Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0036 | 0.6325 | 0.6174 |
Echinococcus multilocularis | lamin | 0.0027 | 0.3843 | 0.4263 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.1953 | 0.1493 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.1953 | 0.1493 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.1953 | 0.1953 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.1953 | 0.1493 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.1953 | 0.2167 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.1953 | 0.1493 |
Echinococcus multilocularis | musashi | 0.0027 | 0.3843 | 0.4263 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.1953 | 0.1493 |
Onchocerca volvulus | 0.0027 | 0.3843 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.1953 | 0.1623 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5702 | 0.6009 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.1953 | 0.2167 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.9014 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.3843 | 0.377 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.1953 | 0.1493 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.9014 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.3843 | 0.4263 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.3843 | 0.3843 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.3843 | 0.359 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0714 | 0.0792 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.6325 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.1953 | 0.1623 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.6325 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.1953 | 0.1493 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.1953 | 0.2167 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.1953 | 0.1623 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3843 | 0.3843 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.1953 | 0.2167 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.1953 | 0.2167 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.1953 | 0.1493 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.1953 | 0.2167 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.6325 | 0.7016 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.1953 | 0.1623 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0714 | 0.0332 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.3843 | 0.4263 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.1953 | 0.1953 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.9014 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.6325 | 0.7016 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.1953 | 0.2167 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0714 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.1953 | 0.1623 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.1953 | 0.2167 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.9014 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.1953 | 0.2167 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0714 | 0.0714 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.1953 | 0.1623 |
Onchocerca volvulus | 0.0027 | 0.3843 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.6325 | 0.676 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.1953 | 0.1953 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.1953 | 0.1493 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.3843 | 0.359 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.1953 | 0.1953 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.6325 | 0.676 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5702 | 0.5702 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.1953 | 0.1623 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.1953 | 0.2167 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.1953 | 0.2167 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.1953 | 0.2167 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.1953 | 0.2167 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0714 | 0.0792 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.9014 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3707 | 0.3707 |
Schistosoma mansoni | lamin | 0.0027 | 0.3843 | 0.377 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.1953 | 0.1493 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.1953 | 0.1623 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.1953 | 0.2167 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.1953 | 0.1493 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0714 | 0.0792 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.1953 | 0.1953 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.9014 | 0.8974 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.6325 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.1953 | 0.1623 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.1953 | 0.2167 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.1953 | 0.2167 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.3843 | 0.3843 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0714 | 0.0792 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.9014 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.1953 | 0.1623 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.1953 | 0.2167 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.3843 | 0.4263 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.1953 | 0.1953 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.1953 | 0.2167 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.1953 | 0.1953 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0714 | 0.0792 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.1953 | 0.1623 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.1953 | 0.1493 |
Schistosoma mansoni | lamin | 0.0027 | 0.3843 | 0.377 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.1953 | 0.1623 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.5702 | 0.5525 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0714 | 0.0332 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.1953 | 0.1623 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.3843 | 0.4263 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.1953 | 0.1623 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.1953 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1953 | 0.1953 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.1953 | 0.1493 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.6325 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.9014 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.9014 | 0.9014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.441 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.