Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Adenosylhomocysteinase | 0.0125 | 0.3699 | 0.6765 |
Onchocerca volvulus | 0.0043 | 0.0149 | 0.5 | |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1644 | 0.1544 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0125 | 0.3699 | 0.3604 |
Trichomonas vaginalis | cyclin A, putative | 0.0043 | 0.0149 | 0.0403 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0125 | 0.3699 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0272 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0125 | 0.3699 | 0.3666 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0149 | 0.0403 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0165 | 0.5397 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0043 | 0.0149 | 0.0403 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0125 | 0.3699 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0125 | 0.3699 | 0.3604 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0043 | 0.0149 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0107 | 0.2911 | 0.5262 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0149 | 0.0403 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0125 | 0.3699 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0125 | 0.3699 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1644 | 0.1544 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1644 | 0.1544 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0149 | 0.0403 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0125 | 0.3699 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0125 | 0.3699 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0272 | 1 | 1 |
Giardia lamblia | Cyclin A | 0.0043 | 0.0149 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0125 | 0.3699 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0268 | 0.9832 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0043 | 0.0149 | 0.0403 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0125 | 0.3699 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0149 | 0.0403 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0125 | 0.3699 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0043 | 0.0149 | 0.0403 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0149 | 0.0403 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0149 | 0.0403 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0125 | 0.3699 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0125 | 0.3699 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0149 | 0.0403 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1644 | 0.1544 |
Giardia lamblia | Hypothetical protein | 0.0043 | 0.0149 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0149 | 0.0403 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0149 | 0.0403 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0149 | 0.0403 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0125 | 0.3699 | 0.3604 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0149 | 0.0403 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0125 | 0.3699 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0125 | 0.3699 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0125 | 0.3699 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0107 | 0.2911 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2743 | 0.2633 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.3 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK2/E) | ChEMBL. | 11354366 |
IC50 (binding) | = 3.3 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK2/E) | ChEMBL. | 11354366 |
IC50 (binding) | > 6.7 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK4/D1) | ChEMBL. | 11354366 |
IC50 (binding) | > 6.7 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK4/D1) | ChEMBL. | 11354366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.