Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5833 | 0.5833 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 1 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.8382 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.8382 | 0.5 |
Echinococcus multilocularis | lamin | 0.0029 | 0.5833 | 0.5833 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0599 | 0.0599 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.5833 | 0.5568 |
Echinococcus granulosus | lamin | 0.0029 | 0.5833 | 0.5833 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.5833 | 0.5568 |
Echinococcus multilocularis | musashi | 0.0029 | 0.5833 | 0.5833 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.5833 | 0.5833 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5627 | 0.5627 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay | ChEMBL. | 22917519 |
Ki (binding) | > 200 uM | Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay | ChEMBL. | 22917519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.