Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0037 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0106 | 0.0106 |
Echinococcus multilocularis | pyruvate kinase | 0.0112 | 0.0382 | 0.0544 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0106 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6603 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0053 | 0.0142 | 0.0462 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.01 | 0.0046 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Echinococcus granulosus | expressed protein | 0.0038 | 0.0083 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0112 | 0.0382 | 0.0317 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0112 | 0.0382 | 0.0317 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0348 | 0.0912 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.01 | 0.1132 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0348 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0037 | 0.0077 | 0.0077 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Brugia malayi | nuclear receptor NHR-88 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0078 | 0.0244 | 0.0244 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0042 | 0.01 | 0.0006 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0154 | 0.0557 | 0.0793 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.2473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Leishmania major | hypothetical protein, conserved | 0.0762 | 0.3033 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0095 | 0.0135 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0078 | 0.0244 | 0.0244 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0074 | 0.0227 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | pyruvate kinase | 0.0023 | 0.0024 | 0.0024 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0042 | 0.01 | 0.0072 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0152 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.0879 | 0.0879 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.01 | 0.0046 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0078 | 0.0244 | 0.0244 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0156 | 0.0156 |
Echinococcus multilocularis | pyruvate kinase | 0.0112 | 0.0382 | 0.0544 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0156 | 0.0156 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0095 | 0.0041 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0078 | 0.0244 | 0.0244 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.01 | 0.0143 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0078 | 0.0244 | 0.0791 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0037 | 0.0079 | 0.0465 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0083 | 0.0029 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0246 | 0.0193 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0078 | 0.0244 | 0.0347 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0041 | 0.0095 | 0.0135 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0022 | 0.0072 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0136 | 0.0082 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0078 | 0.0244 | 0.0244 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0037 | 0.0077 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0092 | 0.0131 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0095 | 0.0308 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0762 | 0.3033 | 0.2995 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0041 | 0.0095 | 0.0095 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0078 | 0.0244 | 0.0347 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0037 | 0.0077 | 0.0109 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0246 | 0.0193 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0017 | 0.0056 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0078 | 0.0245 | 0.0167 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0774 | 0.3081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | nuclear receptor RXR | 0.0041 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0095 | 0.0095 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2473 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | coup transcription factor | 0.0078 | 0.0244 | 0.0791 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0262 | 0.0994 | 0.1322 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0227 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Schistosoma mansoni | thyroid hormone receptor | 0.0078 | 0.0244 | 0.0791 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | zinc finger protein | 0.0037 | 0.0077 | 0.025 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0348 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0112 | 0.0382 | 0.1026 |
Loa Loa (eye worm) | pyruvate kinase | 0.0112 | 0.0382 | 0.0382 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.01 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0017 | 0.0025 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0037 | 0.0077 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0103 | 0.0103 |
Trichomonas vaginalis | set domain proteins, putative | 0.0266 | 0.101 | 0.0961 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0037 | 0.0077 | 0.0077 |
Echinococcus granulosus | pyruvate kinase | 0.0112 | 0.0382 | 0.1241 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0037 | 0.0077 | 0.0109 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0078 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | pyruvate kinase | 0.0112 | 0.0382 | 0.0382 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0095 | 0.0095 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0037 | 0.0077 | 0.025 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Schistosoma mansoni | hypothetical protein | 0.0386 | 0.1502 | 0.4874 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.01 | 0.1132 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0077 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0038 | 0.0083 | 0.0083 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0142 | 0.0462 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0037 | 0.0077 | 0.025 |
