Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | egl-9 family hypoxia-inducible factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Neospora caninum | 2OG-Fe(II) oxygenase family protein, putative | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0378 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.003 | 0.0165 | 0.1041 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0026 | 0.0033 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0378 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0378 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0378 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0026 | 0.0033 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.7953 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0378 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0026 | 0.0033 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0056 | 0.0901 | 0.8401 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0076 | 0.1472 | 1 |
Onchocerca volvulus | 0.0026 | 0.0033 | 0.5 | |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0062 | 0.1066 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0076 | 0.1472 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0026 | 0.0033 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0378 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1472 | 0.1851 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0026 | 0.0033 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0026 | 0.0033 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0052 | 0.0781 | 0.5198 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0052 | 0.0781 | 0.5198 |
Loa Loa (eye worm) | oxidoreductase | 0.0026 | 0.0033 | 0.0041 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0026 | 0.0033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0033 | 0.0041 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0052 | 0.0781 | 0.5871 |
Loa Loa (eye worm) | glutamate receptor | 0.0062 | 0.1066 | 0.1341 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0378 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.0165 | 0.1283 |
Onchocerca volvulus | 0.0026 | 0.0033 | 0.5 | |
Leishmania major | pteridine reductase 1 | 0.0026 | 0.0033 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0026 | 0.0033 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0026 | 0.0033 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0026 | 0.0033 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0071 | 0.1307 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0026 | 0.0033 | 0.0041 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0026 | 0.0033 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0026 | 0.0033 | 0.0041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140 nM | Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis | ChEMBL. | 22364528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.