Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 0.1969 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.2667 | 0.6023 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1257 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0584 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.465 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2667 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2667 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.2042 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.2667 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.2667 | 0.5651 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.465 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4393 | 0.4363 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2667 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1257 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2667 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.2667 | 0.5651 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1257 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2667 | 0.6023 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2667 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1996 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2667 | 0.2628 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2667 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2667 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0056 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2667 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2667 | 0.2966 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4678 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4393 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2667 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4678 | 1 |
Onchocerca volvulus | 0.0029 | 0.4393 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.8867 | 1 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1257 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2667 | 0.2628 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4393 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli 1356 after 24 hrs by two-fold serial dilution method | ChEMBL. | 22703706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.