Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2218 | 0.2518 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0614 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2218 | 0.2518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3096 | 0.3096 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0002 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3096 | 0.3515 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0032 | 0.0037 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1191 | 0.1353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3096 | 0.3096 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3096 | 0.3515 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2218 | 0.2518 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1191 | 0.1191 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3096 | 0.3515 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3096 | 0.3515 |
Brugia malayi | hypothetical protein | 0.003 | 0.0614 | 0.0697 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3096 | 0.3096 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0614 | 0.0697 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3096 | 0.3096 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1191 | 0.1353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3096 | 0.3096 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3096 | 0.3096 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2218 | 0.2518 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0614 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3096 | 0.3515 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.8806 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0614 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6742 | 0.7656 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6742 | 0.7656 |
Onchocerca volvulus | 0.0182 | 0.8806 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6742 | 0.7656 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0614 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3096 | 0.3515 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0182 | 0.8806 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.286 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1554, AID1674] | ChEMBL. | No reference |
EC50 (functional) | = 0.575 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | = 5.115 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | = 31.535 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 0.3548 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.1582 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.