TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 513.975 | Formula: C28H24ClN5O3
H donors: 0 H acceptors: 3 LogP: 4.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc(c1)c1cc(N2CCN(CC2)C(=O)c2cocc2)n2c(n1)cc(n2)c1cccc(c1)Cl
InChi: 1S/C28H24ClN5O3/c1-36-23-7-3-5-20(15-23)24-17-27(32-9-11-33(12-10-32)28(35)21-8-13-37-18-21)34-26(30-24)16-25(31-34)19-4-2-6-22(29)14-19/h2-8,13-18H,9-12H2,1H3
InChiKey: YKIPCRAQHJHAKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0004	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.7068	0.7068
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.1207	1
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1207	0.1207
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Giardia lamblia	MRP-like ABC transporter	0.0004	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0004	0	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.7068	0.7068
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1207	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0013	0.1207	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0004	0	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1207	1
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0004	0	0.5
Brugia malayi	multidrug resistance protein 3	0.0013	0.1207	0.1207
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0013	0.1207	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Echinococcus granulosus	tar DNA binding protein	0.0076	1	1
Entamoeba histolytica	P-glycoprotein-5	0.0013	0.1207	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0013	0.1187	0.1187
Entamoeba histolytica	P-glyco protein 6, putative	0.0013	0.1207	1
Trypanosoma brucei	p-glycoprotein	0.0004	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.7068	0.7068
Trypanosoma brucei	multidrug resistance protein E	0.0004	0	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0676	0.0676
Trichomonas vaginalis	abcb9, putative	0.0013	0.1207	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0676	0.0676
Loa Loa (eye worm)	RNA binding protein	0.0076	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0013	0.1207	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1207	1
Entamoeba histolytica	P-glycoprotein-2	0.0013	0.1207	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Brugia malayi	TAR-binding protein	0.0076	1	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0013	0.1207	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.7068	0.7068
Loa Loa (eye worm)	TAR-binding protein	0.0076	1	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0013	0.1207	0.1207
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1207	1
Entamoeba histolytica	P-glycoprotein-2	0.0013	0.1207	1
Entamoeba histolytica	P-glycoprotein-1	0.0013	0.1207	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0013	0.1207	0.1207
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0004	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1207	0.1207
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0004	0	0.5
Trichomonas vaginalis	abcb9, putative	0.0013	0.1207	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.7068	0.7068
Plasmodium falciparum	multidrug resistance protein 1	0.0013	0.1207	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0004	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1207	0.1207
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0013	0.1207	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0013	0.1207	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0004	0	0.5
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1207	0.1207
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1207	0.1207
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1207	1
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0004	0	0.5
Giardia lamblia	ABC transporter, putative	0.0004	0	0.5
Leishmania major	p-glycoprotein	0.0013	0.1207	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1187	0.1187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.7068	0.7068
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1207	1
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0004	0	0.5
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0004	0	0.5
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1207	0.1207
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1207	0.1207
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.1207	0.1207
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1207	0.1207
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0004	0	0.5
Trichomonas vaginalis	abcb9, putative	0.0013	0.1207	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0013	0.1207	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.7068	0.7068
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0009	0.0676	0.5606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.7068	0.7068
Brugia malayi	RNA recognition motif domain containing protein	0.0076	1	1
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1207	0.1207
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.1207	1
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1207	0.1207
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0013	0.1207	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1207	1
Schistosoma mansoni	smdr2	0.0013	0.1207	0.1207
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0013	0.1187	0.1187
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0004	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1207	1
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1207	0.1207
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0004	0	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1207	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1207	0.1207
Giardia lamblia	Multidrug resistance-associated protein 1	0.0004	0	0.5
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1207	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1207	0.1207
Echinococcus multilocularis	tar DNA binding protein	0.0076	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0004	0	0.5
Echinococcus multilocularis	multidrug resistance protein 1	0.0009	0.0676	0.0676
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1207	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1207	0.1207
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1207	0.1207
Trichomonas vaginalis	taga, putative	0.0013	0.1207	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1207	0.1207
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.1207	0.1207
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1207	0.1207
Brugia malayi	ABC transporter family protein	0.0013	0.1207	0.1207
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.7068	0.7068
Onchocerca volvulus		0.0013	0.1207	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	0.76 uM	PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen. Follow-up assay on set 2. (Class of assay: confirmatory)	ChEMBL.	No reference
EC50 (functional)	2.89 uM	PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. Follow-up assay for Set 2. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1998498

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1673253