Detailed information for compound 166825

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 204.227 | Formula: C7H16N4O3
  • H donors: 5 H acceptors: 3 LogP: -5.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC[C@@H](C(=O)NC(C(=O)O)CN)N
  • InChi: 1S/C7H16N4O3/c8-2-1-4(10)6(12)11-5(3-9)7(13)14/h4-5H,1-3,8-10H2,(H,11,12)(H,13,14)/t4-,5?/m0/s1
  • InChiKey: KPMYCAYNGIDJGA-ROLXFIACSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Plasmodium vivax aldehyde reductase, putative 0.0029 0.0271 0.3215
Echinococcus granulosus voltage gated potassium channel subunit 0.0029 0.0271 0.0233
Schistosoma mansoni pol-related 0.0099 0.1766 0.1766
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0488 1 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0459 0.126
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0029 0.0271 0.032
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0082 0.1389 0.1291
Schistosoma mansoni ran 0.0021 0.0112 0.0112
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.0271 0.032
Loa Loa (eye worm) oxidoreductase 0.0099 0.1766 0.2798
Onchocerca volvulus 0.0038 0.0459 0.0642
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0082 0.1389 0.1389
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0112 0.0074
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0127 0.0142
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0029 0.0271 0.0957
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0459 0.7044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0039 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0459 0.042
Schistosoma mansoni aldo-keto reductase 0.0099 0.1766 0.1766
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Echinococcus granulosus geminin 0.0196 0.3818 0.3794
Trypanosoma brucei aldo-keto reductase, putative 0.0099 0.1766 1
Leishmania major GTP-binding protein, putative 0.0021 0.0112 0.0637
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Echinococcus multilocularis aldo keto reductase 0.0099 0.1766 0.1734
Echinococcus granulosus ubiquitin specific protease 41 0.0082 0.1389 0.1355
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0478 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.1766 0.3342
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0271 0.032
Schistosoma mansoni hypothetical protein 0.0196 0.3818 0.3818
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0459 0.042
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.1766 0.176
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0459 0.2599
Echinococcus granulosus kelch ECH associated protein 1 like 0.0198 0.3862 0.3838
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.0271 0.032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0457 0.042
Brugia malayi beta-lactamase family protein 0.0038 0.0459 0.0452
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0197 0.1723
Entamoeba histolytica aldose reductase, putative 0.0099 0.1766 0.1672
Mycobacterium tuberculosis Conserved protein 0.0038 0.0459 0.042
Loa Loa (eye worm) hypothetical protein 0.004 0.0511 0.0766
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0478 0.037
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.1766 0.176
Entamoeba histolytica hypothetical protein 0.0488 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.1766 0.3342
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0112 0.0074
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0459 0.042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0604 0.0995
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Onchocerca volvulus 0.0038 0.0459 0.0642
Echinococcus multilocularis kelch ECH associated protein 1 0.0198 0.3862 0.3838
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Leishmania major prostaglandin f synthase, putative 0.0099 0.1766 1
Echinococcus granulosus hypothetical protein 0.0099 0.1766 0.1734
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0158 0.0093
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Echinococcus granulosus aldo keto reductase 0.0099 0.1766 0.1734
Echinococcus granulosus zinc finger protein 0.0024 0.0169 0.0131
Onchocerca volvulus 0.0099 0.1766 0.5098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3394 0.6633
Schistosoma mansoni aldo-keto reductase 0.0099 0.1766 0.1766
Schistosoma mansoni hypothetical protein 0.0196 0.3818 0.3818
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Brugia malayi beta-lactamase 0.0038 0.0459 0.0452
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.0271 0.016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0638 0.0971
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.1389 0.1383
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0197 0.1117
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0112 0.0105
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Loa Loa (eye worm) oxidoreductase 0.0099 0.1766 0.2798
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Entamoeba histolytica hypothetical protein 0.0488 1 1
Echinococcus multilocularis aldo keto reductase 0.0099 0.1766 0.1734
Brugia malayi PHD-finger family protein 0.003 0.0287 0.028
Echinococcus multilocularis ubiquitin specific protease 41 0.0082 0.1389 0.1355
Mycobacterium ulcerans lipase LipD 0.0038 0.0459 0.126
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0459 0.0422
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.523 0.8411
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0459 0.2599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0681 0.104
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0459 0.126
Echinococcus granulosus kelch ECH associated protein 1 0.0198 0.3862 0.3838
Echinococcus multilocularis snurportin 1 0.0309 0.6211 0.6196
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.1059 0.1024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.476 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0029 0.0271 0.0233
