 0.0066 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni ferritin 0.0017 0.0015 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0044 0.069
Onchocerca volvulus 0.0019 0.0021 0.0322
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0122 0.0339 1
Schistosoma mansoni alpha-glucosidase 0.0102 0.0278 0.0278
Onchocerca volvulus 0.0068 0.0174 0.274
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0012 0.0063
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0034 0.0531
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0062 0.0155 0.0155
Onchocerca volvulus 0.007 0.0178 0.2794
Entamoeba histolytica acyl-coA synthetase, putative 0.0041 0.009 0.2653
Brugia malayi Trypsin family protein 0.0025 0.004 0.0208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.0555 0.291
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0167 0.0167
Echinococcus granulosus glycoprotein Antigen 5 0.0049 0.0114 0.0114
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0015 0.001 0.093
Brugia malayi MH1 domain containing protein 0.0043 0.0095 0.0499
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.004 0.004
Trichomonas vaginalis sucrase-isomaltase, putative 0.0026 0.0044 0.069
Brugia malayi Cathepsin L-like precursor 0.0019 0.0021 0.0108
Echinococcus multilocularis protein patched 0.0039 0.0083 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Schistosoma mansoni survival motor neuron protein 0.0044 0.01 0.01
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0015 0.1706
Onchocerca volvulus 0.0019 0.0021 0.0322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0056 0.0137 0.2154
Schistosoma mansoni lamin 0.0129 0.0361 0.0361
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0044 0.069
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0166 0.2603
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0025 0.004 0.004
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0025 0.004 0.004
Echinococcus multilocularis microtubule associated protein 2 0.3246 1 1
Brugia malayi FAT domain containing protein 0.0018 0.0018 0.0092
Brugia malayi CXXC zinc finger family protein 0.0026 0.0044 0.0231
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.004 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.009 0.6659
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0016 0.0012 0.0189
Schistosoma mansoni apoferritin-2 0.0017 0.0015 0.0015
Echinococcus granulosus fibropellin Ia 0.0016 0.0012 0.0012
Echinococcus granulosus ferritin 0.0017 0.0015 0.0015
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0021 0.0021
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0023 0.0034 0.0997
Onchocerca volvulus 0.0044 0.01 0.1563
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.009 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.012 0.0402
Entamoeba histolytica hypothetical protein 0.0087 0.0231 0.6829
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Schistosoma mansoni slit 0.0016 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0021 0.0605
Schistosoma mansoni egf-like domain protein 0.0033 0.0066 0.0066
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.009 0.2653
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.009 0.6659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Brugia malayi Cadherin domain containing protein 0.0016 0.0012 0.0063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0122 0.0339 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0382 0.1143 0.5993
Echinococcus multilocularis lamin dm0 0.0129 0.0361 0.0361
Echinococcus multilocularis ferritin 0.0017 0.0015 0.0015
Echinococcus granulosus neurogenic locus protein delta 0.0016 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Onchocerca volvulus Neurogenic locus notch homolog 0.0016 0.0012 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0242 0.3807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Plasmodium vivax vivapain-2 0.0019 0.0021 0.1848
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0049 0.0049
Onchocerca volvulus 0.0173 0.0499 0.784
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0122 0.0339 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0015 0.1136
Schistosoma mansoni hypothetical protein 0.0261 0.077 0.077
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0089 0.0465
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0069 0.0176 0.0922
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0041 0.0089 0.2621
Plasmodium vivax ataxin-2 like protein, putative 0.0015 0.001 0.093
Brugia malayi Muscle positioning protein 4 0.0016 0.0012 0.0063
Schistosoma mansoni hypothetical protein 0.0121 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0057 0.0138 0.0138
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0048 0.0111 0.0582
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0049 0.0164
Loa Loa (eye worm) TAR-binding protein 0.0039 0.0084 0.044
Leishmania major cathepsin L-like protease 0.0019 0.0021 0.0605
Echinococcus multilocularis enteropeptidase 0.0049 0.0114 0.0114
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Leishmania major hypothetical protein, conserved 0.0048 0.0111 0.3276
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0025 0.004 0.004
Echinococcus multilocularis tar DNA binding protein 0.0039 0.0084 0.0084
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0069 0.0176 0.0922
Loa Loa (eye worm) intermediate filament protein 0.0129 0.0361 0.1891
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0017 0.0017
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0084 0.0084
Echinococcus granulosus neural cadherin 0.0016 0.0012 0.0012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0122 0.0339 1
Onchocerca volvulus 0.0218 0.0637 1
Schistosoma mansoni Smad4 0.0043 0.0095 0.0095
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.0577 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0084 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0135 1
Toxoplasma gondii LsmAD domain-containing protein 0.0015 0.001 0.0035
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Echinococcus granulosus neuropeptide s receptor 0.0365 0.1092 0.1092
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0135 0.0135
Onchocerca volvulus 0.0025 0.004 0.0624
Leishmania major hypothetical protein, conserved 0.0015 0.001 0.0305
Echinococcus multilocularis serine protein kinase ATM 0.0023 0.0034 0.0034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.004 0.004
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0021 0.0605
Loa Loa (eye worm) hypothetical protein 0.0126 0.0353 0.1853
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0034 0.0177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0135 0.3984
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0095 0.0499
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0187 0.2943
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0111 0.3276
Echinococcus multilocularis GPCR, family 2 0.0121 0.0336 0.0336
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0022 0.0115
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0041 0.0089 0.2621
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0021 0.0605
Schistosoma mansoni ferritin light chain 0.0017 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0084 0.0084
Brugia malayi Delta serrate ligand family protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0208
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0033 0.0066 0.0345
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0092 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0015 0.1136
Onchocerca volvulus 0.0013 0.0001 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0121 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0471
Schistosoma mansoni hypothetical protein 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.005
