Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 1 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.001 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 1 | 0.5 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 1 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 1 | 1 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 1 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 1 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.001 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 1 | 0.5 |
Trichomonas vaginalis | ferritin, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 1 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 41.1 % | Growth inhibition of human CCRF-CEM cells at 10 uM after 48 hrs by coulter counter analysis | ChEMBL. | 22743242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.