Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3698 | 1 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.1029 | 0.0738 |
Plasmodium falciparum | lysine--tRNA ligase | 0.0028 | 0.1029 | 0.3212 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3698 | 1 |
Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.1029 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3698 | 0.3494 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.254 | 0.658 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.254 | 0.5663 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.254 | 0.2985 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.7773 | 1 |
Leishmania major | trypanothione reductase | 0.0051 | 0.254 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3698 | 1 |
Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0028 | 0.1029 | 0.0407 |
Chlamydia trachomatis | lysine--tRNA ligase | 0.0028 | 0.1029 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.6906 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.254 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3698 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.7773 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.7773 | 1 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.1029 | 0.0738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3698 | 0.3494 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.6906 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0051 | 0.254 | 0.687 |
Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.1029 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0025 | 0.0795 | 0.6732 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0028 | 0.1029 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3698 | 1 |
Leishmania major | lysyl-tRNA synthetase, putative | 0.0028 | 0.1029 | 0.3212 |
Echinococcus multilocularis | lysyl tRNA synthetase | 0.0028 | 0.1029 | 0.2114 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.6906 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.254 | 1 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3698 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3698 | 1 |
Toxoplasma gondii | lysine-tRNA ligase | 0.0028 | 0.1029 | 0.3212 |
Plasmodium vivax | lysine--tRNA ligase, putative | 0.0028 | 0.1029 | 0.3212 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.1029 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0313 | 0.0848 |
Brugia malayi | lysyl-tRNA synthetase | 0.0028 | 0.1029 | 0.2782 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0743 | 0.0576 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.254 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3698 | 0.3494 |
Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0743 | 0.0576 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.7773 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3698 | 0.3494 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.6906 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.254 | 0.687 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.254 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3698 | 0.3494 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.254 | 0.5663 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.254 | 0.658 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.6906 | 0.8766 |
Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0028 | 0.1029 | 0.3212 |
Echinococcus granulosus | lysyl tRNA synthetase | 0.0028 | 0.1029 | 0.2114 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.6906 | 0.8837 |
Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0028 | 0.1029 | 0.3212 |
Giardia lamblia | Lysyl-tRNA synthetase | 0.0028 | 0.1029 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3698 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay | ChEMBL. | 22877633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.