Echinococcus multilocularis | pyruvate kinase | 0.0057 | 0.0161 | 0.0229 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0006 | 0.0019 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.012 | 0.0066 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0348 | 0.0348 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0037 | 0.0077 | 0.0077 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0112 | 0.0382 | 0.1026 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0074 | 0.0227 | 0.0502 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0064 | 0.0092 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0774 | 0.3081 | 0.4386 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0077 | 0.025 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0246 | 0.0351 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0078 | 0.0244 | 0.0791 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0644 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | pyruvate kinase | 0.0112 | 0.0382 | 0.1241 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0078 | 0.0244 | 0.0791 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0078 | 0.0244 | 0.0244 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0077 | 0.0077 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2473 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.0142 | 0.0462 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0095 | 0.0041 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.2473 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0095 | 0.0041 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0078 | 0.0244 | 0.0791 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.0246 | 0.0246 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0034 | 0.0065 | 0.0065 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0031 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Leishmania major | pyruvate kinase | 0.0112 | 0.0382 | 0.1026 |
Echinococcus granulosus | pyruvate kinase | 0.0057 | 0.0161 | 0.0523 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0348 | 0.0283 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2473 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0078 | 0.0244 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0114 | 0.0114 |
Onchocerca volvulus | 0.0041 | 0.0095 | 0.0027 | |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0246 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0068 | 0.0068 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0136 | 0.0082 |
Schistosoma mansoni | nuclear receptor | 0.0037 | 0.0077 | 0.025 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0112 | 0.0382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Plasmodium falciparum | pyruvate kinase | 0.0112 | 0.0382 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0112 | 0.0382 | 0.1026 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.012 | 0.0066 |
Echinococcus granulosus | pyruvate kinase | 0.0057 | 0.0161 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Echinococcus multilocularis | geminin | 0.0386 | 0.1502 | 0.2138 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | steroid hormone receptor | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.01 | 0.0326 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.0473 | 0.0473 |
Onchocerca volvulus | 0.0041 | 0.0095 | 0.0027 | |
Giardia lamblia | Pyruvate kinase | 0.0057 | 0.0161 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0154 | 0.0557 | 0.0557 |
Loa Loa (eye worm) | pyruvate kinase | 0.0112 | 0.0382 | 0.0382 |
Echinococcus granulosus | pyruvate kinase | 0.0112 | 0.0382 | 0.1241 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0804 | 0.3202 | 0.3137 |
Echinococcus multilocularis | pyruvate kinase | 0.0088 | 0.0286 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0095 | 0.0095 |
Leishmania major | basic transcription factor 3a, putative | 0.0074 | 0.0227 | 0.0502 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0037 | 0.0077 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0084 | 0.0084 |
Brugia malayi | beta-NAC-like protein | 0.0074 | 0.0227 | 0.0227 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0074 | 0.0227 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0156 | 0.0156 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1742 | 0.7024 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0112 | 0.0382 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Echinococcus granulosus | geminin | 0.0386 | 0.1502 | 0.4874 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0095 | 0.0308 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0006 | 0.0019 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.0557 | 0.1807 |
Trichomonas vaginalis | rotamase, putative | 0.0038 | 0.0083 | 0.0029 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0078 | 0.0244 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0386 | 0.1502 | 0.4874 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0037 | 0.0077 | 0.025 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0084 | 0.0084 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.2473 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0112 | 0.0382 | 0.033 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0057 | 0.0161 | 0.3044 |
Onchocerca volvulus | 0.2473 | 1 | 1 | |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0112 | 0.0382 | 0.0925 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0804 | 0.3202 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0077 | 0.0109 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2473 | 1 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.2473 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0095 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.171 | 0.6895 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.01 | 0.0326 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0246 | 0.0799 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0112 | 0.0382 | 0.0382 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.1645 | 0.663 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.0879 | 0.0879 |
Echinococcus granulosus | pyruvate kinase | 0.0057 | 0.0161 | 0.0523 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0078 | 0.0244 | 0.0244 |
Onchocerca volvulus | 0.0078 | 0.0244 | 0.0177 | |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0762 | 0.3033 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Giardia lamblia | Pyruvate kinase | 0.0112 | 0.0382 | 0.0285 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.2473 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0112 | 0.0382 | 0.1241 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0023 | 0.0024 | 0.0024 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0348 | 0.0912 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0057 | 0.0161 | 0.3044 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0041 | 0.0095 | 0.0308 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0201 | 0.0651 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0059 | 0.0193 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0112 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0078 | 0.0244 | 0.0791 |
