Detailed information for compound 1670840

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.403 | Formula: C14H13N3S2
  • H donors: 2 H acceptors: 0 LogP: 2.98 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C/1\CCSc2c1c1ccccc1cc2
  • InChi: 1S/C14H13N3S2/c15-14(18)17-16-11-7-8-19-12-6-5-9-3-1-2-4-10(9)13(11)12/h1-6H,7-8H2,(H3,15,17,18)/b16-11+
  • InChiKey: OIQDTDZIZWPLBP-LFIBNONCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cysteine protease 0.0032 0.0059 0.0059
Echinococcus multilocularis solute carrier family 5 0.0046 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Loa Loa (eye worm) hypothetical protein 0.0082 0.0209 0.0217
Loa Loa (eye worm) cysteine protease 0.0032 0.0059 0.0061
Onchocerca volvulus 0.0033 0.0061 0.1196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0077 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0033 0.0034
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1283 0.3787 0.3774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0033 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.029 0.0828 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1436 0.1436
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0117 0.0121
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1283 0.3787 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0118 0.0315 0.0369
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0118 0.0315 0.0315
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1283 0.3787 1
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0118 0.0315 0.0258
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0059 0.0054
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0102 0.0102
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.0473 0.0473
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0088 0.0088
Schistosoma mansoni acetyl-CoA carboxylase 0.3368 1 1
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0456 0.1324 0.2905
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0077
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0033 0.0034
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0033 0.0034
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0033 0.0033
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Schistosoma mansoni aspartate carbamoyltransferase 0.029 0.0828 0.0828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Echinococcus granulosus cathepsin l1 0.0023 0.0032 0.0032
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1283 0.3787 0.3787
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0077 0.008
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0134 0.0076
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0118 0.0315 0.0369
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0456 0.1324 0.3167
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.042 0.1215 0.1259
Onchocerca volvulus 0.0182 0.0507 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0061
Echinococcus multilocularis lamin dm0 0.0033 0.0061 0.0061
Brugia malayi PXA domain containing protein 0.0023 0.0033 0.0034
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0118 0.0315 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0322 0.0334
Entamoeba histolytica hypothetical protein 0.0042 0.0088 0.0414
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0118 0.0315 0.0296
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0102 0.0102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0322 0.0334
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0033 0.0033
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0118 0.0315 0.041
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0456 0.1324 0.1272
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0032 0.0075
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0134 0.0134
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0456 0.1324 0.1272
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0059 0.0054
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.029 0.0828 0.1312
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.002 0.0021
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0118 0.0315 0.048
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0077
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2437 0.7227 1
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0456 0.1324 0.3167
Loa Loa (eye worm) fibroinase 0.0032 0.0059 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus GPCR family 2 0.0038 0.0077 0.0077
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0033 0.0033
Echinococcus multilocularis cpg binding protein 0.0037 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0042 0.0088 0.0414
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.1215 0.1215
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0456 0.1324 0.3167
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0033 0.0033
Brugia malayi Cathepsin L-like precursor 0.0023 0.0032 0.0033
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0473 0.0473
Schistosoma mansoni carbamoyl-phosphate synthetase 0.029 0.0828 0.0828
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0118 0.0315 0.048
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0059 0.0063
Trypanosoma brucei protein kinase, putative 0.0057 0.0134 0.0114
Onchocerca volvulus 0.0032 0.0059 0.1159
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0134 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Echinococcus granulosus cysteine protease 0.0019 0.002 0.002
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0032 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0082 0.0209 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0209 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0059 0.0235
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.0473 0.0735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.325 0.9648 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0118 0.0315 0.048
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0118 0.0315 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0011
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0456 0.1324 0.3233
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0061 0.0063
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0033 0.0033
Onchocerca volvulus 0.0046 0.0102 0.2002
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.002 0.002
Onchocerca volvulus 0.0032 0.0059 0.1159
Entamoeba histolytica cysteine protease, putative 0.0032 0.0059 0.0235
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0102 0.0105
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.3368 1 1
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1283 0.3787 0.375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0117 0.0117
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0182 0.0124
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0456 0.1324 0.2118
Mycobacterium ulcerans pyruvate carboxylase 0.1283 0.3787 1
Schistosoma mansoni high-affinity choline transporter 0.042 0.1215 0.1215
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0182 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Schistosoma mansoni cpg binding protein 0.0037 0.0073 0.0073
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0118 0.0315 0.0258
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0033 0.0033
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0456 0.1324 0.2905
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0033
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1283 0.3787 1
Giardia lamblia Cathepsin B precursor 0.006 0.0142 0.0049
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0059 0.0063
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0456 0.1324 0.3167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0032 0.1018
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0102 0.0102
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0456 0.1324 0.1324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Onchocerca volvulus 0.0035 0.0067 0.132
Loa Loa (eye worm) hypothetical protein 0.0182 0.0507 0.0526
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0034 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Plasmodium vivax vivapain-2 0.0032 0.0059 0.0054