Mycobacterium tuberculosis Conserved protein 0.0038 0.0459 0.042
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0029 0.0271 0.0375
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0082 0.1389 0.7719
Onchocerca volvulus 0.0099 0.1766 0.5098
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3394 0.6633
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0457 0.042
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0082 0.1389 0.7865
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0029 0.0271 0.0957
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Entamoeba histolytica aldose reductase, putative 0.0099 0.1766 0.1672
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0478 0.221
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.0093
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0604 0.0995
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0029 0.0271 0.0264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1389 0.7865
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0274 0.1554
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0118
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0099 0.1766 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0198 0.3862 0.3838
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0459 0.0459
Entamoeba histolytica hypothetical protein 0.0488 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0029 0.0271 0.433
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Brugia malayi hypothetical protein 0.0025 0.0197 0.019
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0197 0.2321
Onchocerca volvulus 0.0099 0.1766 0.5098
Loa Loa (eye worm) beta-lactamase 0.0038 0.0459 0.0681
Echinococcus multilocularis aldo keto reductase 0.0099 0.1766 0.1734
Echinococcus granulosus snurportin 1 0.0309 0.6211 0.6196
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Mycobacterium leprae Probable lipase LipE 0.0038 0.0459 0.126
Mycobacterium leprae Conserved hypothetical protein 0.0071 0.1156 0.5922
Onchocerca volvulus 0.0099 0.1766 0.5098
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0274 0.098
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0197 0.1117
Toxoplasma gondii aldose reductase, putative 0.0099 0.1766 1
Loa Loa (eye worm) acetyltransferase 0.0146 0.2744 0.4383
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0459 0.0422
Toxoplasma gondii ABC1 family protein 0.0038 0.0459 0.2096
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0161 0.0122
Echinococcus granulosus kelch ECH associated protein 1 like 0.0198 0.3862 0.3838
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0604 0.2976
Mycobacterium ulcerans oxidoreductase 0.0099 0.1766 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0169 0.0131
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0604 0.2976
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0459 0.0452
Onchocerca volvulus 0.0038 0.0459 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.1766 0.3342
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.1389 0.258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1389 0.7865
Schistosoma mansoni potassium channel beta 0.0029 0.0271 0.0271
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.2606 0.2577
Loa Loa (eye worm) hypothetical protein 0.0082 0.1389 0.2187
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0604 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.0637
Brugia malayi beta-lactamase family protein 0.0038 0.0459 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0488 1 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0161 0.0161
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.0271 0.032
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0099 0.1766 1
Leishmania major aldo-keto reductase-like protein 0.0099 0.1766 1
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.2744 0.2739
Trypanosoma cruzi aldo/keto reductase, putative 0.0029 0.0271 0.1532
Trypanosoma cruzi aldo/keto reductase, putative 0.0099 0.1766 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0197 0.2321
Echinococcus multilocularis voltage gated potassium channel subunit 0.0029 0.0271 0.0233
Schistosoma mansoni bromodomain containing protein 0.007 0.1138 0.1138
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0459 0.042
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0459 0.07
Echinococcus granulosus aldo keto reductase 0.0099 0.1766 0.1734
Brugia malayi RNA, U transporter 1 0.0082 0.1406 0.1399
Trypanosoma brucei aldo/keto reductase, putative 0.0029 0.0271 0.1532
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1389 0.7865
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0099 0.1766 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.1389 0.258
Plasmodium vivax importin-beta 2, putative 0.0029 0.0274 0.3292
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.1766 0.3342
Plasmodium falciparum importin beta, putative 0.0029 0.0274 0.4434
Schistosoma mansoni ran 0.0021 0.0112 0.0112
Onchocerca volvulus 0.0099 0.1766 0.5098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Echinococcus granulosus aldehyde reductase 0.0071 0.1156 0.1122
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.0271 0.016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0039
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Loa Loa (eye worm) hypothetical protein 0.0099 0.1766 0.2798
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Entamoeba histolytica hypothetical protein 0.0023 0.0158 0.0046
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.506 0.8136
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0158 0.0897
Brugia malayi Bromodomain containing protein 0.0044 0.0584 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.1766 0.176
