Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.222 uM | Antiproliferative activity against human DU145 cells at 96 hrs by WST1 assay | ChEMBL. | 22247790 |
GI50 (functional) | = 0.234 uM | Growth inhibition of human MDA-MB-231 cells | ChEMBL. | 25992880 |
IC50 (functional) | = 230 nM | Antiproliferative activity against human CA46 cells | ChEMBL. | 22247790 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22247790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.