Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0611 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0611 | 0.0814 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0611 | 0.0611 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0611 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0092 | 0.034 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0285 | 0.3721 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0403 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0285 | 0.0285 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0611 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0611 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.002 | 0.0039 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0553 | 0.205 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0611 | 0.2266 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0611 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.002 | 0.0039 | 0.0039 |
Schistosoma mansoni | dep domain containing protein | 0.002 | 0.0039 | 0.0144 |
Schistosoma mansoni | dishevelled | 0.002 | 0.0039 | 0.0144 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.002 | 0.0039 | 0.0144 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.002 | 0.0039 | 0.0144 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.002 | 0.0039 | 0.0144 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.002 | 0.0039 | 0.0039 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0092 | 0.0092 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0611 | 0.0814 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0611 | 0.0611 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.002 | 0.0039 | 0.0039 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0285 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0611 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0122 | 0.2698 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0122 | 0.2698 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.2698 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.2698 | 1 |
Brugia malayi | hypothetical protein | 0.0122 | 0.2698 | 0.2698 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0611 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0611 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.002 | 0.0039 | 0.0039 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.002 | 0.0039 | 0.0144 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.002 | 0.0039 | 0.0144 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0285 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0611 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2698 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0611 | 0.0814 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0611 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0039 | 0.0039 |
Schistosoma mansoni | dishevelled | 0.002 | 0.0039 | 0.0144 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0092 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0285 | 0.3721 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0092 | 0.0092 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.002 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0611 | 0.0814 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.002 | 0.0039 | 0.0144 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.002 | 0.0039 | 0.0144 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.002 | 0.0039 | 0.0144 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.002 | 0.0039 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0611 | 0.0814 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0611 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.103 | 0.103 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0285 | 0.3721 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0611 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0092 | 0.034 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0611 | 0.2266 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0285 | 0.3721 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0039 | 0.0144 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0611 | 0.0814 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0611 | 0.0814 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0611 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0611 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0611 | 0.0814 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0092 | 0.034 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0611 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0015 | 0.0015 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0611 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0611 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0611 | 0.0814 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0611 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.103 | 0.103 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0285 | 0.4299 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0611 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.002 | 0.0039 | 0.0039 |
Schistosoma mansoni | z-protein (S1r protein) | 0.002 | 0.0039 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0611 | 0.2266 |
Onchocerca volvulus | 0.0042 | 0.0611 | 0.0575 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0611 | 0.0611 |
Brugia malayi | hypothetical protein | 0.002 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0611 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0611 | 0.0611 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0611 | 0.0611 |
Brugia malayi | hypothetical protein | 0.002 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0042 | 0.0611 | 0.0575 | |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0092 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0553 | 0.0553 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.2698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0092 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0039 | 0.0039 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0611 | 0.2266 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0611 | 0.0814 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0122 | 0.2698 | 1 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.002 | 0.0039 | 0.0144 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.6474 | 1 |
Onchocerca volvulus | 0.0042 | 0.0611 | 0.0575 | |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0092 | 0.092 |
Entamoeba histolytica | hypothetical protein | 0.0122 | 0.2698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0611 | 0.0611 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0285 | 0.3721 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0092 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0553 | 0.0553 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.103 | 0.103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.