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0136 0.4013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0303
Echinococcus granulosus cpg binding protein 0.0028 0.0049 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0382 0.1143 0.5993
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0139 0.0139
Onchocerca volvulus 0.0019 0.0021 0.0322
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0247 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0382 0.1143 0.5993
Schistosoma mansoni hypothetical protein 0.0121 0.0336 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Onchocerca volvulus 0.0198 0.0576 0.9051
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0345
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0979 0.2991 1
Echinococcus granulosus transmembrane protease serine 3 0.0025 0.004 0.004
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Echinococcus multilocularis protein jagged 1 0.0016 0.0012 0.0012
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0041 0.0089 0.0089
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0021 0.0322
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.004 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Brugia malayi Pre-SET motif family protein 0.0192 0.0555 0.291
Echinococcus granulosus sterol regulatory element binding protein 0.0039 0.0083 0.0083
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0022 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Leishmania major cathepsin L-like protease 0.0019 0.0021 0.0605
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0034 0.0997
Echinococcus granulosus Protein patched homolog 1 0.0039 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0345
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.004 0.004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0039 0.0083 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0185 0.2908
Onchocerca volvulus 0.0025 0.004 0.0624
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0022 0.0344
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0058 0.4276
Trypanosoma cruzi PAB1-binding protein , putative 0.0015 0.001 0.0305
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0022 0.0115
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0012 0.0012
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0025 0.004 0.0208
Brugia malayi MH2 domain containing protein 0.0629 0.1907 1
Schistosoma mansoni septate junction protein 0.0016 0.0012 0.0012
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0188
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0095 0.0095
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.007 0.0178 0.5251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0262 0.4112
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0062 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0087 0.0231 0.6829
Echinococcus multilocularis neuropeptide s receptor 0.0365 0.1092 0.1092
Echinococcus granulosus expressed protein 0.0017 0.0015 0.0015
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0044 0.069
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0023 0.0034 0.0997
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0017 0.0017
Leishmania major hypothetical protein, unknown function 0.007 0.0178 0.5251
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.009 0.6659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0018 0.0277
Echinococcus multilocularis fibropellin Ia 0.0016 0.0012 0.0012
Echinococcus granulosus cathepsin l1 0.0019 0.0021 0.0021
Brugia malayi RNA binding protein 0.0039 0.0084 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni Smad4 0.0019 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0339 0.5321
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0033 0.0066 0.0066
Echinococcus multilocularis neutral alpha glucosidase AB 0.0026 0.0044 0.0044
Echinococcus granulosus laminin 0.0033 0.0066 0.0066
Brugia malayi EGF-like domain containing protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0033 0.0066 0.0345
Schistosoma mansoni notch 0.0016 0.0012 0.0012
Leishmania major cathepsin L-like protease 0.0019 0.0021 0.0605
Trypanosoma cruzi PAB1-binding protein , putative 0.0015 0.001 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0034 0.0531
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.01 0.0522
Brugia malayi Pre-SET motif family protein 0.0028 0.0049 0.0258
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0121 0.0336 0.1762
Plasmodium vivax vivapain-2 0.0019 0.0021 0.1848
Loa Loa (eye worm) hypothetical protein 0.0199 0.0577 0.3024
Echinococcus granulosus lamin dm0 0.0129 0.0361 0.0361
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0015 0.1136
Loa Loa (eye worm) hypothetical protein 0.006 0.0147 0.0773
Toxoplasma gondii MAPEG family protein 0.0057 0.0138 0.0462
Echinococcus granulosus Smad4 0.0043 0.0095 0.0095
Onchocerca volvulus 0.0025 0.004 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0001 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0629 0.1907 1
Onchocerca volvulus 0.0016 0.0012 0.0189
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0183 0.5406
Echinococcus granulosus microsomal glutathione S transferase 3 0.0057 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.006 0.0149 0.0149
Brugia malayi Niemann-Pick C1 protein precursor 0.009 0.0242 0.1269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0021 0.0322
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.007 0.0178 0.0178
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0262 0.4112
Schistosoma mansoni fkbp-rapamycin associated protein 0.0023 0.0034 0.0034
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.0012 0.0063
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0017 0.0017
Trichomonas vaginalis ferritin, putative 0.0017 0.0015 0.0241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0261 0.077 0.4035
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0021 0.0322
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0997
Loa Loa (eye worm) transcription factor SMAD2 0.0629 0.1907 1
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0001 0.0041
Onchocerca volvulus 0.0016 0.0012 0.0189
Loa Loa (eye worm) cysteine protease 0.0019 0.0021 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.009 0.6659
Loa Loa (eye worm) notch protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0217 0.0634 0.0634
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0122 0.0339 0.0339
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0183 0.5406
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0303
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0063
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0033 0.0066 0.0345
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0016 0.0012 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0129 0.0361 0.1891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0034 0.0531
Schistosoma mansoni lamin 0.0129 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0078

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 5400 ng/L Increase in erythropoietin secretion in C57BL/6 mouse plasma at 15 mg/kg, iv measured after 4 hrs ChEMBL. 22364528
IC50 (binding) = 0.3 nM Inhibition of PHD1 ChEMBL. 22364528
IC50 (binding) = 0.5 nM Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis ChEMBL. 22364528
IC50 (binding) = 5.8 nM Inhibition of PHD3 ChEMBL. 22364528
IC50 (binding) = 23 uM Binding affinity to human Erg ChEMBL. 22364528
IC50 (ADMET) > 50 uM Inhibition of CYP3A4 ChEMBL. 22364528
IC50 (ADMET) > 50 uM Inhibition of CYP2C9 ChEMBL. 22364528
IC50 (ADMET) > 50 uM Inhibition of CYP2D6 ChEMBL. 22364528

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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