Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucose-6-phosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate dehydrogenase | 545 aa | 495 aa | 39.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.2579 | 0.2019 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 0.2579 | 0.2579 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0074 | 0.0701 | 0.0775 |
Echinococcus multilocularis | geminin | 0.0176 | 0.3231 | 0.272 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.015 | 0.2579 | 0.2579 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0074 | 0.0701 | 0.2548 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0193 | 0.3637 | 0.3157 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0074 | 0.0701 | 0.0775 |
Echinococcus granulosus | prolyl endopeptidase | 0.0149 | 0.2556 | 0.1995 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0068 | 0.0543 | 0.2295 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0193 | 0.3637 | 0.3157 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0193 | 0.3637 | 0.3637 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0074 | 0.0701 | 0.2548 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.129 | 0.3669 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.045 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3231 | 0.272 |
Trypanosoma cruzi | oligopeptidase b | 0.0068 | 0.0543 | 0.1922 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.045 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0149 | 0.2556 | 0.1995 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0193 | 0.3637 | 0.3637 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0193 | 0.3637 | 0.3157 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 0.2019 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0121 | 0.1855 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0068 | 0.0543 | 0.1922 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0068 | 0.0543 | 0.1922 |
Trypanosoma brucei | prolyl endopeptidase | 0.0149 | 0.2556 | 0.9889 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0193 | 0.3637 | 0.1452 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.045 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0068 | 0.0543 | 0.1922 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.2579 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0068 | 0.0543 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0149 | 0.2556 | 0.988 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.045 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.0095 | 0.0142 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.2579 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2556 | 0.2556 |
Echinococcus granulosus | geminin | 0.0176 | 0.3231 | 0.272 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0149 | 0.2556 | 0.1995 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.015 | 0.2579 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0074 | 0.0701 | 0.0775 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0149 | 0.2556 | 0.2556 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.2579 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.129 | 0.3137 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0074 | 0.0701 | 0.0701 |
Mycobacterium tuberculosis | Probable peptidase | 0.0068 | 0.0543 | 0.2295 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.2579 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.2579 | 0.2019 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.2579 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0149 | 0.2556 | 0.9889 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.045 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0149 | 0.2556 | 0.1995 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.2579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3231 | 0.272 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0149 | 0.2556 | 0.991 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 0.2579 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12.2 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.