Mycobacterium ulcerans hypothetical protein 0.0118 0.0315 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0077
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0118 0.0315 0.0315
Plasmodium vivax vivapain-2 0.0032 0.0059 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0117 0.0117
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1283 0.3787 0.3787
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.002 0.0021
Chlamydia trachomatis biotin carboxylase 0.1165 0.3435 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0134 0.0185
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0034 0.0035
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0134 0.0185
Echinococcus granulosus lamin 0.0033 0.0061 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0059 0.0063
Giardia lamblia Cathepsin B precursor 0.006 0.0142 0.0049
Schistosoma mansoni lamin 0.0033 0.0061 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0182 0.0182
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1436 0.1436
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0134 0.9374
Entamoeba histolytica hypothetical protein 0.0042 0.0088 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Schistosoma mansoni hypothetical protein 0.0494 0.1436 0.1436
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0033 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0059 0.0059
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0118 0.0315 0.048
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0118 0.0315 0.041
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0118 0.0315 0.041
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0456 0.1324 0.2905
Echinococcus multilocularis GPCR, family 2 0.0038 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0034 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0059 0.0063
Onchocerca volvulus 0.0032 0.0059 0.1159
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0322 0.0334
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Leishmania major carbamoyl-phosphate synthase, putative 0.029 0.0828 0.0773
Brugia malayi hypothetical protein 0.0182 0.0507 0.0526
Echinococcus granulosus cathepsin l1 0.0032 0.0059 0.0059
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0456 0.1324 0.3167
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0102 0.0102
Echinococcus multilocularis Biotin lipoyl attachment 0.0118 0.0315 0.0315
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.002 0.002
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0118 0.0315 0.041
Echinococcus granulosus cpg binding protein 0.0037 0.0073 0.0073
Onchocerca volvulus 0.0023 0.0032 0.0635
Echinococcus granulosus Biotin lipoyl attachment 0.0118 0.0315 0.0315
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0118 0.0315 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0117 0.0117
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0034 0.0035
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Loa Loa (eye worm) hypothetical protein 0.0046 0.0102 0.0105
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0059 0.0235
Schistosoma mansoni lamin 0.0033 0.0061 0.0061
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0456 0.1324 0.3167
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0118 0.0315 0.0258
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0034 0.0034
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0456 0.1324 0.2118
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0102 0.0102
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1283 0.3787 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0034 0.0034
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.0142 0.0122
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0059 0.0061
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.029 0.0828 0.1791
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2437 0.7227 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0134 0.0134
Schistosoma mansoni inositol transporter 0.0046 0.0102 0.0102
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0032 0.002
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0456 0.1324 0.1306
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0033 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0183 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0059 0.3201
Brugia malayi CXXC zinc finger family protein 0.0035 0.0067 0.0069
Schistosoma mansoni hypothetical protein 0.0197 0.0551 0.0551
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0159 0.0101
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0059 0.0054
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0456 0.1324 0.3167
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0118 0.0315 0.0327
Echinococcus granulosus solute carrier family 5 0.0046 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0033 0.0033
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1283 0.3787 1
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.002 0.002
Brugia malayi Carboxyl transferase domain containing protein 0.325 0.9648 1
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0456 0.1324 0.1324
Loa Loa (eye worm) ctsf protein 0.0032 0.0059 0.0061
Echinococcus granulosus cathepsin b 0.0171 0.0473 0.0473
Brugia malayi hypothetical protein 0.0023 0.0033 0.0034
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0061
Brugia malayi PXA domain containing protein 0.0023 0.0033 0.0034
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.0142 0.0198
Schistosoma mansoni sodium/solute symporter 0.0046 0.0102 0.0102
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0118 0.0315 0.0315
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0134 0.0134
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1283 0.3787 0.6117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0473 0.0473
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0033 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0118 0.0315 0.0327
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0033 0.0033
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis expressed protein 0.0451 0.1307 0.1307
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0061 0.0063
Toxoplasma gondii cathepsin B 0.006 0.0142 0.0083
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0033 0.0033
Schistosoma mansoni carbamoyl-phosphate synthetase 0.029 0.0828 0.0828
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0118 0.0315 0.0296
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0033 0.0033
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0134 0.0134
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0117 0.0121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis geminin 0.0197 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.012 0.0322 0.0334
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0118 0.0315 0.0327
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0574 0.1675 1
Schistosoma mansoni hypothetical protein 0.0042 0.0088 0.0088
Brugia malayi hypothetical protein 0.0023 0.0033 0.0034
Onchocerca volvulus 0.0032 0.0059 0.1159
Loa Loa (eye worm) hypothetical protein 0.0171 0.0473 0.049
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0033 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0067 0.0069
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0456 0.1324 0.1324
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0118 0.0315 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Echinococcus granulosus cathepsin b 0.0171 0.0473 0.0473
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0033 0.0033
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0102 0.0043
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.3368 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0033 0.1049
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0033 0.0034
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0456 0.1324 0.2118
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0033 0.0033
Echinococcus granulosus high affinity choline transporter 1 0.042 0.1215 0.1215
Echinococcus multilocularis cathepsin b 0.0171 0.0473 0.0473
Echinococcus granulosus intermediate filament protein 0.0033 0.0061 0.0061
Brugia malayi intermediate filament protein 0.0033 0.0061 0.0063