Schistosoma mansoni | transcription factor btf3 | 0.0074 | 0.0227 | 0.0738 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0348 | 0.0272 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0037 | 0.0077 | 0.025 |
Brugia malayi | ecdysone receptor | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0006 | 0.0019 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.0246 | 0.0246 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.0271 | 0.0271 |
Echinococcus multilocularis | transcription factor btf3 | 0.0074 | 0.0227 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | ICD-1 protein | 0.0074 | 0.0227 | 0.0227 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0078 | 0.0244 | 0.0244 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0078 | 0.0244 | 0.0791 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0095 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0095 | 0.0053 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0154 | 0.0557 | 0.1807 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0037 | 0.0077 | 0.025 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0142 | 0.0142 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0095 | 0.0095 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0095 | 0.0095 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0041 | 0.0095 | 0.0308 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0227 | 0.0174 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0348 | 0.0912 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0112 | 0.0382 | 0.033 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0774 | 0.3081 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0095 | 0.0053 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0112 | 0.0382 | 0.0423 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0078 | 0.0244 | 0.0347 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0078 | 0.0244 | 0.0791 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0078 | 0.0244 | 0.0791 |
Brugia malayi | nuclear hormone receptor | 0.0078 | 0.0244 | 0.0244 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.048 | 0.0415 |
Schistosoma mansoni | nuclear receptor | 0.0037 | 0.0077 | 0.025 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6603 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0078 | 0.0244 | 0.0791 |
Brugia malayi | nuclear receptor NHR-67 | 0.0037 | 0.0077 | 0.0077 |
Toxoplasma gondii | NAC domain-containing protein | 0.0074 | 0.0227 | 0.513 |
Schistosoma mansoni | pyruvate kinase | 0.0057 | 0.0161 | 0.0523 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.01 | 0.0072 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0198 | 0.0644 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0078 | 0.0244 | 0.0244 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0037 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.048 | 0.048 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0092 | 0.0299 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0154 | 0.0557 | 0.1807 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0095 | 0.0053 |
Brugia malayi | ecdysteroid receptor | 0.0078 | 0.0244 | 0.0244 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0095 | 0.0095 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.0217 | 0.0705 |
Trichomonas vaginalis | rotamase, putative | 0.0037 | 0.0079 | 0.0025 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0038 | 0.0083 | 0.0083 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0104 |
Echinococcus multilocularis | pyruvate kinase | 0.0057 | 0.0161 | 0.0229 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0078 | 0.0244 | 0.0244 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0762 | 0.3033 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0078 | 0.0244 | 0.0791 |
Loa Loa (eye worm) | DR-78 | 0.0037 | 0.0077 | 0.0077 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.0557 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Brugia malayi | tailless protein | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0348 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.048 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0245 | 0.0245 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.4214 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0074 | 0.0227 | 0.0502 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.01 | 0.01 |
Brugia malayi | conserved hypotetical protein | 0.0037 | 0.0077 | 0.0077 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0078 | 0.0244 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0095 | 0.0041 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0095 | 0.096 |
Onchocerca volvulus | 0.0266 | 0.101 | 0.0949 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0348 | 0.0296 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0064 | 0.0209 |
Onchocerca volvulus | 0.0046 | 0.0116 | 0.0049 | |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.01 | 0.0326 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0095 | 0.0041 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0078 | 0.0244 | 0.0791 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0201 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0084 | 0.0271 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0078 | 0.0244 | 0.0347 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.01 | 0.01 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0246 | 0.0351 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0037 | 0.0077 | 0.0009 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0077 | 0.025 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0078 | 0.0244 | 0.0347 |
Schistosoma mansoni | kinase | 0.0052 | 0.0142 | 0.046 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0078 | 0.0244 | 0.0244 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0078 | 0.0244 | 0.0791 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0106 | 0.0052 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0348 | 0.0912 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.0473 | 0.0473 |
Echinococcus multilocularis | expressed protein | 0.0038 | 0.0083 | 0.0118 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.0103 | 0.0103 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.1645 | 0.663 | 0.6612 |
Onchocerca volvulus | 0.0037 | 0.0077 | 0.0009 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0227 | 0.0174 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0031 | 0.01 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0037 | 0.0077 | 0.025 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0078 | 0.0244 | 0.0244 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0095 | 0.0053 |