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0082 0.1389 0.1355
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0197 0.0513
Echinococcus granulosus aldo keto reductase 0.0099 0.1766 0.1734
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0459 0.07
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Schistosoma mansoni hypothetical protein 0.0488 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.1059 0.1024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.6211 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0459 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Mycobacterium ulcerans hypothetical protein 0.0038 0.0459 0.126
Echinococcus multilocularis geminin 0.0196 0.3818 0.3794
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0459 0.2599
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0459 0.0681
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0604 0.0568
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0197 0.1117
Leishmania major hypothetical protein, conserved 0.0025 0.0197 0.1117
Brugia malayi NADH-dependent xylose reductase 0.0029 0.0271 0.0264
Loa Loa (eye worm) hypothetical protein 0.0029 0.0274 0.0382
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.1766 0.3331
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0459 0.07
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.1766 0.3342
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1389 0.258
Loa Loa (eye worm) oxidoreductase 0.0099 0.1766 0.2798
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0029 0.0271 0.1532
Schistosoma mansoni hypothetical protein 0.0199 0.3874 0.3874
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0459 0.042
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Giardia lamblia Aldose reductase 0.0099 0.1766 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0459 0.126
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.1766 0.176
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0112 0.0119
Leishmania major importin beta-1 subunit, putative 0.0023 0.0158 0.0897
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Onchocerca volvulus 0.0099 0.1766 0.5098
Brugia malayi Importin beta-1 subunit 0.0029 0.0274 0.0267
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0082 0.1389 0.1355
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0459 0.0459
Trypanosoma brucei prostaglandin f synthase 0.0099 0.1766 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0459 0.07
Loa Loa (eye worm) oxidoreductase 0.0099 0.1766 0.2798
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0082 0.1389 0.1355
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0459 0.042
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0118 0.0129
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.0637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.1766 0.3342
Entamoeba histolytica hypothetical protein 0.0488 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0082 0.1389 0.1355
Echinococcus multilocularis aldehyde reductase 0.0071 0.1156 0.1122
Schistosoma mansoni hypothetical protein 0.0309 0.6211 0.6211
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0025 0.0197 0.0256
Schistosoma mansoni zinc finger protein 0.0024 0.0169 0.0169
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0029 0.0271 0.3215
Plasmodium falciparum aldehyde reductase, putative 0.0029 0.0271 0.433
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.3204 1
Entamoeba histolytica aldose reductase, putative 0.0099 0.1766 0.1672
Schistosoma mansoni importin beta-1 0.0029 0.0274 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0039 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3204 0.6247
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.1766 0.1734
Loa Loa (eye worm) hypothetical protein 0.0038 0.0459 0.0681
Brugia malayi follicle stimulating hormone receptor 0.0263 0.523 0.5226
Brugia malayi Bromodomain containing protein 0.0082 0.1398 0.1392
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.506 0.5057
Trypanosoma cruzi aldo-keto reductase 0.0099 0.1766 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0112 0.0637
Loa Loa (eye worm) oxidoreductase 0.0099 0.1766 0.2798
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0459 0.07
Loa Loa (eye worm) hypothetical protein 0.0074 0.1229 0.1928
Toxoplasma gondii aldo-keto reductase 0.0029 0.0271 0.0957
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0161 0.0122
Echinococcus granulosus importin subunit beta 1 0.0029 0.0274 0.0236
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0274 0.0236
Echinococcus multilocularis Kelch repeat type 1 0.0199 0.3874 0.385
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.1766 0.1734
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0274 0.1554
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.506 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.2744 0.2715
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.1766 0.3342
Leishmania major hypothetical protein, conserved 0.0038 0.0459 0.2599
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0459 0.042
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0082 0.1389 0.1389
Trichomonas vaginalis esterase, putative 0.0038 0.0459 0.07
Echinococcus multilocularis aldo keto reductase 0.0099 0.1766 0.1734
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0459 0.126
Schistosoma mansoni transcription factor LCR-F1 0.0488 1 1
Giardia lamblia Aldose reductase 0.0099 0.1766 1

Activities

Activity type Activity value Assay description Source Reference
K obs (binding) 0 Cleavage rate against hairpin ribozyme at 5 mM with 0.5 microM magnesium ions;nd=not determined ChEMBL. 11714598
K obs (binding) = 0.02 Cleavage rate against hairpin ribozyme at 2mM, in presence of 0.5 microM magnesium ions ChEMBL. 11714598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.