Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.3542 | 0.3542 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.2438 | 0.2438 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0154 | 0.0154 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.1034 | 0.1034 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0154 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2396 | 0.2396 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.012 | 0.2415 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0702 | 0.0702 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0154 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.3542 | 0.3542 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0154 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0154 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.065 | 0.065 |
Loa Loa (eye worm) | carboxylesterase | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1078 | 0.1078 |
Echinococcus multilocularis | acetylcholinesterase | 0.0457 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.1462 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | HSF-type DNA-binding domain containing protein | 0.012 | 0.2415 | 0.2415 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.2396 | 0.2396 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4322 | 0.4322 |
Schistosoma mansoni | gliotactin | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1078 | 0.1078 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0077 | 0.1462 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | carboxylesterase | 0.0077 | 0.1462 | 0.1462 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0154 | 0.0154 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4623 | 0.4623 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0077 | 0.1462 | 1 |
Onchocerca volvulus | 0.0077 | 0.1462 | 0.3162 | |
Brugia malayi | Carboxylesterase family protein | 0.0457 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0.1462 | 0.3162 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.0077 | 0.1462 | 0.3162 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0457 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0051 | 0.0872 | 0.0872 |
Onchocerca volvulus | Heat shock factor protein 2 homolog | 0.012 | 0.2415 | 0.5225 |
Echinococcus multilocularis | acetylcholinesterase | 0.0457 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0051 | 0.0872 | 0.0872 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.2396 | 0.2396 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0077 | 0.1462 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4322 | 0.4322 |
Echinococcus granulosus | acetylcholinesterase | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 0.4623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0872 | 0.0872 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0457 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0077 | 0.1462 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0154 | 0.0154 |
Echinococcus granulosus | neuroligin | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.1462 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4322 | 0.4322 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Echinococcus granulosus | geminin | 0.0205 | 0.4322 | 0.4322 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.065 | 0.065 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0831 | 0.0831 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0154 | 0.0154 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0051 | 0.0872 | 0.0872 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0702 | 0.0702 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | carboxylesterase | 0.0457 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0154 | 0.5 |
Onchocerca volvulus | 0.0077 | 0.1462 | 0.3162 | |
Onchocerca volvulus | 0.0077 | 0.1462 | 0.3162 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0702 | 0.0702 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.0872 | 0.0872 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | Carboxylesterase family protein | 0.0077 | 0.1462 | 0.1462 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0154 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0831 | 0.0831 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0154 | 0.0154 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.2396 | 0.9889 |
Brugia malayi | N-terminal motif family protein | 0.0218 | 0.4623 | 0.4623 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0051 | 0.0872 | 0.0872 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0154 | 0.0154 |
Echinococcus multilocularis | neuroligin | 0.0077 | 0.1462 | 0.1462 |
Brugia malayi | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.2234 | 0.2234 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0077 | 0.1462 | 0.1462 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.012 | 0.2415 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0702 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0154 | 0.0154 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.012 | 0.2415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.2396 | 0.2396 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.2234 | 0.2234 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0457 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0702 | 0.0702 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0077 | 0.1462 | 0.1462 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0.1462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0051 | 0.0872 | 0.0872 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0154 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.065 | 0.065 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0077 | 0.1462 | 0.1462 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0077 | 0.1462 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.113 | 0.113 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2415 | 0.2415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.