Echinococcus granulosus | transcription factor btf3 | 0.0074 | 0.0227 | 0.0738 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0074 | 0.0227 | 0.4508 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0078 | 0.0244 | 0.0244 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0095 | 0.0041 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0095 | 0.0308 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0074 | 0.0227 | 0.513 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0104 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0037 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | pyruvate kinase | 0.0023 | 0.0024 | 0.0024 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.2473 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.2473 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0037 | 0.0077 | 0.0109 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0348 | 0.0496 |
Echinococcus granulosus | FTZ F1 alpha | 0.0078 | 0.0244 | 0.0791 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0246 | 0.0799 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0106 | 0.0106 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0112 | 0.0382 | 0.1026 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0031 | 0.0044 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0042 | 0.01 | 0.0021 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0037 | 0.0077 | 0.025 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0053 | 0.0142 | 0.0203 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0227 | 0.0149 |
Onchocerca volvulus | 0.0041 | 0.0095 | 0.0027 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.0473 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0095 | 0.0095 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0057 | 0.0161 | 0.2156 |
Leishmania major | pyruvate kinase | 0.0112 | 0.0382 | 0.1026 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0037 | 0.0077 | 0.0077 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0106 | 0.0052 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0078 | 0.0244 | 0.0791 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0078 | 0.0244 | 0.0347 |
Onchocerca volvulus | 0.0037 | 0.0077 | 0.0009 | |
Schistosoma mansoni | rotamase | 0.0038 | 0.0083 | 0.0269 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0804 | 0.3202 | 0.4569 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0246 | 0.0799 |
Echinococcus multilocularis | pyruvate kinase | 0.0057 | 0.0161 | 0.0229 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0017 | 0.0056 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0037 | 0.0077 | 0.0077 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0078 | 0.0244 | 0.0791 |
Plasmodium vivax | pyruvate kinase, putative | 0.0112 | 0.0382 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0078 | 0.0244 | 0.0791 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0078 | 0.0244 | 0.0244 |
Mycobacterium ulcerans | pyruvate kinase | 0.0112 | 0.0382 | 0.029 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.1645 | 0.663 | 0.6596 |
Brugia malayi | hypothetical protein | 0.0136 | 0.048 | 0.048 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0078 | 0.0244 | 0.0791 |
Schistosoma mansoni | thyroid hormone receptor | 0.0078 | 0.0244 | 0.0791 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0037 | 0.0077 | 0.0109 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.0557 | 0.0481 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.012 | 0.0052 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0198 | 0.0282 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0078 | 0.0244 | 0.0791 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0198 | 0.0104 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0078 | 0.0244 | 0.0347 |
Chlamydia trachomatis | pyruvate kinase | 0.0112 | 0.0382 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0078 | 0.0244 | 0.0177 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0244 | 0.0244 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.0557 | 0.0481 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0762 | 0.3033 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0042 | 0.01 | 0.0008 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0042 | 0.01 | 0.0072 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0046 | 0.0116 | 0.0378 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.0557 | 0.0481 |
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0077 | 0.0077 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.01 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0042 | 0.0042 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.048 | 0.0415 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0762 | 0.3033 | 0.2995 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0078 | 0.0244 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0077 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0078 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0251 | 0.0251 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0198 | 0.0403 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0156 | 0.0156 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0078 | 0.0244 | 0.0177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.55 mg kg-1 | Effective dose against S. aureus MB2985 (methicillin-susceptible) in mouse systemic infection model | ChEMBL. | 10571158 |
MIC (functional) | = 0.031 ug ml-1 | In vivo inhibitory activity against S. aureus MB2985 (methicillin-susceptible) in mouse systemic infection model | ChEMBL. | 10571158 |
MIC50 (functional) | = 0.5 ug ml-1 | Compound was tested in vitro for its activity against methicillin-Resistant Staphylococcus Aureus(MRSA 12) | ChEMBL. | 10571158 |
MIC50 (functional) | = 2 ug ml-1 | Compound was tested in vitro for its activity against Methicillin-Resistant Coagulase Negative Staphylococci(MRCNS 9) | ChEMBL. | 10571158 |
MIC90 (functional) | = 1 ug ml-1 | Compound was tested in vitro for its activity against methicillin-Resistant Staphylococcus Aureus(MRSA 12) | ChEMBL. | 10571158 |
MIC90 (functional) | = 2 ug ml-1 | Compound was tested in vitro for its activity against Methicillin-Resistant Coagulase Negative Staphylococci(MRCNS 9) | ChEMBL. | 10571158 |
PB (functional) | = 95 % | Compound was evaluated in vivo for percent binding to human albumin fraction V. | ChEMBL. | 10571158 |
Plasma MIC (functional) | = 1 ug ml-1 | Compound was evaluated in vivo for plasma MIC in presence of human albumin fraction V (21.5 mg/mL) | ChEMBL. | 10571158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.