Echinococcus granulosus geminin 0.0197 0.0551 0.0551
Echinococcus granulosus cathepsin L 0.0019 0.002 0.002
Echinococcus multilocularis lamin 0.0033 0.0061 0.0061
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0059 0.0061
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0456 0.1324 0.3167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0033 0.0034
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0033 0.0033
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0118 0.0315 0.0369
Toxoplasma gondii pyruvate carboxylase 0.1283 0.3787 0.375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0033 0.0033
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0118 0.0315 0.048
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0118 0.0315 0.0258
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0059 0.0059
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1283 0.3787 0.6117
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0059 0.0059
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0456 0.1324 0.2905
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.029 0.0828 0.1312
Schistosoma mansoni hypothetical protein 0.0197 0.0551 0.0551
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0118 0.0315 0.048
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0059 0.0063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0059 0.0061
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.029 0.0828 0.1121
Brugia malayi hypothetical protein 0.0042 0.0088 0.0092
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0118 0.0315 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0077
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0574 0.1675 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2882 0.2882
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0118 0.0315 0.048
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0118 0.0315 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.0142 1
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.3368 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0134 0.0134
Brugia malayi GH02984p 0.042 0.1215 0.1259
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0033 0.0033
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.0142 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0473 0.0473
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0016 0.0016
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0033 0.0034
Brugia malayi cathepsin L-like precursor 0.0023 0.0032 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0134 0.9374
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0134 0.0139
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0059 0.1159
Giardia lamblia Cathepsin B precursor 0.006 0.0142 0.0049
Brugia malayi MAP kinase sur-1 0.0057 0.0134 0.0139
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0456 0.1324 0.1272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0117 0.0117
Plasmodium falciparum carbamoyl phosphate synthetase 0.029 0.0828 0.1121
Leishmania major acetyl-CoA carboxylase, putative 0.3368 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0088 0.0088
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0118 0.0315 0.0315
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0134 0.0185
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0134 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0059 0.1159
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0059 0.0059
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1283 0.3787 0.3774
Schistosoma mansoni pyruvate carboxylase 0.1283 0.3787 0.3787
Trypanosoma cruzi acetyl-CoA carboxylase 0.2085 0.6177 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0182 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0117 0.0117
Toxoplasma gondii carbamoylphosphate synthetase 0.029 0.0828 0.0773
Brugia malayi Cathepsin L-like precursor 0.0023 0.0032 0.0033
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0182 0.0124
Entamoeba histolytica hypothetical protein 0.0042 0.0088 0.0414
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1283 0.3787 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0032 0.1018
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0118 0.0315 0.0327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Schistosoma mansoni intermediate filament proteins 0.0033 0.0061 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.002 0.002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0033 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.0473 0.049
Echinococcus multilocularis cathepsin b 0.0171 0.0473 0.0473
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0118 0.0315 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Brugia malayi Cathepsin L-like precursor 0.0032 0.0059 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0077 0.0077
Schistosoma mansoni inositol transporter 0.0046 0.0102 0.0102
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1283 0.3787 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0033 0.1049
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0033 0.0034
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0059 0.1159
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1283 0.3787 0.3787
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0118 0.0315 0.0258
Echinococcus multilocularis cathepsin L 0.0019 0.002 0.002
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0118 0.0315 0.0369
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0118 0.0315 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0059 0.3201
Schistosoma mansoni cpg binding protein 0.0037 0.0073 0.0073
Leishmania major carboxylase, putative 0.1283 0.3787 0.375
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0059 0.3201
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0077 0.0077
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0061 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0117 0.0117
Trypanosoma brucei acetyl-CoA carboxylase 0.3368 1 1
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0118 0.0315 0.0258
Onchocerca volvulus 0.0032 0.0059 0.1159
Schistosoma mansoni cpg binding protein 0.0035 0.0067 0.0067
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0118 0.0315 0.0296
Onchocerca volvulus 0.0032 0.0059 0.1159
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0118 0.0315 0.041
Treponema pallidum pyruvate carboxylase subunit B 0.0118 0.0315 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0059 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0134 0.0076
Trypanosoma brucei unspecified product 0.0843 0.2477 0.2462
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0134 0.9374
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0118 0.0315 0.0258
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1283 0.3787 0.3787
Onchocerca volvulus 0.0033 0.0061 0.1196
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0033 0.0033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0134 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0134 0.9374
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0088 0.0088
Echinococcus multilocularis musashi 0.0033 0.0061 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0059 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0033 0.0033
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.029 0.0828 0.0809
Onchocerca volvulus 0.0032 0.0059 0.1159
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0033 0.0033
Echinococcus granulosus expressed protein 0.0451 0.1307 0.1307
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0118 0.0315 0.0369
Loa Loa (eye worm) cathepsin B 0.006 0.0142 0.0147
Echinococcus multilocularis cysteine protease 0.0032 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.001 0.001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.001 0.001
Echinococcus granulosus lamin dm0 0.0033 0.0061 0.0061
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0118 0.0315 0.0315

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analysis ChEMBL. 24900494
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analysis ChEMBL. 24900494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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