Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1521 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.7395 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.1068 | 0.1287 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0563 | 0.0592 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0743 | 0.0667 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1521 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.1068 | 0.1188 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1521 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3751 | 0.3751 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0563 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.9272 | 1 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1471 | 0.1471 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.7395 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1521 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4491 | 0.4769 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4166 | 0.4413 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1521 | 0.1521 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1521 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3348 | 0.4427 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0743 | 0.0774 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1521 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1521 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.1068 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3763 | 0.3972 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1521 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0237 | 0.0114 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3348 | 0.4427 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.8005 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0563 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1521 | 0.1519 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 14.07 uM | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 22677031 |
Survival (functional) | = 42.19 % | Cytotoxicity against human K562 cells assessed as cell survival at 50 uM after 72 hrs by MTT assay relative to control | ChEMBL. | 22677031 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22677031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.